Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	55001
Gene name	Tetratricopeptide repeat domain 22
Gene symbol	TTC22
Synonyms (NCBI Gene)	-
Chromosome	1
Chromosome location	1p32.3
Summary	This gene encodes a protein with seven tetratricopeptide (TPR) repeats. Tetratricopeptide repeat containing motifs are found in a variety of proteins and may mediate protein-protein interactions and chaperone activity. Alternatively spliced transcript var

32 Show/Hide all (32)

miRTarBase ID	miRNA	Experiments	Reference
MIRT052423	hsa-let-7a-5p	CLASH	23622248
MIRT528543	hsa-miR-6858-3p	PAR-CLIP	22012620
MIRT528542	hsa-miR-4676-5p	PAR-CLIP	22012620
MIRT528541	hsa-miR-575	PAR-CLIP	22012620
MIRT528540	hsa-miR-4650-5p	PAR-CLIP	22012620
MIRT528539	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT528538	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT528543	hsa-miR-6858-3p	PAR-CLIP	22012620
MIRT528542	hsa-miR-4676-5p	PAR-CLIP	22012620
MIRT528541	hsa-miR-575	PAR-CLIP	22012620
MIRT528540	hsa-miR-4650-5p	PAR-CLIP	22012620
MIRT528539	hsa-miR-4755-3p	PAR-CLIP	22012620
MIRT528538	hsa-miR-4662a-5p	PAR-CLIP	22012620
MIRT1461059	hsa-miR-1827	CLIP-seq
MIRT1461060	hsa-miR-3612	CLIP-seq
MIRT1461061	hsa-miR-380	CLIP-seq
MIRT1461062	hsa-miR-4459	CLIP-seq
MIRT1461063	hsa-miR-4690-5p	CLIP-seq
MIRT1461064	hsa-miR-4695-5p	CLIP-seq
MIRT1461065	hsa-miR-4722-5p	CLIP-seq
MIRT1461066	hsa-miR-621	CLIP-seq
MIRT1461067	hsa-miR-650	CLIP-seq
MIRT2359406	hsa-miR-218	CLIP-seq
MIRT2359407	hsa-miR-3663-5p	CLIP-seq
MIRT2359408	hsa-miR-4318	CLIP-seq
MIRT2359409	hsa-miR-4663	CLIP-seq
MIRT2359410	hsa-miR-4693-5p	CLIP-seq
MIRT2359411	hsa-miR-4728-3p	CLIP-seq
MIRT2359412	hsa-miR-550b	CLIP-seq
MIRT2359413	hsa-miR-622	CLIP-seq
MIRT2359414	hsa-miR-636	CLIP-seq
MIRT2359415	hsa-miR-892a	CLIP-seq

MIM	HGNC	e!Ensembl
HGNC	N/A	HGNC

Protein Protein information from UniProt database. Download as csv Download as pdf
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.	Q5TAA0
Protein name	Tetratricopeptide repeat protein 22 (TPR repeat protein 22)
Family and domains
Sequence	MAELEAVADDLDALIDDLDYLPGHFHLEMQLNFEPRSPAPQRARDLKLQREGLRQELQLA AAPQRPAVRHLLGAFAFYLEELDEARECFLEVAHEHPGNLNAWANLAHVYGRLGQEEEEE ACAARLADLMGLAEEPEAAGDPQLRAARCLAEQGYAHGFDVGCASPEERARGLAAGIALY DKALGYGQQIPMEEKRGWYFTMATLYIRLDGIFLELGSEEQKRLPAFNRTLALLRQVLKS EDPRHRALAWCYLGMLLERKDTFSTTPMGVHDCGYSGTDPLDCFGKAIEIAKNQPPILNR LAKIFYFLGKQDMAIGTCNMALDVLRDPELNWQAYCTRAKIHIRAYLHDLKRAKMGLGGM PDRNHLACAKADLEEVVRVCPGFKAYLDIGQVYYYMGVDAVQELLAVDEAALNQALVFLA KAGESELGATLPELQLLRGKCLRIKGEDANAAACFKRAVELDDAGSSHTDGFGCLLEALL AQWSQAQLSDGELGREVDAWLRRAQDKYPAARLRQELQRVWRGHTDEVLGLARALVAQGR PALVRLLFETMEREGEGASAPRDRRAVSF
Sequence length	569
Interactions	View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
COLORECTAL ADENOMA	—	GWAS catalog	30510241	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
COLORECTAL CANCER	—	GWAS catalog	30510241, 31089142, 36539618, 38872215	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
EBV-positive nodal T- and NK-cell lymphoma	Likely benign	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining Show/Hide Text Mining Associations (9)
Adenocarcinoma of large intestine	Colorectal Cancer	GWASCAT_DG	30510241, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Adenoma of large intestine	Colorectal adenoma	GWASCAT_DG	30510241		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colon Carcinoma	Colon Carcinoma	BEFREE	30664167		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	GWASCAT_DG	30510241, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal Neoplasms	GWASCAT_DG	30510241, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	30664167	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of large intestine	Colorectal Neoplasms	GWASCAT_DG	30510241, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	GWASCAT_DG	30510241, 31089142		★★★★★ ★☆☆☆☆ Found in Text Mining only
Malignant tumor of colon	Colonic Neoplasms	BEFREE	30664167		★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Genes Genes most often co-reported with TTC22 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for TTC22.

Diseases Linked via Similar Genes Diseases curated for genes most similar to TTC22 (see Related Genes above), that are NOT already directly curated for TTC22 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to TTC22.

TTC22 (tetratricopeptide repeat domain 22)

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