TMEM129 (transmembrane protein 129, E3 ubiquitin ligase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 92305
• Gene name: Transmembrane protein 129, E3 ubiquitin ligase
• Gene symbol: TMEM129
• Synonyms (NCBI Gene): D4S2561E
• Chromosome: 4
• Chromosome location: 4p16.3

miRNA Show/Hide all (112)

miRTarBase ID	miRNA	Experiments	Reference
MIRT043184	hsa-miR-324-5p	CLASH	23622248
MIRT1430605	hsa-miR-1226	CLIP-seq
MIRT1430606	hsa-miR-1286	CLIP-seq
MIRT1430607	hsa-miR-1288	CLIP-seq
MIRT1430608	hsa-miR-1321	CLIP-seq
MIRT1430609	hsa-miR-140-3p	CLIP-seq
MIRT1430610	hsa-miR-188-3p	CLIP-seq
MIRT1430611	hsa-miR-1913	CLIP-seq
MIRT1430612	hsa-miR-214	CLIP-seq
MIRT1430613	hsa-miR-3163	CLIP-seq
MIRT1430614	hsa-miR-3169	CLIP-seq
MIRT1430615	hsa-miR-324-3p	CLIP-seq
MIRT1430616	hsa-miR-340	CLIP-seq
MIRT1430617	hsa-miR-3612	CLIP-seq
MIRT1430618	hsa-miR-3619-5p	CLIP-seq
MIRT1430619	hsa-miR-3674	CLIP-seq
MIRT1430620	hsa-miR-3944-5p	CLIP-seq
MIRT1430621	hsa-miR-4267	CLIP-seq
MIRT1430622	hsa-miR-4313	CLIP-seq
MIRT1430623	hsa-miR-4419a	CLIP-seq
MIRT1430624	hsa-miR-4436a	CLIP-seq
MIRT1430625	hsa-miR-4436b-3p	CLIP-seq
MIRT1430626	hsa-miR-4459	CLIP-seq
MIRT1430627	hsa-miR-4510	CLIP-seq
MIRT1430628	hsa-miR-4519	CLIP-seq
MIRT1430629	hsa-miR-4530	CLIP-seq
MIRT1430630	hsa-miR-4640-5p	CLIP-seq
MIRT1430631	hsa-miR-4688	CLIP-seq
MIRT1430632	hsa-miR-4722-5p	CLIP-seq
MIRT1430633	hsa-miR-4726-5p	CLIP-seq
MIRT1430634	hsa-miR-4739	CLIP-seq
MIRT1430635	hsa-miR-4756-5p	CLIP-seq
MIRT1430636	hsa-miR-4768-3p	CLIP-seq
MIRT1430637	hsa-miR-4779	CLIP-seq
MIRT1430638	hsa-miR-486-3p	CLIP-seq
MIRT1430639	hsa-miR-511	CLIP-seq
MIRT1430640	hsa-miR-532-3p	CLIP-seq
MIRT1430641	hsa-miR-548a-3p	CLIP-seq
MIRT1430642	hsa-miR-548ac	CLIP-seq
MIRT1430643	hsa-miR-548ae	CLIP-seq
MIRT1430644	hsa-miR-548aj	CLIP-seq
MIRT1430645	hsa-miR-548am	CLIP-seq
MIRT1430646	hsa-miR-548d-3p	CLIP-seq
MIRT1430647	hsa-miR-548e	CLIP-seq
MIRT1430648	hsa-miR-548f	CLIP-seq
MIRT1430649	hsa-miR-548x	CLIP-seq
MIRT1430650	hsa-miR-548z	CLIP-seq
MIRT1430651	hsa-miR-583	CLIP-seq
MIRT1430652	hsa-miR-634	CLIP-seq
MIRT1430653	hsa-miR-650	CLIP-seq
MIRT1430654	hsa-miR-665	CLIP-seq
MIRT1430655	hsa-miR-761	CLIP-seq
MIRT2129117	hsa-miR-1184	CLIP-seq
MIRT2129118	hsa-miR-1205	CLIP-seq
MIRT2129119	hsa-miR-1237	CLIP-seq
MIRT1430607	hsa-miR-1288	CLIP-seq
MIRT1430609	hsa-miR-140-3p	CLIP-seq
MIRT1430610	hsa-miR-188-3p	CLIP-seq
MIRT2129120	hsa-miR-1915	CLIP-seq
MIRT2129121	hsa-miR-3158-5p	CLIP-seq
MIRT2129122	hsa-miR-3166	CLIP-seq
MIRT1430614	hsa-miR-3169	CLIP-seq
MIRT2129123	hsa-miR-3614-3p	CLIP-seq
MIRT2129124	hsa-miR-3622a-3p	CLIP-seq
MIRT2129125	hsa-miR-3622b-3p	CLIP-seq
MIRT2129126	hsa-miR-370	CLIP-seq
MIRT2129127	hsa-miR-412	CLIP-seq
MIRT1430621	hsa-miR-4267	CLIP-seq
MIRT2129128	hsa-miR-4297	CLIP-seq
MIRT1430625	hsa-miR-4436b-3p	CLIP-seq
MIRT1430628	hsa-miR-4519	CLIP-seq
MIRT1430630	hsa-miR-4640-5p	CLIP-seq
MIRT2129129	hsa-miR-4685-5p	CLIP-seq
MIRT1430632	hsa-miR-4722-5p	CLIP-seq
MIRT1430633	hsa-miR-4726-5p	CLIP-seq
MIRT2129130	hsa-miR-4771	CLIP-seq
MIRT2129131	hsa-miR-4787-5p	CLIP-seq
MIRT1430638	hsa-miR-486-3p	CLIP-seq
MIRT1430640	hsa-miR-532-3p	CLIP-seq
MIRT2129132	hsa-miR-544	CLIP-seq
MIRT1430654	hsa-miR-665	CLIP-seq
MIRT2350682	hsa-miR-1182	CLIP-seq
MIRT2129120	hsa-miR-1915	CLIP-seq
MIRT2350683	hsa-miR-3132	CLIP-seq
MIRT2350684	hsa-miR-3529	CLIP-seq
MIRT2350685	hsa-miR-379	CLIP-seq
MIRT1430632	hsa-miR-4722-5p	CLIP-seq
MIRT1430638	hsa-miR-486-3p	CLIP-seq
MIRT1430651	hsa-miR-583	CLIP-seq
MIRT2461673	hsa-miR-150	CLIP-seq
MIRT2461674	hsa-miR-4733-5p	CLIP-seq
MIRT2461675	hsa-miR-605	CLIP-seq
MIRT2461676	hsa-miR-671-5p	CLIP-seq
MIRT2644210	hsa-miR-1234	CLIP-seq
MIRT2644211	hsa-miR-3147	CLIP-seq
MIRT2644212	hsa-miR-3690	CLIP-seq
MIRT2644213	hsa-miR-378	CLIP-seq
MIRT2644214	hsa-miR-378b	CLIP-seq
MIRT2644215	hsa-miR-378c	CLIP-seq
MIRT2644216	hsa-miR-378d	CLIP-seq
MIRT2644217	hsa-miR-378e	CLIP-seq
MIRT2644218	hsa-miR-378f	CLIP-seq
MIRT2644219	hsa-miR-378h	CLIP-seq
MIRT2644220	hsa-miR-378i	CLIP-seq
MIRT2644221	hsa-miR-422a	CLIP-seq
MIRT2644222	hsa-miR-4292	CLIP-seq
MIRT2129128	hsa-miR-4297	CLIP-seq
MIRT2644223	hsa-miR-4308	CLIP-seq
MIRT2644224	hsa-miR-4425	CLIP-seq
MIRT2644225	hsa-miR-4786-5p	CLIP-seq
MIRT2644226	hsa-miR-670	CLIP-seq
MIRT2644227	hsa-miR-769-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (21)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000209	Process	Protein polyubiquitination	IDA	24807418
GO:0005515	Function	Protein binding	IPI	32814053
GO:0005783	Component	Endoplasmic reticulum	IBA
GO:0005783	Component	Endoplasmic reticulum	IDA	24807418
GO:0005783	Component	Endoplasmic reticulum	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	IEA
GO:0005789	Component	Endoplasmic reticulum membrane	TAS
GO:0006511	Process	Ubiquitin-dependent protein catabolic process	IDA	24807418
GO:0006986	Process	Response to unfolded protein	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0016567	Process	Protein ubiquitination	IEA
GO:0016567	Process	Protein ubiquitination	TAS
GO:0016740	Function	Transferase activity	IEA
GO:0030970	Process	Retrograde protein transport, ER to cytosol	IMP	24807418
GO:0036503	Process	ERAD pathway	IMP	24807418
GO:0046872	Function	Metal ion binding	IEA
GO:0061630	Function	Ubiquitin protein ligase activity	EXP	24807418, 25030448
GO:0061630	Function	Ubiquitin protein ligase activity	IBA
GO:0061630	Function	Ubiquitin protein ligase activity	IDA	24807418
GO:0061630	Function	Ubiquitin protein ligase activity	IEA

