TMEM198 (transmembrane protein 198)

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Gene miRNA Gene ontology Other IDs Protein Diseases linked via similar genes

Gene

• Entrez ID: 130612
• Gene name: Transmembrane protein 198
• Gene symbol: TMEM198
• Synonyms (NCBI Gene): TMEM198A
• Chromosome: 2
• Chromosome location: 2q35

miRNA Show/Hide all (26)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017954	hsa-miR-335-5p	Microarray	18185580
MIRT645544	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT645543	hsa-miR-4324	HITS-CLIP	23824327
MIRT645542	hsa-miR-6078	HITS-CLIP	23824327
MIRT645541	hsa-miR-6080	HITS-CLIP	23824327
MIRT645540	hsa-miR-4287	HITS-CLIP	23824327
MIRT645539	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645537	hsa-miR-4329	HITS-CLIP	23824327
MIRT645538	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT645536	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT645544	hsa-miR-5088-3p	HITS-CLIP	23824327
MIRT645543	hsa-miR-4324	HITS-CLIP	23824327
MIRT645542	hsa-miR-6078	HITS-CLIP	23824327
MIRT645541	hsa-miR-6080	HITS-CLIP	23824327
MIRT645540	hsa-miR-4287	HITS-CLIP	23824327
MIRT645539	hsa-miR-4685-3p	HITS-CLIP	23824327
MIRT645537	hsa-miR-4329	HITS-CLIP	23824327
MIRT645538	hsa-miR-4524a-3p	HITS-CLIP	23824327
MIRT645536	hsa-miR-6749-3p	HITS-CLIP	23824327
MIRT1434924	hsa-miR-3622b-5p	CLIP-seq
MIRT1434925	hsa-miR-4642	CLIP-seq
MIRT2351695	hsa-miR-329	CLIP-seq
MIRT2351696	hsa-miR-362-3p	CLIP-seq
MIRT2351697	hsa-miR-3941	CLIP-seq
MIRT2351698	hsa-miR-4789-3p	CLIP-seq
MIRT2351699	hsa-miR-603	CLIP-seq

Gene ontology (GO) Show/Hide all (10)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IDA	21536646
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0016055	Process	Wnt signaling pathway	IEA
GO:0031410	Component	Cytoplasmic vesicle	IBA
GO:0031410	Component	Cytoplasmic vesicle	IDA	21536646
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IBA
GO:0090263	Process	Positive regulation of canonical Wnt signaling pathway	IDA	21536646

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q66K66
• Protein name: Transmembrane protein 198
• Protein function: Promotes LRP6 phosphorylation by casein kinases and thereby plays a role in Wnt signaling. May be a membrane scaffold protein involved in the self-aggregation of LRP6 to further enhance its activity.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF13886	DUF4203	40 → 236	Domain of unknown function (DUF4203)	Family

• Sequence:

  MPGTVATLRFQLLPPEPDDAFWGAPCEQPLERRYQALPALVCIMCCLFGVVYCFFGYRCF
  KAVLFLTGLLFGSVVIFLLCYRERVLETQLSAGASAGIALGIGLLCGLVAMLVRSVGLFL
  VGLLLGLLLAAAALLGSAPYYQPGSVWGPLGLLLGGGLLCALLTLRWPRPLTTLATAVTG
  AALIATAADYFAELLLLGRYVVERLRAAPVPPLCWRSWALLALWPLLSLMGVLVQWRVTA
  EGDSHTEVVISRQRRRVQLMRIRQQEDRKEKRRKKRPPRAPLRGPRAPPRPGPPDPAYRR
  RPVPIKRFNGDVLSPSYIQSFRDRQTGSSLSSFMASPTDADYEYGSRGPLTACSGPPVRV
  

• Sequence length: 360

Related Genes

No strongly related genes found yet for TMEM198.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TMEM198.