TIMM23 (translocase of inner mitochondrial membrane 23)

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Gene miRNA Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 100287932
• Gene name: Translocase of inner mitochondrial membrane 23
• Gene symbol: TIMM23
• Synonyms (NCBI Gene): TIM23
• Chromosome: 10
• Chromosome location: 10q11.22
• Summary: The protein encoded by this gene is part of a complex located in the inner mitochondrial membrane that mediates the transport of transit peptide-containing proteins across the membrane. Multiple transcript variants, one protein-coding and others not prote

miRNA Show/Hide all (141)

miRTarBase ID	miRNA	Experiments	Reference
MIRT026070	hsa-miR-196a-5p	Sequencing	20371350
MIRT032261	hsa-let-7b-5p	Proteomics	18668040
MIRT046055	hsa-miR-125b-5p	CLASH	23622248
MIRT042029	hsa-miR-484	CLASH	23622248
MIRT1425012	hsa-miR-1290	CLIP-seq
MIRT1425013	hsa-miR-130a	CLIP-seq
MIRT1425014	hsa-miR-130b	CLIP-seq
MIRT1425015	hsa-miR-148a	CLIP-seq
MIRT1425016	hsa-miR-148b	CLIP-seq
MIRT1425017	hsa-miR-152	CLIP-seq
MIRT1425018	hsa-miR-196a	CLIP-seq
MIRT1425019	hsa-miR-196b	CLIP-seq
MIRT1425020	hsa-miR-301a	CLIP-seq
MIRT1425021	hsa-miR-301b	CLIP-seq
MIRT1425022	hsa-miR-3123	CLIP-seq
MIRT1425023	hsa-miR-3140-5p	CLIP-seq
MIRT1425024	hsa-miR-3145-5p	CLIP-seq
MIRT1425025	hsa-miR-3157-5p	CLIP-seq
MIRT1425026	hsa-miR-3163	CLIP-seq
MIRT1425027	hsa-miR-3192	CLIP-seq
MIRT1425028	hsa-miR-323-3p	CLIP-seq
MIRT1425029	hsa-miR-340	CLIP-seq
MIRT1425030	hsa-miR-3646	CLIP-seq
MIRT1425031	hsa-miR-3666	CLIP-seq
MIRT1425032	hsa-miR-3673	CLIP-seq
MIRT1425033	hsa-miR-3927	CLIP-seq
MIRT1425034	hsa-miR-4295	CLIP-seq
MIRT1425035	hsa-miR-4314	CLIP-seq
MIRT1425036	hsa-miR-4328	CLIP-seq
MIRT1425037	hsa-miR-4452	CLIP-seq
MIRT1425038	hsa-miR-454	CLIP-seq
MIRT1425039	hsa-miR-4646-5p	CLIP-seq
MIRT1425040	hsa-miR-4650-3p	CLIP-seq
MIRT1425041	hsa-miR-4680-3p	CLIP-seq
MIRT1425042	hsa-miR-4691-3p	CLIP-seq
MIRT1425043	hsa-miR-4724-5p	CLIP-seq
MIRT1425044	hsa-miR-4764-3p	CLIP-seq
MIRT1425045	hsa-miR-4777-5p	CLIP-seq
MIRT1425046	hsa-miR-4790-3p	CLIP-seq
MIRT1425047	hsa-miR-548g	CLIP-seq
MIRT1425048	hsa-miR-582-5p	CLIP-seq
MIRT1425049	hsa-miR-665	CLIP-seq
MIRT1425012	hsa-miR-1290	CLIP-seq
MIRT2127376	hsa-miR-1305	CLIP-seq
MIRT1425013	hsa-miR-130a	CLIP-seq
MIRT1425014	hsa-miR-130b	CLIP-seq
MIRT1425015	hsa-miR-148a	CLIP-seq
MIRT1425016	hsa-miR-148b	CLIP-seq
MIRT1425017	hsa-miR-152	CLIP-seq
MIRT1425018	hsa-miR-196a	CLIP-seq
MIRT1425019	hsa-miR-196b	CLIP-seq
MIRT1425020	hsa-miR-301a	CLIP-seq
MIRT1425021	hsa-miR-301b	CLIP-seq
MIRT2127377	hsa-miR-3120-3p	CLIP-seq
MIRT2127378	hsa-miR-3129-3p	CLIP-seq
MIRT1425028	hsa-miR-323-3p	CLIP-seq
MIRT1425031	hsa-miR-3666	CLIP-seq
MIRT1425032	hsa-miR-3673	CLIP-seq
MIRT1425033	hsa-miR-3927	CLIP-seq
MIRT1425034	hsa-miR-4295	CLIP-seq
