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Gene Gene information from NCBI Gene database.
Entrez ID 261726
Gene name TOR signaling pathway regulator
Gene symbol TIPRL
Synonyms (NCBI Gene)
TIPTIP41TIPRL1
Chromosome 1
Chromosome location 1q24.2
Summary TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
miRNA miRNA information provided by mirtarbase database.
559 Show/Hide all (559)
miRTarBase ID miRNA Experiments Reference
MIRT020368 hsa-miR-29c-3p Sequencing 20371350
MIRT029223 hsa-miR-26b-5p Microarray 19088304
MIRT268220 hsa-miR-3928-5p HITS-CLIP 19536157
MIRT268223 hsa-miR-6806-3p HITS-CLIP 19536157
MIRT610649 hsa-miR-6501-5p HITS-CLIP 19536157
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
7 Show/Hide all (7)
GO ID Ontology Definition Evidence Reference
GO:0000077 Process DNA damage checkpoint signaling IMP 17384681
GO:0004864 Function Protein phosphatase inhibitor activity IDA 17384681
GO:0005515 Function Protein binding IPI 16085932, 17384681, 18614045, 22167190, 23892082, 24255178, 27880917
GO:0005737 Component Cytoplasm IEA
GO:0005829 Component Cytosol IBA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
611807 30231 ENSG00000143155
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
O75663
Protein name TIP41-like protein (Putative MAPK-activating protein PM10) (Type 2A-interacting protein) (TIP)
Protein function May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. Acts as a negative regulat
PDB 5D9G
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF04176 TIP41 48 → 225 TIP41-like family Family
Sequence
Sequence length 272
Interactions View interactions