TMEM218 (transmembrane protein 218)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 219854
• Gene name: Transmembrane protein 218
• Gene symbol: TMEM218
• Synonyms (NCBI Gene): JBTS39
• Chromosome: 11
• Chromosome location: 11q24.2

miRNA Show/Hide all (209)

miRTarBase ID	miRNA	Experiments	Reference
MIRT720654	hsa-miR-4803	HITS-CLIP	19536157
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	19536157
MIRT720653	hsa-miR-302b-5p	HITS-CLIP	19536157
MIRT720652	hsa-miR-302d-5p	HITS-CLIP	19536157
MIRT720651	hsa-miR-3143	HITS-CLIP	19536157
MIRT720650	hsa-miR-302c-5p	HITS-CLIP	19536157
MIRT615248	hsa-miR-3685	HITS-CLIP	19536157
MIRT615247	hsa-miR-384	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT621802	hsa-miR-507	HITS-CLIP	23824327
MIRT621801	hsa-miR-557	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT720654	hsa-miR-4803	HITS-CLIP	19536157
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	19536157
MIRT720653	hsa-miR-302b-5p	HITS-CLIP	19536157
MIRT720652	hsa-miR-302d-5p	HITS-CLIP	19536157
MIRT720651	hsa-miR-3143	HITS-CLIP	19536157
MIRT720650	hsa-miR-302c-5p	HITS-CLIP	19536157
MIRT615248	hsa-miR-3685	HITS-CLIP	19536157
MIRT615247	hsa-miR-384	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT712095	hsa-miR-5193	HITS-CLIP	19536157
MIRT712094	hsa-miR-660-3p	HITS-CLIP	19536157
MIRT712093	hsa-miR-5191	HITS-CLIP	19536157
MIRT712092	hsa-miR-1293	HITS-CLIP	19536157
MIRT712091	hsa-miR-4483	HITS-CLIP	19536157
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT621802	hsa-miR-507	HITS-CLIP	23824327
MIRT621801	hsa-miR-557	HITS-CLIP	23824327
MIRT615250	hsa-miR-5009-3p	HITS-CLIP	23824327
MIRT615249	hsa-miR-503-3p	HITS-CLIP	23824327
MIRT615248	hsa-miR-3685	HITS-CLIP	23824327
MIRT615247	hsa-miR-384	HITS-CLIP	23824327
MIRT1435520	hsa-miR-1208	CLIP-seq
MIRT1435521	hsa-miR-204	CLIP-seq
MIRT1435522	hsa-miR-211	CLIP-seq
MIRT1435523	hsa-miR-2278	CLIP-seq
MIRT1435524	hsa-miR-2467-3p	CLIP-seq
MIRT1435525	hsa-miR-2681	CLIP-seq
MIRT1435526	hsa-miR-31	CLIP-seq
MIRT1435527	hsa-miR-3117-5p	CLIP-seq
MIRT1435528	hsa-miR-3613-3p	CLIP-seq
MIRT1435529	hsa-miR-4446-5p	CLIP-seq
MIRT1435530	hsa-miR-4468	CLIP-seq
MIRT1435531	hsa-miR-4696	CLIP-seq
MIRT1435532	hsa-miR-4755-5p	CLIP-seq
MIRT1435533	hsa-miR-4802-3p	CLIP-seq
MIRT1435534	hsa-miR-490-5p	CLIP-seq
MIRT1435535	hsa-miR-548ac	CLIP-seq
MIRT1435536	hsa-miR-548d-3p	CLIP-seq
MIRT1435537	hsa-miR-548z	CLIP-seq
MIRT1435538	hsa-miR-623	CLIP-seq
MIRT1435539	hsa-miR-7	CLIP-seq
MIRT1435520	hsa-miR-1208	CLIP-seq
MIRT2130502	hsa-miR-3074-5p	CLIP-seq
MIRT2351857	hsa-miR-1237	CLIP-seq
MIRT2351858	hsa-miR-1248	CLIP-seq
MIRT2351859	hsa-miR-320e	CLIP-seq
MIRT2351860	hsa-miR-362-5p	CLIP-seq
MIRT2351861	hsa-miR-383	CLIP-seq
MIRT2351862	hsa-miR-4490	CLIP-seq
MIRT2351863	hsa-miR-500b	CLIP-seq
MIRT2351864	hsa-miR-501-5p	CLIP-seq
MIRT2351865	hsa-miR-767-3p	CLIP-seq
MIRT2351857	hsa-miR-1237	CLIP-seq
