THTPA (thiamine triphosphatase)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 79178
• Gene name: Thiamine triphosphatase
• Gene symbol: THTPA
• Synonyms (NCBI Gene): THTP, THTPASE
• Chromosome: 14
• Chromosome location: 14q11.2
• Summary: This gene encodes an enzyme which catalyzes the biosynthesis of thiamine disphophate (vitamin B1) by hydrolysis of thiamine triphosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2011]

miRNA Show/Hide all (151)

miRTarBase ID	miRNA	Experiments	Reference
MIRT439459	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439459	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1424018	hsa-miR-128	CLIP-seq
MIRT1424019	hsa-miR-1285	CLIP-seq
MIRT1424020	hsa-miR-3187-5p	CLIP-seq
MIRT1424021	hsa-miR-3688-5p	CLIP-seq
MIRT1424022	hsa-miR-4470	CLIP-seq
MIRT1424023	hsa-miR-612	CLIP-seq
MIRT1424024	hsa-miR-1321	CLIP-seq
MIRT1424025	hsa-miR-1908	CLIP-seq
MIRT1424026	hsa-miR-21	CLIP-seq
MIRT1424027	hsa-miR-3125	CLIP-seq
MIRT1424028	hsa-miR-3180	CLIP-seq
MIRT1424029	hsa-miR-3180-3p	CLIP-seq
MIRT1424030	hsa-miR-3196	CLIP-seq
MIRT1424031	hsa-miR-3916	CLIP-seq
MIRT1424032	hsa-miR-4271	CLIP-seq
MIRT1424033	hsa-miR-4437	CLIP-seq
MIRT1424034	hsa-miR-4651	CLIP-seq
MIRT1424035	hsa-miR-4706	CLIP-seq
MIRT1424036	hsa-miR-4716-3p	CLIP-seq
MIRT1424037	hsa-miR-4721	CLIP-seq
MIRT1424038	hsa-miR-4725-3p	CLIP-seq
MIRT1424039	hsa-miR-4728-5p	CLIP-seq
MIRT1424040	hsa-miR-4739	CLIP-seq
MIRT1424041	hsa-miR-4749-5p	CLIP-seq
MIRT1424042	hsa-miR-4756-5p	CLIP-seq
MIRT1424043	hsa-miR-4779	CLIP-seq
MIRT1424044	hsa-miR-486-3p	CLIP-seq
MIRT1424045	hsa-miR-590-5p	CLIP-seq
MIRT1424046	hsa-miR-608	CLIP-seq
MIRT1424047	hsa-miR-625	CLIP-seq
MIRT1424048	hsa-miR-659	CLIP-seq
MIRT1424049	hsa-miR-663	CLIP-seq
MIRT1424050	hsa-miR-877	CLIP-seq
MIRT2127049	hsa-miR-296-5p	CLIP-seq
MIRT2127050	hsa-miR-4266	CLIP-seq
MIRT2127051	hsa-miR-4433	CLIP-seq
MIRT1424039	hsa-miR-4728-5p	CLIP-seq
MIRT2127052	hsa-miR-665	CLIP-seq
MIRT2348940	hsa-miR-1207-3p	CLIP-seq
MIRT1424018	hsa-miR-128	CLIP-seq
MIRT2348941	hsa-miR-28-5p	CLIP-seq
MIRT2348942	hsa-miR-3139	CLIP-seq
MIRT2348943	hsa-miR-3175	CLIP-seq
MIRT2348944	hsa-miR-3184	CLIP-seq
MIRT2348945	hsa-miR-423-5p	CLIP-seq
MIRT2127050	hsa-miR-4266	CLIP-seq
MIRT2348946	hsa-miR-512-5p	CLIP-seq
MIRT2348947	hsa-miR-524-3p	CLIP-seq
MIRT2348948	hsa-miR-525-3p	CLIP-seq
MIRT2348949	hsa-miR-651	CLIP-seq
MIRT2348950	hsa-miR-708	CLIP-seq
MIRT2348951	hsa-miR-4270	CLIP-seq
MIRT2348952	hsa-miR-4441	CLIP-seq
MIRT2642004	hsa-miR-1238	CLIP-seq
MIRT1424018	hsa-miR-128	CLIP-seq
MIRT1424019	hsa-miR-1285	CLIP-seq
MIRT2642005	hsa-miR-1912	CLIP-seq
MIRT2642006	hsa-miR-204	CLIP-seq
MIRT2642007	hsa-miR-211	CLIP-seq
MIRT2127049	hsa-miR-296-5p	CLIP-seq
MIRT2642008	hsa-miR-3127-3p	CLIP-seq
MIRT2642009	hsa-miR-3154	CLIP-seq
MIRT2642010	hsa-miR-3168	CLIP-seq
MIRT2348943	hsa-miR-3175	CLIP-seq
MIRT2642011	hsa-miR-3182	CLIP-seq
MIRT2348944	hsa-miR-3184	CLIP-seq
