TRPM5 (transient receptor potential cation channel subfamily M member 5)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 29850
• Gene name: Transient receptor potential cation channel subfamily M member 5
• Gene symbol: TRPM5
• Synonyms (NCBI Gene): LTRPC5, MTR1
• Chromosome: 11
• Chromosome location: 11p15.5
• Summary: This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics

miRNA Show/Hide all (26)

miRTarBase ID	miRNA	Experiments	Reference
MIRT036399	hsa-miR-1227-3p	CLASH	23622248
MIRT1457331	hsa-miR-1193	CLIP-seq
MIRT1457332	hsa-miR-1207-5p	CLIP-seq
MIRT1457333	hsa-miR-1909	CLIP-seq
MIRT1457334	hsa-miR-2278	CLIP-seq
MIRT1457335	hsa-miR-4435	CLIP-seq
MIRT1457336	hsa-miR-4736	CLIP-seq
MIRT1457337	hsa-miR-4758-3p	CLIP-seq
MIRT1457338	hsa-miR-4763-3p	CLIP-seq
MIRT1457339	hsa-miR-4782-5p	CLIP-seq
MIRT1457340	hsa-miR-622	CLIP-seq
MIRT1457341	hsa-miR-646	CLIP-seq
MIRT1457342	hsa-miR-663b	CLIP-seq
MIRT2357949	hsa-miR-3150b-3p	CLIP-seq
MIRT2357950	hsa-miR-4689	CLIP-seq
MIRT2357951	hsa-miR-4784	CLIP-seq
MIRT1457342	hsa-miR-663b	CLIP-seq
MIRT2357949	hsa-miR-3150b-3p	CLIP-seq
MIRT1457335	hsa-miR-4435	CLIP-seq
MIRT2357950	hsa-miR-4689	CLIP-seq
MIRT2357951	hsa-miR-4784	CLIP-seq
MIRT2357949	hsa-miR-3150b-3p	CLIP-seq
MIRT1457335	hsa-miR-4435	CLIP-seq
MIRT2357950	hsa-miR-4689	CLIP-seq
MIRT2357951	hsa-miR-4784	CLIP-seq
MIRT1457342	hsa-miR-663b	CLIP-seq

Gene ontology (GO) Show/Hide all (34)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005216	Function	Monoatomic ion channel activity	IDA	14634208
GO:0005216	Function	Monoatomic ion channel activity	IEA
GO:0005216	Function	Monoatomic ion channel activity	TAS	10607831
GO:0005227	Function	Calcium-activated cation channel activity	IBA
GO:0005227	Function	Calcium-activated cation channel activity	IDA	14634208
GO:0005227	Function	Calcium-activated cation channel activity	IEA
GO:0005267	Function	Potassium channel activity	IEA
GO:0005272	Function	Sodium channel activity	IDA	14634208
GO:0005272	Function	Sodium channel activity	IEA
GO:0005272	Function	Sodium channel activity	TAS
GO:0005509	Function	Calcium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS
GO:0006811	Process	Monoatomic ion transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0016020	Component	Membrane	TAS	10607831
GO:0030001	Process	Metal ion transport	IBA
GO:0030425	Component	Dendrite	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034220	Process	Monoatomic ion transmembrane transport	IEA
GO:0034702	Component	Monoatomic ion channel complex	IEA
GO:0035725	Process	Sodium ion transmembrane transport	IEA
GO:0035774	Process	Positive regulation of insulin secretion involved in cellular response to glucose stimulus	IEA
GO:0042802	Function	Identical protein binding	ISS
GO:0043025	Component	Neuronal cell body	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046873	Function	Metal ion transmembrane transporter activity	IEA
GO:0055085	Process	Transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	IEA
GO:0070588	Process	Calcium ion transmembrane transport	TAS
GO:0071805	Process	Potassium ion transmembrane transport	IEA
GO:0098655	Process	Monoatomic cation transmembrane transport	IBA

