TM4SF5 (transmembrane 4 L six family member 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 9032
• Gene name: Transmembrane 4 L six family member 5
• Gene symbol: TM4SF5
• Synonyms (NCBI Gene): -
• Chromosome: 17
• Chromosome location: 17p13.2
• Summary: The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate

miRNA Show/Hide all (212)

miRTarBase ID	miRNA	Experiments	Reference
MIRT677543	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677542	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT677541	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677540	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677539	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677538	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677537	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677536	hsa-miR-4454	HITS-CLIP	23824327
MIRT677535	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677534	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677533	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT677532	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677531	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT620986	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT620985	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT620984	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT620983	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT620982	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT620981	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT620980	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT620979	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT620978	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT620977	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT620976	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT620975	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620974	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT620973	hsa-miR-302e	HITS-CLIP	23824327
MIRT620972	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT620971	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT620970	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT620969	hsa-miR-520b	HITS-CLIP	23824327
MIRT620968	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT620967	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT620966	hsa-miR-520e	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620964	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT620963	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT620962	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT620961	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT620986	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT620985	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT620984	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT620983	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT620982	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT620981	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT620980	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT620979	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT620978	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT620977	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT620976	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT620975	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620974	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT620973	hsa-miR-302e	HITS-CLIP	23824327
MIRT620972	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT620971	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT620970	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT620969	hsa-miR-520b	HITS-CLIP	23824327
MIRT620968	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT620967	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT620966	hsa-miR-520e	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620964	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT620963	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT620962	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT620961	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT531629	hsa-miR-6514-5p	PAR-CLIP	21572407
MIRT531628	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT531627	hsa-miR-4716-5p	PAR-CLIP	21572407
MIRT531626	hsa-miR-1273f	PAR-CLIP	21572407
MIRT531625	hsa-miR-4534	PAR-CLIP	21572407
MIRT531624	hsa-miR-8082	PAR-CLIP	21572407
MIRT531623	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT531622	hsa-miR-3926	PAR-CLIP	21572407
MIRT531621	hsa-miR-2355-5p	PAR-CLIP	21572407
MIRT531620	hsa-miR-548s	PAR-CLIP	21572407
MIRT531619	hsa-miR-4701-5p	PAR-CLIP	21572407
MIRT531618	hsa-miR-588	PAR-CLIP	21572407
MIRT531617	hsa-miR-4435	PAR-CLIP	21572407
MIRT531616	hsa-miR-3187-3p	PAR-CLIP	21572407
MIRT531615	hsa-miR-3679-3p	PAR-CLIP	21572407
MIRT531629	hsa-miR-6514-5p	PAR-CLIP	22012620
MIRT531628	hsa-miR-4781-3p	PAR-CLIP	22012620
MIRT531627	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT531626	hsa-miR-1273f	PAR-CLIP	22012620
MIRT531625	hsa-miR-4534	PAR-CLIP	22012620
MIRT531624	hsa-miR-8082	PAR-CLIP	22012620
MIRT531623	hsa-miR-4653-3p	PAR-CLIP	22012620
MIRT531622	hsa-miR-3926	PAR-CLIP	22012620
MIRT531621	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT531620	hsa-miR-548s	PAR-CLIP	22012620
MIRT531619	hsa-miR-4701-5p	PAR-CLIP	22012620
MIRT531618	hsa-miR-588	PAR-CLIP	22012620
MIRT531617	hsa-miR-4435	PAR-CLIP	22012620
