THUMPD3 (THUMP domain 3 tRNA guanosine methyltransferase)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 25917
• Gene name: THUMP domain 3 tRNA guanosine methyltransferase
• Gene symbol: THUMPD3
• Synonyms (NCBI Gene): -
• Chromosome: 3
• Chromosome location: 3p25.3

miRNA Show/Hide all (321)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045895	hsa-miR-125b-5p	CLASH	23622248
MIRT040410	hsa-miR-615-3p	CLASH	23622248
MIRT038790	hsa-miR-93-3p	CLASH	23622248
MIRT652691	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT652690	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT652689	hsa-miR-23c	HITS-CLIP	23824327
MIRT652688	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT652687	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT652686	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT652691	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT652690	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT652689	hsa-miR-23c	HITS-CLIP	23824327
MIRT652688	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT652687	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT652686	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT652684	hsa-miR-5096	HITS-CLIP	23824327
MIRT529478	hsa-miR-4445-3p	PAR-CLIP	22012620
MIRT529477	hsa-miR-548al	PAR-CLIP	22012620
MIRT529476	hsa-miR-5584-5p	PAR-CLIP	22012620
MIRT529475	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT529474	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT529473	hsa-miR-9500	PAR-CLIP	22012620
MIRT529471	hsa-miR-3185	PAR-CLIP	22012620
MIRT529472	hsa-miR-4470	PAR-CLIP	22012620
MIRT446473	hsa-miR-4438	PAR-CLIP	22100165
MIRT446472	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT446471	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT446470	hsa-miR-6086	PAR-CLIP	22100165
MIRT446469	hsa-miR-3119	PAR-CLIP	22100165
MIRT446468	hsa-miR-5095	PAR-CLIP	22100165
MIRT446467	hsa-miR-7151-3p	PAR-CLIP	22100165
MIRT446466	hsa-miR-3924	PAR-CLIP	22100165
MIRT652691	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT652690	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT652689	hsa-miR-23c	HITS-CLIP	23824327
MIRT652688	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT652687	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT652686	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT652691	hsa-miR-130a-5p	HITS-CLIP	23824327
MIRT652690	hsa-miR-23a-3p	HITS-CLIP	23824327
MIRT652689	hsa-miR-23c	HITS-CLIP	23824327
MIRT652688	hsa-miR-23b-3p	HITS-CLIP	23824327
MIRT652687	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT652686	hsa-miR-2355-5p	HITS-CLIP	23824327
