TOR2A (torsin family 2 member A)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 27433
• Gene name: Torsin family 2 member A
• Gene symbol: TOR2A
• Synonyms (NCBI Gene): TORP1
• Chromosome: 9
• Chromosome location: 9q34.11
• Summary: This gene encodes a member of the AAA family of adenosine triphosphatases with similarity to Clp proteases and heat shock proteins. Alternative splicing at this locus results in the translation of multiple isoforms of the encoded protein, some of which co

miRNA Show/Hide all (187)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045831	hsa-miR-138-5p	CLASH	23622248
MIRT037608	hsa-miR-744-5p	CLASH	23622248
MIRT465489	hsa-miR-4319	HITS-CLIP	23313552
MIRT465488	hsa-miR-125b-5p	HITS-CLIP	23313552
MIRT465487	hsa-miR-125a-5p	HITS-CLIP	23313552
MIRT465485	hsa-miR-449b-3p	HITS-CLIP	23313552
MIRT465482	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT465473	hsa-miR-345-3p	HITS-CLIP	23313552
MIRT465472	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT698096	hsa-miR-4682	HITS-CLIP	23313552
MIRT465470	hsa-miR-4424	HITS-CLIP	23313552
MIRT465459	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT465458	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT465454	hsa-miR-670-5p	HITS-CLIP	23313552
MIRT465489	hsa-miR-4319	PAR-CLIP	23592263
MIRT465488	hsa-miR-125b-5p	PAR-CLIP	23592263
MIRT465487	hsa-miR-125a-5p	PAR-CLIP	23592263
MIRT465486	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT465485	hsa-miR-449b-3p	PAR-CLIP	23592263
MIRT465484	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT465483	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT465482	hsa-miR-2114-5p	PAR-CLIP	23592263
MIRT465481	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT465480	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT465479	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT465478	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT465477	hsa-miR-3155a	PAR-CLIP	23592263
MIRT465476	hsa-miR-3155b	PAR-CLIP	23592263
MIRT465475	hsa-miR-484	PAR-CLIP	23592263
MIRT465474	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT465473	hsa-miR-345-3p	PAR-CLIP	23592263
MIRT465472	hsa-miR-4732-3p	PAR-CLIP	23592263
MIRT465471	hsa-miR-1205	PAR-CLIP	23592263
MIRT465470	hsa-miR-4424	PAR-CLIP	23592263
MIRT465469	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT465468	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT465467	hsa-miR-3934-3p	PAR-CLIP	23592263
MIRT465466	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT465465	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT465464	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT465463	hsa-miR-5698	PAR-CLIP	23592263
MIRT465462	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT465461	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT465460	hsa-miR-3653-3p	PAR-CLIP	23592263
MIRT465459	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT465458	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT465457	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT465456	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT465455	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT465454	hsa-miR-670-5p	PAR-CLIP	23592263
MIRT465453	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT465471	hsa-miR-1205	PAR-CLIP	27292025
