TOMM22 (translocase of outer mitochondrial membrane 22)

Download as csv Download as pdf

Log in to save this analysis

Save This Analysis

Title Project / Tag (optional) Note (optional)

Cancel Save

On this page

Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 56993
• Gene name: Translocase of outer mitochondrial membrane 22
• Gene symbol: TOMM22
• Synonyms (NCBI Gene): 1C9-2, MST065, MSTP065, TOM22
• Chromosome: 22
• Chromosome location: 22q13.1
• Summary: The protein encoded by this gene is an integral membrane protein of the mitochondrial outer membrane. The encoded protein interacts with TOMM20 and TOMM40, and forms a complex with several other proteins to import cytosolic preproteins into the mitochondr

miRNA Show/Hide all (191)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005470	ebv-miR-BART16	Immunoprecipitaion, Luciferase reporter assay, Microarray, qRT-PCR	20413099
MIRT030384	hsa-miR-24-3p	Microarray	19748357
MIRT048629	hsa-miR-99a-5p	CLASH	23622248
MIRT038383	hsa-miR-296-3p	CLASH	23622248
MIRT621447	hsa-miR-3938	HITS-CLIP	23824327
MIRT621446	hsa-miR-4778-5p	HITS-CLIP	23824327
MIRT621445	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT621444	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT621443	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT621442	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT621441	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT621447	hsa-miR-3938	HITS-CLIP	23824327
MIRT621446	hsa-miR-4778-5p	HITS-CLIP	23824327
MIRT621445	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT621444	hsa-miR-6731-3p	HITS-CLIP	23824327
MIRT621443	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT621442	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT621441	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT1446609	hsa-miR-1294	CLIP-seq
MIRT1446610	hsa-miR-3153	CLIP-seq
MIRT1446611	hsa-miR-3184	CLIP-seq
MIRT1446612	hsa-miR-3609	CLIP-seq
MIRT1446613	hsa-miR-423-5p	CLIP-seq
MIRT1446614	hsa-miR-4316	CLIP-seq
MIRT1446615	hsa-miR-4457	CLIP-seq
MIRT1446616	hsa-miR-4666-5p	CLIP-seq
MIRT1446617	hsa-miR-4688	CLIP-seq
MIRT1446618	hsa-miR-4785	CLIP-seq
MIRT1446619	hsa-miR-486-3p	CLIP-seq
MIRT1446620	hsa-miR-488	CLIP-seq
MIRT1446621	hsa-miR-548ah	CLIP-seq
MIRT2133539	hsa-miR-1184	CLIP-seq
MIRT2133540	hsa-miR-1231	CLIP-seq
MIRT2133541	hsa-miR-1258	CLIP-seq
MIRT2133542	hsa-miR-127-5p	CLIP-seq
MIRT2133543	hsa-miR-145	CLIP-seq
MIRT2133544	hsa-miR-147	CLIP-seq
MIRT2133545	hsa-miR-1913	CLIP-seq
MIRT2133546	hsa-miR-23a	CLIP-seq
MIRT2133547	hsa-miR-23b	CLIP-seq
