TM2D2 (TM2 domain containing 2)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 83877
• Gene name: TM2 domain containing 2
• Gene symbol: TM2D2
• Synonyms (NCBI Gene): BLP1
• Chromosome: 8
• Chromosome location: 8p11.22
• Summary: The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, u

miRNA Show/Hide all (227)

miRTarBase ID	miRNA	Experiments	Reference
MIRT560025	hsa-miR-1273d	PAR-CLIP	20371350
MIRT560024	hsa-miR-3688-3p	PAR-CLIP	20371350
MIRT560022	hsa-miR-4261	PAR-CLIP	20371350
MIRT560023	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560021	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT560025	hsa-miR-1273d	PAR-CLIP	20371350
MIRT560024	hsa-miR-3688-3p	PAR-CLIP	20371350
MIRT560022	hsa-miR-4261	PAR-CLIP	20371350
MIRT560023	hsa-miR-7-5p	PAR-CLIP	20371350
MIRT560021	hsa-miR-379-5p	PAR-CLIP	20371350
MIRT1427089	hsa-miR-1207-5p	CLIP-seq
MIRT1427090	hsa-miR-1255a	CLIP-seq
MIRT1427091	hsa-miR-1255b	CLIP-seq
MIRT1427092	hsa-miR-1267	CLIP-seq
MIRT1427093	hsa-miR-1273e	CLIP-seq
MIRT1427094	hsa-miR-1291	CLIP-seq
MIRT1427095	hsa-miR-1307	CLIP-seq
MIRT1427096	hsa-miR-203	CLIP-seq
MIRT1427097	hsa-miR-2276	CLIP-seq
MIRT1427098	hsa-miR-297	CLIP-seq
MIRT1427099	hsa-miR-3134	CLIP-seq
MIRT1427100	hsa-miR-3149	CLIP-seq
MIRT1427101	hsa-miR-3154	CLIP-seq
MIRT1427102	hsa-miR-3168	CLIP-seq
MIRT1427103	hsa-miR-3200-3p	CLIP-seq
MIRT1427104	hsa-miR-328	CLIP-seq
MIRT1427105	hsa-miR-3616-5p	CLIP-seq
MIRT1427106	hsa-miR-3647-5p	CLIP-seq
MIRT1427107	hsa-miR-3653	CLIP-seq
MIRT1427108	hsa-miR-3660	CLIP-seq
MIRT1427109	hsa-miR-3915	CLIP-seq
MIRT1427110	hsa-miR-3928	CLIP-seq
MIRT1427111	hsa-miR-3929	CLIP-seq
MIRT1427112	hsa-miR-3940-5p	CLIP-seq
MIRT1427113	hsa-miR-4265	CLIP-seq
MIRT1427114	hsa-miR-4276	CLIP-seq
MIRT1427115	hsa-miR-4296	CLIP-seq
MIRT1427116	hsa-miR-4302	CLIP-seq
MIRT1427117	hsa-miR-4322	CLIP-seq
MIRT1427118	hsa-miR-4327	CLIP-seq
MIRT1427119	hsa-miR-4417	CLIP-seq
MIRT1427120	hsa-miR-4419b	CLIP-seq
MIRT1427121	hsa-miR-4423-5p	CLIP-seq
MIRT1427122	hsa-miR-4464	CLIP-seq
MIRT1427123	hsa-miR-4478	CLIP-seq
MIRT1427124	hsa-miR-4507	CLIP-seq
MIRT1427125	hsa-miR-4526	CLIP-seq
MIRT1427126	hsa-miR-4638-5p	CLIP-seq
MIRT1427127	hsa-miR-4645-3p	CLIP-seq
MIRT1427128	hsa-miR-4668-3p	CLIP-seq
MIRT1427129	hsa-miR-4708-3p	CLIP-seq
MIRT1427130	hsa-miR-4736	CLIP-seq
MIRT1427131	hsa-miR-4748	CLIP-seq
MIRT1427132	hsa-miR-4761-3p	CLIP-seq