MIRT652684	hsa-miR-5096	HITS-CLIP	23824327
MIRT529478	hsa-miR-4445-3p	PAR-CLIP	22012620
MIRT529477	hsa-miR-548al	PAR-CLIP	22012620
MIRT529476	hsa-miR-5584-5p	PAR-CLIP	22012620
MIRT529475	hsa-miR-6750-5p	PAR-CLIP	22012620
MIRT529474	hsa-miR-6822-5p	PAR-CLIP	22012620
MIRT529473	hsa-miR-9500	PAR-CLIP	22012620
MIRT529471	hsa-miR-3185	PAR-CLIP	22012620
MIRT529472	hsa-miR-4470	PAR-CLIP	22012620
MIRT446473	hsa-miR-4438	PAR-CLIP	22100165
MIRT446472	hsa-miR-655-5p	PAR-CLIP	22100165
MIRT446471	hsa-miR-377-5p	PAR-CLIP	22100165
MIRT446470	hsa-miR-6086	PAR-CLIP	22100165
MIRT446469	hsa-miR-3119	PAR-CLIP	22100165
MIRT446468	hsa-miR-5095	PAR-CLIP	22100165
MIRT446467	hsa-miR-7151-3p	PAR-CLIP	22100165
MIRT446466	hsa-miR-3924	PAR-CLIP	22100165
MIRT1424219	hsa-miR-101	CLIP-seq
MIRT1424220	hsa-miR-122	CLIP-seq
MIRT1424221	hsa-miR-125a-3p	CLIP-seq
MIRT1424222	hsa-miR-1276	CLIP-seq
MIRT1424223	hsa-miR-129-5p	CLIP-seq
MIRT1424224	hsa-miR-1304	CLIP-seq
MIRT1424225	hsa-miR-130a	CLIP-seq
MIRT1424226	hsa-miR-130b	CLIP-seq
MIRT1424227	hsa-miR-144	CLIP-seq
MIRT1424228	hsa-miR-150	CLIP-seq
MIRT1424229	hsa-miR-301a	CLIP-seq
MIRT1424230	hsa-miR-301b	CLIP-seq
MIRT1424231	hsa-miR-3135b	CLIP-seq
MIRT1424232	hsa-miR-3166	CLIP-seq
MIRT1424233	hsa-miR-3652	CLIP-seq
MIRT1424234	hsa-miR-3655	CLIP-seq
MIRT1424235	hsa-miR-3666	CLIP-seq
MIRT1424236	hsa-miR-3934	CLIP-seq
MIRT1424237	hsa-miR-4295	CLIP-seq
MIRT1424238	hsa-miR-4311	CLIP-seq
MIRT1424239	hsa-miR-4328	CLIP-seq
MIRT1424240	hsa-miR-4418	CLIP-seq
MIRT1424241	hsa-miR-4430	CLIP-seq
MIRT1424242	hsa-miR-4494	CLIP-seq
MIRT1424243	hsa-miR-450b-5p	CLIP-seq
MIRT1424244	hsa-miR-454	CLIP-seq
MIRT1424245	hsa-miR-4694-3p	CLIP-seq
MIRT1424246	hsa-miR-4695-3p	CLIP-seq
MIRT1424247	hsa-miR-4713-5p	CLIP-seq
MIRT1424248	hsa-miR-4771	CLIP-seq
MIRT1424249	hsa-miR-4797-5p	CLIP-seq
MIRT1424250	hsa-miR-493	CLIP-seq
MIRT1424251	hsa-miR-507	CLIP-seq
MIRT1424252	hsa-miR-509-3-5p	CLIP-seq
MIRT1424253	hsa-miR-509-5p	CLIP-seq
MIRT1424254	hsa-miR-522	CLIP-seq
MIRT1424255	hsa-miR-532-3p	CLIP-seq
MIRT1424256	hsa-miR-548aa	CLIP-seq
MIRT1424257	hsa-miR-557	CLIP-seq
MIRT1424258	hsa-miR-583	CLIP-seq
MIRT1424259	hsa-miR-764	CLIP-seq
MIRT1424219	hsa-miR-101	CLIP-seq
MIRT1424220	hsa-miR-122	CLIP-seq
MIRT1424260	hsa-miR-1228	CLIP-seq
MIRT1424261	hsa-miR-124	CLIP-seq
MIRT1424262	hsa-miR-1257	CLIP-seq
MIRT1424222	hsa-miR-1276	CLIP-seq
MIRT1424263	hsa-miR-1284	CLIP-seq
MIRT1424223	hsa-miR-129-5p	CLIP-seq
MIRT1424225	hsa-miR-130a	CLIP-seq
MIRT1424226	hsa-miR-130b	CLIP-seq
MIRT1424227	hsa-miR-144	CLIP-seq
MIRT1424264	hsa-miR-181a	CLIP-seq
MIRT1424265	hsa-miR-181b	CLIP-seq
MIRT1424266	hsa-miR-181c	CLIP-seq
