TRIM52 (tripartite motif containing 52)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Associated diseases Diseases linked via similar genes

Gene

• Entrez ID: 84851
• Gene name: Tripartite motif containing 52
• Gene symbol: TRIM52
• Synonyms (NCBI Gene): RNF102
• Chromosome: 5
• Chromosome location: 5q35.3

miRNA Show/Hide all (149)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1455086	hsa-miR-1208	CLIP-seq
MIRT1455087	hsa-miR-122	CLIP-seq
MIRT1455088	hsa-miR-1273f	CLIP-seq
MIRT1455089	hsa-miR-1289	CLIP-seq
MIRT1455090	hsa-miR-136	CLIP-seq
MIRT1455091	hsa-miR-143	CLIP-seq
MIRT1455092	hsa-miR-198	CLIP-seq
MIRT1455093	hsa-miR-2467-3p	CLIP-seq
MIRT1455094	hsa-miR-298	CLIP-seq
MIRT1455095	hsa-miR-3123	CLIP-seq
MIRT1455096	hsa-miR-3135b	CLIP-seq
MIRT1455097	hsa-miR-3158-5p	CLIP-seq
MIRT1455098	hsa-miR-3198	CLIP-seq
MIRT1455099	hsa-miR-320a	CLIP-seq
MIRT1455100	hsa-miR-320b	CLIP-seq
MIRT1455101	hsa-miR-320c	CLIP-seq
MIRT1455102	hsa-miR-320d	CLIP-seq
MIRT1455103	hsa-miR-3622b-5p	CLIP-seq
MIRT1455104	hsa-miR-3652	CLIP-seq
MIRT1455105	hsa-miR-3678-3p	CLIP-seq
MIRT1455106	hsa-miR-3919	CLIP-seq
MIRT1455107	hsa-miR-3944-3p	CLIP-seq
MIRT1455108	hsa-miR-4294	CLIP-seq
MIRT1455109	hsa-miR-4309	CLIP-seq
MIRT1455110	hsa-miR-431	CLIP-seq
MIRT1455111	hsa-miR-4429	CLIP-seq
MIRT1455112	hsa-miR-4430	CLIP-seq
MIRT1455113	hsa-miR-4457	CLIP-seq
MIRT1455114	hsa-miR-452	CLIP-seq
MIRT1455115	hsa-miR-4534	CLIP-seq
MIRT1455116	hsa-miR-4676-3p	CLIP-seq
MIRT1455117	hsa-miR-4708-5p	CLIP-seq
MIRT1455118	hsa-miR-4765	CLIP-seq
MIRT1455119	hsa-miR-4770	CLIP-seq
MIRT1455120	hsa-miR-513b	CLIP-seq
MIRT1455121	hsa-miR-759	CLIP-seq
MIRT1455122	hsa-miR-924	CLIP-seq
MIRT1557210	hsa-miR-4264	CLIP-seq
MIRT1557211	hsa-miR-622	CLIP-seq
MIRT1455087	hsa-miR-122	CLIP-seq
MIRT2136378	hsa-miR-1307	CLIP-seq
MIRT2136379	hsa-miR-1976	CLIP-seq
MIRT2136380	hsa-miR-217	CLIP-seq
MIRT2136381	hsa-miR-24	CLIP-seq
MIRT1455096	hsa-miR-3135b	CLIP-seq
MIRT1455097	hsa-miR-3158-5p	CLIP-seq
MIRT1455104	hsa-miR-3652	CLIP-seq
MIRT1455105	hsa-miR-3678-3p	CLIP-seq
MIRT1557210	hsa-miR-4264	CLIP-seq
MIRT2136382	hsa-miR-4279	CLIP-seq
MIRT2136383	hsa-miR-4284	CLIP-seq
MIRT2136384	hsa-miR-4418	CLIP-seq
MIRT1455112	hsa-miR-4430	CLIP-seq
MIRT2136385	hsa-miR-4638-5p	CLIP-seq
MIRT2136386	hsa-miR-4722-3p	CLIP-seq
MIRT2136387	hsa-miR-509-3-5p	CLIP-seq
MIRT2136388	hsa-miR-509-5p	CLIP-seq
MIRT2136389	hsa-miR-616	CLIP-seq
MIRT1557211	hsa-miR-622	CLIP-seq
MIRT1455086	hsa-miR-1208	CLIP-seq
MIRT1455087	hsa-miR-122	CLIP-seq
MIRT1455092	hsa-miR-198	CLIP-seq
MIRT2136381	hsa-miR-24	CLIP-seq
MIRT1455093	hsa-miR-2467-3p	CLIP-seq
MIRT1455094	hsa-miR-298	CLIP-seq
MIRT1455095	hsa-miR-3123	CLIP-seq
MIRT1455096	hsa-miR-3135b	CLIP-seq
MIRT1455097	hsa-miR-3158-5p	CLIP-seq
MIRT1455099	hsa-miR-320a	CLIP-seq
MIRT1455100	hsa-miR-320b	CLIP-seq
MIRT1455101	hsa-miR-320c	CLIP-seq
MIRT1455102	hsa-miR-320d	CLIP-seq
MIRT1455104	hsa-miR-3652	CLIP-seq
MIRT1455105	hsa-miR-3678-3p	CLIP-seq
MIRT1455106	hsa-miR-3919	CLIP-seq
MIRT1455107	hsa-miR-3944-3p	CLIP-seq
MIRT1557210	hsa-miR-4264	CLIP-seq
MIRT2136383	hsa-miR-4284	CLIP-seq
MIRT1455108	hsa-miR-4294	CLIP-seq
MIRT1455110	hsa-miR-431	CLIP-seq
MIRT1455111	hsa-miR-4429	CLIP-seq
MIRT1455112	hsa-miR-4430	CLIP-seq
MIRT1455114	hsa-miR-452	CLIP-seq
MIRT1455116	hsa-miR-4676-3p	CLIP-seq
