TRIM68 (tripartite motif containing 68)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55128
• Gene name: Tripartite motif containing 68
• Gene symbol: TRIM68
• Synonyms (NCBI Gene): GC109, RNF137, SS-56, SS56
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: This gene encodes a member of the tripartite motif-containing protein family, whose members are characterized by a "really interesting new gene" (RING) finger domain, a zinc-binding B-box motif, and a coiled-coil region. Members of this family function as

miRNA Show/Hide all (350)

miRTarBase ID	miRNA	Experiments	Reference
MIRT024356	hsa-miR-215-5p	Microarray	19074876
MIRT026905	hsa-miR-192-5p	Microarray	19074876
MIRT030315	hsa-miR-26b-5p	Microarray	19088304
MIRT053016	hsa-miR-1256	Luciferase reporter assay, qRT-PCR, Western blot	22805767
MIRT053017	hsa-miR-29a-3p	Luciferase reporter assay, qRT-PCR, Western blot	22805767
MIRT683044	hsa-miR-596	HITS-CLIP	23706177
MIRT683043	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT683042	hsa-miR-17-3p	HITS-CLIP	23706177
MIRT683041	hsa-miR-4537	HITS-CLIP	23706177
MIRT683040	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT683039	hsa-miR-4252	HITS-CLIP	23706177
MIRT683038	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT683044	hsa-miR-596	HITS-CLIP	23706177
MIRT683043	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT683042	hsa-miR-17-3p	HITS-CLIP	23706177
MIRT683041	hsa-miR-4537	HITS-CLIP	23706177
MIRT683040	hsa-miR-6499-3p	HITS-CLIP	23706177
MIRT683039	hsa-miR-4252	HITS-CLIP	23706177
MIRT683038	hsa-miR-1227-3p	HITS-CLIP	23706177
MIRT1455945	hsa-miR-106a	CLIP-seq
MIRT1455946	hsa-miR-106b	CLIP-seq
MIRT1455947	hsa-miR-1202	CLIP-seq
MIRT1455948	hsa-miR-1227	CLIP-seq
MIRT1455949	hsa-miR-125a-5p	CLIP-seq
MIRT1455950	hsa-miR-125b	CLIP-seq
MIRT1455951	hsa-miR-1291	CLIP-seq
MIRT1455952	hsa-miR-142-5p	CLIP-seq
MIRT1455953	hsa-miR-151-3p	CLIP-seq
MIRT1455954	hsa-miR-17	CLIP-seq
MIRT1455955	hsa-miR-1827	CLIP-seq
MIRT1455956	hsa-miR-20a	CLIP-seq
MIRT1455957	hsa-miR-20b	CLIP-seq
MIRT1455958	hsa-miR-2114	CLIP-seq
MIRT1455959	hsa-miR-24	CLIP-seq
MIRT1455960	hsa-miR-2467-3p	CLIP-seq
MIRT1455961	hsa-miR-3141	CLIP-seq
MIRT1455962	hsa-miR-3150b-3p	CLIP-seq
MIRT1455963	hsa-miR-3178	CLIP-seq
MIRT1455964	hsa-miR-3186-5p	CLIP-seq
