TRIM45 (tripartite motif containing 45)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 80263
• Gene name: Tripartite motif containing 45
• Gene symbol: TRIM45
• Synonyms (NCBI Gene): RNF99
• Chromosome: 1
• Chromosome location: 1p13.1
• Summary: This gene encodes a member of the tripartite motif family. The encoded protein may function as a transcriptional repressor of the mitogen-activated protein kinase pathway. Alternatively spliced transcript variants have been described.[provided by RefSeq,

miRNA Show/Hide all (226)

miRTarBase ID	miRNA	Experiments	Reference
MIRT685693	hsa-miR-548ac	HITS-CLIP	23313552
MIRT685692	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT685691	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT685690	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT685689	hsa-miR-548z	HITS-CLIP	23313552
MIRT685688	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT685687	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT685686	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT685685	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT685684	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT685683	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT685682	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT685681	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT698077	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685680	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT685679	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT698076	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT698075	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT698074	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT685678	hsa-miR-3926	HITS-CLIP	23313552
MIRT685677	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT698073	hsa-miR-3672	HITS-CLIP	23313552
MIRT698072	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT685676	hsa-miR-548s	HITS-CLIP	23313552
MIRT685693	hsa-miR-548ac	HITS-CLIP	23313552
MIRT685692	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT685691	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT685690	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT685689	hsa-miR-548z	HITS-CLIP	23313552
MIRT685688	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT685687	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT685686	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT685685	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT685684	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT685683	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT685682	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT685681	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT685680	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT685679	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT685678	hsa-miR-3926	HITS-CLIP	23313552
MIRT685677	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT685676	hsa-miR-548s	HITS-CLIP	23313552
MIRT685693	hsa-miR-548ac	HITS-CLIP	23313552
MIRT685692	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT685691	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT685690	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT685689	hsa-miR-548z	HITS-CLIP	23313552
MIRT685688	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT685687	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT685686	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT685685	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT685684	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT685683	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT685682	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT685681	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT698077	hsa-miR-6849-3p	HITS-CLIP	23313552