MIRT1557211	hsa-miR-622	CLIP-seq
MIRT1455122	hsa-miR-924	CLIP-seq
MIRT1455097	hsa-miR-3158-5p	CLIP-seq
MIRT1455105	hsa-miR-3678-3p	CLIP-seq
MIRT1455096	hsa-miR-3135b	CLIP-seq
MIRT1455104	hsa-miR-3652	CLIP-seq
MIRT1455108	hsa-miR-4294	CLIP-seq
MIRT1455110	hsa-miR-431	CLIP-seq
MIRT1455112	hsa-miR-4430	CLIP-seq
MIRT1455122	hsa-miR-924	CLIP-seq
MIRT1455087	hsa-miR-122	CLIP-seq
MIRT1455089	hsa-miR-1289	CLIP-seq
MIRT2651008	hsa-miR-1914	CLIP-seq
MIRT1455093	hsa-miR-2467-3p	CLIP-seq
MIRT1455096	hsa-miR-3135b	CLIP-seq
MIRT1455098	hsa-miR-3198	CLIP-seq
MIRT2651009	hsa-miR-362-5p	CLIP-seq
MIRT2651010	hsa-miR-3646	CLIP-seq
MIRT1455104	hsa-miR-3652	CLIP-seq
MIRT1455105	hsa-miR-3678-3p	CLIP-seq
MIRT1455108	hsa-miR-4294	CLIP-seq
MIRT1455109	hsa-miR-4309	CLIP-seq
MIRT1455110	hsa-miR-431	CLIP-seq
MIRT2651011	hsa-miR-4327	CLIP-seq
MIRT1455112	hsa-miR-4430	CLIP-seq
MIRT2651012	hsa-miR-4453	CLIP-seq
MIRT2651013	hsa-miR-4495	CLIP-seq
MIRT1455115	hsa-miR-4534	CLIP-seq
MIRT2651014	hsa-miR-4538	CLIP-seq
MIRT2651015	hsa-miR-4680-5p	CLIP-seq
MIRT2651016	hsa-miR-4762-5p	CLIP-seq
MIRT2651017	hsa-miR-4799-5p	CLIP-seq
MIRT2651018	hsa-miR-500b	CLIP-seq
MIRT2651019	hsa-miR-501-5p	CLIP-seq
MIRT2651020	hsa-miR-550b	CLIP-seq
MIRT2651021	hsa-miR-618	CLIP-seq
MIRT2651022	hsa-miR-7	CLIP-seq
MIRT1455122	hsa-miR-924	CLIP-seq
MIRT2651023	hsa-miR-938	CLIP-seq
MIRT1455087	hsa-miR-122	CLIP-seq
MIRT1455089	hsa-miR-1289	CLIP-seq
MIRT2136378	hsa-miR-1307	CLIP-seq
MIRT2136381	hsa-miR-24	CLIP-seq
MIRT1455093	hsa-miR-2467-3p	CLIP-seq
MIRT1455096	hsa-miR-3135b	CLIP-seq
MIRT1455098	hsa-miR-3198	CLIP-seq
MIRT2651010	hsa-miR-3646	CLIP-seq
MIRT1455104	hsa-miR-3652	CLIP-seq
MIRT1455105	hsa-miR-3678-3p	CLIP-seq
MIRT1557210	hsa-miR-4264	CLIP-seq
MIRT2136383	hsa-miR-4284	CLIP-seq
MIRT1455108	hsa-miR-4294	CLIP-seq
MIRT1455109	hsa-miR-4309	CLIP-seq
MIRT1455110	hsa-miR-431	CLIP-seq
MIRT2651011	hsa-miR-4327	CLIP-seq
MIRT1455112	hsa-miR-4430	CLIP-seq
MIRT2651012	hsa-miR-4453	CLIP-seq
MIRT2651014	hsa-miR-4538	CLIP-seq
MIRT2136385	hsa-miR-4638-5p	CLIP-seq
MIRT2651016	hsa-miR-4762-5p	CLIP-seq
MIRT2651017	hsa-miR-4799-5p	CLIP-seq
MIRT2651020	hsa-miR-550b	CLIP-seq
MIRT1557211	hsa-miR-622	CLIP-seq
MIRT1455122	hsa-miR-924	CLIP-seq
MIRT2651023	hsa-miR-938	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003713	Function	Transcription coactivator activity	IDA	23077300
GO:0005634	Component	Nucleus	IDA	27667714, 28073078
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IDA	28073078
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA	27667714
GO:0005829	Component	Cytosol	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0009967	Process	Positive regulation of signal transduction	IEA
GO:0016567	Process	Protein ubiquitination	IDA	27667714
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043123	Process	Positive regulation of canonical NF-kappaB signal transduction	IDA	27667714, 28073078
GO:0045087	Process	Innate immune response	IBA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IDA	27667714
GO:0051607	Process	Defense response to virus	IEA
GO:0051865	Process	Protein autoubiquitination	IDA	27667714
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	27667714
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 619265
• HGNC: 19024
• e!Ensembl: ENSG00000183718