MIRT2645532	hsa-miR-124	CLIP-seq
MIRT2351858	hsa-miR-1248	CLIP-seq
MIRT2645533	hsa-miR-1252	CLIP-seq
MIRT2645534	hsa-miR-1323	CLIP-seq
MIRT1435521	hsa-miR-204	CLIP-seq
MIRT1435522	hsa-miR-211	CLIP-seq
MIRT2130502	hsa-miR-3074-5p	CLIP-seq
MIRT2351859	hsa-miR-320e	CLIP-seq
MIRT2645535	hsa-miR-3616-3p	CLIP-seq
MIRT2351860	hsa-miR-362-5p	CLIP-seq
MIRT2645536	hsa-miR-3653	CLIP-seq
MIRT2645537	hsa-miR-3667-3p	CLIP-seq
MIRT2645538	hsa-miR-370	CLIP-seq
MIRT2645539	hsa-miR-371-3p	CLIP-seq
MIRT2645540	hsa-miR-3714	CLIP-seq
MIRT2645541	hsa-miR-371b-3p	CLIP-seq
MIRT2645542	hsa-miR-3908	CLIP-seq
MIRT2645543	hsa-miR-3910	CLIP-seq
MIRT2645544	hsa-miR-3942-5p	CLIP-seq
MIRT2645545	hsa-miR-3943	CLIP-seq
MIRT2645546	hsa-miR-3978	CLIP-seq
MIRT2645547	hsa-miR-4297	CLIP-seq
MIRT2645548	hsa-miR-4323	CLIP-seq
MIRT2645549	hsa-miR-4427	CLIP-seq
MIRT2645550	hsa-miR-4446-3p	CLIP-seq
MIRT1435529	hsa-miR-4446-5p	CLIP-seq
MIRT2351862	hsa-miR-4490	CLIP-seq
MIRT2645551	hsa-miR-4662a-3p	CLIP-seq
MIRT2645552	hsa-miR-4675	CLIP-seq
MIRT2645553	hsa-miR-4680-3p	CLIP-seq
MIRT2645554	hsa-miR-4703-5p	CLIP-seq
MIRT2645555	hsa-miR-4721	CLIP-seq
MIRT2645556	hsa-miR-4741	CLIP-seq
MIRT1435532	hsa-miR-4755-5p	CLIP-seq
MIRT2645557	hsa-miR-4766-3p	CLIP-seq
MIRT2351863	hsa-miR-500b	CLIP-seq
MIRT2351864	hsa-miR-501-5p	CLIP-seq
MIRT2645558	hsa-miR-506	CLIP-seq
MIRT2645559	hsa-miR-515-3p	CLIP-seq
MIRT2645560	hsa-miR-519e	CLIP-seq
MIRT2645561	hsa-miR-548ag	CLIP-seq
MIRT2645562	hsa-miR-548ai	CLIP-seq
MIRT2645563	hsa-miR-548o	CLIP-seq
MIRT2645564	hsa-miR-607	CLIP-seq
MIRT1435538	hsa-miR-623	CLIP-seq
MIRT2645565	hsa-miR-760	CLIP-seq
MIRT2351865	hsa-miR-767-3p	CLIP-seq
MIRT2645532	hsa-miR-124	CLIP-seq
MIRT2645533	hsa-miR-1252	CLIP-seq
MIRT2645534	hsa-miR-1323	CLIP-seq
MIRT2693499	hsa-miR-185	CLIP-seq
MIRT2130502	hsa-miR-3074-5p	CLIP-seq
MIRT2645535	hsa-miR-3616-3p	CLIP-seq
MIRT2645537	hsa-miR-3667-3p	CLIP-seq
MIRT2645538	hsa-miR-370	CLIP-seq
MIRT2645539	hsa-miR-371-3p	CLIP-seq
MIRT2645540	hsa-miR-3714	CLIP-seq
MIRT2645541	hsa-miR-371b-3p	CLIP-seq
MIRT2645543	hsa-miR-3910	CLIP-seq
MIRT2693500	hsa-miR-3925-5p	CLIP-seq
MIRT2645547	hsa-miR-4297	CLIP-seq
MIRT2693501	hsa-miR-4306	CLIP-seq
MIRT2645549	hsa-miR-4427	CLIP-seq
MIRT2693502	hsa-miR-4428	CLIP-seq
MIRT2645550	hsa-miR-4446-3p	CLIP-seq
MIRT2693503	hsa-miR-4644	CLIP-seq
MIRT2645552	hsa-miR-4675	CLIP-seq
MIRT2645553	hsa-miR-4680-3p	CLIP-seq
MIRT2645555	hsa-miR-4721	CLIP-seq
MIRT2645556	hsa-miR-4741	CLIP-seq
MIRT2693504	hsa-miR-4773	CLIP-seq
MIRT2645558	hsa-miR-506	CLIP-seq
MIRT2645559	hsa-miR-515-3p	CLIP-seq
MIRT2645560	hsa-miR-519e	CLIP-seq
MIRT2645563	hsa-miR-548o	CLIP-seq
MIRT2645565	hsa-miR-760	CLIP-seq
MIRT2351865	hsa-miR-767-3p	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	25416956, 29892012, 31515488, 32296183, 35137054
GO:0005929	Component	Cilium	IEA
GO:0016020	Component	Membrane	IEA
GO:0042995	Component	Cell projection	IEA

