TRMT112 (tRNA methyltransferase activator subunit 11-2)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51504
• Gene name: TRNA methyltransferase activator subunit 11-2
• Gene symbol: TRMT112
• Synonyms (NCBI Gene): HSPC152, HSPC170, TRM112, TRMT11-2, hTrm112
• Chromosome: 11
• Chromosome location: 11q13.1

miRNA Show/Hide all (107)

miRTarBase ID	miRNA	Experiments	Reference
MIRT021995	hsa-miR-128-3p	Sequencing	20371350
MIRT559959	hsa-miR-141-3p	PAR-CLIP	20371350
MIRT559958	hsa-miR-200a-3p	PAR-CLIP	20371350
MIRT559957	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT559956	hsa-miR-4523	PAR-CLIP	20371350
MIRT559955	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT559954	hsa-miR-5692b	PAR-CLIP	20371350
MIRT559953	hsa-miR-5692c	PAR-CLIP	20371350
MIRT559952	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT559951	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT559950	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT559949	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT559948	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT559947	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT559946	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT559945	hsa-miR-3670	PAR-CLIP	20371350
MIRT559944	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT559943	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT559959	hsa-miR-141-3p	PAR-CLIP	20371350
MIRT559958	hsa-miR-200a-3p	PAR-CLIP	20371350
MIRT559957	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT559956	hsa-miR-4523	PAR-CLIP	20371350
MIRT559955	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT559954	hsa-miR-5692b	PAR-CLIP	20371350
MIRT559953	hsa-miR-5692c	PAR-CLIP	20371350
MIRT559952	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT559951	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT559950	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT559949	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT559948	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT559947	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT559946	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT559945	hsa-miR-3670	PAR-CLIP	20371350
MIRT559944	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT559943	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT486281	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT486280	hsa-miR-665	PAR-CLIP	23592263
MIRT559959	hsa-miR-141-3p	PAR-CLIP	20371350
MIRT559958	hsa-miR-200a-3p	PAR-CLIP	20371350
MIRT559957	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT559956	hsa-miR-4523	PAR-CLIP	20371350
MIRT559955	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT559954	hsa-miR-5692b	PAR-CLIP	20371350
MIRT559953	hsa-miR-5692c	PAR-CLIP	20371350
MIRT559952	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT559951	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT559950	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT559949	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT559948	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT559947	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT559946	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT559945	hsa-miR-3670	PAR-CLIP	20371350
MIRT559944	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT559943	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT559959	hsa-miR-141-3p	PAR-CLIP	20371350
MIRT559958	hsa-miR-200a-3p	PAR-CLIP	20371350
MIRT559957	hsa-miR-1277-5p	PAR-CLIP	20371350
MIRT559956	hsa-miR-4523	PAR-CLIP	20371350
MIRT559955	hsa-miR-369-3p	PAR-CLIP	20371350
MIRT559954	hsa-miR-5692b	PAR-CLIP	20371350
MIRT559953	hsa-miR-5692c	PAR-CLIP	20371350
MIRT559952	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT559951	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT559950	hsa-miR-3613-3p	PAR-CLIP	20371350
MIRT559949	hsa-miR-371b-5p	PAR-CLIP	20371350
MIRT559948	hsa-miR-373-5p	PAR-CLIP	20371350
MIRT559947	hsa-miR-616-5p	PAR-CLIP	20371350
MIRT559946	hsa-miR-539-5p	PAR-CLIP	20371350
MIRT559945	hsa-miR-3670	PAR-CLIP	20371350
MIRT559944	hsa-miR-374a-5p	PAR-CLIP	20371350
MIRT559943	hsa-miR-374b-5p	PAR-CLIP	20371350
MIRT486281	hsa-miR-873-5p	PAR-CLIP	23592263
MIRT486280	hsa-miR-665	PAR-CLIP	23592263
MIRT1456671	hsa-miR-141	CLIP-seq
MIRT1456672	hsa-miR-200a	CLIP-seq
MIRT1456673	hsa-miR-329	CLIP-seq
MIRT1456674	hsa-miR-374a	CLIP-seq
MIRT1456675	hsa-miR-374b	CLIP-seq
MIRT1456676	hsa-miR-410	CLIP-seq
MIRT1456677	hsa-miR-4672	CLIP-seq
MIRT1456678	hsa-miR-539	CLIP-seq
MIRT1456679	hsa-miR-548a-3p	CLIP-seq
MIRT1456680	hsa-miR-548ae	CLIP-seq
MIRT1456681	hsa-miR-548aj	CLIP-seq
MIRT1456682	hsa-miR-548am	CLIP-seq
MIRT1456683	hsa-miR-548e	CLIP-seq
MIRT1456684	hsa-miR-548f	CLIP-seq
MIRT1456685	hsa-miR-548x	CLIP-seq
MIRT1456686	hsa-miR-566	CLIP-seq
MIRT1456687	hsa-miR-616	CLIP-seq
MIRT1456688	hsa-miR-892a	CLIP-seq
MIRT1456671	hsa-miR-141	CLIP-seq
MIRT1456672	hsa-miR-200a	CLIP-seq
MIRT1456673	hsa-miR-329	CLIP-seq
MIRT1456674	hsa-miR-374a	CLIP-seq
MIRT1456675	hsa-miR-374b	CLIP-seq
MIRT1456677	hsa-miR-4672	CLIP-seq
MIRT1456679	hsa-miR-548a-3p	CLIP-seq
MIRT1456680	hsa-miR-548ae	CLIP-seq
MIRT1456681	hsa-miR-548aj	CLIP-seq
MIRT1456682	hsa-miR-548am	CLIP-seq
MIRT1456683	hsa-miR-548e	CLIP-seq
MIRT1456684	hsa-miR-548f	CLIP-seq
MIRT1456685	hsa-miR-548x	CLIP-seq
MIRT1456686	hsa-miR-566	CLIP-seq
MIRT1456687	hsa-miR-616	CLIP-seq
MIRT1456688	hsa-miR-892a	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000470	Process	Maturation of LSU-rRNA	IBA
GO:0005515	Function	Protein binding	IPI	18539146, 20123966, 20308323, 25851604, 28514442, 31061526, 31328227, 31632689, 31636962, 32296183, 33961781, 34669960, 34948388, 35033535
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA	25851604
GO:0005654	Component	Nucleoplasm	IEA
GO:0005654	Component	Nucleoplasm	TAS
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006364	Process	RRNA processing	IEA
GO:0008276	Function	Protein methyltransferase activity	IDA	18539146
GO:0018364	Process	Peptidyl-glutamine methylation	IDA	18539146, 31636962
GO:0030488	Process	TRNA methylation	IMP	34669960
GO:0030490	Process	Maturation of SSU-rRNA	IBA
GO:0031167	Process	RRNA methylation	IDA	31328227, 35033535
GO:0032991	Component	Protein-containing complex	IDA	18539146
GO:0043528	Component	TRNA (m2G10) methyltransferase complex	IBA
GO:0045815	Process	Transcription initiation-coupled chromatin remodeling	IDA	31061526
GO:0046982	Function	Protein heterodimerization activity	IDA	25851604
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	25851604
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0070476	Process	RRNA (guanine-N7)-methylation	IMP	25851604
GO:0141106	Function	TRNA methyltransferase activator activity	IBA
GO:0141106	Function	TRNA methyltransferase activator activity	IDA	34669960
GO:2000234	Process	Positive regulation of rRNA processing	IBA
GO:2000234	Process	Positive regulation of rRNA processing	IMP	25851604