MIRT1424267	hsa-miR-181d	CLIP-seq
MIRT1424268	hsa-miR-2054	CLIP-seq
MIRT1424269	hsa-miR-23a	CLIP-seq
MIRT1424270	hsa-miR-23b	CLIP-seq
MIRT1424229	hsa-miR-301a	CLIP-seq
MIRT1424230	hsa-miR-301b	CLIP-seq
MIRT1424271	hsa-miR-3134	CLIP-seq
MIRT1424231	hsa-miR-3135b	CLIP-seq
MIRT1424272	hsa-miR-3145-3p	CLIP-seq
MIRT1424273	hsa-miR-3149	CLIP-seq
MIRT1424274	hsa-miR-3163	CLIP-seq
MIRT1424232	hsa-miR-3166	CLIP-seq
MIRT1424275	hsa-miR-3168	CLIP-seq
MIRT1424276	hsa-miR-3201	CLIP-seq
MIRT1424277	hsa-miR-323-3p	CLIP-seq
MIRT1424278	hsa-miR-340	CLIP-seq
MIRT1424233	hsa-miR-3652	CLIP-seq
MIRT1424234	hsa-miR-3655	CLIP-seq
MIRT1424235	hsa-miR-3666	CLIP-seq
MIRT1424279	hsa-miR-3672	CLIP-seq
MIRT1424280	hsa-miR-3714	CLIP-seq
MIRT1424281	hsa-miR-377	CLIP-seq
MIRT1424282	hsa-miR-380	CLIP-seq
MIRT1424283	hsa-miR-3910	CLIP-seq
MIRT1424284	hsa-miR-4262	CLIP-seq
MIRT1424237	hsa-miR-4295	CLIP-seq
MIRT1424238	hsa-miR-4311	CLIP-seq
MIRT1424240	hsa-miR-4418	CLIP-seq
MIRT1424241	hsa-miR-4430	CLIP-seq
MIRT1424285	hsa-miR-4477b	CLIP-seq
MIRT1424242	hsa-miR-4494	CLIP-seq
MIRT1424286	hsa-miR-4495	CLIP-seq
MIRT1424243	hsa-miR-450b-5p	CLIP-seq
MIRT1424244	hsa-miR-454	CLIP-seq
MIRT1424287	hsa-miR-4668-3p	CLIP-seq
MIRT1424248	hsa-miR-4771	CLIP-seq
MIRT1424288	hsa-miR-4791	CLIP-seq
MIRT1424249	hsa-miR-4797-5p	CLIP-seq
MIRT1424289	hsa-miR-506	CLIP-seq
MIRT1424251	hsa-miR-507	CLIP-seq
MIRT1424252	hsa-miR-509-3-5p	CLIP-seq
MIRT1424253	hsa-miR-509-5p	CLIP-seq
MIRT1424290	hsa-miR-548a-3p	CLIP-seq
MIRT1424291	hsa-miR-548e	CLIP-seq
MIRT1424292	hsa-miR-548f	CLIP-seq
MIRT1424257	hsa-miR-557	CLIP-seq
MIRT1424258	hsa-miR-583	CLIP-seq
MIRT1424293	hsa-miR-622	CLIP-seq
MIRT1424219	hsa-miR-101	CLIP-seq
MIRT1424220	hsa-miR-122	CLIP-seq
MIRT1424221	hsa-miR-125a-3p	CLIP-seq
MIRT1424263	hsa-miR-1284	CLIP-seq
MIRT1424223	hsa-miR-129-5p	CLIP-seq
MIRT1424225	hsa-miR-130a	CLIP-seq
MIRT1424226	hsa-miR-130b	CLIP-seq
MIRT2127128	hsa-miR-1343	CLIP-seq
MIRT1424227	hsa-miR-144	CLIP-seq
MIRT2127129	hsa-miR-145	CLIP-seq
MIRT2127130	hsa-miR-1825	CLIP-seq
MIRT2127131	hsa-miR-199a-5p	CLIP-seq
MIRT2127132	hsa-miR-199b-5p	CLIP-seq
MIRT1424269	hsa-miR-23a	CLIP-seq
MIRT1424270	hsa-miR-23b	CLIP-seq
MIRT1424229	hsa-miR-301a	CLIP-seq
MIRT1424230	hsa-miR-301b	CLIP-seq
MIRT2127133	hsa-miR-3130-3p	CLIP-seq
MIRT1424231	hsa-miR-3135b	CLIP-seq
MIRT2127134	hsa-miR-3143	CLIP-seq
MIRT2127135	hsa-miR-3161	CLIP-seq
MIRT1424275	hsa-miR-3168	CLIP-seq
MIRT2127136	hsa-miR-3180-5p	CLIP-seq
MIRT2127137	hsa-miR-3187-3p	CLIP-seq
MIRT2127138	hsa-miR-3545-3p	CLIP-seq
MIRT2127139	hsa-miR-3591-3p	CLIP-seq
MIRT1424233	hsa-miR-3652	CLIP-seq
