TOMM6 (translocase of outer mitochondrial membrane 6)

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Gene miRNA Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 100188893
• Gene name: Translocase of outer mitochondrial membrane 6
• Gene symbol: TOMM6
• Synonyms (NCBI Gene): OBTP, TOM6
• Chromosome: 6
• Chromosome location: 6p21.1

miRNA Show/Hide all (196)

miRTarBase ID	miRNA	Experiments	Reference
MIRT1446763	hsa-miR-105	CLIP-seq
MIRT1446764	hsa-miR-1207-5p	CLIP-seq
MIRT1446765	hsa-miR-1208	CLIP-seq
MIRT1446766	hsa-miR-1266	CLIP-seq
MIRT1446767	hsa-miR-1292	CLIP-seq
MIRT1446768	hsa-miR-129-5p	CLIP-seq
MIRT1446769	hsa-miR-147	CLIP-seq
MIRT1446770	hsa-miR-147b	CLIP-seq
MIRT1446771	hsa-miR-21	CLIP-seq
MIRT1446772	hsa-miR-2682	CLIP-seq
MIRT1446773	hsa-miR-298	CLIP-seq
MIRT1446774	hsa-miR-3065-3p	CLIP-seq
MIRT1446775	hsa-miR-3120-5p	CLIP-seq
MIRT1446776	hsa-miR-3123	CLIP-seq
MIRT1446777	hsa-miR-3127-5p	CLIP-seq
MIRT1446778	hsa-miR-3158-5p	CLIP-seq
MIRT1446779	hsa-miR-3179	CLIP-seq
MIRT1446780	hsa-miR-3202	CLIP-seq
MIRT1446781	hsa-miR-323-5p	CLIP-seq
MIRT1446782	hsa-miR-335	CLIP-seq
MIRT1446783	hsa-miR-346	CLIP-seq
MIRT1446784	hsa-miR-3664-3p	CLIP-seq
MIRT1446785	hsa-miR-3671	CLIP-seq
MIRT1446786	hsa-miR-3918	CLIP-seq
MIRT1446787	hsa-miR-3919	CLIP-seq
MIRT1446788	hsa-miR-3929	CLIP-seq
MIRT1446789	hsa-miR-4288	CLIP-seq
MIRT1446790	hsa-miR-4291	CLIP-seq
MIRT1446791	hsa-miR-4307	CLIP-seq
MIRT1446792	hsa-miR-4419b	CLIP-seq
MIRT1446793	hsa-miR-4421	CLIP-seq
MIRT1446794	hsa-miR-4436a	CLIP-seq
MIRT1446795	hsa-miR-4453	CLIP-seq
MIRT1446796	hsa-miR-4471	CLIP-seq
MIRT1446797	hsa-miR-4478	CLIP-seq
MIRT1446798	hsa-miR-4496	CLIP-seq
MIRT1446799	hsa-miR-449c	CLIP-seq
MIRT1446800	hsa-miR-4518	CLIP-seq
MIRT1446801	hsa-miR-4520a-5p	CLIP-seq
MIRT1446802	hsa-miR-4520b-5p	CLIP-seq
MIRT1446803	hsa-miR-4538	CLIP-seq
MIRT1446804	hsa-miR-4640-3p	CLIP-seq
MIRT1446805	hsa-miR-4687-3p	CLIP-seq
MIRT1446806	hsa-miR-4699-5p	CLIP-seq
MIRT1446807	hsa-miR-4720-3p	CLIP-seq
MIRT1446808	hsa-miR-4747-5p	CLIP-seq
MIRT1446809	hsa-miR-4763-3p	CLIP-seq
MIRT1446810	hsa-miR-4769-3p	CLIP-seq
MIRT1446811	hsa-miR-508-3p	CLIP-seq
MIRT1446812	hsa-miR-548c-3p	CLIP-seq
MIRT1446813	hsa-miR-548p	CLIP-seq
MIRT1446814	hsa-miR-581	CLIP-seq
MIRT1446815	hsa-miR-590-5p	CLIP-seq
MIRT1446816	hsa-miR-599	CLIP-seq
MIRT1446817	hsa-miR-607	CLIP-seq
MIRT1446818	hsa-miR-628-5p	CLIP-seq
MIRT1446819	hsa-miR-632	CLIP-seq
MIRT1446820	hsa-miR-7	CLIP-seq
MIRT1446821	hsa-miR-876-3p	CLIP-seq
MIRT1446822	hsa-miR-940	CLIP-seq
MIRT1446775	hsa-miR-3120-5p	CLIP-seq
MIRT1446776	hsa-miR-3123	CLIP-seq
MIRT1446783	hsa-miR-346	CLIP-seq
MIRT1446787	hsa-miR-3919	CLIP-seq
MIRT1446789	hsa-miR-4288	CLIP-seq
MIRT1446793	hsa-miR-4421	CLIP-seq
MIRT1446818	hsa-miR-628-5p	CLIP-seq
MIRT1446819	hsa-miR-632	CLIP-seq
MIRT1446763	hsa-miR-105	CLIP-seq
MIRT2133628	hsa-miR-1207-3p	CLIP-seq
MIRT1446765	hsa-miR-1208	CLIP-seq