MIRT531616	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT531615	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT460540	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT460539	hsa-miR-4532	PAR-CLIP	23592263
MIRT460538	hsa-miR-4722-3p	PAR-CLIP	23592263
MIRT460537	hsa-miR-6727-3p	PAR-CLIP	23592263
MIRT460536	hsa-miR-6747-3p	PAR-CLIP	23592263
MIRT460535	hsa-miR-3653-5p	PAR-CLIP	23592263
MIRT460534	hsa-miR-1976	PAR-CLIP	23592263
MIRT460533	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT460532	hsa-miR-4279	PAR-CLIP	23592263
MIRT677543	hsa-miR-6813-3p	HITS-CLIP	23824327
MIRT677542	hsa-miR-186-3p	HITS-CLIP	23824327
MIRT677541	hsa-miR-1224-3p	HITS-CLIP	23824327
MIRT677540	hsa-miR-212-5p	HITS-CLIP	23824327
MIRT677539	hsa-miR-150-5p	HITS-CLIP	23824327
MIRT677538	hsa-miR-6790-3p	HITS-CLIP	23824327
MIRT677537	hsa-miR-6821-3p	HITS-CLIP	23824327
MIRT677536	hsa-miR-4454	HITS-CLIP	23824327
MIRT677535	hsa-miR-4757-5p	HITS-CLIP	23824327
MIRT677534	hsa-miR-6744-3p	HITS-CLIP	23824327
MIRT677533	hsa-miR-433-3p	HITS-CLIP	23824327
MIRT677532	hsa-miR-378a-5p	HITS-CLIP	23824327
MIRT677531	hsa-miR-6878-3p	HITS-CLIP	23824327
MIRT620986	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT620985	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT620984	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT620983	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT620982	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT620981	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT620980	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT620979	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT620978	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT620977	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT620976	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT620975	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620974	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT620973	hsa-miR-302e	HITS-CLIP	23824327
MIRT620972	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT620971	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT620970	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT620969	hsa-miR-520b	HITS-CLIP	23824327
MIRT620968	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT620967	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT620966	hsa-miR-520e	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620964	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT620963	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT620962	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT620961	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT620986	hsa-miR-548az-5p	HITS-CLIP	23824327
MIRT620985	hsa-miR-548t-5p	HITS-CLIP	23824327
MIRT620984	hsa-miR-106a-5p	HITS-CLIP	23824327
MIRT620983	hsa-miR-106b-5p	HITS-CLIP	23824327
MIRT620982	hsa-miR-17-5p	HITS-CLIP	23824327
MIRT620981	hsa-miR-20a-5p	HITS-CLIP	23824327
MIRT620980	hsa-miR-20b-5p	HITS-CLIP	23824327
MIRT620979	hsa-miR-519d-3p	HITS-CLIP	23824327
MIRT620978	hsa-miR-526b-3p	HITS-CLIP	23824327
MIRT620977	hsa-miR-93-5p	HITS-CLIP	23824327
MIRT620976	hsa-miR-302a-3p	HITS-CLIP	23824327
MIRT620975	hsa-miR-302b-3p	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620974	hsa-miR-302d-3p	HITS-CLIP	23824327
MIRT620973	hsa-miR-302e	HITS-CLIP	23824327
MIRT620972	hsa-miR-372-3p	HITS-CLIP	23824327
MIRT620971	hsa-miR-373-3p	HITS-CLIP	23824327
MIRT620970	hsa-miR-520a-3p	HITS-CLIP	23824327
MIRT620969	hsa-miR-520b	HITS-CLIP	23824327
MIRT620968	hsa-miR-520c-3p	HITS-CLIP	23824327
MIRT620967	hsa-miR-520d-3p	HITS-CLIP	23824327
MIRT620966	hsa-miR-520e	HITS-CLIP	23824327
MIRT620965	hsa-miR-302c-3p	HITS-CLIP	23824327
MIRT620964	hsa-miR-520f-3p	HITS-CLIP	23824327
MIRT620963	hsa-miR-3613-3p	HITS-CLIP	23824327
MIRT620962	hsa-miR-556-3p	HITS-CLIP	23824327
MIRT620961	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT531629	hsa-miR-6514-5p	PAR-CLIP	21572407
MIRT531628	hsa-miR-4781-3p	PAR-CLIP	21572407
MIRT531627	hsa-miR-4716-5p	PAR-CLIP	21572407
MIRT531626	hsa-miR-1273f	PAR-CLIP	21572407
MIRT531625	hsa-miR-4534	PAR-CLIP	21572407
MIRT531624	hsa-miR-8082	PAR-CLIP	21572407
MIRT531623	hsa-miR-4653-3p	PAR-CLIP	21572407
MIRT531622	hsa-miR-3926	PAR-CLIP	21572407
MIRT531621	hsa-miR-2355-5p	PAR-CLIP	21572407
MIRT531620	hsa-miR-548s	PAR-CLIP	21572407
MIRT531619	hsa-miR-4701-5p	PAR-CLIP	21572407
MIRT531618	hsa-miR-588	PAR-CLIP	21572407
MIRT531617	hsa-miR-4435	PAR-CLIP	21572407
MIRT531616	hsa-miR-3187-3p	PAR-CLIP	21572407
MIRT531615	hsa-miR-3679-3p	PAR-CLIP	21572407
MIRT531629	hsa-miR-6514-5p	PAR-CLIP	22012620
MIRT531628	hsa-miR-4781-3p	PAR-CLIP	22012620
MIRT531627	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT531626	hsa-miR-1273f	PAR-CLIP	22012620
MIRT531625	hsa-miR-4534	PAR-CLIP	22012620
MIRT531624	hsa-miR-8082	PAR-CLIP	22012620
MIRT531623	hsa-miR-4653-3p	PAR-CLIP	22012620
MIRT531622	hsa-miR-3926	PAR-CLIP	22012620
MIRT531621	hsa-miR-2355-5p	PAR-CLIP	22012620
MIRT531620	hsa-miR-548s	PAR-CLIP	22012620
MIRT531619	hsa-miR-4701-5p	PAR-CLIP	22012620
MIRT531618	hsa-miR-588	PAR-CLIP	22012620
MIRT531617	hsa-miR-4435	PAR-CLIP	22012620
MIRT531616	hsa-miR-3187-3p	PAR-CLIP	22012620
MIRT531615	hsa-miR-3679-3p	PAR-CLIP	22012620
MIRT460540	hsa-miR-1247-3p	PAR-CLIP	23592263
MIRT460539	hsa-miR-4532	PAR-CLIP	23592263
MIRT460538	hsa-miR-4722-3p	PAR-CLIP	23592263
MIRT460537	hsa-miR-6727-3p	PAR-CLIP	23592263
MIRT460536	hsa-miR-6747-3p	PAR-CLIP	23592263
MIRT460535	hsa-miR-3653-5p	PAR-CLIP	23592263
MIRT460534	hsa-miR-1976	PAR-CLIP	23592263
MIRT460533	hsa-miR-6778-3p	PAR-CLIP	23592263
MIRT460532	hsa-miR-4279	PAR-CLIP	23592263