MIRT1427133	hsa-miR-4763-3p	CLIP-seq
MIRT1427134	hsa-miR-4772-3p	CLIP-seq
MIRT1427135	hsa-miR-4777-5p	CLIP-seq
MIRT1427136	hsa-miR-4795-5p	CLIP-seq
MIRT1427137	hsa-miR-518d-5p	CLIP-seq
MIRT1427138	hsa-miR-519a	CLIP-seq
MIRT1427139	hsa-miR-519b-3p	CLIP-seq
MIRT1427140	hsa-miR-519b-5p	CLIP-seq
MIRT1427141	hsa-miR-519c-3p	CLIP-seq
MIRT1427142	hsa-miR-519c-5p	CLIP-seq
MIRT1427143	hsa-miR-520c-5p	CLIP-seq
MIRT1427144	hsa-miR-526a	CLIP-seq
MIRT1427145	hsa-miR-548ag	CLIP-seq
MIRT1427146	hsa-miR-548ai	CLIP-seq
MIRT1427147	hsa-miR-573	CLIP-seq
MIRT1427148	hsa-miR-616	CLIP-seq
MIRT1427149	hsa-miR-643	CLIP-seq
MIRT1427150	hsa-miR-767-5p	CLIP-seq
MIRT1427151	hsa-miR-106a	CLIP-seq
MIRT1427152	hsa-miR-106b	CLIP-seq
MIRT1427094	hsa-miR-1291	CLIP-seq
MIRT1427153	hsa-miR-130a	CLIP-seq
MIRT1427154	hsa-miR-130b	CLIP-seq
MIRT1427155	hsa-miR-137	CLIP-seq
MIRT1427156	hsa-miR-142-5p	CLIP-seq
MIRT1427157	hsa-miR-17	CLIP-seq
MIRT1427158	hsa-miR-19a	CLIP-seq
MIRT1427159	hsa-miR-19b	CLIP-seq
MIRT1427160	hsa-miR-20a	CLIP-seq
MIRT1427161	hsa-miR-20b	CLIP-seq
MIRT1427162	hsa-miR-217	CLIP-seq
MIRT1427163	hsa-miR-25	CLIP-seq
MIRT1427164	hsa-miR-301a	CLIP-seq
MIRT1427165	hsa-miR-301b	CLIP-seq
MIRT1427166	hsa-miR-3140-5p	CLIP-seq
MIRT1427167	hsa-miR-32	CLIP-seq
MIRT1427104	hsa-miR-328	CLIP-seq
MIRT1427168	hsa-miR-3609	CLIP-seq
MIRT1427169	hsa-miR-363	CLIP-seq
MIRT1427107	hsa-miR-3653	CLIP-seq
MIRT1427170	hsa-miR-3658	CLIP-seq
MIRT1427171	hsa-miR-3666	CLIP-seq
MIRT1427172	hsa-miR-367	CLIP-seq
MIRT1427173	hsa-miR-3714	CLIP-seq
MIRT1427109	hsa-miR-3915	CLIP-seq
MIRT1427110	hsa-miR-3928	CLIP-seq
MIRT1427174	hsa-miR-4295	CLIP-seq
MIRT1427175	hsa-miR-4325	CLIP-seq
MIRT1427118	hsa-miR-4327	CLIP-seq
MIRT1427176	hsa-miR-4427	CLIP-seq
MIRT1427177	hsa-miR-448	CLIP-seq
MIRT1427178	hsa-miR-4514	CLIP-seq
MIRT1427179	hsa-miR-454	CLIP-seq
MIRT1427180	hsa-miR-4692	CLIP-seq
MIRT1427181	hsa-miR-4735-5p	CLIP-seq
MIRT1427182	hsa-miR-4796-3p	CLIP-seq
MIRT1427183	hsa-miR-518a-5p	CLIP-seq
MIRT1427138	hsa-miR-519a	CLIP-seq
MIRT1427139	hsa-miR-519b-3p	CLIP-seq
MIRT1427141	hsa-miR-519c-3p	CLIP-seq
MIRT1427184	hsa-miR-519d	CLIP-seq
MIRT1427185	hsa-miR-527	CLIP-seq
MIRT1427186	hsa-miR-548ah	CLIP-seq
MIRT1427187	hsa-miR-548an	CLIP-seq
MIRT1427188	hsa-miR-576-5p	CLIP-seq
MIRT1427150	hsa-miR-767-5p	CLIP-seq
MIRT1427189	hsa-miR-92a	CLIP-seq
MIRT1427190	hsa-miR-92b	CLIP-seq