MIRT1455965	hsa-miR-3194-5p	CLIP-seq
MIRT1455966	hsa-miR-3609	CLIP-seq
MIRT1455967	hsa-miR-3612	CLIP-seq
MIRT1455968	hsa-miR-3613-3p	CLIP-seq
MIRT1455969	hsa-miR-3647-3p	CLIP-seq
MIRT1455970	hsa-miR-3662	CLIP-seq
MIRT1455971	hsa-miR-3689a-3p	CLIP-seq
MIRT1455972	hsa-miR-3689c	CLIP-seq
MIRT1455973	hsa-miR-3929	CLIP-seq
MIRT1455974	hsa-miR-3972	CLIP-seq
MIRT1455975	hsa-miR-4284	CLIP-seq
MIRT1455976	hsa-miR-4318	CLIP-seq
MIRT1455977	hsa-miR-4319	CLIP-seq
MIRT1455978	hsa-miR-4324	CLIP-seq
MIRT1455979	hsa-miR-4329	CLIP-seq
MIRT1455980	hsa-miR-4419b	CLIP-seq
MIRT1455981	hsa-miR-4433	CLIP-seq
MIRT1455982	hsa-miR-4440	CLIP-seq
MIRT1455983	hsa-miR-4459	CLIP-seq
MIRT1455984	hsa-miR-4463	CLIP-seq
MIRT1455985	hsa-miR-4478	CLIP-seq
MIRT1455986	hsa-miR-4499	CLIP-seq
MIRT1455987	hsa-miR-4530	CLIP-seq
MIRT1455988	hsa-miR-4648	CLIP-seq
MIRT1455989	hsa-miR-4649-3p	CLIP-seq
MIRT1455990	hsa-miR-4654	CLIP-seq
MIRT1455991	hsa-miR-4680-3p	CLIP-seq
MIRT1455992	hsa-miR-4684-5p	CLIP-seq
MIRT1455993	hsa-miR-4685-5p	CLIP-seq
MIRT1455994	hsa-miR-4689	CLIP-seq
MIRT1455995	hsa-miR-4695-5p	CLIP-seq
MIRT1455996	hsa-miR-4722-5p	CLIP-seq
MIRT1455997	hsa-miR-4728-3p	CLIP-seq
MIRT1455998	hsa-miR-4728-5p	CLIP-seq
MIRT1455999	hsa-miR-4738-3p	CLIP-seq
MIRT1456000	hsa-miR-4755-3p	CLIP-seq
MIRT1456001	hsa-miR-4768-3p	CLIP-seq
MIRT1456002	hsa-miR-4769-5p	CLIP-seq
MIRT1456003	hsa-miR-4779	CLIP-seq
MIRT1456004	hsa-miR-4784	CLIP-seq
MIRT1456005	hsa-miR-4796-3p	CLIP-seq
MIRT1456006	hsa-miR-485-5p	CLIP-seq
MIRT1456007	hsa-miR-491-3p	CLIP-seq
MIRT1456008	hsa-miR-519d	CLIP-seq
MIRT1456009	hsa-miR-541	CLIP-seq
MIRT1456010	hsa-miR-548ah	CLIP-seq
MIRT1456011	hsa-miR-548c-3p	CLIP-seq
MIRT1456012	hsa-miR-566	CLIP-seq
MIRT1456013	hsa-miR-650	CLIP-seq
MIRT1456014	hsa-miR-654-5p	CLIP-seq
MIRT1456015	hsa-miR-665	CLIP-seq
MIRT1456016	hsa-miR-922	CLIP-seq
MIRT1456017	hsa-miR-93	CLIP-seq
MIRT1456018	hsa-miR-940	CLIP-seq
MIRT1455955	hsa-miR-1827	CLIP-seq
MIRT1455958	hsa-miR-2114	CLIP-seq
MIRT1455959	hsa-miR-24	CLIP-seq
MIRT1455961	hsa-miR-3141	CLIP-seq
MIRT1455962	hsa-miR-3150b-3p	CLIP-seq
MIRT1455963	hsa-miR-3178	CLIP-seq
MIRT1455964	hsa-miR-3186-5p	CLIP-seq
MIRT1455967	hsa-miR-3612	CLIP-seq
MIRT2136694	hsa-miR-3614-5p	CLIP-seq
MIRT2136695	hsa-miR-3659	CLIP-seq