Gene ontology (GO) Show/Hide all (11)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	30956113, 32296183
GO:0005764	Component	Lysosome	IEA
GO:0005765	Component	Lysosomal membrane	IDA	30956113
GO:0005765	Component	Lysosomal membrane	IEA
GO:0005886	Component	Plasma membrane	IDA	30956113
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	TAS	9479038
GO:0016020	Component	Membrane	IBA
GO:0016020	Component	Membrane	IEA
GO:0034618	Function	Arginine binding	IMP	30956113
GO:2000045	Process	Regulation of G1/S transition of mitotic cell cycle	IDA	20399237

Other IDs

• MIM: 604657
• HGNC: 11857
• e!Ensembl: ENSG00000142484

Protein

• UniProt ID: O14894
• Protein name: Transmembrane 4 L6 family member 5 (Tetraspan transmembrane protein L6H)
• Protein function: Acts as a lysosomal membrane arginine sensor (PubMed:30956113). Forms a complex with MTOR and SLC38A9 on lysosomal membranes in an arginine-regulated manner, leading to arginine efflux which enables the activation of mTORC1 which subsequently le
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05805	L6_membrane	1 → 190	L6 membrane protein	Family

• Tissue specificity: TISSUE SPECIFICITY: Intestine. Overexpressed in pancreatic cancers.
• Sequence:

  MCTGKCARCVGLSLITLCLVCIVANALLLVPNGETSWTNTNHLSLQVWLMGGFIGGGLMV
  LCPGIAAVRAGGKGCCGAGCCGNRCRMLRSVFSSAFGVLGAIYCLSVSGAGLRNGPRCLM
  NGEWGYHFEDTAGAYLLNRTLWDRCEAPPRVVPWNVTLFSLLVAASCLEIVLCGIQLVNA
  TIGVFCGDCRKKQDTPH

• Sequence length: 197

Related Genes

No strongly related genes found yet for TM4SF5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TM4SF5.