TSSK1B (testis specific serine kinase 1B)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 83942
• Gene name: Testis specific serine kinase 1B
• Gene symbol: TSSK1B
• Synonyms (NCBI Gene): FKSG81, SPOGA4, STK22D, TSK1, TSSK1
• Chromosome: 5
• Chromosome location: 5q22.2
• Summary: TSSK1 belongs to a family of serine/threonine kinases highly expressed in testis (Hao et al., 2004 [PubMed 15044604]).[supplied by OMIM, Mar 2008]

miRNA Show/Hide all (49)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1460580	hsa-miR-1206	CLIP-seq
MIRT1460581	hsa-miR-1236	CLIP-seq
MIRT1460582	hsa-miR-1275	CLIP-seq
MIRT1460583	hsa-miR-302a	CLIP-seq
MIRT1460584	hsa-miR-302b	CLIP-seq
MIRT1460585	hsa-miR-302c	CLIP-seq
MIRT1460586	hsa-miR-302d	CLIP-seq
MIRT1460587	hsa-miR-302e	CLIP-seq
MIRT1460588	hsa-miR-3074-5p	CLIP-seq
MIRT1460589	hsa-miR-3148	CLIP-seq
MIRT1460590	hsa-miR-3161	CLIP-seq
MIRT1460591	hsa-miR-326	CLIP-seq
MIRT1460592	hsa-miR-330-5p	CLIP-seq
MIRT1460593	hsa-miR-3667-3p	CLIP-seq
MIRT1460594	hsa-miR-3691-3p	CLIP-seq
MIRT1460595	hsa-miR-370	CLIP-seq
MIRT1460596	hsa-miR-372	CLIP-seq
MIRT1460597	hsa-miR-373	CLIP-seq
MIRT1460598	hsa-miR-4297	CLIP-seq
MIRT1460599	hsa-miR-4525	CLIP-seq
MIRT1460600	hsa-miR-4665-5p	CLIP-seq
MIRT1460601	hsa-miR-4667-5p	CLIP-seq
MIRT1460602	hsa-miR-4700-5p	CLIP-seq
MIRT1460603	hsa-miR-4723-5p	CLIP-seq
MIRT1460604	hsa-miR-4729	CLIP-seq
MIRT1460605	hsa-miR-4796-5p	CLIP-seq
MIRT1460606	hsa-miR-520a-3p	CLIP-seq
MIRT1460607	hsa-miR-520b	CLIP-seq
MIRT1460608	hsa-miR-520c-3p	CLIP-seq
MIRT1460609	hsa-miR-520d-3p	CLIP-seq
MIRT1460610	hsa-miR-520e	CLIP-seq
MIRT1460611	hsa-miR-625	CLIP-seq
MIRT1460612	hsa-miR-637	CLIP-seq
MIRT2138320	hsa-miR-4314	CLIP-seq
MIRT2359200	hsa-miR-3150a-3p	CLIP-seq
MIRT2359201	hsa-miR-3175	CLIP-seq
MIRT2359202	hsa-miR-3182	CLIP-seq
MIRT2359203	hsa-miR-342-5p	CLIP-seq
MIRT2138320	hsa-miR-4314	CLIP-seq
MIRT2359204	hsa-miR-4659a-3p	CLIP-seq
MIRT2359205	hsa-miR-4659b-3p	CLIP-seq
MIRT2359206	hsa-miR-4664-5p	CLIP-seq
MIRT1460601	hsa-miR-4667-5p	CLIP-seq
MIRT1460602	hsa-miR-4700-5p	CLIP-seq
MIRT2359207	hsa-miR-4731-5p	CLIP-seq
MIRT1460612	hsa-miR-637	CLIP-seq
MIRT2359208	hsa-miR-939	CLIP-seq
MIRT2462535	hsa-miR-4688	CLIP-seq
MIRT2462536	hsa-miR-4757-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0000287	Function	Magnesium ion binding	IDA	15733851
GO:0000287	Function	Magnesium ion binding	IEA
GO:0001669	Component	Acrosomal vesicle	IEA
GO:0004672	Function	Protein kinase activity	IEA
GO:0004674	Function	Protein serine/threonine kinase activity	IBA
GO:0004674	Function	Protein serine/threonine kinase activity	IDA	15733851, 19530700
GO:0004674	Function	Protein serine/threonine kinase activity	IEA
GO:0005515	Function	Protein binding	IPI	22939624, 25416956, 32296183, 32707033, 36931259
GO:0005524	Function	ATP binding	IDA	15733851
GO:0005524	Function	ATP binding	IEA
GO:0005737	Component	Cytoplasm	IEA
GO:0005929	Component	Cilium	IEA
GO:0006468	Process	Protein phosphorylation	IDA	15733851
GO:0007283	Process	Spermatogenesis	IEA
GO:0007286	Process	Spermatid development	IBA
GO:0007286	Process	Spermatid development	IEA
GO:0007286	Process	Spermatid development	ISS
GO:0016301	Function	Kinase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0030154	Process	Cell differentiation	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0031514	Component	Motile cilium	IEA
GO:0031514	Component	Motile cilium	ISS
GO:0042995	Component	Cell projection	IEA
GO:0044877	Function	Protein-containing complex binding	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0106310	Function	Protein serine kinase activity	IEA

Other IDs

• MIM: 610709
• HGNC: 14968
• e!Ensembl: ENSG00000212122

Protein

• UniProt ID: Q9BXA7
• Protein name: Testis-specific serine/threonine-protein kinase 1 (TSK-1) (TSK1) (TSSK-1) (Testis-specific kinase 1) (EC 2.7.11.1) (Serine/threonine-protein kinase 22A)
• Protein function: Testis-specific serine/threonine-protein kinase required during spermatid development. Phosphorylates 'Ser-288' of TSKS. Involved in the late stages of spermatogenesis, during the reconstruction of the cytoplasm. During spermatogenesis, required
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00069	Pkinase	12 → 272	Protein kinase domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Testis-specific. Present in sperm (at protein level). {ECO:0000269|PubMed:15044604, ECO:0000269|PubMed:20729278}.
• Sequence:

  MDDAAVLKRRGYLLGINLGEGSYAKVKSAYSERLKFNVAIKIIDRKKAPADFLEKFLPRE
  IEILAMLNHCSIIKTYEIFETSHGKVYIVMELAVQGDLLELIKTRGALHEDEARKKFHQL
  SLAIKYCHDLDVVHRDLKCDNLLLDKDFNIKLSDFSFSKRCLRDDSGRMALSKTFCGSPA
  YAAPEVLQGIPYQPKVYDIWSLGVILYIMVCGSMPYDDSNIKKMLRIQKEHRVNFPRSKH
  LTGECKDLIYHMLQPDVNRRLHIDEILSHCWMQPKARGSPSVAINKEGESSRGTEPLWTP
  EPGSDKKSATKLEPEGEAQPQAQPETKPEGTAMQMSRQSEILGFPSKPSTMETEEGPPQQ
  PPETRAQ

• Sequence length: 367

Related Genes

No strongly related genes found yet for TSSK1B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TSSK1B.