MIRT2127140	hsa-miR-3662	CLIP-seq
MIRT2127141	hsa-miR-3663-5p	CLIP-seq
MIRT1424235	hsa-miR-3666	CLIP-seq
MIRT2127142	hsa-miR-3684	CLIP-seq
MIRT2127143	hsa-miR-3687	CLIP-seq
MIRT2127144	hsa-miR-370	CLIP-seq
MIRT1424281	hsa-miR-377	CLIP-seq
MIRT2127145	hsa-miR-384	CLIP-seq
MIRT1424236	hsa-miR-3934	CLIP-seq
MIRT2127146	hsa-miR-3974	CLIP-seq
MIRT2127147	hsa-miR-4258	CLIP-seq
MIRT2127148	hsa-miR-4259	CLIP-seq
MIRT1424237	hsa-miR-4295	CLIP-seq
MIRT2127149	hsa-miR-4301	CLIP-seq
MIRT2127150	hsa-miR-4425	CLIP-seq
MIRT1424241	hsa-miR-4430	CLIP-seq
MIRT2127151	hsa-miR-4435	CLIP-seq
MIRT2127152	hsa-miR-4442	CLIP-seq
MIRT2127153	hsa-miR-4460	CLIP-seq
MIRT2127154	hsa-miR-450b-3p	CLIP-seq
MIRT1424243	hsa-miR-450b-5p	CLIP-seq
MIRT1424244	hsa-miR-454	CLIP-seq
MIRT2127155	hsa-miR-4540	CLIP-seq
MIRT1424246	hsa-miR-4695-3p	CLIP-seq
MIRT2127156	hsa-miR-4701-5p	CLIP-seq
MIRT2127157	hsa-miR-4703-3p	CLIP-seq
MIRT2127158	hsa-miR-4707-3p	CLIP-seq
MIRT2127159	hsa-miR-4715-5p	CLIP-seq
MIRT2127160	hsa-miR-4747-5p	CLIP-seq
MIRT2127161	hsa-miR-4753-3p	CLIP-seq
MIRT2127162	hsa-miR-4755-3p	CLIP-seq
MIRT2127163	hsa-miR-4768-3p	CLIP-seq
MIRT2127164	hsa-miR-4768-5p	CLIP-seq
MIRT2127165	hsa-miR-4781-3p	CLIP-seq
MIRT2127166	hsa-miR-4793-3p	CLIP-seq
MIRT1424250	hsa-miR-493	CLIP-seq
MIRT1424251	hsa-miR-507	CLIP-seq
MIRT2127167	hsa-miR-520d-5p	CLIP-seq
MIRT2127168	hsa-miR-524-5p	CLIP-seq
MIRT2127169	hsa-miR-541	CLIP-seq
MIRT2127170	hsa-miR-543	CLIP-seq
MIRT1424256	hsa-miR-548aa	CLIP-seq
MIRT2127171	hsa-miR-548s	CLIP-seq
MIRT1424257	hsa-miR-557	CLIP-seq
MIRT2127172	hsa-miR-588	CLIP-seq
MIRT2127173	hsa-miR-654-5p	CLIP-seq
MIRT2127174	hsa-miR-665	CLIP-seq
MIRT1424259	hsa-miR-764	CLIP-seq
MIRT2127175	hsa-miR-769-3p	CLIP-seq
MIRT2127176	hsa-miR-938	CLIP-seq
MIRT1424260	hsa-miR-1228	CLIP-seq
MIRT1424264	hsa-miR-181a	CLIP-seq
MIRT1424265	hsa-miR-181b	CLIP-seq
MIRT1424266	hsa-miR-181c	CLIP-seq
MIRT1424267	hsa-miR-181d	CLIP-seq
MIRT1424269	hsa-miR-23a	CLIP-seq
MIRT1424270	hsa-miR-23b	CLIP-seq
MIRT1424277	hsa-miR-323-3p	CLIP-seq
MIRT1424284	hsa-miR-4262	CLIP-seq
MIRT2349029	hsa-miR-4431	CLIP-seq
MIRT1424246	hsa-miR-4695-3p	CLIP-seq
MIRT2642100	hsa-miR-2052	CLIP-seq
MIRT2642101	hsa-miR-3148	CLIP-seq
MIRT2642102	hsa-miR-329	CLIP-seq
MIRT2642103	hsa-miR-362-3p	CLIP-seq
MIRT2642104	hsa-miR-3647-3p	CLIP-seq
MIRT1424234	hsa-miR-3655	CLIP-seq
MIRT2642105	hsa-miR-3688-3p	CLIP-seq
MIRT2642106	hsa-miR-4293	CLIP-seq
MIRT2349029	hsa-miR-4431	CLIP-seq
MIRT1424246	hsa-miR-4695-3p	CLIP-seq
MIRT2642107	hsa-miR-4717-5p	CLIP-seq
MIRT1424249	hsa-miR-4797-5p	CLIP-seq
MIRT2642108	hsa-miR-570	CLIP-seq
MIRT2642109	hsa-miR-642b	CLIP-seq