Other IDs

• MIM: 619285
• HGNC: 27344
• e!Ensembl: ENSG00000150433

Protein

• UniProt ID: A2RU14
• Protein name: Transmembrane protein 218
• Protein function: May be involved in ciliary biogenesis or function.
• Sequence:

  MAGTVLGVGAGVFILALLWVAVLLLCVLLSRASGAARFSVIFLFFGAVIITSVLLLFPRA
  GEFPAPEVEVKIVDDFFIGRYVLLAFLSAIFLGGLFLVLIHYVLEPIYAKPLHSY

• Sequence length: 115

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Joubert syndrome	Likely pathogenic; Pathogenic	rs141744337, rs1950967763	RCV001263490 RCV001263491	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Joubert syndrome 39	Likely pathogenic; Pathogenic	rs1248550491, rs141744337, rs1950967763	RCV002223152 RCV001729826 RCV001729827	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)
Meckel syndrome, type 4	Likely pathogenic; Pathogenic	rs141744337, rs758805438	RCV001263493 RCV001263492	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (11)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
CILIOPATHIES	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CILIOPATHY	—	GenCC	35137054, 33791682	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL ABSENCE OF PART OF BRAIN	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
CONGENITAL HYPOPLASIA OF PART OF BRAIN	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
FAMILIAL APLASIA OF THE VERMIS	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
HYDRANENCEPHALY	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
ISOLATED JOUBERT SYNDROME	—	Orphanet	33791682	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LISSENCEPHALY	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
LUNG ADENOCARCINOMA	—	GWAS catalog	29924316	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MACROGYRIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MICROGYRIA	—	Disgenet	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Cerebral Infarction	Ischemic stroke	Pubtator	32785988	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

