TRIM7 (tripartite motif containing 7)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 81786
• Gene name: Tripartite motif containing 7
• Gene symbol: TRIM7
• Synonyms (NCBI Gene): GNIP, RNF90
• Chromosome: 5
• Chromosome location: 5q35.3
• Summary: The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1, a B-box type 2, and a coiled-coil region. The protein localizes to both the nucleus and the cyt

miRNA Show/Hide all (167)

miRTarBase ID	miRNA	Experiments	Reference
MIRT022939	hsa-miR-124-3p	Microarray	18668037
MIRT735561	hsa-miR-4491	Luciferase reporter assay, Western blotting, qRT-PCR	34149902
MIRT1456049	hsa-miR-1302	CLIP-seq
MIRT1456050	hsa-miR-134	CLIP-seq
MIRT1456051	hsa-miR-145	CLIP-seq
MIRT1456052	hsa-miR-2052	CLIP-seq
MIRT1456053	hsa-miR-3118	CLIP-seq
MIRT1456054	hsa-miR-3136-5p	CLIP-seq
MIRT1456055	hsa-miR-3925-3p	CLIP-seq
MIRT1456056	hsa-miR-4298	CLIP-seq
MIRT1456057	hsa-miR-4439	CLIP-seq
MIRT1456058	hsa-miR-4503	CLIP-seq
MIRT1456059	hsa-miR-450b-5p	CLIP-seq
MIRT1456060	hsa-miR-4513	CLIP-seq
MIRT1456061	hsa-miR-4676-5p	CLIP-seq
MIRT1456062	hsa-miR-507	CLIP-seq
MIRT1456063	hsa-miR-557	CLIP-seq
MIRT1456064	hsa-miR-575	CLIP-seq
MIRT1456065	hsa-miR-639	CLIP-seq
MIRT1456066	hsa-miR-759	CLIP-seq
MIRT1456067	hsa-miR-1285	CLIP-seq
MIRT1456068	hsa-miR-3130-5p	CLIP-seq
MIRT1456069	hsa-miR-3187-5p	CLIP-seq
MIRT1456070	hsa-miR-3667-5p	CLIP-seq
MIRT1456071	hsa-miR-4482	CLIP-seq
MIRT1456072	hsa-miR-451b	CLIP-seq
MIRT1456073	hsa-miR-4696	CLIP-seq
MIRT1456074	hsa-miR-612	CLIP-seq
MIRT1456075	hsa-miR-661	CLIP-seq
MIRT1456076	hsa-miR-1304	CLIP-seq
MIRT1456051	hsa-miR-145	CLIP-seq
MIRT1456077	hsa-miR-1909	CLIP-seq
MIRT1456078	hsa-miR-3136-3p	CLIP-seq
MIRT1456079	hsa-miR-3160-3p	CLIP-seq
MIRT1456080	hsa-miR-3176	CLIP-seq
MIRT1456081	hsa-miR-3614-5p	CLIP-seq
MIRT1456082	hsa-miR-3616-3p	CLIP-seq
MIRT1456083	hsa-miR-3667-3p	CLIP-seq
MIRT1456084	hsa-miR-3909	CLIP-seq
MIRT1456085	hsa-miR-3921	CLIP-seq
MIRT1456086	hsa-miR-3922-3p	CLIP-seq
MIRT1456087	hsa-miR-4277	CLIP-seq
MIRT1456088	hsa-miR-4303	CLIP-seq
MIRT1456089	hsa-miR-4433	CLIP-seq
MIRT1456090	hsa-miR-4436b-3p	CLIP-seq
MIRT1456091	hsa-miR-4459	CLIP-seq
MIRT1456092	hsa-miR-4487	CLIP-seq
MIRT1456093	hsa-miR-4494	CLIP-seq
MIRT1456094	hsa-miR-4653-5p	CLIP-seq
MIRT1456095	hsa-miR-4768-3p	CLIP-seq
MIRT1456096	hsa-miR-483-5p	CLIP-seq
MIRT1456097	hsa-miR-503	CLIP-seq
MIRT1456098	hsa-miR-558	CLIP-seq
MIRT1456099	hsa-miR-665	CLIP-seq
MIRT1456100	hsa-miR-765	CLIP-seq
MIRT1456101	hsa-miR-888	CLIP-seq
MIRT1456067	hsa-miR-1285	CLIP-seq
MIRT1456076	hsa-miR-1304	CLIP-seq
MIRT1456069	hsa-miR-3187-5p	CLIP-seq
MIRT1456081	hsa-miR-3614-5p	CLIP-seq
MIRT1456089	hsa-miR-4433	CLIP-seq
MIRT1456074	hsa-miR-612	CLIP-seq
MIRT1456075	hsa-miR-661	CLIP-seq
MIRT1456099	hsa-miR-665	CLIP-seq
MIRT1456100	hsa-miR-765	CLIP-seq
MIRT1456102	hsa-miR-1273f	CLIP-seq
MIRT1456103	hsa-miR-1321	CLIP-seq
MIRT1456104	hsa-miR-3162-5p	CLIP-seq
MIRT1456105	hsa-miR-3688-3p	CLIP-seq
MIRT1456106	hsa-miR-4261	CLIP-seq
MIRT1456107	hsa-miR-4267	CLIP-seq
MIRT1456108	hsa-miR-4738-3p	CLIP-seq
MIRT1456109	hsa-miR-4739	CLIP-seq
MIRT1456110	hsa-miR-4756-5p	CLIP-seq
MIRT2136707	hsa-miR-4313	CLIP-seq
MIRT2357521	hsa-miR-581	CLIP-seq
MIRT1456067	hsa-miR-1285	CLIP-seq
MIRT1456076	hsa-miR-1304	CLIP-seq
MIRT1456069	hsa-miR-3187-5p	CLIP-seq
MIRT1456081	hsa-miR-3614-5p	CLIP-seq
MIRT1456089	hsa-miR-4433	CLIP-seq
MIRT1456072	hsa-miR-451b	CLIP-seq
MIRT1456073	hsa-miR-4696	CLIP-seq