MIRT1427191	hsa-miR-93	CLIP-seq
MIRT1427192	hsa-miR-940	CLIP-seq
MIRT1427193	hsa-miR-944	CLIP-seq
MIRT1427092	hsa-miR-1267	CLIP-seq
MIRT1427094	hsa-miR-1291	CLIP-seq
MIRT1427104	hsa-miR-328	CLIP-seq
MIRT2127961	hsa-miR-3664-5p	CLIP-seq
MIRT1427121	hsa-miR-4423-5p	CLIP-seq
MIRT2127962	hsa-miR-4711-3p	CLIP-seq
MIRT2127963	hsa-miR-574-5p	CLIP-seq
MIRT1427150	hsa-miR-767-5p	CLIP-seq
MIRT2127964	hsa-miR-4699-5p	CLIP-seq
MIRT1427089	hsa-miR-1207-5p	CLIP-seq
MIRT1427105	hsa-miR-3616-5p	CLIP-seq
MIRT1427106	hsa-miR-3647-5p	CLIP-seq
MIRT1427111	hsa-miR-3929	CLIP-seq
MIRT2349607	hsa-miR-432	CLIP-seq
MIRT1427120	hsa-miR-4419b	CLIP-seq
MIRT1427123	hsa-miR-4478	CLIP-seq
MIRT2127964	hsa-miR-4699-5p	CLIP-seq
MIRT1427181	hsa-miR-4735-5p	CLIP-seq
MIRT1427130	hsa-miR-4736	CLIP-seq
MIRT1427133	hsa-miR-4763-3p	CLIP-seq
MIRT2349608	hsa-miR-4775	CLIP-seq
MIRT1427136	hsa-miR-4795-5p	CLIP-seq
MIRT1427138	hsa-miR-519a	CLIP-seq
MIRT1427139	hsa-miR-519b-3p	CLIP-seq
MIRT1427141	hsa-miR-519c-3p	CLIP-seq
MIRT1427147	hsa-miR-573	CLIP-seq
MIRT2349609	hsa-miR-590-3p	CLIP-seq
MIRT2395874	hsa-miR-219-5p	CLIP-seq
MIRT2349608	hsa-miR-4775	CLIP-seq
MIRT2395875	hsa-miR-4782-3p	CLIP-seq
MIRT2349609	hsa-miR-590-3p	CLIP-seq
MIRT2461516	hsa-miR-4495	CLIP-seq
MIRT2461517	hsa-miR-548ac	CLIP-seq
MIRT2461518	hsa-miR-548ae	CLIP-seq
MIRT2461519	hsa-miR-548aj	CLIP-seq
MIRT2461520	hsa-miR-548am	CLIP-seq
MIRT2461521	hsa-miR-548d-3p	CLIP-seq
MIRT2461522	hsa-miR-548x	CLIP-seq
MIRT2461523	hsa-miR-548z	CLIP-seq
MIRT2643112	hsa-miR-1	CLIP-seq
MIRT2643113	hsa-miR-101	CLIP-seq
MIRT2643114	hsa-miR-1299	CLIP-seq
MIRT2643115	hsa-miR-1323	CLIP-seq
MIRT1427155	hsa-miR-137	CLIP-seq
MIRT2643116	hsa-miR-144	CLIP-seq
MIRT2643117	hsa-miR-206	CLIP-seq
MIRT1427162	hsa-miR-217	CLIP-seq
MIRT1427163	hsa-miR-25	CLIP-seq
MIRT2643118	hsa-miR-3119	CLIP-seq
MIRT2643119	hsa-miR-3145-5p	CLIP-seq
MIRT1427167	hsa-miR-32	CLIP-seq
MIRT1427169	hsa-miR-363	CLIP-seq
MIRT1427172	hsa-miR-367	CLIP-seq
MIRT2643120	hsa-miR-3673	CLIP-seq
MIRT2643121	hsa-miR-3691-3p	CLIP-seq
MIRT2643122	hsa-miR-377	CLIP-seq
MIRT1427114	hsa-miR-4276	CLIP-seq
MIRT2643123	hsa-miR-4282	CLIP-seq
MIRT1427116	hsa-miR-4302	CLIP-seq
MIRT1427175	hsa-miR-4325	CLIP-seq
MIRT1427177	hsa-miR-448	CLIP-seq
MIRT2643124	hsa-miR-4502	CLIP-seq
MIRT2643125	hsa-miR-4803	CLIP-seq
MIRT2643126	hsa-miR-485-3p	CLIP-seq
MIRT2643127	hsa-miR-508-5p	CLIP-seq