MIRT1424020	hsa-miR-3187-5p	CLIP-seq
MIRT2642012	hsa-miR-326	CLIP-seq
MIRT2642013	hsa-miR-330-5p	CLIP-seq
MIRT2642014	hsa-miR-3612	CLIP-seq
MIRT2642015	hsa-miR-3684	CLIP-seq
MIRT1424021	hsa-miR-3688-5p	CLIP-seq
MIRT2642016	hsa-miR-3692	CLIP-seq
MIRT2642017	hsa-miR-378g	CLIP-seq
MIRT2348945	hsa-miR-423-5p	CLIP-seq
MIRT2127051	hsa-miR-4433	CLIP-seq
MIRT2642018	hsa-miR-4459	CLIP-seq
MIRT1424022	hsa-miR-4470	CLIP-seq
MIRT2642019	hsa-miR-4475	CLIP-seq
MIRT2642020	hsa-miR-4476	CLIP-seq
MIRT2642021	hsa-miR-4486	CLIP-seq
MIRT2642022	hsa-miR-4487	CLIP-seq
MIRT2642023	hsa-miR-4640-5p	CLIP-seq
MIRT2642024	hsa-miR-4652-3p	CLIP-seq
MIRT2642025	hsa-miR-4659a-3p	CLIP-seq
MIRT2642026	hsa-miR-4659b-3p	CLIP-seq
MIRT2642027	hsa-miR-4695-5p	CLIP-seq
MIRT2642028	hsa-miR-4726-5p	CLIP-seq
MIRT2642029	hsa-miR-4755-5p	CLIP-seq
MIRT2642030	hsa-miR-4777-5p	CLIP-seq
MIRT2642031	hsa-miR-518d-5p	CLIP-seq
MIRT2642032	hsa-miR-519b-5p	CLIP-seq
MIRT2642033	hsa-miR-519c-5p	CLIP-seq
MIRT2642034	hsa-miR-520c-5p	CLIP-seq
MIRT2642035	hsa-miR-526a	CLIP-seq
MIRT1424023	hsa-miR-612	CLIP-seq
MIRT2642036	hsa-miR-623	CLIP-seq
MIRT2642037	hsa-miR-650	CLIP-seq
MIRT2127052	hsa-miR-665	CLIP-seq
MIRT2642004	hsa-miR-1238	CLIP-seq
MIRT2693128	hsa-miR-1260	CLIP-seq
MIRT2693129	hsa-miR-1260b	CLIP-seq
MIRT1424018	hsa-miR-128	CLIP-seq
MIRT1424019	hsa-miR-1285	CLIP-seq
MIRT2693130	hsa-miR-188-3p	CLIP-seq
MIRT2642005	hsa-miR-1912	CLIP-seq
MIRT2642006	hsa-miR-204	CLIP-seq
MIRT2642007	hsa-miR-211	CLIP-seq
MIRT2127049	hsa-miR-296-5p	CLIP-seq
MIRT2642008	hsa-miR-3127-3p	CLIP-seq
MIRT2642009	hsa-miR-3154	CLIP-seq
MIRT2693131	hsa-miR-3156-3p	CLIP-seq
MIRT2642010	hsa-miR-3168	CLIP-seq
MIRT2348943	hsa-miR-3175	CLIP-seq
MIRT2642011	hsa-miR-3182	CLIP-seq
MIRT2348944	hsa-miR-3184	CLIP-seq
MIRT1424020	hsa-miR-3187-5p	CLIP-seq
MIRT2642012	hsa-miR-326	CLIP-seq
MIRT2642013	hsa-miR-330-5p	CLIP-seq
MIRT2642014	hsa-miR-3612	CLIP-seq
MIRT2642015	hsa-miR-3684	CLIP-seq
MIRT1424021	hsa-miR-3688-5p	CLIP-seq
MIRT2642016	hsa-miR-3692	CLIP-seq
MIRT2642017	hsa-miR-378g	CLIP-seq
MIRT2348945	hsa-miR-423-5p	CLIP-seq
MIRT2127051	hsa-miR-4433	CLIP-seq
MIRT2642018	hsa-miR-4459	CLIP-seq
MIRT1424022	hsa-miR-4470	CLIP-seq
MIRT2642019	hsa-miR-4475	CLIP-seq
MIRT2642021	hsa-miR-4486	CLIP-seq
MIRT2642022	hsa-miR-4487	CLIP-seq
MIRT2642023	hsa-miR-4640-5p	CLIP-seq
MIRT2642024	hsa-miR-4652-3p	CLIP-seq
MIRT2642025	hsa-miR-4659a-3p	CLIP-seq
MIRT2642026	hsa-miR-4659b-3p	CLIP-seq
MIRT2642027	hsa-miR-4695-5p	CLIP-seq
MIRT2642028	hsa-miR-4726-5p	CLIP-seq
MIRT2693132	hsa-miR-4733-5p	CLIP-seq
MIRT2642029	hsa-miR-4755-5p	CLIP-seq
MIRT2642030	hsa-miR-4777-5p	CLIP-seq
MIRT2642031	hsa-miR-518d-5p	CLIP-seq
MIRT2642032	hsa-miR-519b-5p	CLIP-seq
MIRT2642033	hsa-miR-519c-5p	CLIP-seq
MIRT2642034	hsa-miR-520c-5p	CLIP-seq
MIRT2642035	hsa-miR-526a	CLIP-seq
MIRT1424023	hsa-miR-612	CLIP-seq
MIRT2642036	hsa-miR-623	CLIP-seq
MIRT2642037	hsa-miR-650	CLIP-seq
MIRT2127052	hsa-miR-665	CLIP-seq