MIRT1446766	hsa-miR-1266	CLIP-seq
MIRT1446767	hsa-miR-1292	CLIP-seq
MIRT1446768	hsa-miR-129-5p	CLIP-seq
MIRT1446769	hsa-miR-147	CLIP-seq
MIRT1446770	hsa-miR-147b	CLIP-seq
MIRT1446771	hsa-miR-21	CLIP-seq
MIRT2133629	hsa-miR-22	CLIP-seq
MIRT1446773	hsa-miR-298	CLIP-seq
MIRT1446775	hsa-miR-3120-5p	CLIP-seq
MIRT1446776	hsa-miR-3123	CLIP-seq
MIRT1446777	hsa-miR-3127-5p	CLIP-seq
MIRT1446778	hsa-miR-3158-5p	CLIP-seq
MIRT1446781	hsa-miR-323-5p	CLIP-seq
MIRT1446782	hsa-miR-335	CLIP-seq
MIRT1446783	hsa-miR-346	CLIP-seq
MIRT1446784	hsa-miR-3664-3p	CLIP-seq
MIRT1446785	hsa-miR-3671	CLIP-seq
MIRT1446786	hsa-miR-3918	CLIP-seq
MIRT1446787	hsa-miR-3919	CLIP-seq
MIRT1446788	hsa-miR-3929	CLIP-seq
MIRT1446789	hsa-miR-4288	CLIP-seq
MIRT1446791	hsa-miR-4307	CLIP-seq
MIRT1446792	hsa-miR-4419b	CLIP-seq
MIRT1446793	hsa-miR-4421	CLIP-seq
MIRT2133630	hsa-miR-4427	CLIP-seq
MIRT1446794	hsa-miR-4436a	CLIP-seq
MIRT1446795	hsa-miR-4453	CLIP-seq
MIRT1446796	hsa-miR-4471	CLIP-seq
MIRT1446797	hsa-miR-4478	CLIP-seq
MIRT1446800	hsa-miR-4518	CLIP-seq
MIRT1446803	hsa-miR-4538	CLIP-seq
MIRT1446804	hsa-miR-4640-3p	CLIP-seq
MIRT2133631	hsa-miR-4680-3p	CLIP-seq
MIRT1446805	hsa-miR-4687-3p	CLIP-seq
MIRT1446806	hsa-miR-4699-5p	CLIP-seq
MIRT1446807	hsa-miR-4720-3p	CLIP-seq
MIRT1446810	hsa-miR-4769-3p	CLIP-seq
MIRT1446811	hsa-miR-508-3p	CLIP-seq
MIRT1446812	hsa-miR-548c-3p	CLIP-seq
MIRT1446813	hsa-miR-548p	CLIP-seq
MIRT1446814	hsa-miR-581	CLIP-seq
MIRT1446815	hsa-miR-590-5p	CLIP-seq
MIRT1446816	hsa-miR-599	CLIP-seq
MIRT1446817	hsa-miR-607	CLIP-seq
MIRT1446818	hsa-miR-628-5p	CLIP-seq
MIRT1446819	hsa-miR-632	CLIP-seq
MIRT1446820	hsa-miR-7	CLIP-seq
MIRT1446821	hsa-miR-876-3p	CLIP-seq
MIRT1446763	hsa-miR-105	CLIP-seq
MIRT1446764	hsa-miR-1207-5p	CLIP-seq
MIRT2354833	hsa-miR-1231	CLIP-seq
MIRT2354834	hsa-miR-1245b-3p	CLIP-seq
MIRT1446766	hsa-miR-1266	CLIP-seq
MIRT1446767	hsa-miR-1292	CLIP-seq
MIRT1446768	hsa-miR-129-5p	CLIP-seq
MIRT1446771	hsa-miR-21	CLIP-seq
MIRT2354835	hsa-miR-2276	CLIP-seq
MIRT1446772	hsa-miR-2682	CLIP-seq
MIRT1446773	hsa-miR-298	CLIP-seq
MIRT1446774	hsa-miR-3065-3p	CLIP-seq
MIRT1446775	hsa-miR-3120-5p	CLIP-seq
MIRT1446776	hsa-miR-3123	CLIP-seq
MIRT1446777	hsa-miR-3127-5p	CLIP-seq
MIRT1446778	hsa-miR-3158-5p	CLIP-seq
MIRT1446779	hsa-miR-3179	CLIP-seq
MIRT1446780	hsa-miR-3202	CLIP-seq
MIRT1446781	hsa-miR-323-5p	CLIP-seq
MIRT1446782	hsa-miR-335	CLIP-seq
MIRT1446783	hsa-miR-346	CLIP-seq
MIRT1446784	hsa-miR-3664-3p	CLIP-seq
MIRT1446786	hsa-miR-3918	CLIP-seq
MIRT1446787	hsa-miR-3919	CLIP-seq
MIRT1446788	hsa-miR-3929	CLIP-seq
MIRT2354836	hsa-miR-4271	CLIP-seq
MIRT1446789	hsa-miR-4288	CLIP-seq
MIRT1446790	hsa-miR-4291	CLIP-seq
MIRT1446791	hsa-miR-4307	CLIP-seq
MIRT1446792	hsa-miR-4419b	CLIP-seq
MIRT1446793	hsa-miR-4421	CLIP-seq
MIRT1446794	hsa-miR-4436a	CLIP-seq
MIRT1446795	hsa-miR-4453	CLIP-seq
MIRT1446796	hsa-miR-4471	CLIP-seq
