TRABD2A (TraB domain containing 2A)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 129293
• Gene name: TraB domain containing 2A
• Gene symbol: TRABD2A
• Synonyms (NCBI Gene): C2orf89, TIKI1
• Chromosome: 2
• Chromosome location: 2p11.2

miRNA Show/Hide all (56)

miRTarBase ID	miRNA	Experiments	Reference
MIRT721291	hsa-miR-10a-3p	HITS-CLIP	19536157
MIRT721290	hsa-miR-5002-5p	HITS-CLIP	19536157
MIRT721289	hsa-miR-520a-5p	HITS-CLIP	19536157
MIRT721288	hsa-miR-525-5p	HITS-CLIP	19536157
MIRT721287	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT721286	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT721285	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT721284	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT716768	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT716767	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT716766	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT716765	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT716764	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT716763	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT716762	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT716761	hsa-miR-2117	HITS-CLIP	19536157
MIRT716760	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT716759	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT716758	hsa-miR-4273	HITS-CLIP	19536157
MIRT716757	hsa-miR-7156-5p	HITS-CLIP	19536157
MIRT716756	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT716755	hsa-miR-6739-3p	HITS-CLIP	19536157
MIRT637017	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT637016	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT637015	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT637013	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT637014	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT637012	hsa-miR-6809-3p	HITS-CLIP	23824327
MIRT721291	hsa-miR-10a-3p	HITS-CLIP	19536157
MIRT721290	hsa-miR-5002-5p	HITS-CLIP	19536157
MIRT721289	hsa-miR-520a-5p	HITS-CLIP	19536157
MIRT721288	hsa-miR-525-5p	HITS-CLIP	19536157
MIRT721287	hsa-miR-337-3p	HITS-CLIP	19536157
MIRT721286	hsa-miR-202-5p	HITS-CLIP	19536157
MIRT721285	hsa-miR-3180-5p	HITS-CLIP	19536157
MIRT721284	hsa-miR-659-3p	HITS-CLIP	19536157
MIRT716768	hsa-miR-5571-5p	HITS-CLIP	19536157
MIRT716767	hsa-miR-371b-5p	HITS-CLIP	19536157
MIRT716766	hsa-miR-373-5p	HITS-CLIP	19536157
MIRT716765	hsa-miR-616-5p	HITS-CLIP	19536157
MIRT716764	hsa-miR-371a-5p	HITS-CLIP	19536157
MIRT716763	hsa-miR-372-5p	HITS-CLIP	19536157
MIRT716762	hsa-miR-3124-3p	HITS-CLIP	19536157
MIRT716761	hsa-miR-2117	HITS-CLIP	19536157
MIRT716760	hsa-miR-513c-5p	HITS-CLIP	19536157
MIRT716759	hsa-miR-514b-5p	HITS-CLIP	19536157
MIRT716758	hsa-miR-4273	HITS-CLIP	19536157
MIRT716757	hsa-miR-7156-5p	HITS-CLIP	19536157
MIRT716756	hsa-miR-4677-5p	HITS-CLIP	19536157
MIRT716755	hsa-miR-6739-3p	HITS-CLIP	19536157
MIRT637017	hsa-miR-130b-5p	HITS-CLIP	23824327
MIRT637016	hsa-miR-1298-5p	HITS-CLIP	23824327
MIRT637015	hsa-miR-4753-3p	HITS-CLIP	23824327
MIRT637013	hsa-miR-4768-5p	HITS-CLIP	23824327
MIRT637014	hsa-miR-6833-3p	HITS-CLIP	23824327
MIRT637012	hsa-miR-6809-3p	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0004175	Function	Endopeptidase activity	IDA	22726442
GO:0004175	Function	Endopeptidase activity	IEA
GO:0004222	Function	Metalloendopeptidase activity	IBA
GO:0004222	Function	Metalloendopeptidase activity	IDA	22726442
GO:0004222	Function	Metalloendopeptidase activity	ISS	22726442
GO:0005886	Component	Plasma membrane	IDA	22726442
GO:0005886	Component	Plasma membrane	IEA
GO:0006508	Process	Proteolysis	IDA	22726442
GO:0006508	Process	Proteolysis	IEA
GO:0008233	Function	Peptidase activity	IEA
GO:0008237	Function	Metallopeptidase activity	IEA
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0016787	Function	Hydrolase activity	IEA
GO:0017147	Function	Wnt-protein binding	IDA	22726442
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IDA	22726442
GO:0030178	Process	Negative regulation of Wnt signaling pathway	IEA
GO:0031090	Component	Organelle membrane	IDA	22726442
GO:0031334	Process	Positive regulation of protein-containing complex assembly	ISS	22726442
GO:0046872	Function	Metal ion binding	IEA
GO:0060322	Process	Head development	ISS

Other IDs

• MIM: 614912
• HGNC: 27013
• e!Ensembl: ENSG00000186854

Protein

• UniProt ID: Q86V40
• Protein name: Metalloprotease TIKI1 (EC 3.4.-.-) (TRAB domain-containing protein 2A)
• Protein function: Metalloprotease that acts as a negative regulator of the Wnt signaling pathway by mediating the cleavage of the 8 N-terminal residues of a subset of Wnt proteins. Following cleavage, Wnt proteins become oxidized and form large disulfide-bond oli
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01963	TraB	43 → 352	TraB family	Family

• Sequence:

  MSPWSWFLLQTLCLLPTGAASRRGAPGTANCELKPQQSELNSFLWTIKRDPPSYFFGTIH
  VPYTRVWDFIPDNSKEAFLQSSIVYFELDLTDPYTISALTSCQMLPQGENLQDVLPRDIY
  CRLKRHLEYVKLMMPLWMTPDQRGKGLYADYLFNAIAGNWERKRPVWVMLMVNSLTEVDI
  KSRGVPVLDLFLAQEAERLRKQTGAVEKVEEQCHPLNGLNFSQVIFALNQTLLQQESLRA
  GSLQIPYTTEDLIKHYNCGDLSSVILSHDSSQVPNFINATLPPQERITAQEIDSYLRREL
  IYKRNERIGKRVKALLEEFPDKGFFFAFGAGHFMGNNTVLDVLRREGYEVEHAPAGRPIH
  KGKSKKTSTRPTLSTIFAPKVPTLEVPAPEAVSSGHSTLPPLVSRPGSADTPSEAEQRFR
  KKRRRSQRRPRLRQFSDLWVRLEESDIVPQLQVPVLDRHISTELRLPRRGHSHHSQMVAS
  SACLSLWTPVFWVLVLAFQTETPLL

• Sequence length: 505

Related Genes

No strongly related genes found yet for TRABD2A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TRABD2A.