TRMT10B (tRNA methyltransferase 10B)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 158234
• Gene name: TRNA methyltransferase 10B
• Gene symbol: TRMT10B
• Synonyms (NCBI Gene): RG9MTD3, bA3J10.9
• Chromosome: 9
• Chromosome location: 9p13.2

miRNA Show/Hide all (64)

miRTarBase ID	miRNA	Experiments	Reference
MIRT648409	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT648408	hsa-miR-4794	HITS-CLIP	23824327
MIRT648407	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT648406	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT648405	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT648404	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT648403	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT648402	hsa-miR-760	HITS-CLIP	23824327
MIRT648401	hsa-miR-8057	HITS-CLIP	23824327
MIRT635645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635644	hsa-miR-1281	HITS-CLIP	23824327
MIRT635643	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635642	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635641	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635640	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635638	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635637	hsa-miR-4284	HITS-CLIP	23824327
MIRT518219	hsa-miR-3154	PAR-CLIP	23446348
MIRT518217	hsa-miR-3925-5p	PAR-CLIP	23446348
MIRT518216	hsa-miR-3123	PAR-CLIP	23446348
MIRT518215	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT518214	hsa-miR-936	PAR-CLIP	23446348
MIRT518213	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT518212	hsa-miR-6770-5p	PAR-CLIP	23446348
MIRT518211	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT518210	hsa-miR-548s	PAR-CLIP	23446348
MIRT518209	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT518208	hsa-miR-588	PAR-CLIP	23446348
MIRT518207	hsa-miR-4435	PAR-CLIP	23446348
MIRT518205	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT518206	hsa-miR-5096	PAR-CLIP	23446348
MIRT648409	hsa-miR-5007-5p	HITS-CLIP	23824327
MIRT648408	hsa-miR-4794	HITS-CLIP	23824327
MIRT648407	hsa-miR-664a-5p	HITS-CLIP	23824327
MIRT648406	hsa-miR-149-5p	HITS-CLIP	23824327
MIRT648405	hsa-miR-3064-5p	HITS-CLIP	23824327
MIRT648404	hsa-miR-6504-5p	HITS-CLIP	23824327
MIRT648403	hsa-miR-6822-3p	HITS-CLIP	23824327
MIRT648402	hsa-miR-760	HITS-CLIP	23824327
MIRT648401	hsa-miR-8057	HITS-CLIP	23824327
MIRT635645	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT635644	hsa-miR-1281	HITS-CLIP	23824327
MIRT635643	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT635642	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT635641	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT635640	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT635639	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT635638	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT635637	hsa-miR-4284	HITS-CLIP	23824327
MIRT518219	hsa-miR-3154	PAR-CLIP	23446348
MIRT518217	hsa-miR-3925-5p	PAR-CLIP	23446348
MIRT518216	hsa-miR-3123	PAR-CLIP	23446348
MIRT518215	hsa-miR-4781-3p	PAR-CLIP	23446348
MIRT518214	hsa-miR-936	PAR-CLIP	23446348
MIRT518213	hsa-miR-4716-5p	PAR-CLIP	23446348
MIRT518212	hsa-miR-6770-5p	PAR-CLIP	23446348
MIRT518211	hsa-miR-6832-5p	PAR-CLIP	23446348
MIRT518210	hsa-miR-548s	PAR-CLIP	23446348
MIRT518209	hsa-miR-4701-5p	PAR-CLIP	23446348
MIRT518208	hsa-miR-588	PAR-CLIP	23446348
MIRT518207	hsa-miR-4435	PAR-CLIP	23446348
MIRT518205	hsa-miR-3187-3p	PAR-CLIP	23446348
MIRT518206	hsa-miR-5096	PAR-CLIP	23446348

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IBA
GO:0002939	Process	TRNA N1-guanine methylation	IBA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IBA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	32901109
GO:0005829	Component	Cytosol	IDA	23042678
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0032259	Process	Methylation	IEA
GO:0042721	Component	TIM22 mitochondrial import inner membrane insertion complex	IPI	32901109
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	IDA	32901109
GO:0052905	Function	TRNA (guanosine(9)-N1)-methyltransferase activity	IDA	23042678
GO:0052905	Function	TRNA (guanosine(9)-N1)-methyltransferase activity	IEA

Other IDs

• MIM: 620957
• HGNC: 26454
• e!Ensembl: ENSG00000165275

Protein

• UniProt ID: Q6PF06
• Protein name: tRNA methyltransferase 10 homolog B (EC 2.1.1.221) (RNA (guanine-9-)-methyltransferase domain-containing protein 3) (tRNA (guanine(9)-N(1))-methyltransferase TRMT10B)
• Protein function: S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in tRNAs (PubMed:23042678). Probably not able to catalyze formation of N(1)-methyladenine at position 9 (m1A
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01746	tRNA_m1G_MT	134 → 307	tRNA (Guanine-1)-methyltransferase	Family

• Sequence:

  MDWKLEGSTQKVESPVLQGQEGILEETGEDGLPEGFQLLQIDAEGECQEGEILATGSTAW
  CSKNVQRKQRHWEKIVAAKKSKRKQEKERRKANRAENPGICPQHSKRFLRALTKDKLLEA
  KHSGPRLCIDLSMTHYMSKKELSRLAGQIRRLYGSNKKADRPFWICLTGFTTDSPLYEEC
  VRMNDGFSSYLLDITEEDCFSLFPLETLVYLTPDSEHALEDVDLNKVYILGGLVDESIQK
  KVTFQKAREYSVKTARLPIQEYMVRNQNGKNYHSEILAINQVFDILSTYLETHNWPEALK
  KGVSSGKGYILRNSVE

• Sequence length: 316

Related Genes

No strongly related genes found yet for TRMT10B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRMT10B.