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Gene Gene information from NCBI Gene database.
Entrez ID 7247
Gene name Translin
Gene symbol TSN
Synonyms (NCBI Gene)
BCLF-1C3PORCHF1REHF-1TBRBPTRSLN
Chromosome 2
Chromosome location 2q14.3
Summary This gene encodes a DNA-binding protein which specifically recognizes conserved target sequences at the breakpoint junction of chromosomal translocations. Translin polypeptides form a multimeric structure that is responsible for its DNA-binding activity.
miRNA miRNA information provided by mirtarbase database.
610 Show/Hide all (610)
miRTarBase ID miRNA Experiments Reference
MIRT022293 hsa-miR-124-3p Microarray 18668037
MIRT025313 hsa-miR-34a-5p Proteomics 21566225
MIRT025673 hsa-miR-7-5p Microarray 19073608
MIRT027952 hsa-miR-93-5p Sequencing 20371350
MIRT046853 hsa-miR-221-3p CLASH 23622248
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
26 Show/Hide all (26)
GO ID Ontology Definition Evidence Reference
GO:0001673 Component Male germ cell nucleus IEA
GO:0003676 Function Nucleic acid binding IEA
GO:0003677 Function DNA binding IEA
GO:0003677 Function DNA binding TAS 7663511
GO:0003697 Function Single-stranded DNA binding IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
600575 12379 ENSG00000211460
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q15631
Protein name Translin (EC 3.1.-.-) (Component 3 of promoter of RISC) (C3PO)
Protein function DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends gener
PDB 1J1J , 3PJA , 3QB5 , 4WYV
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01997 Translin 19 → 216 Translin family Family
Sequence
Sequence length 228
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Small interfering RNA (siRNA) biogenesis