TRIM41 (tripartite motif containing 41)

Download as csv Download as pdf

Log in to bookmark this gene

Bookmark This Gene

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 90933
• Gene name: Tripartite motif containing 41
• Gene symbol: TRIM41
• Synonyms (NCBI Gene): RINCK
• Chromosome: 5
• Chromosome location: 5q35.3
• Summary: This gene encodes a member of the tripartite motif (TRIM) family. The TRIM family is characterized by a signature motif composed of a RING finger, one or more B-box domains, and a coiled-coil region. This encoded protein may play a role in protein kinase

miRNA Show/Hide all (95)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1454738	hsa-miR-1	CLIP-seq
MIRT1454739	hsa-miR-1912	CLIP-seq
MIRT1454740	hsa-miR-206	CLIP-seq
MIRT1454741	hsa-miR-3130-5p	CLIP-seq
MIRT1454742	hsa-miR-3136-3p	CLIP-seq
MIRT1454743	hsa-miR-328	CLIP-seq
MIRT1454744	hsa-miR-3673	CLIP-seq
MIRT1454745	hsa-miR-4267	CLIP-seq
MIRT1454746	hsa-miR-4482	CLIP-seq
MIRT1454747	hsa-miR-4694-3p	CLIP-seq
MIRT1454748	hsa-miR-4711-5p	CLIP-seq
MIRT1454749	hsa-miR-596	CLIP-seq
MIRT1454750	hsa-miR-613	CLIP-seq
MIRT1454751	hsa-miR-3179	CLIP-seq
MIRT1454752	hsa-miR-3202	CLIP-seq
MIRT1454753	hsa-miR-4271	CLIP-seq
MIRT1454754	hsa-miR-4716-3p	CLIP-seq
MIRT1454755	hsa-miR-4725-3p	CLIP-seq
MIRT1454756	hsa-miR-4747-5p	CLIP-seq
MIRT1454757	hsa-miR-625	CLIP-seq
MIRT2136202	hsa-miR-1253	CLIP-seq
MIRT2136203	hsa-miR-185	CLIP-seq
MIRT1454739	hsa-miR-1912	CLIP-seq
MIRT2136204	hsa-miR-2117	CLIP-seq
MIRT2136205	hsa-miR-2467-3p	CLIP-seq
MIRT2136206	hsa-miR-2682	CLIP-seq
MIRT1454741	hsa-miR-3130-5p	CLIP-seq
MIRT2136207	hsa-miR-3166	CLIP-seq
MIRT2136208	hsa-miR-3192	CLIP-seq
MIRT2136209	hsa-miR-361-5p	CLIP-seq
MIRT1454745	hsa-miR-4267	CLIP-seq
MIRT2136210	hsa-miR-4270	CLIP-seq
MIRT1454753	hsa-miR-4271	CLIP-seq
MIRT2136211	hsa-miR-4273	CLIP-seq
MIRT2136212	hsa-miR-4306	CLIP-seq
MIRT2136213	hsa-miR-4441	CLIP-seq
MIRT2136214	hsa-miR-4463	CLIP-seq
MIRT1454746	hsa-miR-4482	CLIP-seq
MIRT2136215	hsa-miR-4494	CLIP-seq
MIRT2136216	hsa-miR-449c	CLIP-seq
MIRT2136217	hsa-miR-4514	CLIP-seq
MIRT2136218	hsa-miR-4528	CLIP-seq
MIRT2136219	hsa-miR-4644	CLIP-seq
MIRT2136220	hsa-miR-4645-5p	CLIP-seq
MIRT2136221	hsa-miR-4673	CLIP-seq
MIRT2136222	hsa-miR-4692	CLIP-seq
MIRT1454754	hsa-miR-4716-3p	CLIP-seq
MIRT1454755	hsa-miR-4725-3p	CLIP-seq
MIRT2136223	hsa-miR-4729	CLIP-seq
MIRT1454756	hsa-miR-4747-5p	CLIP-seq
MIRT2136224	hsa-miR-4771	CLIP-seq
MIRT2136225	hsa-miR-556-3p	CLIP-seq
MIRT2136226	hsa-miR-711	CLIP-seq
MIRT2136227	hsa-miR-940	CLIP-seq
MIRT2357201	hsa-let-7a	CLIP-seq
MIRT2357202	hsa-let-7b	CLIP-seq
MIRT2357203	hsa-let-7c	CLIP-seq
MIRT2357204	hsa-let-7d	CLIP-seq
MIRT2357205	hsa-let-7e	CLIP-seq
MIRT2357206	hsa-let-7f	CLIP-seq
MIRT2357207	hsa-let-7g	CLIP-seq
MIRT2357208	hsa-let-7i	CLIP-seq
MIRT2357209	hsa-miR-1224-5p	CLIP-seq
MIRT2357210	hsa-miR-1252	CLIP-seq
MIRT2357211	hsa-miR-1470	CLIP-seq
MIRT2357212	hsa-miR-184	CLIP-seq
MIRT2357213	hsa-miR-1909	CLIP-seq
MIRT1454739	hsa-miR-1912	CLIP-seq
MIRT1454741	hsa-miR-3130-5p	CLIP-seq
MIRT2357214	hsa-miR-3689d	CLIP-seq
MIRT2357215	hsa-miR-3915	CLIP-seq
MIRT2357216	hsa-miR-3927	CLIP-seq
MIRT1454745	hsa-miR-4267	CLIP-seq
MIRT2357217	hsa-miR-4458	CLIP-seq
MIRT1454746	hsa-miR-4482	CLIP-seq
MIRT2357218	hsa-miR-4500	CLIP-seq
MIRT2357219	hsa-miR-4519	CLIP-seq
MIRT2357220	hsa-miR-4533	CLIP-seq
MIRT2357221	hsa-miR-4650-3p	CLIP-seq
MIRT2357222	hsa-miR-4667-3p	CLIP-seq
MIRT2357223	hsa-miR-4689	CLIP-seq
MIRT2136223	hsa-miR-4729	CLIP-seq
MIRT1454756	hsa-miR-4747-5p	CLIP-seq
MIRT2357224	hsa-miR-4751	CLIP-seq
MIRT2357225	hsa-miR-4802-5p	CLIP-seq
MIRT2136225	hsa-miR-556-3p	CLIP-seq
MIRT2357226	hsa-miR-561	CLIP-seq
MIRT2357227	hsa-miR-802	CLIP-seq
MIRT2357228	hsa-miR-98	CLIP-seq
MIRT1454739	hsa-miR-1912	CLIP-seq
MIRT1454741	hsa-miR-3130-5p	CLIP-seq
MIRT1454745	hsa-miR-4267	CLIP-seq
MIRT1454746	hsa-miR-4482	CLIP-seq
MIRT2136223	hsa-miR-4729	CLIP-seq
MIRT2136225	hsa-miR-556-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001650	Component	Fibrillar center	IDA
GO:0005515	Function	Protein binding	IPI	16189514, 17893151, 21516116, 22493164, 25416956, 25910212, 27812135, 28169297, 28514442, 29892012, 31515488, 32296183, 33961781
GO:0005634	Component	Nucleus	IEA
GO:0005654	Component	Nucleoplasm	IDA
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0006513	Process	Protein monoubiquitination	IDA	29760876
GO:0008270	Function	Zinc ion binding	IEA
GO:0009967	Process	Positive regulation of signal transduction	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016740	Function	Transferase activity	IEA
GO:0042802	Function	Identical protein binding	IPI	22493164, 25416956, 32296183
GO:0045087	Process	Innate immune response	IBA
GO:0046872	Function	Metal ion binding	IEA
GO:0051607	Process	Defense response to virus	IDA	29760876
GO:0051607	Process	Defense response to virus	IEA
GO:0060340	Process	Positive regulation of type I interferon-mediated signaling pathway	IDA	29760876
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	29760876
GO:0061630	Function	Ubiquitin protein ligase activity	IEA
GO:0071222	Process	Cellular response to lipopolysaccharide	IMP	27812135
GO:0071225	Process	Cellular response to muramyl dipeptide	IMP	27812135

