TPPP3 (tubulin polymerization promoting protein family member 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51673
• Gene name: Tubulin polymerization promoting protein family member 3
• Gene symbol: TPPP3
• Synonyms (NCBI Gene): CGI-38, TPPP/p20, p20, p25gamma
• Chromosome: 16
• Chromosome location: 16q22.1

miRNA Show/Hide all (32)

miRTarBase ID	miRNA	Experiments	Reference
MIRT004470	hsa-miR-16-5p	Luciferase reporter assay	15131085
MIRT018242	hsa-miR-335-5p	Microarray	18185580
MIRT004470	hsa-miR-16-5p	Reporter assay;Other	15131085
MIRT048660	hsa-miR-99a-5p	CLASH	23622248
MIRT1450143	hsa-miR-15a	CLIP-seq
MIRT1450144	hsa-miR-15b	CLIP-seq
MIRT1450145	hsa-miR-16	CLIP-seq
MIRT1450146	hsa-miR-195	CLIP-seq
MIRT1450147	hsa-miR-2278	CLIP-seq
MIRT1450148	hsa-miR-3187-3p	CLIP-seq
MIRT1450149	hsa-miR-424	CLIP-seq
MIRT1450150	hsa-miR-4435	CLIP-seq
MIRT1450151	hsa-miR-4701-5p	CLIP-seq
MIRT1450152	hsa-miR-497	CLIP-seq
MIRT1450153	hsa-miR-548s	CLIP-seq
MIRT1450154	hsa-miR-588	CLIP-seq
MIRT1450155	hsa-miR-646	CLIP-seq
MIRT1450156	hsa-miR-3141	CLIP-seq
MIRT1450147	hsa-miR-2278	CLIP-seq
MIRT1450143	hsa-miR-15a	CLIP-seq
MIRT1450144	hsa-miR-15b	CLIP-seq
MIRT1450145	hsa-miR-16	CLIP-seq
MIRT1450146	hsa-miR-195	CLIP-seq
MIRT1450147	hsa-miR-2278	CLIP-seq
MIRT1450149	hsa-miR-424	CLIP-seq
MIRT2355870	hsa-miR-4517	CLIP-seq
MIRT1450152	hsa-miR-497	CLIP-seq
MIRT1450155	hsa-miR-646	CLIP-seq
MIRT2649371	hsa-miR-3179	CLIP-seq
MIRT2649372	hsa-miR-3202	CLIP-seq
MIRT2649373	hsa-miR-4476	CLIP-seq
MIRT2649374	hsa-miR-765	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001578	Process	Microtubule bundle formation	IBA
GO:0001578	Process	Microtubule bundle formation	IDA	17105200
GO:0005737	Component	Cytoplasm	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IBA
GO:0005874	Component	Microtubule	IEA
GO:0007566	Process	Embryo implantation	IEA
GO:0007566	Process	Embryo implantation	ISS
GO:0015631	Function	Tubulin binding	IBA
GO:0015631	Function	Tubulin binding	IDA	17105200
GO:0015631	Function	Tubulin binding	IEA
GO:0032273	Process	Positive regulation of protein polymerization	IBA
GO:0046697	Process	Decidualization	IMP	30667362
GO:0046785	Process	Microtubule polymerization	IBA
GO:0046785	Process	Microtubule polymerization	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IDA	17105200
GO:0097427	Component	Microtubule bundle	IDA	17105200

Other IDs

• MIM: 616957
• HGNC: 24162
• e!Ensembl: ENSG00000159713

Protein

• UniProt ID: Q9BW30
• Protein name: Tubulin polymerization-promoting protein family member 3 (TPPP/p20)
• Protein function: Regulator of microtubule dynamic that has microtubule bundling activity (PubMed:17105200, PubMed:19633818). Required for embryo implantation; possibly by regulating beta-catenin (By similarity). Also required for decidualization via regulation o
• PDB: 2JRF
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05517	p25-alpha	11 → 166	p25-alpha	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in endometrium during the mid-secretory phase (LH + 7) (at protein level). {ECO:0000269|PubMed:30667362}.
• Sequence:

  MAASTDMAGLEESFRKFAIHGDPKASGQEMNGKNWAKLCKDCKVADGKSVTGTDVDIVFS
  KVKGKSARVINYEEFKKALEELATKRFKGKSKEEAFDAICQLVAGKEPANVGVTKAKTGG
  AVDRLTDTSRYTGSHKERFDESGKGKGIAGRQDILDDSGYVSAYKNAGTYDAKVKK

• Sequence length: 176

Related Genes

No strongly related genes found yet for TPPP3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TPPP3.