MIRT1456074	hsa-miR-612	CLIP-seq
MIRT1456075	hsa-miR-661	CLIP-seq
MIRT1456099	hsa-miR-665	CLIP-seq
MIRT1456100	hsa-miR-765	CLIP-seq
MIRT2462367	hsa-miR-1228	CLIP-seq
MIRT1456102	hsa-miR-1273f	CLIP-seq
MIRT1456103	hsa-miR-1321	CLIP-seq
MIRT1456051	hsa-miR-145	CLIP-seq
MIRT2462368	hsa-miR-1913	CLIP-seq
MIRT1456078	hsa-miR-3136-3p	CLIP-seq
MIRT1456104	hsa-miR-3162-5p	CLIP-seq
MIRT1456080	hsa-miR-3176	CLIP-seq
MIRT2462369	hsa-miR-324-3p	CLIP-seq
MIRT2462370	hsa-miR-331-3p	CLIP-seq
MIRT2462371	hsa-miR-3647-3p	CLIP-seq
MIRT1456083	hsa-miR-3667-3p	CLIP-seq
MIRT1456086	hsa-miR-3922-3p	CLIP-seq
MIRT1456107	hsa-miR-4267	CLIP-seq
MIRT1456087	hsa-miR-4277	CLIP-seq
MIRT2136707	hsa-miR-4313	CLIP-seq
MIRT1456109	hsa-miR-4739	CLIP-seq
MIRT1456110	hsa-miR-4756-5p	CLIP-seq
MIRT2466268	hsa-miR-106a	CLIP-seq
MIRT2466269	hsa-miR-106b	CLIP-seq
MIRT2466270	hsa-miR-17	CLIP-seq
MIRT2466271	hsa-miR-20a	CLIP-seq
MIRT2466272	hsa-miR-20b	CLIP-seq
MIRT2466273	hsa-miR-3978	CLIP-seq
MIRT2466274	hsa-miR-519d	CLIP-seq
MIRT2466275	hsa-miR-93	CLIP-seq
MIRT2462367	hsa-miR-1228	CLIP-seq
MIRT1456102	hsa-miR-1273f	CLIP-seq
MIRT1456067	hsa-miR-1285	CLIP-seq
MIRT1456076	hsa-miR-1304	CLIP-seq
MIRT1456103	hsa-miR-1321	CLIP-seq
MIRT1456068	hsa-miR-3130-5p	CLIP-seq
MIRT1456104	hsa-miR-3162-5p	CLIP-seq
MIRT1456069	hsa-miR-3187-5p	CLIP-seq
MIRT1456081	hsa-miR-3614-5p	CLIP-seq
MIRT1456070	hsa-miR-3667-5p	CLIP-seq
MIRT1456105	hsa-miR-3688-3p	CLIP-seq
MIRT1456106	hsa-miR-4261	CLIP-seq
MIRT1456107	hsa-miR-4267	CLIP-seq
MIRT1456089	hsa-miR-4433	CLIP-seq
MIRT1456071	hsa-miR-4482	CLIP-seq
MIRT1456072	hsa-miR-451b	CLIP-seq
MIRT1456073	hsa-miR-4696	CLIP-seq
MIRT1456108	hsa-miR-4738-3p	CLIP-seq
MIRT1456109	hsa-miR-4739	CLIP-seq
MIRT1456110	hsa-miR-4756-5p	CLIP-seq
MIRT1456074	hsa-miR-612	CLIP-seq
MIRT1456075	hsa-miR-661	CLIP-seq
MIRT1456099	hsa-miR-665	CLIP-seq
MIRT1456100	hsa-miR-765	CLIP-seq
MIRT2462367	hsa-miR-1228	CLIP-seq
MIRT1456102	hsa-miR-1273f	CLIP-seq
MIRT1456067	hsa-miR-1285	CLIP-seq
MIRT1456076	hsa-miR-1304	CLIP-seq
MIRT1456103	hsa-miR-1321	CLIP-seq
MIRT1456068	hsa-miR-3130-5p	CLIP-seq
MIRT2694199	hsa-miR-3137	CLIP-seq
MIRT2694200	hsa-miR-3155	CLIP-seq
MIRT2694201	hsa-miR-3155b	CLIP-seq
MIRT1456104	hsa-miR-3162-5p	CLIP-seq
MIRT1456069	hsa-miR-3187-5p	CLIP-seq
MIRT1456081	hsa-miR-3614-5p	CLIP-seq
MIRT1456070	hsa-miR-3667-5p	CLIP-seq
MIRT1456105	hsa-miR-3688-3p	CLIP-seq
MIRT1456106	hsa-miR-4261	CLIP-seq
MIRT1456107	hsa-miR-4267	CLIP-seq
MIRT1456089	hsa-miR-4433	CLIP-seq
MIRT1456071	hsa-miR-4482	CLIP-seq
MIRT1456072	hsa-miR-451b	CLIP-seq
MIRT2694202	hsa-miR-4690-5p	CLIP-seq
MIRT1456073	hsa-miR-4696	CLIP-seq
MIRT1456108	hsa-miR-4738-3p	CLIP-seq
MIRT1456109	hsa-miR-4739	CLIP-seq
MIRT1456110	hsa-miR-4756-5p	CLIP-seq
MIRT2694203	hsa-miR-484	CLIP-seq
MIRT1456074	hsa-miR-612	CLIP-seq
MIRT2694204	hsa-miR-635	CLIP-seq
MIRT1456075	hsa-miR-661	CLIP-seq
MIRT1456099	hsa-miR-665	CLIP-seq
MIRT1456100	hsa-miR-765	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 32296183
GO:0005634	Component	Nucleus	IDA	11331580
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	35893676
GO:0005737	Component	Cytoplasm	IDA	11331580
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0045087	Process	Innate immune response	IBA
GO:0045087	Process	Innate immune response	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	35893676
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0140374	Process	Antiviral innate immune response	IDA	35893676