Sort by: Blended Diseases Pathways Evidence source

B9D2 10 shared diseasesCiliopathy, Lissencephaly, Congenital brain malformation, Congenital hypoplasia of part of brain, Aplasia of the vermis, Hydranencephaly, Joubert syndrome, Macrogyria, Meckel-gruber syndrome, Microgyria 11 shared evidence sourcesDisgenet (Ciliopathy), Disgenet (Lissencephaly), Disgenet (Congenital brain malformation), Disgenet (Congenital hypoplasia of part of brain), Disgenet (Aplasia of the vermis), Disgenet (Hydranencephaly), Orphanet (Joubert syndrome), Disgenet (Joubert syndrome), Disgenet (Macrogyria), Disgenet (Meckel-gruber syndrome), Disgenet (Microgyria) Related via 10 shared diseases including Ciliopathy, Lissencephaly — evidence mostly Disgenet. TOGARAM1 9 shared diseasesCiliopathy, Lissencephaly, Congenital brain malformation, Congenital hypoplasia of part of brain, Aplasia of the vermis, Hydranencephaly, Joubert syndrome, Macrogyria, Microgyria 12 shared evidence sourcesDisgenet (Ciliopathy), Disgenet (Lissencephaly), Disgenet (Congenital brain malformation), Disgenet (Congenital hypoplasia of part of brain), Disgenet (Aplasia of the vermis), Disgenet (Hydranencephaly), Orphanet (Joubert syndrome), Disgenet (Joubert syndrome), ClinVar (Joubert syndrome), HPO (Joubert syndrome), Disgenet (Macrogyria), Disgenet (Microgyria) Related via 9 shared diseases including Ciliopathy, Lissencephaly — evidence mostly Disgenet. FAM149B1 8 shared diseasesLissencephaly, Congenital brain malformation, Congenital hypoplasia of part of brain, Aplasia of the vermis, Hydranencephaly, Joubert syndrome, Macrogyria, Microgyria 10 shared evidence sourcesDisgenet (Lissencephaly), Disgenet (Congenital brain malformation), Disgenet (Congenital hypoplasia of part of brain), Disgenet (Aplasia of the vermis), Disgenet (Hydranencephaly), Disgenet (Joubert syndrome), ClinVar (Joubert syndrome), HPO (Joubert syndrome), Disgenet (Macrogyria), Disgenet (Microgyria) Related via 8 shared diseases including Lissencephaly, Congenital brain malformation — evidence mostly Disgenet. TMEM237 9 shared diseasesLissencephaly, Congenital brain malformation, Congenital hypoplasia of part of brain, Aplasia of the vermis, Hydranencephaly, Joubert syndrome, Macrogyria, Meckel-gruber syndrome, Microgyria 12 shared evidence sourcesDisgenet (Lissencephaly), Disgenet (Congenital brain malformation), Disgenet (Congenital hypoplasia of part of brain), Disgenet (Aplasia of the vermis), Disgenet (Hydranencephaly), Orphanet (Joubert syndrome), Disgenet (Joubert syndrome), ClinVar (Joubert syndrome), HPO (Joubert syndrome), Disgenet (Macrogyria), Disgenet (Meckel-gruber syndrome), Disgenet (Microgyria) Related via 9 shared diseases including Lissencephaly, Congenital brain malformation — evidence mostly Disgenet. TMEM216 10 shared diseasesCiliopathy, Lissencephaly, Congenital brain malformation, Congenital hypoplasia of part of brain, Aplasia of the vermis, Hydranencephaly, Joubert syndrome, Macrogyria, Meckel-gruber syndrome, Microgyria 14 shared evidence sourcesDisgenet (Ciliopathy), Disgenet (Lissencephaly), Disgenet (Congenital brain malformation), Disgenet (Congenital hypoplasia of part of brain), Disgenet (Aplasia of the vermis), Disgenet (Hydranencephaly), Orphanet (Joubert syndrome), Disgenet (Joubert syndrome), CTD (Joubert syndrome), ClinVar (Joubert syndrome), HPO (Joubert syndrome), Disgenet (Macrogyria) +2 more Related via 10 shared diseases including Ciliopathy, Lissencephaly — evidence mostly Disgenet.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