MIRT2642110	hsa-miR-659	CLIP-seq
MIRT1424220	hsa-miR-122	CLIP-seq
MIRT1424225	hsa-miR-130a	CLIP-seq
MIRT1424226	hsa-miR-130b	CLIP-seq
MIRT2693137	hsa-miR-1913	CLIP-seq
MIRT2642100	hsa-miR-2052	CLIP-seq
MIRT2693138	hsa-miR-216a	CLIP-seq
MIRT1424229	hsa-miR-301a	CLIP-seq
MIRT1424230	hsa-miR-301b	CLIP-seq
MIRT2693139	hsa-miR-3121-5p	CLIP-seq
MIRT1424231	hsa-miR-3135b	CLIP-seq
MIRT2642101	hsa-miR-3148	CLIP-seq
MIRT1424274	hsa-miR-3163	CLIP-seq
MIRT2693140	hsa-miR-324-3p	CLIP-seq
MIRT2642102	hsa-miR-329	CLIP-seq
MIRT2693141	hsa-miR-342-3p	CLIP-seq
MIRT2642103	hsa-miR-362-3p	CLIP-seq
MIRT2642104	hsa-miR-3647-3p	CLIP-seq
MIRT1424233	hsa-miR-3652	CLIP-seq
MIRT1424234	hsa-miR-3655	CLIP-seq
MIRT2127140	hsa-miR-3662	CLIP-seq
MIRT1424235	hsa-miR-3666	CLIP-seq
MIRT2693142	hsa-miR-3667-3p	CLIP-seq
MIRT2642105	hsa-miR-3688-3p	CLIP-seq
MIRT2127144	hsa-miR-370	CLIP-seq
MIRT2642106	hsa-miR-4293	CLIP-seq
MIRT1424237	hsa-miR-4295	CLIP-seq
MIRT1424241	hsa-miR-4430	CLIP-seq
MIRT2349029	hsa-miR-4431	CLIP-seq
MIRT1424244	hsa-miR-454	CLIP-seq
MIRT2693143	hsa-miR-4640-5p	CLIP-seq
MIRT1424246	hsa-miR-4695-3p	CLIP-seq
MIRT2642107	hsa-miR-4717-5p	CLIP-seq
MIRT2693144	hsa-miR-4726-5p	CLIP-seq
MIRT2693145	hsa-miR-4731-5p	CLIP-seq
MIRT1424249	hsa-miR-4797-5p	CLIP-seq
MIRT2693146	hsa-miR-4799-5p	CLIP-seq
MIRT2693147	hsa-miR-548a-5p	CLIP-seq
MIRT2693148	hsa-miR-548ab	CLIP-seq
MIRT2693149	hsa-miR-548ak	CLIP-seq
MIRT2693150	hsa-miR-548b-5p	CLIP-seq
MIRT2693151	hsa-miR-548c-5p	CLIP-seq
MIRT2693152	hsa-miR-548d-5p	CLIP-seq
MIRT2693153	hsa-miR-548h	CLIP-seq
MIRT2693154	hsa-miR-548i	CLIP-seq
MIRT2693155	hsa-miR-548j	CLIP-seq
MIRT2693156	hsa-miR-548k	CLIP-seq
MIRT2693157	hsa-miR-548l	CLIP-seq
MIRT2693158	hsa-miR-548w	CLIP-seq
MIRT2693159	hsa-miR-548y	CLIP-seq
MIRT2693160	hsa-miR-559	CLIP-seq
MIRT2642108	hsa-miR-570	CLIP-seq
MIRT2642109	hsa-miR-642b	CLIP-seq
MIRT2642110	hsa-miR-659	CLIP-seq
MIRT2127176	hsa-miR-938	CLIP-seq

Gene ontology (GO) Show/Hide all (19)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000049	Function	TRNA binding	IEA
GO:0003723	Function	RNA binding	IEA
GO:0005515	Function	Protein binding	IPI	28514442, 32296183, 33961781, 34669960, 34948388
GO:0005730	Component	Nucleolus	IDA
GO:0005737	Component	Cytoplasm	IDA	34669960, 34948388
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0006396	Process	RNA processing	IEA
GO:0008033	Process	TRNA processing	IEA
GO:0008168	Function	Methyltransferase activity	IEA
GO:0016423	Function	TRNA (guanine) methyltransferase activity	IBA
GO:0016740	Function	Transferase activity	IEA
GO:0030488	Process	TRNA methylation	IBA
GO:0030488	Process	TRNA methylation	IMP	34669960
