TRMT6 (tRNA methyltransferase 6 non-catalytic subunit)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51605
• Gene name: TRNA methyltransferase 6 non-catalytic subunit
• Gene symbol: TRMT6
• Synonyms (NCBI Gene): CGI-09, GCD10, Gcd10p, TRM6
• Chromosome: 20
• Chromosome location: 20p12.3
• Summary: This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladeno

miRNA Show/Hide all (80)

miRTarBase ID	miRNA	Experiments	Reference
MIRT465207	hsa-miR-153-5p	PAR-CLIP	23592263
MIRT465206	hsa-miR-1205	PAR-CLIP	23592263
MIRT465205	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT465204	hsa-miR-1286	PAR-CLIP	23592263
MIRT465203	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT465202	hsa-miR-8071	PAR-CLIP	23592263
MIRT465201	hsa-miR-3138	PAR-CLIP	23592263
MIRT465207	hsa-miR-153-5p	PAR-CLIP	23592263
MIRT465206	hsa-miR-1205	PAR-CLIP	23592263
MIRT465205	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT465204	hsa-miR-1286	PAR-CLIP	23592263
MIRT465203	hsa-miR-4722-5p	PAR-CLIP	23592263
MIRT465202	hsa-miR-8071	PAR-CLIP	23592263
MIRT465201	hsa-miR-3138	PAR-CLIP	23592263
MIRT2137044	hsa-miR-1279	CLIP-seq
MIRT2137045	hsa-miR-137	CLIP-seq
MIRT2137046	hsa-miR-2116	CLIP-seq
MIRT2137047	hsa-miR-219-2-3p	CLIP-seq
MIRT2137048	hsa-miR-2964a-3p	CLIP-seq
MIRT2137049	hsa-miR-450b-3p	CLIP-seq
MIRT2137050	hsa-miR-4659a-3p	CLIP-seq
MIRT2137051	hsa-miR-4659b-3p	CLIP-seq
MIRT2137052	hsa-miR-4677-5p	CLIP-seq
MIRT2137053	hsa-miR-507	CLIP-seq
MIRT2137054	hsa-miR-513a-3p	CLIP-seq
MIRT2137055	hsa-miR-557	CLIP-seq
MIRT2137056	hsa-miR-635	CLIP-seq
MIRT2137057	hsa-miR-769-3p	CLIP-seq
MIRT2357760	hsa-miR-1263	CLIP-seq
MIRT2137044	hsa-miR-1279	CLIP-seq
MIRT2137045	hsa-miR-137	CLIP-seq
MIRT2357761	hsa-miR-21	CLIP-seq
MIRT2357762	hsa-miR-4709-3p	CLIP-seq
MIRT2357763	hsa-miR-513c	CLIP-seq
MIRT2357764	hsa-miR-514b-5p	CLIP-seq
MIRT2357765	hsa-miR-590-5p	CLIP-seq
MIRT2137044	hsa-miR-1279	CLIP-seq
MIRT2137045	hsa-miR-137	CLIP-seq
MIRT2651367	hsa-miR-191	CLIP-seq
MIRT2137047	hsa-miR-219-2-3p	CLIP-seq
MIRT2137048	hsa-miR-2964a-3p	CLIP-seq
MIRT2651368	hsa-miR-3125	CLIP-seq
MIRT2651369	hsa-miR-3157-3p	CLIP-seq
MIRT2651370	hsa-miR-377	CLIP-seq
MIRT2651371	hsa-miR-3916	CLIP-seq
MIRT2651372	hsa-miR-3925-5p	CLIP-seq
MIRT2651373	hsa-miR-4258	CLIP-seq
MIRT2651374	hsa-miR-4290	CLIP-seq
MIRT2651375	hsa-miR-4307	CLIP-seq
MIRT2651376	hsa-miR-4436b-5p	CLIP-seq
MIRT2137050	hsa-miR-4659a-3p	CLIP-seq
MIRT2137051	hsa-miR-4659b-3p	CLIP-seq
MIRT2651377	hsa-miR-4667-3p	CLIP-seq
MIRT2357762	hsa-miR-4709-3p	CLIP-seq
MIRT2651378	hsa-miR-4716-5p	CLIP-seq
MIRT2651379	hsa-miR-4795-3p	CLIP-seq
MIRT2651380	hsa-miR-4798-5p	CLIP-seq
MIRT2137054	hsa-miR-513a-3p	CLIP-seq
MIRT2651381	hsa-miR-874	CLIP-seq
MIRT2137044	hsa-miR-1279	CLIP-seq
MIRT2137045	hsa-miR-137	CLIP-seq
MIRT2651367	hsa-miR-191	CLIP-seq
MIRT2137047	hsa-miR-219-2-3p	CLIP-seq
MIRT2137048	hsa-miR-2964a-3p	CLIP-seq
MIRT2651368	hsa-miR-3125	CLIP-seq
MIRT2651369	hsa-miR-3157-3p	CLIP-seq
MIRT2651370	hsa-miR-377	CLIP-seq
MIRT2651371	hsa-miR-3916	CLIP-seq
MIRT2651372	hsa-miR-3925-5p	CLIP-seq
MIRT2651373	hsa-miR-4258	CLIP-seq
MIRT2651374	hsa-miR-4290	CLIP-seq
MIRT2651375	hsa-miR-4307	CLIP-seq
MIRT2137050	hsa-miR-4659a-3p	CLIP-seq
MIRT2137051	hsa-miR-4659b-3p	CLIP-seq
MIRT2651377	hsa-miR-4667-3p	CLIP-seq
MIRT2357762	hsa-miR-4709-3p	CLIP-seq
MIRT2651378	hsa-miR-4716-5p	CLIP-seq
MIRT2651380	hsa-miR-4798-5p	CLIP-seq
MIRT2137054	hsa-miR-513a-3p	CLIP-seq
MIRT2651381	hsa-miR-874	CLIP-seq

