TGM7 (transglutaminase 7)

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Gene Gene information from NCBI Gene database.
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Entrez ID 116179
Gene name Transglutaminase 7
Gene symbol TGM7
Synonyms (NCBI Gene)
TGMZ
Chromosome 15
Chromosome location 15q15.2-q15.3
Summary Transglutaminases (TGM; EC 2.3.2.13) are a family of structurally and functionally related enzymes that stabilize protein assemblies through the formation of gamma-glutamyl-epsilon lysine crosslinks. For additional background information on transglutamina
miRNA miRNA information provided by mirtarbase database.
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miRTarBase ID miRNA Experiments Reference
MIRT019276 hsa-miR-148b-3p Microarray 17612493
MIRT1421907 hsa-miR-1207-5p CLIP-seq
MIRT1421908 hsa-miR-1909 CLIP-seq
MIRT1421909 hsa-miR-3151 CLIP-seq
MIRT1421910 hsa-miR-342-5p CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
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GO ID Ontology Definition Evidence Reference
GO:0003810 Function Protein-glutamine gamma-glutamyltransferase activity IBA
GO:0003810 Function Protein-glutamine gamma-glutamyltransferase activity IEA
GO:0005515 Function Protein binding IPI 32296183
GO:0016740 Function Transferase activity IEA
GO:0016746 Function Acyltransferase activity IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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MIM HGNC e!Ensembl
606776 30790 ENSG00000159495
Protein Protein information from UniProt database.
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UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
Q96PF1
Protein name Protein-glutamine gamma-glutamyltransferase Z (Transglutaminase Z) (TG(Z)) (TGZ) (TGase Z) (EC 2.3.2.13) (Transglutaminase-7) (TGase-7)
Protein function Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins.
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF00868 Transglut_N 6 → 123 Transglutaminase family Domain
PF00927 Transglut_C 608 → 706 Transglutaminase family, C-terminal ig like domain Domain
PF01841 Transglut_core 256 → 362 Transglutaminase-like superfamily Family
Tissue specificity TISSUE SPECIFICITY: Widely expressed.
Sequence 
MDQVATLRLESVDLQSSRNNKEHHTQEMGVKRLTVRRGQPFYLRLSFSRPFQSQNDHITF
VAETGPKPSELLGTRATFFLTRVQPGNVWSASDFTIDSNSLQVSLFTPANAVIGHYTLKI
EISQGQGHSVTYPLGTFILLFNPWSPEDDVYLPSEILLQEYIMRDYGFVYKGHERFITSW
PWNYGQFEEDIIDICFEILNKSLYHLKNPAKDCSQRNDVVYVCRVVSAMINSNDDNGVLQ
GNWGEDYSKGVSPLEWKGSVAILQQWSARGGQPVKYGQCWVFASVMCTVMRCLGVPTRVV
SNFRSAHNVDRNLTIDTYYDRNAEMLSTQKRDKIWNFHVWNECWMIRKDLPPGYNGWQVL
DPTPQQTSSGLFCCGPASVKAIREGDVHLAYDTPFVYAEVNADEVIWLLGDGQAQEILAH
NTSSIGKEISTKMVGSDQRQSITSSYKYPEGSPEERAVFMKASRKMLGPQRASLPFLDLL
ESGGLRDQPAQLQLHLARIPEWGQDLQLLLRIQRVPDSTHPRGPIGLVVRFCAQALLHGG
GTQKPFWRHTVRMNLDFGKETQWPLLLPYSNYRNKLTDEKLIRVSGIAEVEETGRSMLVL
KDICLEPPHLSIEVSERAEVGKALRVHVTLTNTLMVALSSCTMVLEGSGLINGQIAKDLG
TLVAGHTLQIQLDLYPTKAGPRQLQVLISSNEVKEIKGYKDIFVTVAGAP
Sequence length 710
Interactions View interactions

No strongly related genes found yet for TGM7.

No additional diseases found yet through genes similar to TGM7.