GO:0032259	Process	Methylation	IEA
GO:0043527	Component	TRNA methyltransferase complex	IDA	37283053
GO:0160117	Function	TRNA (guanine(6)-N2)-methyltransferase activity	IDA	37283053
GO:0160117	Function	TRNA (guanine(6)-N2)-methyltransferase activity	IMP	34669960
GO:0160118	Function	TRNA (guanine(7)-N2)-methyltransferase activity	IMP	34669960

Other IDs

• MIM: HGNC
• HGNC: N/A
• e!Ensembl: HGNC

Protein

• UniProt ID: Q9BV44
• Protein name: tRNA (guanine(6)-N(2))-methyltransferase THUMP3 (EC 2.1.1.256) (THUMP domain-containing protein 3) (tRNA(Trp) (guanine(7)-N(2))-methyltransferase THUMP3) (EC 2.1.1.-)
• Protein function: Catalytic subunit of the THUMPD3-TRM112 methyltransferase complex, that specifically mediates the S-adenosyl-L-methionine-dependent N(2)-methylation of guanosine nucleotide at position 6 (m2G6) in tRNAs (PubMed:34669960, PubMed:37283053). This i
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01170	UPF0020	292 → 478	Putative RNA methylase family UPF0020	Domain
  PF02926	THUMP	134 → 285	THUMP domain	Domain

• Sequence:

  MCDIEEATNQLLDVNLHENQKSVQVTESDLGSESELLVTIGATVPTGFEQTAADEVREKL
  GSSCKISRDRGKIYFVISVESLAQVHCLRSVDNLFVVVQEFQDYQFKQTKEEVLKDFEDL
  AGKLPWSNPLKVWKINASFKKKKAKRKKINQNSSKEKINNGQEVKIDQRNVKKEFTSHAL
  DSHILDYYENPAIKEDVSTLIGDDLASCKDETDESSKEETEPQVLKFRVTCNRAGEKHCF
  TSNEAARDFGGAVQDYFKWKADMTNFDVEVLLNIHDNEVIVGIALTEESLHRRNITHFGP
  TTLRSTLAYGMLRLCDPLPYDIIVDPMCGTGAIPIEGATEWSDCFHIAGDNNPLAVNRAA
  NNIASLLTKSQIKEGKPSWGLPIDAVQWDICNLPLRTGSVDIIVTDLPFGKRMGSKKRNW
  NLYPACLREMSRVCTPTTGRAVLLTQDTKCFTKALSGMRHVWRKVDTVWVNVGGLRAAVY
  VLIRTPQAFVHPSEQDGERGTLWQCKE

• Sequence length: 507

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (6)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Acute myeloid leukemia	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Nonpapillary renal cell carcinoma	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Thyroid cancer, nonmedullary, 1	Uncertain significance	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Alzheimer Disease	Alzheimer disease	Pubtator	38092781	Associate	★☆☆☆☆ Found in Text Mining only
Carcinoma Hepatocellular	Hepatocellular carcinoma	Pubtator	34588321	Associate	★☆☆☆☆ Found in Text Mining only
Lung Neoplasms	Lung neoplasms	Pubtator	39656728	Associate	★☆☆☆☆ Found in Text Mining only
Prostatic Neoplasms	Prostatic neoplasm	Pubtator	36514044	Associate	★☆☆☆☆ Found in Text Mining only
Urinary Bladder Neoplasms	Urinary bladder neoplasms	Pubtator	34414701	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for THUMPD3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to THUMPD3.