MIRT685680	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT685679	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT698076	hsa-miR-3190-5p	HITS-CLIP	23313552
MIRT698075	hsa-miR-4786-5p	HITS-CLIP	23313552
MIRT698074	hsa-miR-769-5p	HITS-CLIP	23313552
MIRT685678	hsa-miR-3926	HITS-CLIP	23313552
MIRT685677	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT698073	hsa-miR-3672	HITS-CLIP	23313552
MIRT698072	hsa-miR-6864-3p	HITS-CLIP	23313552
MIRT685676	hsa-miR-548s	HITS-CLIP	23313552
MIRT685693	hsa-miR-548ac	HITS-CLIP	23313552
MIRT685692	hsa-miR-548bb-3p	HITS-CLIP	23313552
MIRT685691	hsa-miR-548d-3p	HITS-CLIP	23313552
MIRT685690	hsa-miR-548h-3p	HITS-CLIP	23313552
MIRT685689	hsa-miR-548z	HITS-CLIP	23313552
MIRT685688	hsa-miR-548ae-3p	HITS-CLIP	23313552
MIRT685687	hsa-miR-548ah-3p	HITS-CLIP	23313552
MIRT685686	hsa-miR-548aj-3p	HITS-CLIP	23313552
MIRT685685	hsa-miR-548am-3p	HITS-CLIP	23313552
MIRT685684	hsa-miR-548aq-3p	HITS-CLIP	23313552
MIRT685683	hsa-miR-548j-3p	HITS-CLIP	23313552
MIRT685682	hsa-miR-548x-3p	HITS-CLIP	23313552
MIRT685681	hsa-miR-6771-3p	HITS-CLIP	23313552
MIRT685680	hsa-miR-340-3p	HITS-CLIP	23313552
MIRT685679	hsa-miR-6827-3p	HITS-CLIP	23313552
MIRT685678	hsa-miR-3926	HITS-CLIP	23313552
MIRT685677	hsa-miR-4684-5p	HITS-CLIP	23313552
MIRT685676	hsa-miR-548s	HITS-CLIP	23313552
MIRT1454943	hsa-miR-1262	CLIP-seq
MIRT1454944	hsa-miR-132	CLIP-seq
MIRT1454945	hsa-miR-212	CLIP-seq
MIRT1454946	hsa-miR-3122	CLIP-seq
MIRT1454947	hsa-miR-3165	CLIP-seq
MIRT1454948	hsa-miR-3665	CLIP-seq
MIRT1454949	hsa-miR-3689a-3p	CLIP-seq
MIRT1454950	hsa-miR-3689c	CLIP-seq
MIRT1454951	hsa-miR-3913-5p	CLIP-seq
MIRT1454952	hsa-miR-4433	CLIP-seq
MIRT1454953	hsa-miR-4459	CLIP-seq
MIRT1454954	hsa-miR-4509	CLIP-seq
MIRT1454955	hsa-miR-4701-3p	CLIP-seq
MIRT1454956	hsa-miR-4728-5p	CLIP-seq
MIRT1454957	hsa-miR-4736	CLIP-seq
MIRT1454958	hsa-miR-4744	CLIP-seq
MIRT1454959	hsa-miR-4768-3p	CLIP-seq
MIRT1454960	hsa-miR-4793-3p	CLIP-seq
MIRT1454961	hsa-miR-4797-5p	CLIP-seq
MIRT1454962	hsa-miR-508-5p	CLIP-seq
MIRT1454963	hsa-miR-542-3p	CLIP-seq
MIRT1454964	hsa-miR-548ae	CLIP-seq
MIRT1454965	hsa-miR-548aj	CLIP-seq
MIRT1454966	hsa-miR-548am	CLIP-seq
MIRT1454967	hsa-miR-548u	CLIP-seq
MIRT1454968	hsa-miR-548x	CLIP-seq
MIRT1454969	hsa-miR-661	CLIP-seq
MIRT1454970	hsa-miR-759	CLIP-seq
MIRT1454971	hsa-miR-766	CLIP-seq
MIRT1454972	hsa-miR-940	CLIP-seq
MIRT1454973	hsa-miR-124	CLIP-seq
MIRT1454974	hsa-miR-130a	CLIP-seq
MIRT1454975	hsa-miR-130b	CLIP-seq
MIRT1454976	hsa-miR-148a	CLIP-seq
MIRT1454977	hsa-miR-148b	CLIP-seq
MIRT1454978	hsa-miR-152	CLIP-seq
MIRT1454979	hsa-miR-1825	CLIP-seq
MIRT1454980	hsa-miR-199a-5p	CLIP-seq
MIRT1454981	hsa-miR-199b-5p	CLIP-seq
MIRT1454982	hsa-miR-298	CLIP-seq
MIRT1454983	hsa-miR-301a	CLIP-seq
MIRT1454984	hsa-miR-301b	CLIP-seq
MIRT1454985	hsa-miR-3120-5p	CLIP-seq
MIRT1454986	hsa-miR-3177-5p	CLIP-seq
MIRT1454987	hsa-miR-3183	CLIP-seq
MIRT1454988	hsa-miR-338-3p	CLIP-seq
MIRT1454989	hsa-miR-3653	CLIP-seq
MIRT1454990	hsa-miR-3664-5p	CLIP-seq
MIRT1454991	hsa-miR-3666	CLIP-seq
MIRT1454992	hsa-miR-3686	CLIP-seq
MIRT1454993	hsa-miR-3714	CLIP-seq
MIRT1454994	hsa-miR-3910	CLIP-seq
MIRT1454995	hsa-miR-3925-3p	CLIP-seq
MIRT1454996	hsa-miR-4260	CLIP-seq
MIRT1454997	hsa-miR-4295	CLIP-seq
MIRT1454998	hsa-miR-4493	CLIP-seq
MIRT1454999	hsa-miR-4522	CLIP-seq
MIRT1455000	hsa-miR-4530	CLIP-seq
MIRT1455001	hsa-miR-454	CLIP-seq
MIRT1455002	hsa-miR-4645-5p	CLIP-seq
MIRT1455003	hsa-miR-4652-3p	CLIP-seq