MIRT1455971	hsa-miR-3689a-3p	CLIP-seq
MIRT1455972	hsa-miR-3689c	CLIP-seq
MIRT1455973	hsa-miR-3929	CLIP-seq
MIRT1455975	hsa-miR-4284	CLIP-seq
MIRT1455976	hsa-miR-4318	CLIP-seq
MIRT1455980	hsa-miR-4419b	CLIP-seq
MIRT1455982	hsa-miR-4440	CLIP-seq
MIRT1455983	hsa-miR-4459	CLIP-seq
MIRT1455985	hsa-miR-4478	CLIP-seq
MIRT1455988	hsa-miR-4648	CLIP-seq
MIRT1455989	hsa-miR-4649-3p	CLIP-seq
MIRT1455990	hsa-miR-4654	CLIP-seq
MIRT2136696	hsa-miR-4658	CLIP-seq
MIRT1455994	hsa-miR-4689	CLIP-seq
MIRT2136697	hsa-miR-4693-3p	CLIP-seq
MIRT1455995	hsa-miR-4695-5p	CLIP-seq
MIRT2136698	hsa-miR-4714-3p	CLIP-seq
MIRT1455996	hsa-miR-4722-5p	CLIP-seq
MIRT1455998	hsa-miR-4728-5p	CLIP-seq
MIRT1456000	hsa-miR-4755-3p	CLIP-seq
MIRT2136699	hsa-miR-4758-5p	CLIP-seq
MIRT1456001	hsa-miR-4768-3p	CLIP-seq
MIRT1456002	hsa-miR-4769-5p	CLIP-seq
MIRT1456003	hsa-miR-4779	CLIP-seq
MIRT1456004	hsa-miR-4784	CLIP-seq
MIRT1456006	hsa-miR-485-5p	CLIP-seq
MIRT2136700	hsa-miR-505	CLIP-seq
MIRT1456009	hsa-miR-541	CLIP-seq
MIRT2136701	hsa-miR-548m	CLIP-seq
MIRT2136702	hsa-miR-548p	CLIP-seq
MIRT1456012	hsa-miR-566	CLIP-seq
MIRT2136703	hsa-miR-574-5p	CLIP-seq
MIRT1456013	hsa-miR-650	CLIP-seq
MIRT1456014	hsa-miR-654-5p	CLIP-seq
MIRT1456015	hsa-miR-665	CLIP-seq
MIRT1456018	hsa-miR-940	CLIP-seq
MIRT1455948	hsa-miR-1227	CLIP-seq
MIRT1455955	hsa-miR-1827	CLIP-seq
MIRT1455967	hsa-miR-3612	CLIP-seq
MIRT1455983	hsa-miR-4459	CLIP-seq
MIRT1455989	hsa-miR-4649-3p	CLIP-seq
MIRT2357516	hsa-miR-4666-3p	CLIP-seq
MIRT1455995	hsa-miR-4695-5p	CLIP-seq
MIRT1455996	hsa-miR-4722-5p	CLIP-seq
MIRT1456001	hsa-miR-4768-3p	CLIP-seq
MIRT1456013	hsa-miR-650	CLIP-seq
MIRT1456015	hsa-miR-665	CLIP-seq
MIRT1456016	hsa-miR-922	CLIP-seq
MIRT1456018	hsa-miR-940	CLIP-seq
MIRT1455983	hsa-miR-4459	CLIP-seq
MIRT1456015	hsa-miR-665	CLIP-seq
MIRT1455961	hsa-miR-3141	CLIP-seq
MIRT1455962	hsa-miR-3150b-3p	CLIP-seq
MIRT1455981	hsa-miR-4433	CLIP-seq
MIRT1455983	hsa-miR-4459	CLIP-seq
MIRT2462365	hsa-miR-4683	CLIP-seq
MIRT1455994	hsa-miR-4689	CLIP-seq
MIRT1456001	hsa-miR-4768-3p	CLIP-seq
MIRT1456003	hsa-miR-4779	CLIP-seq
MIRT1456004	hsa-miR-4784	CLIP-seq
MIRT2462366	hsa-miR-4786-5p	CLIP-seq
MIRT2651162	hsa-miR-1197	CLIP-seq
MIRT2651163	hsa-miR-1224-5p	CLIP-seq
MIRT2651164	hsa-miR-124	CLIP-seq
MIRT2651165	hsa-miR-1273g	CLIP-seq
