TTLL2 (tubulin tyrosine ligase like 2)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 83887
• Gene name: Tubulin tyrosine ligase like 2
• Gene symbol: TTLL2
• Synonyms (NCBI Gene): C6orf104, NYD-TSPG, dJ366N23.3
• Chromosome: 6
• Chromosome location: 6q27

miRNA Show/Hide all (21)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1462388	hsa-miR-19a	CLIP-seq
MIRT1462389	hsa-miR-19b	CLIP-seq
MIRT1462390	hsa-miR-3920	CLIP-seq
MIRT1462391	hsa-miR-3922-5p	CLIP-seq
MIRT1462392	hsa-miR-4504	CLIP-seq
MIRT1462393	hsa-miR-4753-5p	CLIP-seq
MIRT1462394	hsa-miR-498	CLIP-seq
MIRT1462395	hsa-miR-522	CLIP-seq
MIRT2359796	hsa-miR-30a	CLIP-seq
MIRT2359797	hsa-miR-30b	CLIP-seq
MIRT2359798	hsa-miR-30c	CLIP-seq
MIRT2359799	hsa-miR-30d	CLIP-seq
MIRT2359800	hsa-miR-30e	CLIP-seq
MIRT2653096	hsa-miR-1246	CLIP-seq
MIRT2653097	hsa-miR-1290	CLIP-seq
MIRT2653098	hsa-miR-3134	CLIP-seq
MIRT2653099	hsa-miR-3140-3p	CLIP-seq
MIRT2653100	hsa-miR-3167	CLIP-seq
MIRT2653101	hsa-miR-4534	CLIP-seq
MIRT2653102	hsa-miR-4686	CLIP-seq
MIRT2653103	hsa-miR-876-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000226	Process	Microtubule cytoskeleton organization	IBA
GO:0005515	Function	Protein binding	IPI	28514442, 33961781
GO:0005524	Function	ATP binding	IEA
GO:0015631	Function	Tubulin binding	IBA
GO:0016874	Function	Ligase activity	IEA
GO:0036064	Component	Ciliary basal body	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0070740	Function	Tubulin-glutamic acid ligase activity	IBA

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BWV7
• Protein name: Probable tubulin polyglutamylase TTLL2 (EC 6.-.-.-) (Testis-specific protein NYD-TSPG) (Tubulin--tyrosine ligase-like protein 2)
• Protein function: Probable tubulin polyglutamylase that generates side chains of glutamate on the gamma-carboxyl group of specific glutamate residues within the C-terminal tail of target proteins (By similarity). Similar to TTLL1, may acquire enzymatic activity o
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03133	TTL	131 → 423	Tubulin-tyrosine ligase family	Family

• Tissue specificity: TISSUE SPECIFICITY: Testis. {ECO:0000305|Ref.1}.
• Sequence:

  MRGRDLCSSTQSQALGSLRTTTPAFTLNIPSEANHTEQPPAGLGARLQEAGVSIPPRRGR
  PTPTLEKKKKPHLMAEDEPSGALLKPLVFRVDETTPAVVQSVLLERGWNKFDKQEQNAED
  WNLYWRTSSFRMTEHNSVKPWQQLNHHPGTTKLTRKDCLAKHLKHMRRMYGTSLYQFIPL
  TFVMPNDYTKFVAEYFQERQMLGTKHSYWICKPAELSRGRGILIFSDFKDFIFDDMYIVQ
  KYISNPLLIGRYKCDLRIYVCVTGFKPLTIYVYQEGLVRFATEKFDLSNLQNNYAHLTNS
  SINKSGASYEKIKEVIGHGCKWTLSRFFSYLRSWDVDDLLLWKKIHRMVILTILAIAPSV
  PFAANCFELFGFDILIDDNLKPWLLEVNYSPALTLDCSTDVLVKRKLVHDIIDLIYLNGL
  RNEGREASNATHGNSNIDAAKSDRGGLDAPDCLPYDSLSFTSRMYNEDDSVVEKAVSVRP
  EAAPASQLEGEMSGQDFHLSTREMPQSKPKLRSRHTPHKTLMPYASLFQSHSCKTKTSPC
  VLSDRGKAPDPQAGNFVLVFPFNEATLGASRNGLNVKRIIQELQKLMNKQHS

• Sequence length: 592

Pathways

Reactome Pathway:

Carboxyterminal post-translational modifications of tubulin

Related Genes

No strongly related genes found yet for TTLL2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TTLL2.