MIRT1455004	hsa-miR-4673	CLIP-seq
MIRT1455005	hsa-miR-4696	CLIP-seq
MIRT1455006	hsa-miR-4723-3p	CLIP-seq
MIRT1455007	hsa-miR-4742-3p	CLIP-seq
MIRT1455008	hsa-miR-4765	CLIP-seq
MIRT1455009	hsa-miR-4777-5p	CLIP-seq
MIRT1455010	hsa-miR-486-3p	CLIP-seq
MIRT1455011	hsa-miR-506	CLIP-seq
MIRT1455012	hsa-miR-511	CLIP-seq
MIRT1455013	hsa-miR-515-5p	CLIP-seq
MIRT1455014	hsa-miR-568	CLIP-seq
MIRT1455015	hsa-miR-646	CLIP-seq
MIRT1454971	hsa-miR-766	CLIP-seq
MIRT2136346	hsa-miR-24	CLIP-seq
MIRT2136347	hsa-miR-4284	CLIP-seq
MIRT1454960	hsa-miR-4793-3p	CLIP-seq
MIRT1454962	hsa-miR-508-5p	CLIP-seq
MIRT1454971	hsa-miR-766	CLIP-seq
MIRT1454973	hsa-miR-124	CLIP-seq
MIRT1455008	hsa-miR-4765	CLIP-seq
MIRT1455011	hsa-miR-506	CLIP-seq
MIRT2136348	hsa-miR-875-5p	CLIP-seq
MIRT1454973	hsa-miR-124	CLIP-seq
MIRT1454943	hsa-miR-1262	CLIP-seq
MIRT1454946	hsa-miR-3122	CLIP-seq
MIRT1454947	hsa-miR-3165	CLIP-seq
MIRT1454990	hsa-miR-3664-5p	CLIP-seq
MIRT1454948	hsa-miR-3665	CLIP-seq
MIRT1454949	hsa-miR-3689a-3p	CLIP-seq
MIRT1454950	hsa-miR-3689c	CLIP-seq
MIRT1454951	hsa-miR-3913-5p	CLIP-seq
MIRT1454952	hsa-miR-4433	CLIP-seq
MIRT1454953	hsa-miR-4459	CLIP-seq
MIRT1454999	hsa-miR-4522	CLIP-seq
MIRT1454955	hsa-miR-4701-3p	CLIP-seq
MIRT1454956	hsa-miR-4728-5p	CLIP-seq
MIRT1454957	hsa-miR-4736	CLIP-seq
MIRT1454959	hsa-miR-4768-3p	CLIP-seq
MIRT1454960	hsa-miR-4793-3p	CLIP-seq
MIRT1454961	hsa-miR-4797-5p	CLIP-seq
MIRT1455011	hsa-miR-506	CLIP-seq
MIRT1454962	hsa-miR-508-5p	CLIP-seq
MIRT1454963	hsa-miR-542-3p	CLIP-seq
MIRT1454969	hsa-miR-661	CLIP-seq
MIRT1454970	hsa-miR-759	CLIP-seq
MIRT1454971	hsa-miR-766	CLIP-seq
MIRT1454972	hsa-miR-940	CLIP-seq
MIRT1454946	hsa-miR-3122	CLIP-seq
MIRT1454947	hsa-miR-3165	CLIP-seq
MIRT1454948	hsa-miR-3665	CLIP-seq
MIRT1454949	hsa-miR-3689a-3p	CLIP-seq
MIRT1454950	hsa-miR-3689c	CLIP-seq
MIRT1454951	hsa-miR-3913-5p	CLIP-seq
MIRT1454952	hsa-miR-4433	CLIP-seq
MIRT1454953	hsa-miR-4459	CLIP-seq
MIRT1454956	hsa-miR-4728-5p	CLIP-seq
MIRT1454957	hsa-miR-4736	CLIP-seq
MIRT1454959	hsa-miR-4768-3p	CLIP-seq
MIRT1454972	hsa-miR-940	CLIP-seq
MIRT1454947	hsa-miR-3165	CLIP-seq
MIRT1454948	hsa-miR-3665	CLIP-seq
MIRT1454952	hsa-miR-4433	CLIP-seq
MIRT1454953	hsa-miR-4459	CLIP-seq
MIRT1454957	hsa-miR-4736	CLIP-seq
MIRT1454959	hsa-miR-4768-3p	CLIP-seq
MIRT1454964	hsa-miR-548ae	CLIP-seq
MIRT1454965	hsa-miR-548aj	CLIP-seq
MIRT1454966	hsa-miR-548am	CLIP-seq
MIRT1454968	hsa-miR-548x	CLIP-seq
MIRT1454972	hsa-miR-940	CLIP-seq
MIRT1454947	hsa-miR-3165	CLIP-seq
MIRT1454948	hsa-miR-3665	CLIP-seq
MIRT1454952	hsa-miR-4433	CLIP-seq
MIRT1454953	hsa-miR-4459	CLIP-seq
MIRT1454957	hsa-miR-4736	CLIP-seq
MIRT1454959	hsa-miR-4768-3p	CLIP-seq
MIRT1454964	hsa-miR-548ae	CLIP-seq
MIRT1454965	hsa-miR-548aj	CLIP-seq
MIRT1454966	hsa-miR-548am	CLIP-seq
MIRT1454968	hsa-miR-548x	CLIP-seq
MIRT1454972	hsa-miR-940	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183, 32814053
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IBA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IDA	36681779
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006954	Process	Inflammatory response	IDA	34017102, 36681779
GO:0008270	Function	Zinc ion binding	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0043161	Process	Proteasome-mediated ubiquitin-dependent protein catabolic process	IDA	36681779
GO:0045171	Component	Intercellular bridge	IDA
GO:0046872	Function	Metal ion binding	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IDA	36681779
GO:0060348	Process	Bone development	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	28542145, 36681779
GO:0070936	Process	Protein K48-linked ubiquitination	IDA	36681779