Other IDs

• MIM: 618630
• HGNC: 26940
• e!Ensembl: ENSG00000173113

Protein

• UniProt ID: Q9UI30
• Protein name: Multifunctional methyltransferase subunit TRM112-like protein (tRNA methyltransferase 112 homolog)
• Protein function: Acts as an activator of both rRNA/tRNA and protein methyltransferases (PubMed:18539146, PubMed:20308323, PubMed:25851604, PubMed:31061526, PubMed:31328227, PubMed:31636962, PubMed:37283053). Together with methyltransferase BUD23, methylates the
• PDB: 6G4W , 6H1D , 6H1E , 6H2U , 6H2V , 6K0X , 6KHS , 6KMR , 6KMS , 6PED , 7WTS , 7WTT , 7WTU , 7WTV , 7WTW , 8CNC , 8QDG , 8QDI
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF03966	Trm112p	2 → 112	Trm112p-like protein	Domain

• Sequence:

  MKLLTHNLLSSHVRGVGSRGFPLRLQATEVRICPVEFNPNFVARMIPKVEWSAFLEAADN
  LRLIQVPKGPVEGYEENEEFLRTMHHLLLEVEVIEGTLQCPESGRMFPISRGIPNMLLSE
  EETES

• Sequence length: 125

Pathways

Reactome Pathway

Methylation

rRNA modification in the nucleus and cytosol

Eukaryotic Translation Termination

Related Genes

N6AMT1 2 shared pathwaysMethylation, Eukaryotic Translation Termination Related via 2 shared pathways including Methylation, Eukaryotic Translation Termination.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
N6AMT1	0	[]	2	["Methylation","Eukaryotic Translation Termination"]	0	[]

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRMT112.