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000287	Function	Magnesium ion binding	IBA
GO:0000287	Function	Magnesium ion binding	IEA
GO:0000287	Function	Magnesium ion binding	ISS
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005829	Component	Cytosol	TAS
GO:0006091	Process	Generation of precursor metabolites and energy	NAS	11827967
GO:0006772	Process	Thiamine metabolic process	IEA
GO:0006772	Process	Thiamine metabolic process	TAS	11827967
GO:0006796	Process	Phosphate-containing compound metabolic process	IEA
GO:0009229	Process	Thiamine diphosphate biosynthetic process	IEA
GO:0016311	Process	Dephosphorylation	IDA	11827967
GO:0016787	Function	Hydrolase activity	IEA
GO:0016787	Function	Hydrolase activity	TAS	11827967
GO:0042357	Process	Thiamine diphosphate metabolic process	IBA
GO:0042357	Process	Thiamine diphosphate metabolic process	IEA
GO:0042357	Process	Thiamine diphosphate metabolic process	ISS
GO:0042723	Process	Thiamine-containing compound metabolic process	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050333	Function	Thiamine triphosphate phosphatase activity	IBA
GO:0050333	Function	Thiamine triphosphate phosphatase activity	IDA	11827967
GO:0050333	Function	Thiamine triphosphate phosphatase activity	IEA

Other IDs

• MIM: 611612
• HGNC: 18987
• e!Ensembl: ENSG00000259431

Protein

• UniProt ID: Q9BU02
• Protein name: Thiamine-triphosphatase (ThTPase) (EC 3.6.1.28)
• Protein function: Hydrolase highly specific for thiamine triphosphate (ThTP).
• PDB: 3BHD , 3TVL
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF01928	CYTH	5 → 192	CYTH domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Widely expressed but at a low level. {ECO:0000269|PubMed:11827967}.
• Sequence:

  MAQGLIEVERKFLPGPGTEERLQELGGTLEYRVTFRDTYYDTPELSLMQADHWLRRREDS
  GWELKCPGAAGVLGPHTEYKELTAEPTIVAQLCKVLRADGLGAGDVAAVLGPLGLQEVAS
  FVTKRSAWKLVLLGADEEEPQLRVDLDTADFGYAVGEVEALVHEEAEVPTALEKIHRLSS
  MLGVPAQETAPAKLIVYLQRFRPQDYQRLLEVNSSRERPQETEDPDHCLG

• Sequence length: 230

Pathways

KEGG Pathway	Reactome Pathway
Thiamine metabolism	Vitamin B1 (thiamin) metabolism
Metabolic pathways

Related Genes

TPK1 2 shared pathwaysThiamine metabolism, Vitamin B1 (thiamin) metabolism Related via 2 shared pathways including Thiamine metabolism, Vitamin B1 (thiamin) metabolism.

Related Gene	Shared Diseases	Shared Disease Names	Shared Pathways	Shared Pathway Names	Shared Evidence Sources	Shared Evidence Names
TPK1	0	[]	2	["Thiamine metabolism","Vitamin B1 (thiamin) metabolism"]	0	[]

Diseases Linked via Similar Genes

Breast cancer Linked via 1 of 1 related geneTPK1 Lymphocytic leukemia Linked via 1 of 1 related geneTPK1 Leigh syndrome Linked via 1 of 1 related geneTPK1 Metabolic syndrome Linked via 1 of 1 related geneTPK1 Thiamine metabolism dysfunction syndrome Linked via 1 of 1 related geneTPK1

Disease	Linked Via (Gene Count)	Linked Via (Gene Names)
Breast cancer	1	["TPK1"]
Lymphocytic leukemia	1	["TPK1"]
Leigh syndrome	1	["TPK1"]
Metabolic syndrome	1	["TPK1"]
Thiamine metabolism dysfunction syndrome	1	["TPK1"]