TIMM8B (translocase of inner mitochondrial membrane 8 homolog B)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26521
• Gene name: Translocase of inner mitochondrial membrane 8 homolog B
• Gene symbol: TIMM8B
• Synonyms (NCBI Gene): DDP2, TIM8B
• Chromosome: 11
• Chromosome location: 11q23.1
• Summary: This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into com

miRNA Show/Hide all (159)

miRTarBase ID	miRNA	Experiments	Reference
MIRT023062	hsa-miR-124-3p	Proteomics;Microarray	18668037
MIRT665825	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT621825	hsa-miR-4307	HITS-CLIP	23824327
MIRT621823	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT621822	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT665824	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT621821	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT621820	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT621818	hsa-miR-578	HITS-CLIP	23824327
MIRT665823	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT621825	hsa-miR-4307	HITS-CLIP	23824327
MIRT621823	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT621822	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621821	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT621820	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT621819	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT621818	hsa-miR-578	HITS-CLIP	23824327
MIRT444366	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444365	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444364	hsa-miR-8077	PAR-CLIP	22100165
MIRT444362	hsa-miR-4656	PAR-CLIP	22100165
MIRT444363	hsa-miR-6829-5p	PAR-CLIP	22100165
MIRT444361	hsa-miR-4492	PAR-CLIP	22100165
MIRT444360	hsa-miR-4498	PAR-CLIP	22100165
MIRT444359	hsa-miR-5001-5p	PAR-CLIP	22100165
MIRT444358	hsa-miR-762	PAR-CLIP	22100165
MIRT444357	hsa-miR-4675	PAR-CLIP	22100165
MIRT444356	hsa-miR-4741	PAR-CLIP	22100165
MIRT444355	hsa-miR-1587	PAR-CLIP	22100165
MIRT444354	hsa-miR-3620-5p	PAR-CLIP	22100165
MIRT444366	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444365	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444364	hsa-miR-8077	PAR-CLIP	22100165
MIRT444362	hsa-miR-4656	PAR-CLIP	22100165
MIRT444363	hsa-miR-6829-5p	PAR-CLIP	22100165
MIRT444361	hsa-miR-4492	PAR-CLIP	22100165
MIRT444360	hsa-miR-4498	PAR-CLIP	22100165
MIRT444359	hsa-miR-5001-5p	PAR-CLIP	22100165
MIRT444358	hsa-miR-762	PAR-CLIP	22100165
MIRT444357	hsa-miR-4675	PAR-CLIP	22100165
MIRT444356	hsa-miR-4741	PAR-CLIP	22100165
MIRT444355	hsa-miR-1587	PAR-CLIP	22100165
MIRT444354	hsa-miR-3620-5p	PAR-CLIP	22100165
MIRT665825	hsa-miR-129-5p	HITS-CLIP	23824327
MIRT621825	hsa-miR-4307	HITS-CLIP	23824327
MIRT621823	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT621822	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT665824	hsa-miR-5590-5p	HITS-CLIP	23824327
MIRT621821	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT621820	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT621818	hsa-miR-578	HITS-CLIP	23824327
MIRT665823	hsa-miR-4776-3p	HITS-CLIP	23824327
MIRT621825	hsa-miR-4307	HITS-CLIP	23824327
MIRT621823	hsa-miR-4716-5p	HITS-CLIP	23824327
MIRT621822	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT621821	hsa-miR-4659a-5p	HITS-CLIP	23824327
MIRT621820	hsa-miR-4659b-5p	HITS-CLIP	23824327
MIRT621819	hsa-miR-5587-5p	HITS-CLIP	23824327
MIRT621818	hsa-miR-578	HITS-CLIP	23824327
MIRT444366	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444365	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444364	hsa-miR-8077	PAR-CLIP	22100165