MIRT2643128	hsa-miR-544	CLIP-seq
MIRT2643129	hsa-miR-548o	CLIP-seq
MIRT2643130	hsa-miR-583	CLIP-seq
MIRT2643131	hsa-miR-607	CLIP-seq
MIRT2643132	hsa-miR-613	CLIP-seq
MIRT2643133	hsa-miR-875-3p	CLIP-seq
MIRT1427189	hsa-miR-92a	CLIP-seq
MIRT1427190	hsa-miR-92b	CLIP-seq
MIRT1427193	hsa-miR-944	CLIP-seq
MIRT2643125	hsa-miR-4803	CLIP-seq
MIRT2643131	hsa-miR-607	CLIP-seq
MIRT2643112	hsa-miR-1	CLIP-seq
MIRT2643115	hsa-miR-1323	CLIP-seq
MIRT2693234	hsa-miR-199a-3p	CLIP-seq
MIRT2693235	hsa-miR-199b-3p	CLIP-seq
MIRT2643117	hsa-miR-206	CLIP-seq
MIRT2643118	hsa-miR-3119	CLIP-seq
MIRT2693236	hsa-miR-3129-5p	CLIP-seq
MIRT1427101	hsa-miR-3154	CLIP-seq
MIRT1427107	hsa-miR-3653	CLIP-seq
MIRT2643120	hsa-miR-3673	CLIP-seq
MIRT2643122	hsa-miR-377	CLIP-seq
MIRT2643123	hsa-miR-4282	CLIP-seq
MIRT2643124	hsa-miR-4502	CLIP-seq
MIRT1427127	hsa-miR-4645-3p	CLIP-seq
MIRT1427181	hsa-miR-4735-5p	CLIP-seq
MIRT1427132	hsa-miR-4761-3p	CLIP-seq
MIRT2349608	hsa-miR-4775	CLIP-seq
MIRT2643125	hsa-miR-4803	CLIP-seq
MIRT2693237	hsa-miR-5095	CLIP-seq
MIRT2643129	hsa-miR-548o	CLIP-seq
MIRT2693238	hsa-miR-552	CLIP-seq
MIRT2349609	hsa-miR-590-3p	CLIP-seq
MIRT2643131	hsa-miR-607	CLIP-seq
MIRT2643132	hsa-miR-613	CLIP-seq
MIRT2693239	hsa-miR-764	CLIP-seq
MIRT2693240	hsa-miR-936	CLIP-seq

Gene ontology (GO)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	32296183
GO:0016020	Component	Membrane	IEA

Other IDs

• MIM: 610081
• HGNC: 24127
• e!Ensembl: ENSG00000169490

Protein

• UniProt ID: Q9BX73
• Protein name: TM2 domain-containing protein 2 (Beta-amyloid-binding protein-like protein 1) (BBP-like protein 1)
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF05154	TM2	146 → 195	TM2 domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed. {ECO:0000269|PubMed:11278849}.
• Sequence:

  MVLGGCPVSYLLLCGQAALLLGNLLLLHCVSRSHSQNATAEPELTSAGAAQPEGPGGAAS
  WEYGDPHSPVILCSYLPDEFIECEDPVDHVGNATASQELGYGCLKFGGQAYSDVEHTSVQ
  CHALDGIECASPRTFLRENKPCIKYTGHYFITTLLYSFFLGCFGVDRFCLGHTGTAVGKL
  LTLGGLGIWWFVDLILLITGGLMPSDGSNWCTVY

• Sequence length: 214

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Familial cancer of breast	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Nasopharyngeal carcinoma	Nasopharyngeal Carcinoma	BEFREE	11968052		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for TM2D2.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TM2D2.