B9D2	10	["Ciliopathy","Lissencephaly","Congenital brain malformation","Congenital hypoplasia of part of brain","Aplasia of the vermis","Hydranencephaly","Joubert syndrome","Macrogyria","Meckel-gruber syndrome","Microgyria"]	0	[]	11	["Disgenet (Ciliopathy)","Disgenet (Lissencephaly)","Disgenet (Congenital brain malformation)","Disgenet (Congenital hypoplasia of part of brain)","Disgenet (Aplasia of the vermis)","Disgenet (Hydranencephaly)","Orphanet (Joubert syndrome)","Disgenet (Joubert syndrome)","Disgenet (Macrogyria)","Disgenet (Meckel-gruber syndrome)","Disgenet (Microgyria)"]
TOGARAM1	9	["Ciliopathy","Lissencephaly","Congenital brain malformation","Congenital hypoplasia of part of brain","Aplasia of the vermis","Hydranencephaly","Joubert syndrome","Macrogyria","Microgyria"]	0	[]	12	["Disgenet (Ciliopathy)","Disgenet (Lissencephaly)","Disgenet (Congenital brain malformation)","Disgenet (Congenital hypoplasia of part of brain)","Disgenet (Aplasia of the vermis)","Disgenet (Hydranencephaly)","Orphanet (Joubert syndrome)","Disgenet (Joubert syndrome)","ClinVar (Joubert syndrome)","HPO (Joubert syndrome)","Disgenet (Macrogyria)","Disgenet (Microgyria)"]
FAM149B1	8	["Lissencephaly","Congenital brain malformation","Congenital hypoplasia of part of brain","Aplasia of the vermis","Hydranencephaly","Joubert syndrome","Macrogyria","Microgyria"]	0	[]	10	["Disgenet (Lissencephaly)","Disgenet (Congenital brain malformation)","Disgenet (Congenital hypoplasia of part of brain)","Disgenet (Aplasia of the vermis)","Disgenet (Hydranencephaly)","Disgenet (Joubert syndrome)","ClinVar (Joubert syndrome)","HPO (Joubert syndrome)","Disgenet (Macrogyria)","Disgenet (Microgyria)"]
TMEM237	9	["Lissencephaly","Congenital brain malformation","Congenital hypoplasia of part of brain","Aplasia of the vermis","Hydranencephaly","Joubert syndrome","Macrogyria","Meckel-gruber syndrome","Microgyria"]	0	[]	12	["Disgenet (Lissencephaly)","Disgenet (Congenital brain malformation)","Disgenet (Congenital hypoplasia of part of brain)","Disgenet (Aplasia of the vermis)","Disgenet (Hydranencephaly)","Orphanet (Joubert syndrome)","Disgenet (Joubert syndrome)","ClinVar (Joubert syndrome)","HPO (Joubert syndrome)","Disgenet (Macrogyria)","Disgenet (Meckel-gruber syndrome)","Disgenet (Microgyria)"]
TMEM216	10	["Ciliopathy","Lissencephaly","Congenital brain malformation","Congenital hypoplasia of part of brain","Aplasia of the vermis","Hydranencephaly","Joubert syndrome","Macrogyria","Meckel-gruber syndrome","Microgyria"]	0	[]	14	["Disgenet (Ciliopathy)","Disgenet (Lissencephaly)","Disgenet (Congenital brain malformation)","Disgenet (Congenital hypoplasia of part of brain)","Disgenet (Aplasia of the vermis)","Disgenet (Hydranencephaly)","Orphanet (Joubert syndrome)","Disgenet (Joubert syndrome)","CTD (Joubert syndrome)","ClinVar (Joubert syndrome)","HPO (Joubert syndrome)","Disgenet (Macrogyria)"]

Diseases Linked via Similar Genes

Orofaciodigital syndrome Linked via 2 of 5 related genesFAM149B1, TMEM216 Arima syndrome Linked via 2 of 5 related genesTMEM237, TMEM216 Retinitis pigmentosa Linked via 2 of 5 related genesTMEM237, TMEM216 Coronary artery disease Linked via 1 of 5 related genesB9D2 Migraine Linked via 1 of 5 related genesB9D2

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Orofaciodigital syndrome	2	["FAM149B1","TMEM216"]
Arima syndrome	2	["TMEM237","TMEM216"]
Retinitis pigmentosa	2	["TMEM237","TMEM216"]
Coronary artery disease	1	["B9D2"]
Migraine	1	["B9D2"]