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Gene Gene information from NCBI Gene database.
Entrez ID 29767
Gene name Tropomodulin 2
Gene symbol TMOD2
Synonyms (NCBI Gene)
N-TMODNTMOD
Chromosome 15
Chromosome location 15q21.2
Summary This gene encodes a neuronal-specific member of the tropomodulin family of actin-regulatory proteins. The encoded protein caps the pointed end of actin filaments preventing both elongation and depolymerization. The capping activity of this protein is depe
miRNA miRNA information provided by mirtarbase database.
1044 Show/Hide all (1044)
miRTarBase ID miRNA Experiments Reference
MIRT018829 hsa-miR-335-5p Microarray 18185580
MIRT025435 hsa-miR-34a-5p Proteomics 21566225
MIRT025435 hsa-miR-34a-5p Proteomics 21566225
MIRT041699 hsa-miR-484 CLASH 23622248
MIRT634203 hsa-miR-1306-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
19 Show/Hide all (19)
GO ID Ontology Definition Evidence Reference
GO:0003779 Function Actin binding IEA
GO:0005515 Function Protein binding IPI 32814053
GO:0005523 Function Tropomyosin binding IBA
GO:0005523 Function Tropomyosin binding IEA
GO:0005523 Function Tropomyosin binding TAS 10662549
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602928 11872 ENSG00000128872
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q9NZR1
Protein name Tropomodulin-2 (Neuronal tropomodulin) (N-Tmod)
Protein function Blocks the elongation and depolymerization of the actin filaments at the pointed end. The Tmod/TM complex contributes to the formation of the short actin protofilament, which in turn defines the geometry of the membrane skeleton (By similarity).
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF03250 Tropomodulin 5 → 146 Tropomodulin Family
Tissue specificity TISSUE SPECIFICITY: Neuronal-tissue specific. {ECO:0000269|PubMed:10662549}.
Sequence
MALPFQKELEKYKNIDEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAA
TGPFDREHLLMYLEKEALEQKDREDFVPFTGEKKGRVFIPKEKPIETRKEEKVTLDPELE
EALASASDTELYDLAAVLGVHNLLNN
PKFDEETANNKGGKGPVRNVVKGEKVKPVFEEPP
NPTNVEISLQQMKANDPSLQEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSND
PVAIAFADMLKVNKTLTSLNIESNFITGTGILALVEALKENDTLTEIKIDNQRQQLGTAV
EMEIAQMLEENSRILKFGYQFTKQGPRTRVAAAITKNNDLVRKKRVEADRR
Sequence length 351
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Cytoskeleton in muscle cells Striated Muscle Contraction
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
Thyroid cancer, nonmedullary, 1 Uncertain significance ClinVar —
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations
Associations from Text Mining Disease associations identified through text mining
Disease Name Disease (Merged) Source PMID Relationship Type Evidence Score
Glioblastoma Glioblastoma Pubtator 35788194 Associate
★★★★★
★☆☆☆☆
Found in Text Mining only
Malignant Neoplasms Malignant Neoplasm BEFREE 19082487
★★★★★
★☆☆☆☆
Found in Text Mining only