Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 137695
Gene name Transmembrane protein 68
Gene symbol TMEM68
Synonyms (NCBI Gene)
DIESLMGAT/DGAT
Chromosome 8
Chromosome location 8q12.1
miRNA miRNA information provided by mirtarbase database.
404 Show/Hide all (404)
miRTarBase ID miRNA Experiments Reference
MIRT023909 hsa-miR-1-3p Microarray 18668037
MIRT452209 hsa-miR-5692a PAR-CLIP 24398324
MIRT452208 hsa-miR-495-3p PAR-CLIP 24398324
MIRT452206 hsa-miR-5688 PAR-CLIP 24398324
MIRT452207 hsa-miR-7-1-3p PAR-CLIP 24398324
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
10 Show/Hide all (10)
GO ID Ontology Definition Evidence Reference
GO:0005783 Component Endoplasmic reticulum IEA
GO:0005789 Component Endoplasmic reticulum membrane IDA 37648867
GO:0005789 Component Endoplasmic reticulum membrane IEA
GO:0006629 Process Lipid metabolic process IEA
GO:0016020 Component Membrane IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
HGNC N/A HGNC
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96MH6
Protein name DGAT1/2-independent enzyme synthesizing storage lipids (DIESL) (EC 2.3.1.-) (2-acylglycerol/1,2-diacylglycerol O-acyltransferase) (Monoacylglycerol/Diacylglycerol O-acyltransferase) (MGAT/DGAT) (EC 2.3.1.20, EC 2.3.1.22) (Transmembrane protein 68)
Protein function Catalytic subunit of the alternative triglyceride biosynthesis pathway, which mediates formation of triacylglycerol from diacylglycerol and membrane phospholipids (PubMed:37648867). Synthesizes triacylglycerol at the expense of membrane phosphol
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF01553 Acyltransferase 109 → 237 Acyltransferase Family
Sequence
MIDKNQTCGVGQDSVPYMICLIHILEEWFGVEQLEDYLNFANYLLWVFTPLILLILPYFT
IFLLYLTIIFLHIYKRKNVLKEAYSHNLWDGARKTVATLWDGHAAVWHGYEVHGMEKIPE
DGPALIIFYHGAIPIDFYYFMAKIFIHKGRTCRVVADHFVFKIPGFSLLLDVFCALHGPR
EKCVEILRSGHLLAISPGGVREALISDETYNIVWGHRRGFAQVAIDAKVPIIPMFTQ
NIR
EGFRSLGGTRLFRWLYEKFRYPFAPMYGGFPVKLRTYLGDPIPYDPQITAEELAEKTKNA
VQALIDKHQRIPGNIMSALLERFH
Sequence length 324
Interactions View interactions
Associated diseases Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
1
Evidence Score: ★☆☆☆☆  Gene-disease association found in Text Mining only ★★☆☆☆  Found in Text Mining and Unknown/Other Associations ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
Phenotype Name Clinical Significance Source Reference Evidence Score
MIGRAINE DISORDER — GWAS catalog 23793025
★★★★★
★★☆☆☆
Found in Text Mining + Unknown/Other Associations