Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 493829
Gene name Tripartite motif containing 72
Gene symbol TRIM72
Synonyms (NCBI Gene)
MG53
Chromosome 16
Chromosome location 16p11.2
miRNA miRNA information provided by mirtarbase database.
416 Show/Hide all (416)
miRTarBase ID miRNA Experiments Reference
MIRT694533 hsa-miR-29a-3p HITS-CLIP 23313552
MIRT694532 hsa-miR-29b-3p HITS-CLIP 23313552
MIRT694531 hsa-miR-29c-3p HITS-CLIP 23313552
MIRT694530 hsa-miR-6871-3p HITS-CLIP 23313552
MIRT458625 hsa-miR-1910-3p HITS-CLIP 23313552
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
36 Show/Hide all (36)
GO ID Ontology Definition Evidence Reference
GO:0001778 Process Plasma membrane repair IEA
GO:0001778 Process Plasma membrane repair ISS
GO:0001786 Function Phosphatidylserine binding IEA
GO:0001786 Function Phosphatidylserine binding ISS
GO:0003012 Process Muscle system process IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
613288 32671 ENSG00000177238
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q6ZMU5
Protein name Tripartite motif-containing protein 72 (EC 2.3.2.27) (Mitsugumin-53) (Mg53)
Protein function Muscle-specific E3 ubiquitin-protein ligase that plays a central role in cell membrane repair by nucleating the assembly of the repair machinery at injury sites (PubMed:36944613). Its ubiquitination activity is mediated by E2 ubiquitin-conjugati
PDB 3KB5 , 7XT2 , 7Y4S
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00622 SPRY 344 → 465 SPRY domain Family
PF00643 zf-B_box 81 → 122 B-box zinc finger Domain
PF13765 PRY 291 → 340 SPRY-associated domain Family
PF15227 zf-C3HC4_4 14 → 56 Domain
Sequence
MSAAPGLLHQELSCPLCLQLFDAPVTAECGHSFCRACLGRVAGEPAADGTVLCPCCQAPT
RPQALSTNLQLARLVEGLAQVPQGHCEEHLDPLSIYCEQDRALVCGVCASLGSHRGHRLL
PA
AEAHARLKTQLPQQKLQLQEACMRKEKSVAVLEHQLVEVEETVRQFRGAVGEQLGKMR
VFLAALEGSLDREAERVRGEAGVALRRELGSLNSYLEQLRQMEKVLEEVADKPQTEFLMK
YCLVTSRLQKILAESPPPARLDIQLPIISDDFKFQVWRKMFRALMPALEELTFDPSSAHP
SLVVSSSGRRVECSEQKAPPAGEDPRQFDKAVAVVAHQQL
SEGEHYWEVDVGDKPRWALG
VIAAEAPRRGRLHAVPSQGLWLLGLREGKILEAHVEAKEPRALRSPERRPTRIGLYLSFG
DGVLSFYDASDADALVPLFAFHERLPRPVYPFFDVCWHDKGKNAQ
PLLLVGPEGAEA
Sequence length 477
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
Reactome Pathway
Smooth Muscle Contraction