Gene ontology (GO) Show/Hide all (12)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003723	Function	RNA binding	HDA	22658674
GO:0005515	Function	Protein binding	IPI	16043508, 28514442, 32814053, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	NAS	16043508
GO:0005654	Component	Nucleoplasm	TAS
GO:0006397	Process	MRNA processing	IDA	29072297, 29107537
GO:0008033	Process	TRNA processing	IEA
GO:0030488	Process	TRNA methylation	IEA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IBA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IEA
GO:0031515	Component	TRNA (m1A) methyltransferase complex	IPI	26470919

Other IDs

• MIM: 620886
• HGNC: 20900
• e!Ensembl: ENSG00000089195

Protein

• UniProt ID: Q9UJA5
• Protein name: tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6 (mRNA methyladenosine-N(1)-methyltransferase non-catalytic subunit TRM6) (tRNA(m1A58)-methyltransferase subunit TRM6) (tRNA(m1A58)MTase subunit TRM6)
• Protein function: Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA (PubMed:16043508). Together with the TRMT61A catalytic subunit, part of a
• PDB: 5CCB , 5CCX , 5CD1
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04189	Gcd10p	19 → 322	Gcd10p family	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in brain, liver, testis and ovary. {ECO:0000269|PubMed:10574461}.
• Sequence:

  MEGSGEQPGPQPQHPGDHRIRDGDFVVLKREDVFKAVQVQRRKKVTFEKQWFYLDNVIGH
  SYGTAFEVTSGGSLQPKKKREEPTAETKEAGTDNRNIVDDGKSQKLTQDDIKALKDKGIK
  GEEIVQQLIENSTTFRDKTEFAQDKYIKKKKKKYEAIITVVKPSTRILSIMYYAREPGKI
  NHMRYDTLAQMLTLGNIRAGNKMIVMETCAGLVLGAMMERMGGFGSIIQLYPGGGPVRAA
  TACFGFPKSFLSGLYEFPLNKVDSLLHGTFSAKMLSSEPKDSALVEESNGTLEEKQASEQ
  ENEDSMAEAPESNHPEDQETMETISQDPEHKGPKERGSKKDYIQEKQRRQEEQRKRHLEA
  AALLSERNADGLIVASRFHPTPLLLSLLDFVAPSRPFVVYCQYKEPLLECYTKLRERGGV
  INLRLSETWLRNYQVLPDRSHPKLLMSGGGGYLLSGFTVAMDNLKADTSLKSNASTLESH
  ETEEPAAKKRKCPESDS

• Sequence length: 497

Pathways

Reactome Pathway:

tRNA modification in the nucleus and cytosol

Related Genes

No strongly related genes found yet for TRMT6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRMT6.