MIRT1446797	hsa-miR-4478	CLIP-seq
MIRT1446799	hsa-miR-449c	CLIP-seq
MIRT1446800	hsa-miR-4518	CLIP-seq
MIRT1446801	hsa-miR-4520a-5p	CLIP-seq
MIRT1446802	hsa-miR-4520b-5p	CLIP-seq
MIRT1446803	hsa-miR-4538	CLIP-seq
MIRT1446804	hsa-miR-4640-3p	CLIP-seq
MIRT1446805	hsa-miR-4687-3p	CLIP-seq
MIRT1446806	hsa-miR-4699-5p	CLIP-seq
MIRT1446807	hsa-miR-4720-3p	CLIP-seq
MIRT2354837	hsa-miR-4725-3p	CLIP-seq
MIRT1446808	hsa-miR-4747-5p	CLIP-seq
MIRT1446809	hsa-miR-4763-3p	CLIP-seq
MIRT1446810	hsa-miR-4769-3p	CLIP-seq
MIRT2354838	hsa-miR-4772-3p	CLIP-seq
MIRT1446811	hsa-miR-508-3p	CLIP-seq
MIRT1446812	hsa-miR-548c-3p	CLIP-seq
MIRT1446813	hsa-miR-548p	CLIP-seq
MIRT1446814	hsa-miR-581	CLIP-seq
MIRT1446815	hsa-miR-590-5p	CLIP-seq
MIRT1446818	hsa-miR-628-5p	CLIP-seq
MIRT1446819	hsa-miR-632	CLIP-seq
MIRT1446820	hsa-miR-7	CLIP-seq
MIRT1446821	hsa-miR-876-3p	CLIP-seq
MIRT1446822	hsa-miR-940	CLIP-seq
MIRT1446765	hsa-miR-1208	CLIP-seq
MIRT1446766	hsa-miR-1266	CLIP-seq
MIRT1446767	hsa-miR-1292	CLIP-seq
MIRT1446773	hsa-miR-298	CLIP-seq
MIRT1446777	hsa-miR-3127-5p	CLIP-seq
MIRT1446778	hsa-miR-3158-5p	CLIP-seq
MIRT1446781	hsa-miR-323-5p	CLIP-seq
MIRT1446784	hsa-miR-3664-3p	CLIP-seq
MIRT1446786	hsa-miR-3918	CLIP-seq
MIRT1446795	hsa-miR-4453	CLIP-seq
MIRT1446796	hsa-miR-4471	CLIP-seq
MIRT1446800	hsa-miR-4518	CLIP-seq
MIRT1446803	hsa-miR-4538	CLIP-seq
MIRT1446804	hsa-miR-4640-3p	CLIP-seq
MIRT1446810	hsa-miR-4769-3p	CLIP-seq
MIRT1446811	hsa-miR-508-3p	CLIP-seq
MIRT1446814	hsa-miR-581	CLIP-seq
MIRT1446821	hsa-miR-876-3p	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IBA
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	NAS	18331822
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005742	Component	Mitochondrial outer membrane translocase complex	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0045040	Process	Protein insertion into mitochondrial outer membrane	NAS	18331822
GO:0140596	Component	TOM complex	NAS	18331822

Other IDs

• MIM: 616168
• HGNC: 34528
• e!Ensembl: ENSG00000214736

Protein

• UniProt ID: Q96B49
• Protein name: Mitochondrial import receptor subunit TOM6 homolog (Overexpressed breast tumor protein) (Translocase of outer membrane 6 kDa subunit homolog)
• PDB: 7CK6 , 7CP9 , 7VBY , 7VC4 , 7VD2 , 7VDD , 8XVA , 9EIH , 9EII , 9EIJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF15184	TOM6p	1 → 74	Mitochondrial import receptor subunit TOM6 homolog	Family

• Sequence:

  MASSTVPVSAAGSANETPEIPDNVGDWLRGVYRFATDRNDFRRNLILNLGLFAAGVWLAR
  NLSDIDLMAPQPGV

• Sequence length: 74

Pathways

Reactome Pathway:

Pink/Parkin Mediated Mitophagy

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Colon adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Colorectal Neoplasms	Colorectal neoplasm	Pubtator	32815531	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for TOMM6.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TOMM6.