MIRT2133548	hsa-miR-23c	CLIP-seq
MIRT2133549	hsa-miR-3117-5p	CLIP-seq
MIRT1446610	hsa-miR-3153	CLIP-seq
MIRT2133550	hsa-miR-3189-5p	CLIP-seq
MIRT2133551	hsa-miR-324-3p	CLIP-seq
MIRT1446612	hsa-miR-3609	CLIP-seq
MIRT2133552	hsa-miR-3677-5p	CLIP-seq
MIRT2133553	hsa-miR-3934	CLIP-seq
MIRT2133554	hsa-miR-4266	CLIP-seq
MIRT2133555	hsa-miR-4286	CLIP-seq
MIRT2133556	hsa-miR-4288	CLIP-seq
MIRT2133557	hsa-miR-4289	CLIP-seq
MIRT2133558	hsa-miR-4469	CLIP-seq
MIRT2133559	hsa-miR-4642	CLIP-seq
MIRT2133560	hsa-miR-4701-5p	CLIP-seq
MIRT2133561	hsa-miR-4704-5p	CLIP-seq
MIRT2133562	hsa-miR-4713-5p	CLIP-seq
MIRT2133563	hsa-miR-4720-5p	CLIP-seq
MIRT2133564	hsa-miR-4722-3p	CLIP-seq
MIRT2133565	hsa-miR-4733-3p	CLIP-seq
MIRT2133566	hsa-miR-4758-3p	CLIP-seq
MIRT2133567	hsa-miR-4760-5p	CLIP-seq
MIRT2133568	hsa-miR-4763-5p	CLIP-seq
MIRT2133569	hsa-miR-4799-3p	CLIP-seq
MIRT1446621	hsa-miR-548ah	CLIP-seq
MIRT2133570	hsa-miR-552	CLIP-seq
MIRT2133571	hsa-miR-586	CLIP-seq
MIRT2133572	hsa-miR-587	CLIP-seq
MIRT2133573	hsa-miR-588	CLIP-seq
MIRT2133574	hsa-miR-596	CLIP-seq
MIRT2133575	hsa-miR-626	CLIP-seq
MIRT2133576	hsa-miR-632	CLIP-seq
MIRT2133577	hsa-miR-759	CLIP-seq
MIRT2133539	hsa-miR-1184	CLIP-seq
MIRT2133541	hsa-miR-1258	CLIP-seq
MIRT2133542	hsa-miR-127-5p	CLIP-seq
MIRT2133543	hsa-miR-145	CLIP-seq
MIRT2354765	hsa-miR-1470	CLIP-seq
MIRT2133545	hsa-miR-1913	CLIP-seq
MIRT2354766	hsa-miR-28-5p	CLIP-seq
MIRT2354767	hsa-miR-3139	CLIP-seq
MIRT2354768	hsa-miR-3183	CLIP-seq
MIRT2133550	hsa-miR-3189-5p	CLIP-seq
MIRT2133551	hsa-miR-324-3p	CLIP-seq
MIRT2354769	hsa-miR-3616-3p	CLIP-seq
MIRT2354770	hsa-miR-376a	CLIP-seq
MIRT2354771	hsa-miR-376b	CLIP-seq
MIRT2354772	hsa-miR-376c	CLIP-seq
MIRT2354773	hsa-miR-3911	CLIP-seq
MIRT2133554	hsa-miR-4266	CLIP-seq
MIRT2133558	hsa-miR-4469	CLIP-seq
MIRT2354774	hsa-miR-4667-3p	CLIP-seq
MIRT2354775	hsa-miR-4684-3p	CLIP-seq
MIRT2133564	hsa-miR-4722-3p	CLIP-seq
MIRT2354776	hsa-miR-4723-3p	CLIP-seq
MIRT2133566	hsa-miR-4758-3p	CLIP-seq
MIRT2133568	hsa-miR-4763-5p	CLIP-seq
MIRT1446618	hsa-miR-4785	CLIP-seq
MIRT2354777	hsa-miR-485-3p	CLIP-seq
MIRT1446620	hsa-miR-488	CLIP-seq
MIRT2133574	hsa-miR-596	CLIP-seq
MIRT2354778	hsa-miR-648	CLIP-seq
MIRT2354779	hsa-miR-708	CLIP-seq
MIRT2648522	hsa-miR-1227	CLIP-seq
MIRT2133541	hsa-miR-1258	CLIP-seq
MIRT2133543	hsa-miR-145	CLIP-seq
MIRT2354766	hsa-miR-28-5p	CLIP-seq
MIRT2648523	hsa-miR-299-3p	CLIP-seq
MIRT2133549	hsa-miR-3117-5p	CLIP-seq
MIRT2648524	hsa-miR-3120-3p	CLIP-seq
MIRT2354767	hsa-miR-3139	CLIP-seq
MIRT2648525	hsa-miR-3151	CLIP-seq
MIRT1446610	hsa-miR-3153	CLIP-seq
