TRIM65 (tripartite motif containing 65)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 201292 |
| Gene name | Tripartite motif containing 65 |
| Gene symbol | TRIM65 |
| Synonyms (NCBI Gene) |
4732463G12Rik
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| Chromosome | 17 |
| Chromosome location | 17q25.1 |
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miRNA
miRNA information provided by mirtarbase database.
456
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
32
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q6PJ69 | ||||||||||||||||||||
| Protein name | E3 ubiquitin-protein ligase TRIM65 (EC 2.3.2.27) (Tripartite motif-containing protein 65) | ||||||||||||||||||||
| Protein function | E3 ubiquitin ligase that plays a role in several processes including innate immnity, autophagy or inflammation (PubMed:28594402, PubMed:34512673). Negatively regulates miRNAs by modulating the ubiquitination and stability of TNRC6A, a protein in | ||||||||||||||||||||
| PDB | 7JL0 , 7JL2 , 7JL4 | ||||||||||||||||||||
| Family and domains |
Pfam
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| Sequence |
MAAQLLEEKLTCAICLGLYQDPVTLPCGHNFCGACIRDWWDRCGKACPECREPFPDGAEL |
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| Sequence length | 517 | ||||||||||||||||||||
| Interactions | View interactions | ||||||||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
5
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with TRIM65 across shared curated disease and pathway associations.
0
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to TRIM65 (see Related Genes above), that are NOT already directly curated for TRIM65 itself -- a lead worth checking, not a confirmed association.
0
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