MIRT2651166	hsa-miR-128	CLIP-seq
MIRT2651167	hsa-miR-1284	CLIP-seq
MIRT2651168	hsa-miR-1285	CLIP-seq
MIRT2651169	hsa-miR-1293	CLIP-seq
MIRT2651170	hsa-miR-1324	CLIP-seq
MIRT2651171	hsa-miR-146b-3p	CLIP-seq
MIRT2651172	hsa-miR-150	CLIP-seq
MIRT1455955	hsa-miR-1827	CLIP-seq
MIRT2651173	hsa-miR-183	CLIP-seq
MIRT2651174	hsa-miR-19a	CLIP-seq
MIRT2651175	hsa-miR-19b	CLIP-seq
MIRT1455958	hsa-miR-2114	CLIP-seq
MIRT2651176	hsa-miR-2115	CLIP-seq
MIRT2651177	hsa-miR-224	CLIP-seq
MIRT2651178	hsa-miR-2681	CLIP-seq
MIRT2651179	hsa-miR-3134	CLIP-seq
MIRT1455961	hsa-miR-3141	CLIP-seq
MIRT1455962	hsa-miR-3150b-3p	CLIP-seq
MIRT2651180	hsa-miR-3153	CLIP-seq
MIRT2651181	hsa-miR-3157-5p	CLIP-seq
MIRT2651182	hsa-miR-3166	CLIP-seq
MIRT1455963	hsa-miR-3178	CLIP-seq
MIRT1455964	hsa-miR-3186-5p	CLIP-seq
MIRT2651183	hsa-miR-3187-5p	CLIP-seq
MIRT2651184	hsa-miR-3192	CLIP-seq
MIRT2651185	hsa-miR-3194-3p	CLIP-seq
MIRT2651186	hsa-miR-339-5p	CLIP-seq
MIRT2651187	hsa-miR-3605-3p	CLIP-seq
MIRT1455967	hsa-miR-3612	CLIP-seq
MIRT1455968	hsa-miR-3613-3p	CLIP-seq
MIRT1455970	hsa-miR-3662	CLIP-seq
MIRT2651188	hsa-miR-3672	CLIP-seq
MIRT1455971	hsa-miR-3689a-3p	CLIP-seq
MIRT1455972	hsa-miR-3689c	CLIP-seq
MIRT2651189	hsa-miR-4270	CLIP-seq
MIRT2651190	hsa-miR-4314	CLIP-seq
MIRT1455976	hsa-miR-4318	CLIP-seq
MIRT2651191	hsa-miR-4426	CLIP-seq
MIRT1455981	hsa-miR-4433	CLIP-seq
MIRT1455982	hsa-miR-4440	CLIP-seq
MIRT2651192	hsa-miR-4441	CLIP-seq
MIRT2651193	hsa-miR-4446-5p	CLIP-seq
MIRT1455983	hsa-miR-4459	CLIP-seq
MIRT2651194	hsa-miR-4483	CLIP-seq
MIRT2651195	hsa-miR-4494	CLIP-seq
MIRT2651196	hsa-miR-450b-3p	CLIP-seq
MIRT2651197	hsa-miR-4633-5p	CLIP-seq
MIRT2651198	hsa-miR-4646-5p	CLIP-seq
MIRT2651199	hsa-miR-4647	CLIP-seq
MIRT1455988	hsa-miR-4648	CLIP-seq
MIRT1455989	hsa-miR-4649-3p	CLIP-seq
MIRT1455990	hsa-miR-4654	CLIP-seq
MIRT2651200	hsa-miR-4662b	CLIP-seq
MIRT2651201	hsa-miR-4668-3p	CLIP-seq
MIRT2651202	hsa-miR-4668-5p	CLIP-seq
MIRT2651203	hsa-miR-4681	CLIP-seq
MIRT2462365	hsa-miR-4683	CLIP-seq
MIRT1455992	hsa-miR-4684-5p	CLIP-seq
MIRT1455994	hsa-miR-4689	CLIP-seq
MIRT2651204	hsa-miR-4690-3p	CLIP-seq
MIRT1455995	hsa-miR-4695-5p	CLIP-seq
MIRT2651205	hsa-miR-4713-3p	CLIP-seq
MIRT1455996	hsa-miR-4722-5p	CLIP-seq
MIRT1455998	hsa-miR-4728-5p	CLIP-seq
MIRT1455999	hsa-miR-4738-3p	CLIP-seq