MIRT1425036	hsa-miR-4328	CLIP-seq
MIRT1425038	hsa-miR-454	CLIP-seq
MIRT1425048	hsa-miR-582-5p	CLIP-seq
MIRT2127379	hsa-miR-607	CLIP-seq
MIRT1425049	hsa-miR-665	CLIP-seq
MIRT1425012	hsa-miR-1290	CLIP-seq
MIRT1425013	hsa-miR-130a	CLIP-seq
MIRT1425014	hsa-miR-130b	CLIP-seq
MIRT1425015	hsa-miR-148a	CLIP-seq
MIRT1425016	hsa-miR-148b	CLIP-seq
MIRT1425017	hsa-miR-152	CLIP-seq
MIRT1425020	hsa-miR-301a	CLIP-seq
MIRT1425021	hsa-miR-301b	CLIP-seq
MIRT2127377	hsa-miR-3120-3p	CLIP-seq
MIRT1425028	hsa-miR-323-3p	CLIP-seq
MIRT1425030	hsa-miR-3646	CLIP-seq
MIRT1425031	hsa-miR-3666	CLIP-seq
MIRT1425032	hsa-miR-3673	CLIP-seq
MIRT2349183	hsa-miR-3689a-5p	CLIP-seq
MIRT2349184	hsa-miR-3689b	CLIP-seq
MIRT2349185	hsa-miR-3689e	CLIP-seq
MIRT2349186	hsa-miR-3689f	CLIP-seq
MIRT1425034	hsa-miR-4295	CLIP-seq
MIRT1425036	hsa-miR-4328	CLIP-seq
MIRT1425038	hsa-miR-454	CLIP-seq
MIRT1425046	hsa-miR-4790-3p	CLIP-seq
MIRT2349187	hsa-miR-545	CLIP-seq
MIRT1425048	hsa-miR-582-5p	CLIP-seq
MIRT2642452	hsa-miR-1206	CLIP-seq
MIRT2642453	hsa-miR-1275	CLIP-seq
MIRT2642454	hsa-miR-140-5p	CLIP-seq
MIRT1425023	hsa-miR-3140-5p	CLIP-seq
MIRT2642455	hsa-miR-3150b-3p	CLIP-seq
MIRT2642456	hsa-miR-3156-5p	CLIP-seq
MIRT1425027	hsa-miR-3192	CLIP-seq
MIRT2642457	hsa-miR-3925-3p	CLIP-seq
MIRT2642458	hsa-miR-4276	CLIP-seq
MIRT1425035	hsa-miR-4314	CLIP-seq
MIRT1425037	hsa-miR-4452	CLIP-seq
MIRT2642459	hsa-miR-4525	CLIP-seq
MIRT1425039	hsa-miR-4646-5p	CLIP-seq
MIRT2642460	hsa-miR-4665-5p	CLIP-seq
MIRT1425041	hsa-miR-4680-3p	CLIP-seq
MIRT2642461	hsa-miR-4696	CLIP-seq
MIRT2642462	hsa-miR-4723-5p	CLIP-seq
MIRT2642463	hsa-miR-4773	CLIP-seq
MIRT2642464	hsa-miR-4784	CLIP-seq
MIRT2642465	hsa-miR-510	CLIP-seq
MIRT2642466	hsa-miR-512-5p	CLIP-seq
MIRT2642467	hsa-miR-520a-5p	CLIP-seq
MIRT2642468	hsa-miR-525-5p	CLIP-seq
MIRT2642469	hsa-miR-570	CLIP-seq
MIRT2642470	hsa-miR-625	CLIP-seq
MIRT2642471	hsa-miR-766	CLIP-seq
MIRT2642452	hsa-miR-1206	CLIP-seq
MIRT2642453	hsa-miR-1275	CLIP-seq
MIRT2642454	hsa-miR-140-5p	CLIP-seq
MIRT1425023	hsa-miR-3140-5p	CLIP-seq
MIRT2642455	hsa-miR-3150b-3p	CLIP-seq
MIRT2642456	hsa-miR-3156-5p	CLIP-seq
MIRT2693193	hsa-miR-3174	CLIP-seq
MIRT1425027	hsa-miR-3192	CLIP-seq
MIRT2642457	hsa-miR-3925-3p	CLIP-seq
MIRT2642458	hsa-miR-4276	CLIP-seq
MIRT1425035	hsa-miR-4314	CLIP-seq
MIRT1425037	hsa-miR-4452	CLIP-seq
MIRT2642459	hsa-miR-4525	CLIP-seq
MIRT1425039	hsa-miR-4646-5p	CLIP-seq
MIRT2642460	hsa-miR-4665-5p	CLIP-seq
MIRT1425041	hsa-miR-4680-3p	CLIP-seq
MIRT2642461	hsa-miR-4696	CLIP-seq
MIRT2642462	hsa-miR-4723-5p	CLIP-seq
MIRT2642463	hsa-miR-4773	CLIP-seq
MIRT2642464	hsa-miR-4784	CLIP-seq
MIRT2642465	hsa-miR-510	CLIP-seq
MIRT2642466	hsa-miR-512-5p	CLIP-seq
MIRT2642467	hsa-miR-520a-5p	CLIP-seq
MIRT2642468	hsa-miR-525-5p	CLIP-seq
MIRT2642469	hsa-miR-570	CLIP-seq
MIRT2642470	hsa-miR-625	CLIP-seq
MIRT2642471	hsa-miR-766	CLIP-seq

