TNFAIP8L2 (TNF alpha induced protein 8 like 2)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79626
• Gene name: TNF alpha induced protein 8 like 2
• Gene symbol: TNFAIP8L2
• Synonyms (NCBI Gene): TIPE2
• Chromosome: 1
• Chromosome location: 1q21.3

miRNA Show/Hide all (30)

miRTarBase ID	miRNA	Experiments	Reference
MIRT646019	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT646017	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT646016	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT646015	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT646014	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT646013	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT646012	hsa-miR-3182	HITS-CLIP	23824327
MIRT646011	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT646010	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT646009	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT646008	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT646019	hsa-miR-6895-5p	HITS-CLIP	23824327
MIRT646017	hsa-miR-6887-3p	HITS-CLIP	23824327
MIRT646016	hsa-miR-6795-3p	HITS-CLIP	23824327
MIRT646015	hsa-miR-877-3p	HITS-CLIP	23824327
MIRT646014	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT646013	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT646012	hsa-miR-3182	HITS-CLIP	23824327
MIRT646011	hsa-miR-6830-3p	HITS-CLIP	23824327
MIRT646010	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT646009	hsa-miR-511-5p	HITS-CLIP	23824327
MIRT646008	hsa-miR-4743-3p	HITS-CLIP	23824327
MIRT2132434	hsa-miR-1587	CLIP-seq
MIRT2132435	hsa-miR-412	CLIP-seq
MIRT2132436	hsa-miR-4492	CLIP-seq
MIRT2132437	hsa-miR-4498	CLIP-seq
MIRT2132438	hsa-miR-4656	CLIP-seq
MIRT2132439	hsa-miR-4675	CLIP-seq
MIRT2132440	hsa-miR-4741	CLIP-seq
MIRT2132441	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	22949657, 24274578
GO:0005634	Component	Nucleus	IEA
GO:0005737	Component	Cytoplasm	IBA
GO:0005737	Component	Cytoplasm	IEA
GO:0005764	Component	Lysosome	IEA
GO:0042110	Process	T cell activation	IEA
GO:0042981	Process	Regulation of apoptotic process	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0050728	Process	Negative regulation of inflammatory response	IBA
GO:0050728	Process	Negative regulation of inflammatory response	IEA
GO:0050868	Process	Negative regulation of T cell activation	IBA
GO:0050868	Process	Negative regulation of T cell activation	IEA

Other IDs

• MIM: 612112
• HGNC: 26277
• e!Ensembl: ENSG00000163154

Protein

• UniProt ID: Q6P589
• Protein name: Tumor necrosis factor alpha-induced protein 8-like protein 2 (TIPE2) (TNF alpha-induced protein 8-like protein 2) (TNFAIP8-like protein 2) (Inflammation factor protein 20)
• Protein function: Acts as a negative regulator of innate and adaptive immunity by maintaining immune homeostasis (PubMed:27043859). Plays a regulatory role in the Toll-like signaling pathway by determining the strength of LPS-induced signaling and gene expression
• PDB: 3F4M
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05527	DUF758	4 → 182	Domain of unknown function (DUF758)	Family

• Tissue specificity: TISSUE SPECIFICITY: Expressed in T-cells, B-cells, macrophages, neurons in the brain and brainstem, and stratified squamous epithelia of the esophagus, cervix and skin. {ECO:0000269|PubMed:21459448}.
• Sequence:

  MESFSSKSLALQAEKKLLSKMAGRSVAHLFIDETSSEVLDELYRVSKEYTHSRPQAQRVI
  KDLIKVAIKVAVLHRNGSFGPSELALATRFRQKLRQGAMTALSFGEVDFTFEAAVLAGLL
  TECRDVLLELVEHHLTPKSHGRIRHVFDHFSDPGLLTALYGPDFTQHLGKICDGLRKLLD
  EGKL

• Sequence length: 184

Pathways

Reactome Pathway:

PI Metabolism

Related Genes

No strongly related genes found yet for TNFAIP8L2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TNFAIP8L2.