Other IDs

• MIM: 615975
• HGNC: 25137
• e!Ensembl: ENSG00000168936

Protein

• UniProt ID: A0AVI4
• Protein name: E3 ubiquitin-protein ligase TM129 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase TM129)
• Protein function: E3 ubiquitin-protein ligase involved in ER-associated protein degradation, preferentially associates with the E2 enzyme UBE2J2. Exploited by viral US11 proteins to mediate HLA class I proteins degradation.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10272	Tmpp129	17 → 361	Putative transmembrane protein precursor	Family

• Sequence:

  MDSPEVTFTLAYLVFAVCFVFTPNEFHAAGLTVQNLLSGWLGSEDAAFVPFHLRRTAATL
  LCHSLLPLGYYVGMCLAASEKRLHALSQAPEAWRLFLLLAVTLPSIACILIYYWSRDRWA
  CHPLARTLALYALPQSGWQAVASSVNTEFRRIDKFATGAPGARVIVTDTWVMKVTTYRVH
  VAQQQDVHLTVTESRQHELSPDSNLPVQLLTIRVASTNPAVQAFDIWLNSTEYGELCEKL
  RAPIRRAAHVVIHQSLGDLFLETFASLVEVNPAYSVPSSQELEACIGCMQTRASVKLVKT
  CQEAATGECQQCYCRPMWCLTCMGKWFASRQDPLRPDTWLASRVPCPTCRARFCILDVCT
  VR

• Sequence length: 362

Pathways

Reactome Pathway:

E3 ubiquitin ligases ubiquitinate target proteins

Related Genes

No strongly related genes found yet for TMEM129.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TMEM129.