Protein

• UniProt ID: Q96A61
• Protein name: E3 ubiquitin-protein ligase TRIM52 (EC 2.3.2.27) (RING finger protein 102) (Tripartite motif-containing protein 52)
• Protein function: E3 ubiquitin-protein ligase (PubMed:27667714). Positively regulates the NF-kappa-B signaling pathway (PubMed:27667714, PubMed:28073078). ; (Microbial infection) Exhibits antivi
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00643	zf-B_box	222 → 263	B-box zinc finger	Domain
  PF15227	zf-C3HC4_4	20 → 57		Domain

• Sequence:

  MAGYATTPSPMQTLQEEAVCAICLDYFKDPVSISCGHNFCRGCVTQLWSKEDEEDQNEEE
  DEWEEEEDEEAVGAMDGWDGSIREVLYRGNADEELFQDQDDDELWLGDSGITNWDNVDYM
  WDEEEEEEEEDQDYYLGGLRPDLRIDVYREEEILEAYDEDEDEELYPDIHPPPSLPLPGQ
  FTCPQCRKSFTRRSFRPNLQLANMVQIIRQMCPTPYRGNRSNDQGMCFKHQEALKLFCEV
  DKEAICVVCRESRSHKQHSVLPLEEVVQEYQEIKLETTLVGILQIEQESIHSKAYNQ

• Sequence length: 297

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Gastric cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (13)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	29089476, 34692847	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31002351		★☆☆☆☆ Found in Text Mining only
Carcinoma, Ovarian Epithelial	Ovarian Epithelial carcinoma	BEFREE	30185771		★☆☆☆☆ Found in Text Mining only
Colorectal Carcinoma	Colorectal Cancer	BEFREE	30918473		★☆☆☆☆ Found in Text Mining only
Hepatitis B	Hepatitis b	Pubtator	29089476	Associate	★☆☆☆☆ Found in Text Mining only
Liver carcinoma	Liver carcinoma	BEFREE	29089476, 29898761		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31002351		★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of ovary	Ovarian cancer	BEFREE	30185771		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	30185771		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	30185771, 30918473		★☆☆☆☆ Found in Text Mining only
ovarian neoplasm	Ovarian neoplasm	BEFREE	30185771		★☆☆☆☆ Found in Text Mining only
Periodontitis	Periodontitis	Pubtator	32735017	Associate	★☆☆☆☆ Found in Text Mining only
Uterine Cervical Neoplasms	Uterine neoplasm	Pubtator	34837692, 36354205	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for TRIM52.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRIM52.