MIRT2651206	hsa-miR-4751	CLIP-seq
MIRT1456000	hsa-miR-4755-3p	CLIP-seq
MIRT2651207	hsa-miR-4763-5p	CLIP-seq
MIRT1456001	hsa-miR-4768-3p	CLIP-seq
MIRT1456002	hsa-miR-4769-5p	CLIP-seq
MIRT2651208	hsa-miR-4771	CLIP-seq
MIRT1456003	hsa-miR-4779	CLIP-seq
MIRT1456004	hsa-miR-4784	CLIP-seq
MIRT2462366	hsa-miR-4786-5p	CLIP-seq
MIRT2651209	hsa-miR-4789-3p	CLIP-seq
MIRT2651210	hsa-miR-4793-3p	CLIP-seq
MIRT2651211	hsa-miR-4797-5p	CLIP-seq
MIRT2651212	hsa-miR-4802-3p	CLIP-seq
MIRT2651213	hsa-miR-499a-5p	CLIP-seq
MIRT2651214	hsa-miR-506	CLIP-seq
MIRT2651215	hsa-miR-508-5p	CLIP-seq
MIRT2651216	hsa-miR-516a-3p	CLIP-seq
MIRT2651217	hsa-miR-532-5p	CLIP-seq
MIRT1456009	hsa-miR-541	CLIP-seq
MIRT2651218	hsa-miR-548aa	CLIP-seq
MIRT2651219	hsa-miR-548an	CLIP-seq
MIRT1456011	hsa-miR-548c-3p	CLIP-seq
MIRT2136702	hsa-miR-548p	CLIP-seq
MIRT1456012	hsa-miR-566	CLIP-seq
MIRT2651220	hsa-miR-612	CLIP-seq
MIRT2651221	hsa-miR-638	CLIP-seq
MIRT2651222	hsa-miR-642a	CLIP-seq
MIRT2651223	hsa-miR-642b	CLIP-seq
MIRT1456013	hsa-miR-650	CLIP-seq
MIRT1456014	hsa-miR-654-5p	CLIP-seq
MIRT2651224	hsa-miR-660	CLIP-seq
MIRT2651225	hsa-miR-661	CLIP-seq
MIRT1456015	hsa-miR-665	CLIP-seq
MIRT2651226	hsa-miR-759	CLIP-seq
MIRT2651227	hsa-miR-766	CLIP-seq
MIRT2651228	hsa-miR-769-3p	CLIP-seq
MIRT2651229	hsa-miR-873	CLIP-seq
MIRT2651230	hsa-miR-876-3p	CLIP-seq
MIRT1456018	hsa-miR-940	CLIP-seq
MIRT2651162	hsa-miR-1197	CLIP-seq
MIRT2651163	hsa-miR-1224-5p	CLIP-seq
MIRT2651164	hsa-miR-124	CLIP-seq
MIRT2694190	hsa-miR-1261	CLIP-seq
MIRT2651165	hsa-miR-1273g	CLIP-seq
MIRT2651166	hsa-miR-128	CLIP-seq
MIRT2651169	hsa-miR-1293	CLIP-seq
MIRT2651170	hsa-miR-1324	CLIP-seq
MIRT2651171	hsa-miR-146b-3p	CLIP-seq
MIRT1455955	hsa-miR-1827	CLIP-seq
MIRT2651173	hsa-miR-183	CLIP-seq
MIRT2651174	hsa-miR-19a	CLIP-seq
MIRT2651175	hsa-miR-19b	CLIP-seq
MIRT1455958	hsa-miR-2114	CLIP-seq
MIRT2651177	hsa-miR-224	CLIP-seq
MIRT2651178	hsa-miR-2681	CLIP-seq
MIRT2694191	hsa-miR-3125	CLIP-seq
MIRT2651179	hsa-miR-3134	CLIP-seq
MIRT2651180	hsa-miR-3153	CLIP-seq
MIRT2651181	hsa-miR-3157-5p	CLIP-seq
MIRT2651182	hsa-miR-3166	CLIP-seq
MIRT1455963	hsa-miR-3178	CLIP-seq
MIRT1455964	hsa-miR-3186-5p	CLIP-seq
MIRT2694192	hsa-miR-3189-3p	CLIP-seq
MIRT2651185	hsa-miR-3194-3p	CLIP-seq
MIRT2651186	hsa-miR-339-5p	CLIP-seq
