Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	150921
Gene name	Transcription factor 23
Gene symbol	TCF23
Synonyms (NCBI Gene)	OUTTCF-23bHLHa24
Chromosome	2
Chromosome location	2p23.3
Summary	The gene encodes a member of the basic helix-loop-helix transcription factor family. Studies of the orthologous gene in mouse have shown the encoded protein does not bind DNA but may negatively regulate other basic helix-loop-helix factors via the formati

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miRTarBase ID	miRNA	Experiments	Reference
MIRT695438	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT695437	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT695436	hsa-miR-940	HITS-CLIP	23313552
MIRT695435	hsa-miR-3929	HITS-CLIP	23313552
MIRT695434	hsa-miR-4419b	HITS-CLIP	23313552
MIRT695433	hsa-miR-4478	HITS-CLIP	23313552
MIRT695432	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT695431	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT695430	hsa-miR-1827	HITS-CLIP	23313552
MIRT695429	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT695428	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT695427	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT695426	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT695425	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT695424	hsa-miR-665	HITS-CLIP	23313552
MIRT673743	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673741	hsa-miR-5693	HITS-CLIP	23824327
MIRT673742	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT673740	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673739	hsa-miR-3135b	HITS-CLIP	23824327
MIRT673738	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT673737	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT673736	hsa-miR-4284	HITS-CLIP	23824327
MIRT673735	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673734	hsa-miR-3652	HITS-CLIP	23824327
MIRT673733	hsa-miR-4430	HITS-CLIP	23824327
MIRT673732	hsa-miR-8057	HITS-CLIP	23824327
MIRT673731	hsa-miR-5698	HITS-CLIP	23824327
MIRT520781	hsa-miR-181a-2-3p	PAR-CLIP	23446348
MIRT520780	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT520779	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT520778	hsa-miR-3064-5p	PAR-CLIP	23446348
MIRT520777	hsa-miR-6504-5p	PAR-CLIP	23446348
MIRT520776	hsa-miR-2114-3p	PAR-CLIP	23446348
MIRT520775	hsa-miR-6823-3p	PAR-CLIP	23446348
MIRT520774	hsa-miR-4252	PAR-CLIP	23446348
MIRT520773	hsa-miR-7974	PAR-CLIP	23446348
MIRT520772	hsa-miR-4687-3p	PAR-CLIP	23446348
MIRT520771	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT520770	hsa-miR-562	PAR-CLIP	23446348
MIRT520768	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT520769	hsa-miR-455-5p	PAR-CLIP	23446348
MIRT520767	hsa-miR-5697	PAR-CLIP	23446348
MIRT520766	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT520765	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT520764	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT520763	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT520762	hsa-miR-1227-3p	PAR-CLIP	23446348
MIRT520761	hsa-miR-3170	PAR-CLIP	23446348
MIRT520760	hsa-miR-6855-5p	PAR-CLIP	23446348
MIRT695438	hsa-miR-6808-5p	HITS-CLIP	23313552
MIRT695437	hsa-miR-6893-5p	HITS-CLIP	23313552
MIRT695436	hsa-miR-940	HITS-CLIP	23313552
MIRT695435	hsa-miR-3929	HITS-CLIP	23313552
MIRT695434	hsa-miR-4419b	HITS-CLIP	23313552
MIRT695433	hsa-miR-4478	HITS-CLIP	23313552
MIRT695432	hsa-miR-6746-5p	HITS-CLIP	23313552
MIRT695431	hsa-miR-4649-3p	HITS-CLIP	23313552
MIRT695430	hsa-miR-1827	HITS-CLIP	23313552
MIRT695429	hsa-miR-485-5p	HITS-CLIP	23313552
MIRT695428	hsa-miR-6884-5p	HITS-CLIP	23313552
MIRT695427	hsa-miR-4722-5p	HITS-CLIP	23313552
MIRT695426	hsa-miR-7160-5p	HITS-CLIP	23313552
MIRT695425	hsa-miR-6771-5p	HITS-CLIP	23313552
MIRT695424	hsa-miR-665	HITS-CLIP	23313552
MIRT673743	hsa-miR-6890-3p	HITS-CLIP	23824327
MIRT673741	hsa-miR-5693	HITS-CLIP	23824327
MIRT673742	hsa-miR-4485-5p	HITS-CLIP	23824327
MIRT673740	hsa-miR-4772-3p	HITS-CLIP	23824327
MIRT673739	hsa-miR-3135b	HITS-CLIP	23824327
MIRT673738	hsa-miR-504-3p	HITS-CLIP	23824327
MIRT673737	hsa-miR-122-5p	HITS-CLIP	23824327
MIRT673736	hsa-miR-4284	HITS-CLIP	23824327
MIRT673735	hsa-miR-24-3p	HITS-CLIP	23824327
MIRT673734	hsa-miR-3652	HITS-CLIP	23824327
MIRT673733	hsa-miR-4430	HITS-CLIP	23824327
MIRT673732	hsa-miR-8057	HITS-CLIP	23824327
MIRT673731	hsa-miR-5698	HITS-CLIP	23824327
MIRT520781	hsa-miR-181a-2-3p	PAR-CLIP	23446348
MIRT520780	hsa-miR-1199-5p	PAR-CLIP	23446348
MIRT520779	hsa-miR-6751-3p	PAR-CLIP	23446348
MIRT520778	hsa-miR-3064-5p	PAR-CLIP	23446348
MIRT520777	hsa-miR-6504-5p	PAR-CLIP	23446348
MIRT520776	hsa-miR-2114-3p	PAR-CLIP	23446348
MIRT520775	hsa-miR-6823-3p	PAR-CLIP	23446348
MIRT520774	hsa-miR-4252	PAR-CLIP	23446348
MIRT520773	hsa-miR-7974	PAR-CLIP	23446348
MIRT520772	hsa-miR-4687-3p	PAR-CLIP	23446348
MIRT520771	hsa-miR-6807-5p	PAR-CLIP	23446348
MIRT520770	hsa-miR-562	PAR-CLIP	23446348
MIRT520768	hsa-miR-1295b-3p	PAR-CLIP	23446348
MIRT520769	hsa-miR-455-5p	PAR-CLIP	23446348
MIRT520767	hsa-miR-5697	PAR-CLIP	23446348
MIRT520766	hsa-miR-6814-5p	PAR-CLIP	23446348
MIRT520765	hsa-miR-7155-5p	PAR-CLIP	23446348
MIRT520764	hsa-miR-4731-5p	PAR-CLIP	23446348
MIRT520763	hsa-miR-193b-5p	PAR-CLIP	23446348
MIRT520762	hsa-miR-1227-3p	PAR-CLIP	23446348
MIRT520761	hsa-miR-3170	PAR-CLIP	23446348
MIRT520760	hsa-miR-6855-5p	PAR-CLIP	23446348