Other IDs

• MIM: 604600
• HGNC: 14323
• e!Ensembl: ENSG00000070985

Protein

• UniProt ID: Q9NZQ8
• Protein name: Transient receptor potential cation channel subfamily M member 5 (Long transient receptor potential channel 5) (LTrpC-5) (LTrpC5) (MLSN1- and TRP-related gene 1 protein)
• Protein function: Monovalent cation-selective ion channel activated by intracellular Ca(2+) in a voltage- and temperature-dependent manner (PubMed:14634208). Mediates the transport of Na(+), K(+) and Cs(+) ions equally well (PubMed:14634208). Activated directly b
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00520	Ion_trans	738 → 990	Ion transport protein	Family
  PF18139	LSDAT_euk	38 → 289	SLOG in TRPM	Family

• Tissue specificity: TISSUE SPECIFICITY: Strongly expressed in fetal brain, liver and kidney, and in adult prostate, testis, ovary, colon and peripheral blood leukocytes. Also expressed in a large proportion of Wilms' tumors and rhabdomyosarcomas. In monochromosomal cell line
• Sequence:

  MQDVQGPRPGSPGDAEDRRELGLHRGEVNFGGSGKKRGKFVRVPSGVAPSVLFDLLLAEW
  HLPAPNLVVSLVGEEQPFAMKSWLRDVLRKGLVKAAQSTGAWILTSALRVGLARHVGQAV
  RDHSLASTSTKVRVVAVGMASLGRVLHRRILEEAQEDFPVHYPEDDGGSQGPLCSLDSNL
  SHFILVEPGPPGKGDGLTELRLRLEKHISEQRAGYGGTGSIEIPVLCLLVNGDPNTLERI
  SRAVEQAAPWLILVGSGGIADVLAALVNQPHLLVPKVAEKQFKEKFPSKHFSWEDIVRWT
  KLLQNITSHQHLLTVYDFEQEGSEELDTVILKALVKACKSHSQEPQDYLDELKLAVAWDR
  VDIAKSEIFNGDVEWKSCDLEEVMVDALVSNKPEFVRLFVDNGADVADFLTYGRLQELYR
  SVSRKSLLFDLLQRKQEEARLTLAGLGTQQAREPPAGPPAFSLHEVSRVLKDFLQDACRG
  FYQDGRPGDRRRAEKGPAKRPTGQKWLLDLNQKSENPWRDLFLWAVLQNRHEMATYFWAM
  GQEGVAAALAACKILKEMSHLETEAEAARATREAKYERLALDLFSECYSNSEARAFALLV
  RRNRCWSKTTCLHLATEADAKAFFAHDGVQAFLTRIWWGDMAAGTPILRLLGAFLCPALV
  YTNLITFSEEAPLRTGLEDLQDLDSLDTEKSPLYGLQSRVEELVEAPRAQGDRGPRAVFL
  LTRWRKFWGAPVTVFLGNVVMYFAFLFLFTYVLLVDFRPPPQGPSGPEVTLYFWVFTLVL
  EEIRQGFFTDEDTHLVKKFTLYVGDNWNKCDMVAIFLFIVGVTCRMLPSAFEAGRTVLAM
  DFMVFTLRLIHIFAIHKQLGPKIIVVERMMKDVFFFLFFLSVWLVAYGVTTQALLHPHDG
  RLEWIFRRVLYRPYLQIFGQIPLDEIDEARVNCSTHPLLLEDSPSCPSLYANWLVILLLV
  TFLLVTNVLLMNLLIAMFSYTFQVVQGNADMFWKFQRYNLIVEYHERPALAPPFILLSHL
  SLTLRRVFKKEAEHKREHLERDLPDPLDQKVVTWETVQKENFLSKMEKRRRDSEGEVLRK
  TAHRVDFIAKYLGGLREQEKRIKCLESQINYCSVLVSSVADVLAQGGGPRSSQHCGEGSQ
  LVAADHRGGLDGWEQPGAGQPPSDT

• Sequence length: 1165

Pathways

KEGG Pathway:

Taste transduction

Reactome Pathway:

TRP channels

Related Genes

No strongly related genes found yet for TRPM5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRPM5.