Other IDs

• MIM: 609318
• HGNC: 19018
• e!Ensembl: ENSG00000134253

Protein

• UniProt ID: Q9H8W5
• Protein name: E3 ubiquitin-protein ligase TRIM45 (EC 2.3.2.27) (RING finger protein 99)
• Protein function: E3 ubiquitin-protein ligase that plays a role in the regulation of inflammatory response (PubMed:36681779). Mechanistically, mediates the 'Lys-48'-linked polyubiquitination of TAB2, a regulatory protein of the kinase TAK1, leading to its degrada
• PDB: 2DS4
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00630	Filamin	396 → 494	Filamin/ABP280 repeat	Domain
  PF00643	zf-B_box	186 → 227	B-box zinc finger	Domain
  PF13445	zf-RING_UBOX	29 → 78	RING-type zinc-finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in skeletal muscle, brain, heart and pancreas. {ECO:0000269|PubMed:15351693}.
• Sequence:

  MSENRKPLLGFVSKLTSGTALGNSGKTHCPLCLGLFKAPRLLPCLHTVCTTCLEQLEPFS
  VVDIRGGDSDTSSEGSIFQELKPRSLQSQIGILCPVCDAQVDLPMGGVKALTIDHLAVND
  VMLESLRGEGQGLVCDLCNDREVEKRCQTCKANLCHFCCQAHRRQKKTTYHTMVDLKDLK
  GYSRIGKPILCPVHPAEELRLFCEFCDRPVCQDCVVGEHREHPCDFTSNVIHKHGDSVWE
  LLKGTQPHVEALEEALAQIHIINSALQKRVEAVAADVRTFSEGYIKAIEEHRDKLLKQLE
  DIRAQKENSLQLQKAQLEQLLADMRTGVEFTEHLLTSGSDLEILITKRVVVERLRKLNKV
  QYSTRPGVNDKIRFCPQEKAGQCRGYEIYGTINTKEVDPAKCVLQGEDLHRAREKQTASF
  TLLCKDAAGEIMGRGGDNVQVAVVPKDKKDSPVRTMVQDNKDGTYYISYTPKEPGVYTVW
  VCIKEQHVQGSPFTVMVRRKHRPHSGVFHCCTFCSSGGQKTARCACGGTMPGGYLGCGHG
  HKGHPGHPHWSCCGKFNEKSECTWTGGQSAPRSLLRTVAL

• Sequence length: 580

Pathways

Reactome Pathway:

Interferon gamma signaling

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Clear cell carcinoma of kidney	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant lymphoma, large B-cell, diffuse	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (11)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Breast Neoplasms	Breast neoplasm	Pubtator	24098497	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	35142083	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma of lung	Lung carcinoma	BEFREE	31663468		★☆☆☆☆ Found in Text Mining only
Glioblastoma	Glioblastoma	BEFREE	28542145		★☆☆☆☆ Found in Text Mining only
Glioblastoma Multiforme	Glioblastoma	BEFREE	28542145		★☆☆☆☆ Found in Text Mining only
Glioma	Glioma	BEFREE	28542145		★☆☆☆☆ Found in Text Mining only
Idiopathic Pulmonary Fibrosis	Idiopathic pulmonary fibrosis	Pubtator	36474231	Associate	★☆☆☆☆ Found in Text Mining only
Malignant neoplasm of lung	Lung Cancer	BEFREE	31663468		★☆☆☆☆ Found in Text Mining only
Malignant Neoplasms	Malignant Neoplasm	BEFREE	28542145		★☆☆☆☆ Found in Text Mining only
Neoplasms	Neoplasms	BEFREE	28542145, 31663468		★☆☆☆☆ Found in Text Mining only
Non-Small Cell Lung Carcinoma	Lung carcinoma	BEFREE	31663468		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for TRIM45.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRIM45.