MIRT1455967	hsa-miR-3612	CLIP-seq
MIRT1455968	hsa-miR-3613-3p	CLIP-seq
MIRT2694193	hsa-miR-362-5p	CLIP-seq
MIRT1455970	hsa-miR-3662	CLIP-seq
MIRT2694194	hsa-miR-383	CLIP-seq
MIRT2694195	hsa-miR-3916	CLIP-seq
MIRT2651189	hsa-miR-4270	CLIP-seq
MIRT2651191	hsa-miR-4426	CLIP-seq
MIRT1455982	hsa-miR-4440	CLIP-seq
MIRT2651192	hsa-miR-4441	CLIP-seq
MIRT2651193	hsa-miR-4446-5p	CLIP-seq
MIRT1455983	hsa-miR-4459	CLIP-seq
MIRT2651194	hsa-miR-4483	CLIP-seq
MIRT2651195	hsa-miR-4494	CLIP-seq
MIRT2651197	hsa-miR-4633-5p	CLIP-seq
MIRT2651199	hsa-miR-4647	CLIP-seq
MIRT1455989	hsa-miR-4649-3p	CLIP-seq
MIRT2651200	hsa-miR-4662b	CLIP-seq
MIRT2651201	hsa-miR-4668-3p	CLIP-seq
MIRT2651202	hsa-miR-4668-5p	CLIP-seq
MIRT2651203	hsa-miR-4681	CLIP-seq
MIRT1455992	hsa-miR-4684-5p	CLIP-seq
MIRT2651204	hsa-miR-4690-3p	CLIP-seq
MIRT1455995	hsa-miR-4695-5p	CLIP-seq
MIRT1455996	hsa-miR-4722-5p	CLIP-seq
MIRT1455999	hsa-miR-4738-3p	CLIP-seq
MIRT2651206	hsa-miR-4751	CLIP-seq
MIRT1456000	hsa-miR-4755-3p	CLIP-seq
MIRT2651207	hsa-miR-4763-5p	CLIP-seq
MIRT1456001	hsa-miR-4768-3p	CLIP-seq
MIRT2651208	hsa-miR-4771	CLIP-seq
MIRT2651209	hsa-miR-4789-3p	CLIP-seq
MIRT2651212	hsa-miR-4802-3p	CLIP-seq
MIRT2651213	hsa-miR-499a-5p	CLIP-seq
MIRT2694196	hsa-miR-500a	CLIP-seq
MIRT2694197	hsa-miR-500b	CLIP-seq
MIRT2651214	hsa-miR-506	CLIP-seq
MIRT2651217	hsa-miR-532-5p	CLIP-seq
MIRT1456009	hsa-miR-541	CLIP-seq
MIRT2651218	hsa-miR-548aa	CLIP-seq
MIRT2651219	hsa-miR-548an	CLIP-seq
MIRT1456011	hsa-miR-548c-3p	CLIP-seq
MIRT2136702	hsa-miR-548p	CLIP-seq
MIRT1456012	hsa-miR-566	CLIP-seq
MIRT2651223	hsa-miR-642b	CLIP-seq
MIRT1456013	hsa-miR-650	CLIP-seq
MIRT1456014	hsa-miR-654-5p	CLIP-seq
MIRT2651224	hsa-miR-660	CLIP-seq
MIRT1456015	hsa-miR-665	CLIP-seq
MIRT2651229	hsa-miR-873	CLIP-seq
MIRT2651230	hsa-miR-876-3p	CLIP-seq
MIRT1456018	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (28)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004842	Function	Ubiquitin-protein transferase activity	IDA	18451177
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781, 36931259
GO:0005634	Component	Nucleus	IDA	18451177
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005794	Component	Golgi apparatus	IDA
GO:0005829	Component	Cytosol	IBA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	TAS