MIRT465453	hsa-miR-1273h-5p	PAR-CLIP	27292025
MIRT465469	hsa-miR-1909-3p	PAR-CLIP	27292025
MIRT465466	hsa-miR-24-3p	PAR-CLIP	27292025
MIRT465477	hsa-miR-3155a	PAR-CLIP	27292025
MIRT465476	hsa-miR-3155b	PAR-CLIP	27292025
MIRT465481	hsa-miR-3922-5p	PAR-CLIP	27292025
MIRT465467	hsa-miR-3934-3p	PAR-CLIP	27292025
MIRT465484	hsa-miR-4716-3p	PAR-CLIP	27292025
MIRT465464	hsa-miR-4723-5p	PAR-CLIP	27292025
MIRT465475	hsa-miR-484	PAR-CLIP	27292025
MIRT465463	hsa-miR-5698	PAR-CLIP	27292025
MIRT465454	hsa-miR-670-5p	PAR-CLIP	27292025
MIRT465468	hsa-miR-6722-3p	PAR-CLIP	27292025
MIRT465483	hsa-miR-6794-5p	PAR-CLIP	27292025
MIRT465474	hsa-miR-6798-5p	PAR-CLIP	27292025
MIRT465465	hsa-miR-6799-5p	PAR-CLIP	27292025
MIRT465462	hsa-miR-6870-5p	PAR-CLIP	27292025
MIRT465461	hsa-miR-7111-5p	PAR-CLIP	27292025
MIRT465489	hsa-miR-4319	HITS-CLIP	23313552
MIRT465488	hsa-miR-125b-5p	HITS-CLIP	23313552
MIRT465487	hsa-miR-125a-5p	HITS-CLIP	23313552
MIRT465485	hsa-miR-449b-3p	HITS-CLIP	23313552
MIRT465482	hsa-miR-2114-5p	HITS-CLIP	23313552
MIRT465473	hsa-miR-345-3p	HITS-CLIP	23313552
MIRT465472	hsa-miR-4732-3p	HITS-CLIP	23313552
MIRT698096	hsa-miR-4682	HITS-CLIP	23313552
MIRT465470	hsa-miR-4424	HITS-CLIP	23313552
MIRT465459	hsa-miR-374a-5p	HITS-CLIP	23313552
MIRT465458	hsa-miR-374b-5p	HITS-CLIP	23313552
MIRT465454	hsa-miR-670-5p	HITS-CLIP	23313552
MIRT465489	hsa-miR-4319	PAR-CLIP	23592263
MIRT465488	hsa-miR-125b-5p	PAR-CLIP	23592263
MIRT465487	hsa-miR-125a-5p	PAR-CLIP	23592263
MIRT465486	hsa-miR-4760-3p	PAR-CLIP	23592263
MIRT465485	hsa-miR-449b-3p	PAR-CLIP	23592263
MIRT465484	hsa-miR-4716-3p	PAR-CLIP	23592263
MIRT465483	hsa-miR-6794-5p	PAR-CLIP	23592263
MIRT465482	hsa-miR-2114-5p	PAR-CLIP	23592263
MIRT465481	hsa-miR-3922-5p	PAR-CLIP	23592263
MIRT465480	hsa-miR-128-3p	PAR-CLIP	23592263
MIRT465479	hsa-miR-216a-3p	PAR-CLIP	23592263
MIRT465478	hsa-miR-3681-3p	PAR-CLIP	23592263
MIRT465477	hsa-miR-3155a	PAR-CLIP	23592263
MIRT465476	hsa-miR-3155b	PAR-CLIP	23592263
MIRT465475	hsa-miR-484	PAR-CLIP	23592263
MIRT465474	hsa-miR-6798-5p	PAR-CLIP	23592263
MIRT465473	hsa-miR-345-3p	PAR-CLIP	23592263
MIRT465472	hsa-miR-4732-3p	PAR-CLIP	23592263
MIRT465471	hsa-miR-1205	PAR-CLIP	23592263
MIRT465470	hsa-miR-4424	PAR-CLIP	23592263
MIRT465469	hsa-miR-1909-3p	PAR-CLIP	23592263
MIRT465468	hsa-miR-6722-3p	PAR-CLIP	23592263
MIRT465467	hsa-miR-3934-3p	PAR-CLIP	23592263
MIRT465466	hsa-miR-24-3p	PAR-CLIP	23592263
MIRT465465	hsa-miR-6799-5p	PAR-CLIP	23592263
MIRT465464	hsa-miR-4723-5p	PAR-CLIP	23592263
MIRT465463	hsa-miR-5698	PAR-CLIP	23592263
MIRT465462	hsa-miR-6870-5p	PAR-CLIP	23592263
MIRT465461	hsa-miR-7111-5p	PAR-CLIP	23592263
MIRT465460	hsa-miR-3653-3p	PAR-CLIP	23592263
MIRT465459	hsa-miR-374a-5p	PAR-CLIP	23592263
MIRT465458	hsa-miR-374b-5p	PAR-CLIP	23592263
MIRT465457	hsa-miR-513a-5p	PAR-CLIP	23592263
MIRT465456	hsa-miR-27a-3p	PAR-CLIP	23592263
MIRT465455	hsa-miR-27b-3p	PAR-CLIP	23592263
MIRT465454	hsa-miR-670-5p	PAR-CLIP	23592263
MIRT465453	hsa-miR-1273h-5p	PAR-CLIP	23592263
MIRT1447807	hsa-miR-125b	CLIP-seq
MIRT1447808	hsa-miR-128	CLIP-seq
MIRT1447809	hsa-miR-1909	CLIP-seq
MIRT1447810	hsa-miR-2114	CLIP-seq
MIRT1447811	hsa-miR-24	CLIP-seq
MIRT1447812	hsa-miR-27a	CLIP-seq
MIRT1447813	hsa-miR-27b	CLIP-seq
MIRT1447814	hsa-miR-3074-5p	CLIP-seq
MIRT1447815	hsa-miR-3155	CLIP-seq
MIRT1447816	hsa-miR-3653	CLIP-seq