MIRT444362	hsa-miR-4656	PAR-CLIP	22100165
MIRT444363	hsa-miR-6829-5p	PAR-CLIP	22100165
MIRT444361	hsa-miR-4492	PAR-CLIP	22100165
MIRT444360	hsa-miR-4498	PAR-CLIP	22100165
MIRT444359	hsa-miR-5001-5p	PAR-CLIP	22100165
MIRT444358	hsa-miR-762	PAR-CLIP	22100165
MIRT444357	hsa-miR-4675	PAR-CLIP	22100165
MIRT444356	hsa-miR-4741	PAR-CLIP	22100165
MIRT444355	hsa-miR-1587	PAR-CLIP	22100165
MIRT444354	hsa-miR-3620-5p	PAR-CLIP	22100165
MIRT444366	hsa-miR-100-3p	PAR-CLIP	22100165
MIRT444365	hsa-miR-570-3p	PAR-CLIP	22100165
MIRT444364	hsa-miR-8077	PAR-CLIP	22100165
MIRT444362	hsa-miR-4656	PAR-CLIP	22100165
MIRT444363	hsa-miR-6829-5p	PAR-CLIP	22100165
MIRT444361	hsa-miR-4492	PAR-CLIP	22100165
MIRT444360	hsa-miR-4498	PAR-CLIP	22100165
MIRT444359	hsa-miR-5001-5p	PAR-CLIP	22100165
MIRT444358	hsa-miR-762	PAR-CLIP	22100165
MIRT444357	hsa-miR-4675	PAR-CLIP	22100165
MIRT444356	hsa-miR-4741	PAR-CLIP	22100165
MIRT444355	hsa-miR-1587	PAR-CLIP	22100165
MIRT444354	hsa-miR-3620-5p	PAR-CLIP	22100165
MIRT1425132	hsa-miR-29a	CLIP-seq
MIRT1425133	hsa-miR-29b	CLIP-seq
MIRT1425134	hsa-miR-29c	CLIP-seq
MIRT1425135	hsa-miR-4639-3p	CLIP-seq
MIRT1425136	hsa-miR-499a-5p	CLIP-seq
MIRT1425137	hsa-miR-513a-3p	CLIP-seq
MIRT2349216	hsa-miR-1293	CLIP-seq
MIRT2349217	hsa-miR-135a	CLIP-seq
MIRT2349218	hsa-miR-135b	CLIP-seq
MIRT1425132	hsa-miR-29a	CLIP-seq
MIRT1425133	hsa-miR-29b	CLIP-seq
MIRT1425134	hsa-miR-29c	CLIP-seq
MIRT2349219	hsa-miR-3121-5p	CLIP-seq
MIRT2349220	hsa-miR-3161	CLIP-seq
MIRT2349221	hsa-miR-3182	CLIP-seq
MIRT2349222	hsa-miR-3977	CLIP-seq
MIRT2349223	hsa-miR-4293	CLIP-seq
MIRT2349224	hsa-miR-4483	CLIP-seq
MIRT2349225	hsa-miR-4686	CLIP-seq
MIRT2349226	hsa-miR-4728-3p	CLIP-seq
MIRT1425136	hsa-miR-499a-5p	CLIP-seq
MIRT2349227	hsa-miR-616	CLIP-seq
MIRT2349228	hsa-miR-802	CLIP-seq
MIRT2349229	hsa-miR-876-3p	CLIP-seq
MIRT2642525	hsa-miR-1275	CLIP-seq
MIRT2642526	hsa-miR-1343	CLIP-seq
MIRT2642527	hsa-miR-1976	CLIP-seq
MIRT2349219	hsa-miR-3121-5p	CLIP-seq
MIRT2349221	hsa-miR-3182	CLIP-seq
MIRT2642528	hsa-miR-361-3p	CLIP-seq
MIRT2642529	hsa-miR-3614-3p	CLIP-seq
MIRT2642530	hsa-miR-3679-3p	CLIP-seq
MIRT2642531	hsa-miR-3940-5p	CLIP-seq
MIRT2349222	hsa-miR-3977	CLIP-seq
MIRT2642532	hsa-miR-4279	CLIP-seq
MIRT2642533	hsa-miR-4286	CLIP-seq
MIRT2642534	hsa-miR-4297	CLIP-seq
MIRT2642535	hsa-miR-4506	CLIP-seq
MIRT2642536	hsa-miR-4507	CLIP-seq
MIRT2642537	hsa-miR-4525	CLIP-seq
MIRT2642538	hsa-miR-4665-5p	CLIP-seq
MIRT2349225	hsa-miR-4686	CLIP-seq
MIRT2642539	hsa-miR-4723-5p	CLIP-seq
MIRT2642540	hsa-miR-4725-5p	CLIP-seq
MIRT2642541	hsa-miR-504	CLIP-seq
MIRT2349227	hsa-miR-616	CLIP-seq
MIRT2642542	hsa-miR-625	CLIP-seq
MIRT2642543	hsa-miR-637	CLIP-seq
MIRT2349228	hsa-miR-802	CLIP-seq
MIRT2642525	hsa-miR-1275	CLIP-seq
MIRT2642526	hsa-miR-1343	CLIP-seq
MIRT2642527	hsa-miR-1976	CLIP-seq
MIRT2349219	hsa-miR-3121-5p	CLIP-seq
MIRT2349221	hsa-miR-3182	CLIP-seq
MIRT2642528	hsa-miR-361-3p	CLIP-seq
MIRT2642529	hsa-miR-3614-3p	CLIP-seq
MIRT2642530	hsa-miR-3679-3p	CLIP-seq
MIRT2642531	hsa-miR-3940-5p	CLIP-seq
MIRT2349222	hsa-miR-3977	CLIP-seq
MIRT2642532	hsa-miR-4279	CLIP-seq
MIRT2642533	hsa-miR-4286	CLIP-seq
MIRT2642534	hsa-miR-4297	CLIP-seq
MIRT2642535	hsa-miR-4506	CLIP-seq
MIRT2642536	hsa-miR-4507	CLIP-seq
MIRT2642537	hsa-miR-4525	CLIP-seq
MIRT2642538	hsa-miR-4665-5p	CLIP-seq
MIRT2349225	hsa-miR-4686	CLIP-seq
MIRT2642539	hsa-miR-4723-5p	CLIP-seq
MIRT2642540	hsa-miR-4725-5p	CLIP-seq
MIRT2642541	hsa-miR-504	CLIP-seq
MIRT2349227	hsa-miR-616	CLIP-seq
MIRT2642542	hsa-miR-625	CLIP-seq
MIRT2642543	hsa-miR-637	CLIP-seq
MIRT2349228	hsa-miR-802	CLIP-seq

