TSIX (TSIX transcript, XIST antisense RNA)

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Gene Transcription factors Other IDs Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9383
• Gene name: TSIX transcript, XIST antisense RNA
• Gene symbol: TSIX
• Synonyms (NCBI Gene): LINC00013, NCRNA00013, XIST-AS, XIST-AS1, XISTAS
• Chromosome: X
• Chromosome location: Xq13.2
• Summary: In mammals, dosage compensation of genes on the X chromosome occurs by X inactivation, which is regulated in cis by the X-inactivation center (XIC) and expression of the XIST non-coding RNA. This gene expresses a non-coding antisense transcript across the

Transcription factors

Transcription factor	Regulation	Reference
YY1	Unknown	18458536

Other IDs

• MIM: 300181
• HGNC: 12377
• e!Ensembl: ENSG00000270641

Interactions View interactions

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
TSIX-related disorder	Likely benign; Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (19)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Asthma	Asthma	Pubtator	33998076	Associate	★☆☆☆☆ Found in Text Mining only
Congestive heart failure	Congestive Heart Failure	BEFREE	30605239		★☆☆☆☆ Found in Text Mining only
Conventional (Clear Cell) Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30717973		★☆☆☆☆ Found in Text Mining only
Fibroid Tumor	Leiomyoma	BEFREE	28587571		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	31680298		★☆☆☆☆ Found in Text Mining only
Heart failure	Heart Failure	BEFREE	30605239		★☆☆☆☆ Found in Text Mining only
Heart Failure	Heart failure	Pubtator	35346191	Associate	★☆☆☆☆ Found in Text Mining only
Hydatidiform Mole	Hydatidiform mole	Pubtator	33021557	Associate	★☆☆☆☆ Found in Text Mining only
Hypertension	Hypertension	Pubtator	34987319	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	28587571, 31004302, 31049832		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	29577911		★☆☆☆☆ Found in Text Mining only
Myocardial Infarction	Myocardial infarction	Pubtator	33083450	Associate	★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	27501756		★☆☆☆☆ Found in Text Mining only
Osteosarcoma	Osteosarcoma	BEFREE	28682435		★☆☆☆☆ Found in Text Mining only
Renal Cell Carcinoma	Renal Carcinoma	BEFREE	30717973		★☆☆☆☆ Found in Text Mining only
Scleroderma	Scleroderma	BEFREE	26566700		★☆☆☆☆ Found in Text Mining only
Sleep Apnea Obstructive	Sleep apnea	Pubtator	34987319	Associate	★☆☆☆☆ Found in Text Mining only
Systemic Scleroderma	Scleroderma	BEFREE	26566700		★☆☆☆☆ Found in Text Mining only
Uterine Fibroids	Uterine Fibroids	BEFREE	28587571		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for TSIX.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TSIX.