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GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IEA
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	ISS
GO:0000785	Component	Chromatin	ISA
GO:0000791	Component	Euchromatin	IEA
GO:0000791	Component	Euchromatin	ISS
GO:0000977	Function	RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	IBA
GO:0000981	Function	DNA-binding transcription factor activity, RNA polymerase II-specific	ISA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005634	Component	Nucleus	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0007517	Process	Muscle organ development	IEA
GO:0010628	Process	Positive regulation of gene expression	IMP	24571987
GO:0030154	Process	Cell differentiation	IEA
GO:0032502	Process	Developmental process	IBA
GO:0046697	Process	Decidualization	IMP	24571987
GO:0046983	Function	Protein dimerization activity	IEA
GO:0051148	Process	Negative regulation of muscle cell differentiation	IEA
GO:0051148	Process	Negative regulation of muscle cell differentiation	ISS
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IEA
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	ISS
GO:0140416	Function	Transcription regulator inhibitor activity	IEA
GO:0140416	Function	Transcription regulator inhibitor activity	ISS

MIM	HGNC	e!Ensembl
609635	18602	ENSG00000163792

Q7RTU1

Protein name

Transcription factor 23 (TCF-23) (Class A basic helix-loop-helix protein 24) (bHLHa24)

Protein function

Inhibits E-box-mediated binding and transactivation of bHLH factors. Inhibitory effect is similar to that of ID proteins. Inhibits the formation of TCF3 and MYOD1 homodimers and heterodimers. Lacks DNA binding activity. Seems to play a role in t

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF00010	HLH	80 → 129	Helix-loop-helix DNA-binding domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Expressed in liver, kidney and spleen. {ECO:0000269|PubMed:14516699}.

Sequence

MSQRKARGPPAMPGVGHSQTQAKARLLPGADRKRSRLSRTRQDPWEERSWSNQRWSRATP
GPRGTRAGGLALGRSEASPENAARERSRVRTLRQAFLALQAALPAVPPDTKLSKLDVLVL
AASYIAHLTRTLGHELPGPAWPPFLRGLRYLHPLKKWPMRSRLYAGGLGYSDLDSTTAST
PSQRTRDAEVGSQVPGEADALLSTTPLSPALGDK

Sequence length

214

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
METABOLIC SYNDROME	—	GWAS catalog	39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
TYPE 2 DIABETES MELLITUS	—	GWAS catalog	39349817	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations
UTERINE FIBROID	—	GWAS catalog	40050615	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Related Genes Genes most often co-reported with TCF23 across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for TCF23.

Diseases Linked via Similar Genes Diseases curated for genes most similar to TCF23 (see Related Genes above), that are NOT already directly curated for TCF23 itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to TCF23.

TCF23 (transcription factor 23)

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