Gene ontology (GO) Show/Hide all (17)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005615	Component	Extracellular space	HDA	23580065
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005758	Component	Mitochondrial intermembrane space	NAS	11956200
GO:0006626	Process	Protein targeting to mitochondrion	TAS	10552927
GO:0007605	Process	Sensory perception of sound	TAS	10552927
GO:0008270	Function	Zinc ion binding	TAS	10552927
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0042719	Component	Mitochondrial intermembrane space chaperone complex	ISS
GO:0042719	Component	Mitochondrial intermembrane space chaperone complex	TAS	10552927
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	ISS
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	NAS	11956200
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	TAS	16387659
GO:0046872	Function	Metal ion binding	IEA
GO:0140318	Function	Protein transporter activity	ISS

Other IDs

• MIM: 606659
• HGNC: 11818
• e!Ensembl: ENSG00000150779

Protein

• UniProt ID: Q9Y5J9
• Protein name: Mitochondrial import inner membrane translocase subunit Tim8 B (DDP-like protein) (Deafness dystonia protein 2)
• Protein function: Probable mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM c
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02953	zf-Tim10_DDP	14 → 76	Tim10/DDP family zinc finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:10611480}.
• Sequence:

  MAELGEADEAELQRLVAAEQQKAQFTAQVHHFMELCWDKCVEKPGNRLDSRTENCLSSCV
  DRFIDTTLAITSRFAQIVQKGGQ

• Sequence length: 83

Related Genes

No strongly related genes found yet for TIMM8B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TIMM8B.