MIRT2648526	hsa-miR-3156-3p	CLIP-seq
MIRT1446612	hsa-miR-3609	CLIP-seq
MIRT2648527	hsa-miR-361-5p	CLIP-seq
MIRT2648528	hsa-miR-3673	CLIP-seq
MIRT2648529	hsa-miR-3685	CLIP-seq
MIRT2648530	hsa-miR-371-5p	CLIP-seq
MIRT2354773	hsa-miR-3911	CLIP-seq
MIRT2648531	hsa-miR-3942-5p	CLIP-seq
MIRT2133554	hsa-miR-4266	CLIP-seq
MIRT2133555	hsa-miR-4286	CLIP-seq
MIRT2648532	hsa-miR-4301	CLIP-seq
MIRT2648533	hsa-miR-4447	CLIP-seq
MIRT2648534	hsa-miR-4450	CLIP-seq
MIRT1446615	hsa-miR-4457	CLIP-seq
MIRT2648535	hsa-miR-4472	CLIP-seq
MIRT2648536	hsa-miR-4487	CLIP-seq
MIRT2648537	hsa-miR-4490	CLIP-seq
MIRT2648538	hsa-miR-455-5p	CLIP-seq
MIRT2133559	hsa-miR-4642	CLIP-seq
MIRT2648539	hsa-miR-4703-5p	CLIP-seq
MIRT2133562	hsa-miR-4713-5p	CLIP-seq
MIRT2133563	hsa-miR-4720-5p	CLIP-seq
MIRT2133565	hsa-miR-4733-3p	CLIP-seq
MIRT2133567	hsa-miR-4760-5p	CLIP-seq
MIRT2648540	hsa-miR-4774-5p	CLIP-seq
MIRT1446618	hsa-miR-4785	CLIP-seq
MIRT2648541	hsa-miR-4793-3p	CLIP-seq
MIRT2133569	hsa-miR-4799-3p	CLIP-seq
MIRT1446620	hsa-miR-488	CLIP-seq
MIRT2648542	hsa-miR-491-5p	CLIP-seq
MIRT2648543	hsa-miR-532-3p	CLIP-seq
MIRT1446621	hsa-miR-548ah	CLIP-seq
MIRT2648544	hsa-miR-604	CLIP-seq
MIRT2648545	hsa-miR-647	CLIP-seq
MIRT2354778	hsa-miR-648	CLIP-seq
MIRT2354779	hsa-miR-708	CLIP-seq
MIRT2133577	hsa-miR-759	CLIP-seq
MIRT2648546	hsa-miR-889	CLIP-seq
MIRT2648522	hsa-miR-1227	CLIP-seq
MIRT2133541	hsa-miR-1258	CLIP-seq
MIRT2133543	hsa-miR-145	CLIP-seq
MIRT2354766	hsa-miR-28-5p	CLIP-seq
MIRT2648523	hsa-miR-299-3p	CLIP-seq
MIRT2648524	hsa-miR-3120-3p	CLIP-seq
MIRT2354767	hsa-miR-3139	CLIP-seq
MIRT2648525	hsa-miR-3151	CLIP-seq
MIRT1446610	hsa-miR-3153	CLIP-seq
MIRT1446612	hsa-miR-3609	CLIP-seq
MIRT2648527	hsa-miR-361-5p	CLIP-seq
MIRT2648529	hsa-miR-3685	CLIP-seq
MIRT2648530	hsa-miR-371-5p	CLIP-seq
MIRT2354773	hsa-miR-3911	CLIP-seq
MIRT2648531	hsa-miR-3942-5p	CLIP-seq
MIRT2133554	hsa-miR-4266	CLIP-seq
MIRT2133555	hsa-miR-4286	CLIP-seq
MIRT2648533	hsa-miR-4447	CLIP-seq
MIRT2648534	hsa-miR-4450	CLIP-seq
MIRT1446615	hsa-miR-4457	CLIP-seq
MIRT2648535	hsa-miR-4472	CLIP-seq
MIRT2648536	hsa-miR-4487	CLIP-seq
MIRT2648537	hsa-miR-4490	CLIP-seq
MIRT2648538	hsa-miR-455-5p	CLIP-seq
MIRT2133559	hsa-miR-4642	CLIP-seq
MIRT2648539	hsa-miR-4703-5p	CLIP-seq
MIRT2133562	hsa-miR-4713-5p	CLIP-seq
MIRT2133565	hsa-miR-4733-3p	CLIP-seq
MIRT2133567	hsa-miR-4760-5p	CLIP-seq
MIRT2648540	hsa-miR-4774-5p	CLIP-seq
MIRT1446618	hsa-miR-4785	CLIP-seq
MIRT2648541	hsa-miR-4793-3p	CLIP-seq
MIRT1446620	hsa-miR-488	CLIP-seq
MIRT2648542	hsa-miR-491-5p	CLIP-seq
MIRT1446621	hsa-miR-548ah	CLIP-seq