GO:0008270	Function	Zinc ion binding	IEA
GO:0010468	Process	Regulation of gene expression	IBA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0035035	Function	Histone acetyltransferase binding	IPI	18451177
GO:0042802	Function	Identical protein binding	IPI	32296183
GO:0045087	Process	Innate immune response	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0050681	Function	Nuclear androgen receptor binding	IPI	18451177
GO:0051865	Process	Protein autoubiquitination	IDA	18451177
GO:0060765	Process	Regulation of androgen receptor signaling pathway	IDA	18451177
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 613184
• HGNC: 21161
• e!Ensembl: ENSG00000167333

Protein

• UniProt ID: Q6AZZ1
• Protein name: E3 ubiquitin-protein ligase TRIM68 (EC 2.3.2.27) (RING finger protein 137) (RING-type E3 ubiquitin transferase TRIM68) (SSA protein SS-56) (SS-56) (Tripartite motif-containing protein 68)
• Protein function: Functions as a ubiquitin E3 ligase. Acts as a coactivator of androgen receptor (AR) depending on its ubiquitin ligase activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	357 → 473	SPRY domain	Family
  PF00643	zf-B_box	94 → 134	B-box zinc finger	Domain
  PF13765	PRY	305 → 353	SPRY-associated domain	Family
  PF15227	zf-C3HC4_4	16 → 60		Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. Expressed at high levels in prostate cancer cell lines. Up-regulation could be restricted to androgen-dependent cells. {ECO:0000269|PubMed:11560955, ECO:0000269|PubMed:11597395, ECO:0000269|PubMed:18451177}.
• Sequence:

  MDPTALVEAIVEEVACPICMTFLREPMSIDCGHSFCHSCLSGLWEIPGESQNWGYTCPLC
  RAPVQPRNLRPNWQLANVVEKVRLLRLHPGMGLKGDLCERHGEKLKMFCKEDVLIMCEAC
  SQSPEHEAHSVVPMEDVAWEYKWELHEALEHLKKEQEEAWKLEVGERKRTATWKIQVETR
  KQSIVWEFEKYQRLLEKKQPPHRQLGAEVAAALASLQREAAETMQKLELNHSELIQQSQV
  LWRMIAELKERSQRPVRWMLQDIQEVLNRSKSWSLQQPEPISLELKTDCRVLGLREILKT
  YAADVRLDPDTAYSRLIVSEDRKRVHYGDTNQKLPDNPERFYRYNIVLGSQCISSGRHYW
  EVEVGDRSEWGLGVCKQNVDRKEVVYLSPHYGFWVIRLRKGNEYRAGTDEYPILSLPVPP
  RRVGIFVDYEAHDISFYNVTDCGSHIFTFPRYPFPGRLLPYFSPCYSIGTNNTAPLAICS
  LDGED

• Sequence length: 485

Pathways

Reactome Pathway:

Interferon gamma signaling

Related Genes

No strongly related genes found yet for TRIM68.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRIM68.