TIMM10B (translocase of inner mitochondrial membrane 10B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26515
• Gene name: Translocase of inner mitochondrial membrane 10B
• Gene symbol: TIMM10B
• Synonyms (NCBI Gene): FXC1, TIM10B, Tim9b
• Chromosome: 11
• Chromosome location: 11p15.4
• Summary: FXC1, or TIMM10B, belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the

miRNA Show/Hide all (55)

miRTarBase ID	miRNA	Experiments	Reference
MIRT031455	hsa-miR-16-5p	Sequencing	20371350
MIRT031455	hsa-miR-16-5p	Proteomics	18668040
MIRT037012	hsa-miR-877-3p	CLASH	23622248
MIRT683111	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT683110	hsa-miR-181a-2-3p	HITS-CLIP	23706177
MIRT683109	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT683108	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT683107	hsa-miR-6742-3p	HITS-CLIP	23706177
MIRT683106	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT683105	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT683104	hsa-miR-6776-5p	HITS-CLIP	23706177
MIRT683103	hsa-miR-661	HITS-CLIP	23706177
MIRT683102	hsa-miR-6509-3p	HITS-CLIP	23706177
MIRT683101	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT683100	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT683099	hsa-miR-7703	HITS-CLIP	23706177
MIRT683098	hsa-miR-1262	HITS-CLIP	23706177
MIRT683097	hsa-miR-4701-3p	HITS-CLIP	23706177
MIRT683096	hsa-miR-6736-5p	HITS-CLIP	23706177
MIRT652630	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT652629	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT652628	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT652627	hsa-miR-3612	HITS-CLIP	23824327
MIRT652626	hsa-miR-650	HITS-CLIP	23824327
MIRT652625	hsa-miR-7977	HITS-CLIP	23824327
MIRT652624	hsa-miR-4443	HITS-CLIP	23824327
MIRT652623	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT652622	hsa-miR-7850-5p	HITS-CLIP	23824327
MIRT440605	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT440605	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT683111	hsa-miR-508-5p	HITS-CLIP	23706177
MIRT683110	hsa-miR-181a-2-3p	HITS-CLIP	23706177
MIRT683109	hsa-miR-1273g-3p	HITS-CLIP	23706177
MIRT683108	hsa-miR-6849-3p	HITS-CLIP	23706177
MIRT683107	hsa-miR-6742-3p	HITS-CLIP	23706177
MIRT683106	hsa-miR-766-3p	HITS-CLIP	23706177
MIRT683105	hsa-miR-4793-3p	HITS-CLIP	23706177
MIRT683104	hsa-miR-6776-5p	HITS-CLIP	23706177
MIRT683103	hsa-miR-661	HITS-CLIP	23706177
MIRT683102	hsa-miR-6509-3p	HITS-CLIP	23706177
MIRT683101	hsa-miR-6512-3p	HITS-CLIP	23706177
MIRT683100	hsa-miR-6720-5p	HITS-CLIP	23706177
MIRT683099	hsa-miR-7703	HITS-CLIP	23706177
MIRT683098	hsa-miR-1262	HITS-CLIP	23706177
MIRT683097	hsa-miR-4701-3p	HITS-CLIP	23706177
MIRT683096	hsa-miR-6736-5p	HITS-CLIP	23706177
MIRT652630	hsa-miR-1228-3p	HITS-CLIP	23824327
MIRT652629	hsa-miR-383-3p	HITS-CLIP	23824327
MIRT652628	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT652627	hsa-miR-3612	HITS-CLIP	23824327
MIRT652626	hsa-miR-650	HITS-CLIP	23824327
MIRT652625	hsa-miR-7977	HITS-CLIP	23824327
MIRT652624	hsa-miR-4443	HITS-CLIP	23824327
MIRT652623	hsa-miR-6515-5p	HITS-CLIP	23824327
MIRT652622	hsa-miR-7850-5p	HITS-CLIP	23824327

Gene ontology (GO) Show/Hide all (22)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	27554484, 32296183, 33961781
GO:0005739	Component	Mitochondrion	HTP	34800366
GO:0005739	Component	Mitochondrion	IEA
GO:0005743	Component	Mitochondrial inner membrane	IBA
GO:0005743	Component	Mitochondrial inner membrane	IDA	14726512
GO:0005743	Component	Mitochondrial inner membrane	IEA
GO:0005743	Component	Mitochondrial inner membrane	TAS
GO:0005758	Component	Mitochondrial intermembrane space	IDA	14726512
GO:0005758	Component	Mitochondrial intermembrane space	TAS	14726512
GO:0007160	Process	Cell-matrix adhesion	TAS	9731230
GO:0015031	Process	Protein transport	IEA
GO:0016020	Component	Membrane	IEA
GO:0042719	Component	Mitochondrial intermembrane space chaperone complex	IBA
GO:0042719	Component	Mitochondrial intermembrane space chaperone complex	IDA	14726512
GO:0042719	Component	Mitochondrial intermembrane space chaperone complex	IPI	14726512
GO:0042721	Component	TIM22 mitochondrial import inner membrane insertion complex	IDA	28712724
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	IBA
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	ISS
GO:0045039	Process	Protein insertion into mitochondrial inner membrane	NAS	14726512
GO:0046872	Function	Metal ion binding	IEA
GO:0051082	Function	Unfolded protein binding	ISS
GO:0140318	Function	Protein transporter activity	IBA

Other IDs

• MIM: 607388
• HGNC: 4022
• e!Ensembl: ENSG00000132286

Protein

• UniProt ID: Q9Y5J6
• Protein name: Mitochondrial import inner membrane translocase subunit Tim10 B (Fracture callus protein 1) (FxC1) (Mitochondrial import inner membrane translocase subunit Tim9 B) (TIMM10B) (Tim10b)
• Protein function: Component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as the
• PDB: 7CGP
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02953	zf-Tim10_DDP	3 → 69	Tim10/DDP family zinc finger	Domain

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitous, with highest expression in heart, kidney, liver and skeletal muscle. {ECO:0000269|PubMed:10611480, ECO:0000269|PubMed:14726512}.
• Sequence:

  MERQQQQQQQLRNLRDFLLVYNRMTELCFQRCVPSLHHRALDAEEEACLHSCAGKLIHSN
  HRLMAAYVQLMPALVQRRIADYEAASAVPGVAAEQPGVSPSGS

• Sequence length: 103

Pathways

Reactome Pathway:

Mitochondrial protein import

Related Genes

No strongly related genes found yet for TIMM10B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TIMM10B.