TFDP3 (transcription factor Dp family member 3)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 51270
• Gene name: Transcription factor Dp family member 3
• Gene symbol: TFDP3
• Synonyms (NCBI Gene): CT30, DP4, HCA661
• Chromosome: X
• Chromosome location: Xq26.2
• Summary: This gene encodes a member of the DP family of transcription factors. These factors heterodimerize with E2F proteins to enhance their DNA-binding activity and promote transcription from E2F target genes. This protein functions as a negative regulator and

miRNA Show/Hide all (42)

miRTarBase ID	miRNA	Experiments	Reference
MIRT620418	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT620417	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620416	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT620415	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT620414	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT620413	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT620412	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT620418	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT620417	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620416	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT620415	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT620414	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT620413	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT620412	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT620418	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT620417	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620416	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT620415	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT620414	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT620413	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT620412	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT620418	hsa-miR-561-3p	HITS-CLIP	23824327
MIRT620417	hsa-miR-627-3p	HITS-CLIP	23824327
MIRT620416	hsa-miR-6883-3p	HITS-CLIP	23824327
MIRT620415	hsa-miR-4755-5p	HITS-CLIP	23824327
MIRT620414	hsa-miR-5006-3p	HITS-CLIP	23824327
MIRT620413	hsa-miR-4446-5p	HITS-CLIP	23824327
MIRT620412	hsa-miR-4668-5p	HITS-CLIP	23824327
MIRT1420429	hsa-miR-21	CLIP-seq
MIRT1420430	hsa-miR-4778-3p	CLIP-seq
MIRT1420431	hsa-miR-590-5p	CLIP-seq
MIRT1420432	hsa-miR-635	CLIP-seq
MIRT1420429	hsa-miR-21	CLIP-seq
MIRT2348277	hsa-miR-361-5p	CLIP-seq
MIRT2348278	hsa-miR-362-5p	CLIP-seq
MIRT2348279	hsa-miR-4257	CLIP-seq
MIRT2348280	hsa-miR-448	CLIP-seq
MIRT2348281	hsa-miR-4799-5p	CLIP-seq
MIRT2348282	hsa-miR-500a	CLIP-seq
MIRT2348283	hsa-miR-500b	CLIP-seq
MIRT2348284	hsa-miR-502-5p	CLIP-seq
MIRT1420431	hsa-miR-590-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000785	Component	Chromatin	ISA
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0003677	Function	DNA binding	IEA
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005667	Component	Transcription regulator complex	IEA
GO:0005737	Component	Cytoplasm	IDA	17062573
GO:0005737	Component	Cytoplasm	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006974	Process	DNA damage response	IDA	20559320
GO:0043433	Process	Negative regulation of DNA-binding transcription factor activity	IDA	17062573
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	17062573
GO:0140297	Function	DNA-binding transcription factor binding	IPI	17062573
GO:0140416	Function	Transcription regulator inhibitor activity	IDA	17062573
GO:2000134	Process	Negative regulation of G1/S transition of mitotic cell cycle	IDA	17062573

Other IDs

• MIM: 300772
• HGNC: 24603
• e!Ensembl: ENSG00000183434

Protein

• UniProt ID: Q5H9I0
• Protein name: Transcription factor Dp family member 3 (Cancer/testis antigen 30) (CT30) (Hepatocellular carcinoma-associated antigen 661)
• Protein function: Competitive inhibitor of E2F-mediated transactivation activity. Impairs E2F-mediated cell-cycle progression from G(1) to S phase.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF02319	E2F_TDP	107 → 188	E2F/DP family winged-helix DNA-binding domain	Domain
  PF08781	DP	195 → 333	Transcription factor DP	Domain

• Tissue specificity: TISSUE SPECIFICITY: Predominantly expressed in testis. Low level of expression in pancreas. Highly expressed in ovarian and colon cancer cell lines. {ECO:0000269|PubMed:12097419, ECO:0000269|PubMed:16418725}.
• Sequence:

  MAKYVSLTEANEELKVLMDENQTSRPVAVHTSTVNPLGKQLLPKTFGQSSVNIDQQVVIG
  MPQRPAASNIPVVGSPNPPSTHFASQNQHSYSSPPWAGQHNRKGEKNGMGLCRLSMKVWE
  TVQRKGTTSCQEVVGELVAKFRAASNHASPNESAYDVKNIKRRTYDALNVLMAMNIISRE
  KKKIKWIGLTTNSAQNCQNLRVERQKRLERIKQKQSELQQLILQQIAFKNLVLRNQYVEE
  QVSQRPLPNSVIHVPFIIISSSKKTVINCSISDDKSEYLFKFNSSFEIHDDTEVLMWMGM
  TFGLESGSCSAEDLKMARNLVPKALEPYVTEMAQGTFGGVFTTAGSRSNGTWLSASDLTN
  IAIGMLATSSGGSQYSGSRVETPAVEEEEEEDNNDDDLSENDEDD

• Sequence length: 405

Related Genes

No strongly related genes found yet for TFDP3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TFDP3.