Other IDs

• MIM: 610530
• HGNC: 19013
• e!Ensembl: ENSG00000146063

Protein

• UniProt ID: Q8WV44
• Protein name: E3 ubiquitin-protein ligase TRIM41 (EC 2.3.2.27) (RING finger-interacting protein with C kinase) (RINCK) (Tripartite motif-containing protein 41)
• Protein function: E3 ligase that plays essential roles in innate antiviral response (PubMed:28169297, PubMed:29760876, PubMed:29899090, PubMed:31979016). Directly binds to influenza A virus or vesicular stomatitis virus nucleoproteins and targets them for ubiquit
• PDB: 2EGM
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00622	SPRY	485 → 629	SPRY domain	Family
  PF00643	zf-B_box	222 → 263	B-box zinc finger	Domain
  PF13765	PRY	433 → 481	SPRY-associated domain	Family
  PF15227	zf-C3HC4_4	20 → 56		Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in multiple tissues with the highest levels in heart and skeletal muscle. {ECO:0000269|PubMed:17893151}.
• Sequence:

  MAAVAMTPNPVQTLQEEAVCAICLDYFTDPVSIGCGHNFCRVCVTQLWGGEDEEDRDELD
  REEEEEDGEEEEVEAVGAGAGWDTPMRDEDYEGDMEEEVEEEEEGVFWTSGMSRSSWDNM
  DYVWEEEDEEEDLDYYLGDMEEEDLRGEDEEDEEEVLEEVEEEDLDPVTPLPPPPAPRRC
  FTCPQCRKSFPRRSFRPNLQLANMVQVIRQMHPTPGRGSRVTDQGICPKHQEALKLFCEV
  DEEAICVVCRESRSHKQHSVVPLEEVVQEYKAKLQGHVEPLRKHLEAVQKMKAKEERRVT
  ELKSQMKSELAAVASEFGRLTRFLAEEQAGLERRLREMHEAQLGRAGAAASRLAEQAAQL
  SRLLAEAQERSQQGGLRLLQDIKETFNRCEEVQLQPPEVWSPDPCQPHSHDFLTDAIVRK
  MSRMFCQAARVDLTLDPDTAHPALMLSPDRRGVRLAERRQEVADHPKRFSADCCVLGAQG
  FRSGRHYWEVEVGGRRGWAVGAARESTHHKEKVGPGGSSVGSGDASSSRHHHRRRRLHLP
  QQPLLQREVWCVGTNGKRYQAQSSTEQTLLSPSEKPRRFGVYLDYEAGRLGFYNAETLAH
  VHTFSAAFLGERVFPFFRVLSKGTRIKLCP

• Sequence length: 630

Pathways

Reactome Pathway:

Antigen processing: Ubiquitination & Proteasome degradation

Related Genes

No strongly related genes found yet for TRIM41.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRIM41.