MIRT1447817	hsa-miR-3663-3p	CLIP-seq
MIRT1447818	hsa-miR-374a	CLIP-seq
MIRT1447819	hsa-miR-374b	CLIP-seq
MIRT1447820	hsa-miR-670	CLIP-seq
MIRT1447821	hsa-miR-1225-3p	CLIP-seq
MIRT1447822	hsa-miR-1233	CLIP-seq
MIRT1447811	hsa-miR-24	CLIP-seq
MIRT1447823	hsa-miR-2467-5p	CLIP-seq
MIRT1447824	hsa-miR-3919	CLIP-seq
MIRT1447825	hsa-miR-4251	CLIP-seq
MIRT1447826	hsa-miR-4643	CLIP-seq
MIRT1447827	hsa-miR-466	CLIP-seq
MIRT1447828	hsa-miR-4663	CLIP-seq
MIRT1447829	hsa-miR-4756-3p	CLIP-seq
MIRT1447830	hsa-miR-4789-3p	CLIP-seq
MIRT1447831	hsa-miR-580	CLIP-seq
MIRT1447832	hsa-miR-628-5p	CLIP-seq
MIRT2133960	hsa-miR-1914	CLIP-seq
MIRT2133961	hsa-miR-3194-3p	CLIP-seq
MIRT2133962	hsa-miR-326	CLIP-seq
MIRT2133963	hsa-miR-330-5p	CLIP-seq
MIRT2133964	hsa-miR-3614-5p	CLIP-seq
MIRT2133965	hsa-miR-3907	CLIP-seq
MIRT2133966	hsa-miR-4494	CLIP-seq
MIRT2133967	hsa-miR-4499	CLIP-seq
MIRT2133968	hsa-miR-4504	CLIP-seq
MIRT2133969	hsa-miR-4771	CLIP-seq
MIRT2133970	hsa-miR-542-3p	CLIP-seq
MIRT1447820	hsa-miR-670	CLIP-seq
MIRT2354986	hsa-miR-1253	CLIP-seq
MIRT1447807	hsa-miR-125b	CLIP-seq
MIRT1447808	hsa-miR-128	CLIP-seq
MIRT2354987	hsa-miR-190	CLIP-seq
MIRT1447809	hsa-miR-1909	CLIP-seq
MIRT2354988	hsa-miR-190b	CLIP-seq
MIRT1447810	hsa-miR-2114	CLIP-seq
MIRT1447811	hsa-miR-24	CLIP-seq
MIRT1447812	hsa-miR-27a	CLIP-seq
MIRT1447813	hsa-miR-27b	CLIP-seq
MIRT2354989	hsa-miR-3150b-3p	CLIP-seq
MIRT1447815	hsa-miR-3155	CLIP-seq
MIRT1447816	hsa-miR-3653	CLIP-seq
MIRT1447817	hsa-miR-3663-3p	CLIP-seq
MIRT1447818	hsa-miR-374a	CLIP-seq
MIRT1447819	hsa-miR-374b	CLIP-seq
MIRT1447825	hsa-miR-4251	CLIP-seq
MIRT2354990	hsa-miR-4261	CLIP-seq
MIRT2354991	hsa-miR-4419a	CLIP-seq
MIRT2133966	hsa-miR-4494	CLIP-seq
MIRT2133967	hsa-miR-4499	CLIP-seq
MIRT2354992	hsa-miR-4510	CLIP-seq
MIRT2354993	hsa-miR-4689	CLIP-seq
MIRT2354994	hsa-miR-4738-3p	CLIP-seq
MIRT2133969	hsa-miR-4771	CLIP-seq
MIRT2354995	hsa-miR-4779	CLIP-seq
MIRT2354996	hsa-miR-4784	CLIP-seq
MIRT1447820	hsa-miR-670	CLIP-seq
MIRT2354997	hsa-miR-875-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000166	Function	Nucleotide binding	IEA
GO:0005179	Function	Hormone activity	IDA	12910263
GO:0005179	Function	Hormone activity	IEA
GO:0005524	Function	ATP binding	IEA
GO:0005576	Component	Extracellular region	IDA	12910263
GO:0005576	Component	Extracellular region	IEA
GO:0005635	Component	Nuclear envelope	IBA
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005788	Component	Endoplasmic reticulum lumen	IBA
GO:0005788	Component	Endoplasmic reticulum lumen	IDA	20015956
GO:0005788	Component	Endoplasmic reticulum lumen	IEA
GO:0007165	Process	Signal transduction	IEA
GO:0007267	Process	Cell-cell signaling	IDA	12910263
GO:0010628	Process	Positive regulation of gene expression	IDA	12910263
GO:0016887	Function	ATP hydrolysis activity	IEA
GO:0030103	Process	Vasopressin secretion	IDA	12910263
GO:0031640	Process	Killing of cells of another organism	IMP	24881665
GO:0042802	Function	Identical protein binding	IEA
GO:0042802	Function	Identical protein binding	IPI	20015956
GO:0043950	Process	Positive regulation of cAMP-mediated signaling	IDA	12910263
GO:0061844	Process	Antimicrobial humoral immune response mediated by antimicrobial peptide	IC	24881665
GO:1904427	Process	Positive regulation of calcium ion transmembrane transport	IDA	12910263