Other IDs

• MIM: 609315
• HGNC: 16278
• e!Ensembl: ENSG00000146054

Protein

• UniProt ID: Q9C029
• Protein name: E3 ubiquitin-protein ligase TRIM7 (EC 2.3.2.27) (Glycogenin-interacting protein) (RING finger protein 90) (Tripartite motif-containing protein 7)
• Protein function: E3 ubiquitin-protein ligase that have both tumor-promoting and tumor-suppressing activities and functions in several biological processes including innate immunity, regulation of ferroptosis as well as cell proliferation and migration (PubMed:25
• PDB: 6UMA , 6UMB , 7OVX , 7OW2 , 7W0Q , 7W0S , 7W0T , 7X6Y , 7X6Z , 7X70 , 7Y3A , 7Y3B , 7Y3C , 8A5L , 8A5M , 8A8X , 8R5B , 8R5C , 8R5D , 9HIN
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	396 → 509	SPRY domain	Family
  PF00643	zf-B_box	126 → 166	B-box zinc finger	Domain
  PF13765	PRY	344 → 392	SPRY-associated domain	Family
  PF15227	zf-C3HC4_4	29 → 81		Domain

• Tissue specificity: TISSUE SPECIFICITY: Skeletal muscle and placenta, at lower levels in heart, brain and pancreas. Isoform 1 is widely expressed with high level in testis, kidney and heart. {ECO:0000269|PubMed:14984203}.
• Sequence:

  MAAVGPRTGPGTGAEALALAAELQGEATCSICLELFREPVSVECGHSFCRACIGRCWERP
  GAGSVGAATRAPPFPLPCPQCREPARPSQLRPNRQLAAVATLLRRFSLPAAAPGEHGSQA
  AAARAAAARCGQHGEPFKLYCQDDGRAICVVCDRAREHREHAVLPLDEAVQEAKELLESR
  LRVLKKELEDCEVFRSTEKKESKELLKQMAAEQEKVGAEFQALRAFLVEQEGRLLGRLEE
  LSREVAQKQNENLAQLGVEITQLSKLSSQIQETAQKPDLDFLQEFKSTLSRCSNVPGPKP
  TTVSSEMKNKVWNVSLKTFVLKGMLKKFKEDLRGELEKEEKVELTLDPDTANPRLILSLD
  LKGVRLGERAQDLPNHPCRFDTNTRVLASCGFSSGRHHWEVEVGSKDGWAFGVARESVRR
  KGLTPFTPEEGVWALQLNGGQYWAVTSPERSPLSCGHLSRVRVALDLEVGAVSFYAVEDM
  RHLYTFRVNFQERVFPLFSVCSTGTYLRIWP

• Sequence length: 511

Related Genes

No strongly related genes found yet for TRIM7.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRIM7.