Gene ontology (GO) Show/Hide all (23)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	15044455, 23260140, 23263864, 32296183, 32814053, 37160114
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IDA
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IDA	10339406, 20053669, 25997101
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	NAS	10339406
GO:0005743	Component	Mitochondrial inner membrane	TAS	14726512
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IBA
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IDA	10339406, 30598479
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	IEA
GO:0005744	Component	TIM23 mitochondrial import inner membrane translocase complex	NAS	10339406
GO:0005758	Component	Mitochondrial intermembrane space	IDA	15044455
GO:0006626	Process	Protein targeting to mitochondrion	TAS	10339406
GO:0006886	Process	Intracellular protein transport	NAS	10339406
GO:0008320	Function	Protein transmembrane transporter activity	IBA
GO:0008320	Function	Protein transmembrane transporter activity	IEA
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0022857	Function	Transmembrane transporter activity	IEA
GO:0030150	Process	Protein import into mitochondrial matrix	IBA
GO:0030150	Process	Protein import into mitochondrial matrix	IEA
GO:0061734	Process	Type 2 mitophagy	IMP	37160114

Other IDs

• MIM: 605034
• HGNC: 17312
• e!Ensembl: ENSG00000265354

Protein

• UniProt ID: O14925
• Protein name: Mitochondrial import inner membrane translocase subunit Tim23
• Protein function: Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane (PubMed:10339406). Has a role in the activation of stress-induced mitophagy by pro
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02466	Tim17	76 → 188		Family

• Sequence:

  MEGGGGSGNKTTGGLAGFFGAGGAGYSHADLAGVPLTGMNPLSPYLNVDPRYLVQDTDEF
  ILPTGANKTRGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKETQNMAWSKPRNVQILNMV
  TRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAAGTMTGMLYKCTGGLRGIARG
  GLTGLTLTSLYALYNNWEHMKGSLLQQSL

• Sequence length: 209

Pathways

Reactome Pathway:

Mitochondrial protein import

Related Genes

No strongly related genes found yet for TIMM23.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TIMM23.