Other IDs

• MIM: 608052
• HGNC: 11996
• e!Ensembl: ENSG00000160404

Protein

• UniProt ID: Q8N2E6
• Protein name: Prosalusin (Torsin family 2 member A) (Torsin-2A) [Cleaved into: Salusin-alpha; Salusin-beta]
• Protein function: Salusins -alpha and -beta may be endocrine and/or paracrine factors able to increase intracellular calcium concentrations and induce cell mitogenesis. Salusins may also be potent hypotensive peptides.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06309	Torsin	35 → 160	Torsin	Family

• Tissue specificity: TISSUE SPECIFICITY: Isoform 4 is ubiquitously expressed, with high level in vascular endothelial cells and vascular smooth muscle cells. {ECO:0000269|PubMed:12910263}.
• Sequence:

  MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL
  AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV
  HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS
  SWVVYGTNYRKAIFIFIRWLLKLGHHGRAPPRRSGALPPAPAAPRPALRAQRAGPAGPGA
  KG

• Sequence length: 242
• UniProt ID: Q5JU69
• Protein name: Torsin-2A (Torsin family 2 member A) (Torsin-related protein 1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF06309	Torsin	35 → 160	Torsin	Family

• Tissue specificity: TISSUE SPECIFICITY: Isoform 1 is expressed ubiquitously, except in cardiac and endothelial tissues. {ECO:0000269|PubMed:12910263}.
• Sequence:

  MAAATRGCRPWGSLLGLLGLVSAAAAAWDLASLRCTLGAFCECDFRPDLPGLECDLAQHL
  AGQHLAKALVVKALKAFVRDPAPTKPLVLSLHGWTGTGKSYVSSLLAHYLFQGGLRSPRV
  HHFSPVLHFPHPSHIERYKKDLKSWVQGNLTACGRSLFLFDEMDKMPPGLMEVLRPFLGS
  SWVVYGTNYRKAIFIFISNTGGKQINQVALEAWRSRRDREEILLQELEPVISRAVLDNPH
  HGFSNSGIMEERLLDAVVPFLPLQRHHVRHCVLNELAQLGLEPRDEVVQAVLDSTTFFPE
  DEQLFSSNGCKTVASRIAFFL

• Sequence length: 321

Related Genes

No strongly related genes found yet for TOR2A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TOR2A.