MIRT2648544	hsa-miR-604	CLIP-seq
MIRT2648545	hsa-miR-647	CLIP-seq
MIRT2354778	hsa-miR-648	CLIP-seq
MIRT2354779	hsa-miR-708	CLIP-seq
MIRT2133577	hsa-miR-759	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	12198123, 14557246, 25556234, 32296183, 32814053
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005741	Component	Mitochondrial outer membrane	IEA
GO:0005741	Component	Mitochondrial outer membrane	NAS	18331822
GO:0005741	Component	Mitochondrial outer membrane	TAS
GO:0005742	Component	Mitochondrial outer membrane translocase complex	IBA
GO:0005742	Component	Mitochondrial outer membrane translocase complex	IDA	12198123, 15644312
GO:0006626	Process	Protein targeting to mitochondrion	TAS	10982837, 14557246
GO:0006886	Process	Intracellular protein transport	IEA
GO:0008320	Function	Protein transmembrane transporter activity	IBA
GO:0008320	Function	Protein transmembrane transporter activity	ISS
GO:0008320	Function	Protein transmembrane transporter activity	TAS	15644312
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	HDA	19946888
GO:0016020	Component	Membrane	IDA	15644312
GO:0016020	Component	Membrane	IEA
GO:0030150	Process	Protein import into mitochondrial matrix	IBA
GO:0030150	Process	Protein import into mitochondrial matrix	IDA	15644312
GO:0030943	Function	Mitochondrion targeting sequence binding	IDA	35733257
GO:0045040	Process	Protein insertion into mitochondrial outer membrane	NAS	18331822
GO:0140596	Component	TOM complex	NAS	18331822

Other IDs

• MIM: 607046
• HGNC: 18002
• e!Ensembl: ENSG00000100216

Protein

• UniProt ID: Q9NS69
• Protein name: Mitochondrial import receptor subunit TOM22 homolog (hTom22) (1C9-2) (Translocase of outer membrane 22 kDa subunit homolog)
• Protein function: Central receptor component of the translocase of the outer membrane of mitochondria (TOM complex) responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. Together with the peripheral receptor TOM
• PDB: 7CK6 , 7CP9 , 7VBY , 7VC4 , 7VD2 , 7VDD , 8XVA , 9EIH , 9EII , 9EIJ
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF04281	Tom22	7 → 121	Mitochondrial import receptor subunit Tom22	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous.
• Sequence:

  MAAAVAAAGAGEPQSPDELLPKGDAEKPEEELEEDDDEELDETLSERLWGLTEMFPERVR
  SAAGATFDLSLFVAQKMYRFSRAALWIGTTSFMILVLPVVFETEKLQMEQQQQLQQRQIL
  LGPNTGLSGGMPGALPSLPGKI

• Sequence length: 142

Pathways

Reactome Pathway:

Pink/Parkin Mediated Mitophagy

Related Genes

No strongly related genes found yet for TOMM22.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TOMM22.