TMIGD2 (transmembrane and immunoglobulin domain containing 2)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 126259
• Gene name: Transmembrane and immunoglobulin domain containing 2
• Gene symbol: TMIGD2
• Synonyms (NCBI Gene): CD28H, IGPR-1, IGPR1
• Chromosome: 19
• Chromosome location: 19p13.3

miRNA Show/Hide all (135)

miRTarBase ID	miRNA	Experiments	Reference
MIRT672721	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625022	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625021	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625020	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625019	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625018	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT625017	hsa-miR-1281	HITS-CLIP	23824327
MIRT672720	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT679672	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT672718	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT672717	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625014	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679671	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT672716	hsa-miR-4284	HITS-CLIP	23824327
MIRT625012	hsa-miR-498	HITS-CLIP	23824327
MIRT672721	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625022	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625021	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625020	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625019	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625018	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT625017	hsa-miR-1281	HITS-CLIP	23824327
MIRT672720	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT672719	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT672718	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT672717	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625016	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT625015	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT625014	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT625013	hsa-miR-6131	HITS-CLIP	23824327
MIRT672716	hsa-miR-4284	HITS-CLIP	23824327
MIRT625012	hsa-miR-498	HITS-CLIP	23824327
MIRT625022	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625021	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625020	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625019	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625018	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT625017	hsa-miR-1281	HITS-CLIP	23824327
MIRT625016	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT625015	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT625014	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT625013	hsa-miR-6131	HITS-CLIP	23824327
MIRT625012	hsa-miR-498	HITS-CLIP	23824327
MIRT672721	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625022	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625021	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625020	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625019	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625018	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT625017	hsa-miR-1281	HITS-CLIP	23824327
MIRT672720	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT679672	hsa-miR-1307-3p	HITS-CLIP	23824327
MIRT672718	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT672717	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625014	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT679671	hsa-miR-6722-5p	HITS-CLIP	23824327
MIRT672716	hsa-miR-4284	HITS-CLIP	23824327
MIRT625012	hsa-miR-498	HITS-CLIP	23824327
MIRT672721	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT625022	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625021	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625020	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625019	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625018	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT625017	hsa-miR-1281	HITS-CLIP	23824327
MIRT672720	hsa-miR-6741-3p	HITS-CLIP	23824327
MIRT672719	hsa-miR-1304-3p	HITS-CLIP	23824327
MIRT672718	hsa-miR-4638-5p	HITS-CLIP	23824327
MIRT672717	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT625016	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT625015	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT625014	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT625013	hsa-miR-6131	HITS-CLIP	23824327
MIRT672716	hsa-miR-4284	HITS-CLIP	23824327
MIRT625012	hsa-miR-498	HITS-CLIP	23824327
MIRT625022	hsa-miR-6840-3p	HITS-CLIP	23824327
MIRT625021	hsa-miR-1915-3p	HITS-CLIP	23824327
MIRT625020	hsa-miR-6764-5p	HITS-CLIP	23824327
MIRT625019	hsa-miR-4726-3p	HITS-CLIP	23824327
MIRT625018	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT625017	hsa-miR-1281	HITS-CLIP	23824327
MIRT625016	hsa-miR-3663-5p	HITS-CLIP	23824327
MIRT625015	hsa-miR-4755-3p	HITS-CLIP	23824327
MIRT625014	hsa-miR-6778-3p	HITS-CLIP	23824327
MIRT625013	hsa-miR-6131	HITS-CLIP	23824327
MIRT625012	hsa-miR-498	HITS-CLIP	23824327
MIRT1440050	hsa-miR-1275	CLIP-seq
MIRT1440051	hsa-miR-3153	CLIP-seq
MIRT1440052	hsa-miR-4300	CLIP-seq
MIRT1440053	hsa-miR-4525	CLIP-seq
MIRT1440054	hsa-miR-4665-5p	CLIP-seq
MIRT1440055	hsa-miR-4723-5p	CLIP-seq
MIRT1440056	hsa-miR-4796-3p	CLIP-seq
MIRT1440057	hsa-miR-625	CLIP-seq
MIRT1440058	hsa-miR-635	CLIP-seq
MIRT1440059	hsa-miR-920	CLIP-seq
MIRT2131769	hsa-miR-122	CLIP-seq
MIRT2131770	hsa-miR-129-5p	CLIP-seq
MIRT2131771	hsa-miR-1307	CLIP-seq
MIRT2131772	hsa-miR-139-3p	CLIP-seq
MIRT2131773	hsa-miR-1915	CLIP-seq
MIRT2131774	hsa-miR-3135b	CLIP-seq
MIRT2131775	hsa-miR-3652	CLIP-seq
MIRT2131776	hsa-miR-3664-5p	CLIP-seq
MIRT2131777	hsa-miR-3672	CLIP-seq
MIRT2131778	hsa-miR-4294	CLIP-seq
MIRT2131779	hsa-miR-4430	CLIP-seq
MIRT2131780	hsa-miR-4639-3p	CLIP-seq
MIRT2131769	hsa-miR-122	CLIP-seq
MIRT2131771	hsa-miR-1307	CLIP-seq
MIRT2131773	hsa-miR-1915	CLIP-seq
MIRT2131774	hsa-miR-3135b	CLIP-seq
MIRT2131775	hsa-miR-3652	CLIP-seq
MIRT2131776	hsa-miR-3664-5p	CLIP-seq
MIRT2131778	hsa-miR-4294	CLIP-seq
MIRT2131779	hsa-miR-4430	CLIP-seq
MIRT2131780	hsa-miR-4639-3p	CLIP-seq
MIRT2131769	hsa-miR-122	CLIP-seq
MIRT2131771	hsa-miR-1307	CLIP-seq
MIRT2131773	hsa-miR-1915	CLIP-seq
MIRT2131774	hsa-miR-3135b	CLIP-seq
MIRT2131775	hsa-miR-3652	CLIP-seq
MIRT2131779	hsa-miR-4430	CLIP-seq
MIRT2131769	hsa-miR-122	CLIP-seq
MIRT2131771	hsa-miR-1307	CLIP-seq
MIRT2131773	hsa-miR-1915	CLIP-seq
MIRT2131774	hsa-miR-3135b	CLIP-seq
MIRT2131775	hsa-miR-3652	CLIP-seq
MIRT2131779	hsa-miR-4430	CLIP-seq
MIRT2131769	hsa-miR-122	CLIP-seq
MIRT2131771	hsa-miR-1307	CLIP-seq
MIRT2131773	hsa-miR-1915	CLIP-seq
MIRT2131774	hsa-miR-3135b	CLIP-seq
MIRT2131775	hsa-miR-3652	CLIP-seq
MIRT2131779	hsa-miR-4430	CLIP-seq

Gene ontology (GO) Show/Hide all (9)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001819	Process	Positive regulation of cytokine production	IDA	23784006
GO:0005515	Function	Protein binding	IPI	23784006
GO:0005886	Component	Plasma membrane	IEA
GO:0015026	Function	Coreceptor activity	IDA	23784006
GO:0016020	Component	Membrane	IEA
GO:0031295	Process	T cell costimulation	IDA	23784006
GO:0042104	Process	Positive regulation of activated T cell proliferation	IDA	23784006
GO:0043005	Component	Neuron projection	IBA
GO:0045766	Process	Positive regulation of angiogenesis	IMP	22419821

Other IDs

• MIM: 614715
• HGNC: 28324
• e!Ensembl: ENSG00000167664

Protein

• UniProt ID: Q96BF3
• Protein name: Transmembrane and immunoglobulin domain-containing protein 2 (CD28 homolog) (Immunoglobulin and proline-rich receptor 1) (IGPR-1)
• Protein function: Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent s
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF07686	V-set	27 → 134	Immunoglobulin V-set domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed, mainly by epithelial and endothelial cells, including bronchial epithelial cells of lung, breast glandular and lobular epithelia cells, urothelium of the bladder, skin epidermis, epithelium of gastrointestinal, rectum
• Sequence:

  MGSPGMVLGLLVQIWALQEASSLSVQQGPNLLQVRQGSQATLVCQVDQATAWERLRVKWT
  KDGAILCQPYITNGSLSLGVCGPQGRLSWQAPSHLTLQLDPVSLNHSGAYVCWAAVEIPE
  LEEAEGNITRLFVDPDDPTQNRNRIASFPGFLFVLLGVGSMGVAAIVWGAWFWGRRSCQQ
  RDSGNSPGNAFYSNVLYRPRGAPKKSEDCSGEGKDQRGQSIYSTSFPQPAPRQPHLASRP
  CPSPRPCPSPRPGHPVSMVRVSPRPSPTQQPRPKGFPKVGEE

• Sequence length: 282

Related Genes

No strongly related genes found yet for TMIGD2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TMIGD2.