TCERG1 (transcription elongation regulator 1)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10915
• Gene name: Transcription elongation regulator 1
• Gene symbol: TCERG1
• Synonyms (NCBI Gene): CA150, TAF2S, Urn1
• Chromosome: 5
• Chromosome location: 5q32
• Summary: This gene encodes a nuclear protein that regulates transcriptional elongation and pre-mRNA splicing. The encoded protein interacts with the hyperphosphorylated C-terminal domain of RNA polymerase II via multiple FF domains, and with the pre-mRNA splicing

miRNA Show/Hide all (175)

miRTarBase ID	miRNA	Experiments	Reference
MIRT027828	hsa-miR-98-5p	Microarray	19088304
MIRT052589	hsa-let-7a-5p	CLASH	23622248
MIRT046720	hsa-miR-222-3p	CLASH	23622248
MIRT043747	hsa-miR-328-3p	CLASH	23622248
MIRT040393	hsa-miR-615-3p	CLASH	23622248
MIRT039212	hsa-miR-769-5p	CLASH	23622248
MIRT037086	hsa-miR-877-3p	CLASH	23622248
MIRT648477	hsa-miR-4418	HITS-CLIP	23824327
MIRT648476	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT648475	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT648474	hsa-miR-217	HITS-CLIP	23824327
MIRT648473	hsa-miR-6807-3p	HITS-CLIP	23824327
MIRT648472	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648471	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648470	hsa-miR-1283	HITS-CLIP	23824327
MIRT648469	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT095688	hsa-miR-299-5p	PAR-CLIP	20371350
MIRT095689	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT561465	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT561464	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT329362	hsa-miR-3163	PAR-CLIP	20371350
MIRT561463	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT561462	hsa-miR-4703-3p	PAR-CLIP	20371350
MIRT357882	hsa-miR-5701	PAR-CLIP	20371350
MIRT095692	hsa-miR-3671	PAR-CLIP	20371350
MIRT561461	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT095690	hsa-miR-607	PAR-CLIP	20371350
MIRT648477	hsa-miR-4418	HITS-CLIP	23824327
MIRT648476	hsa-miR-509-3-5p	HITS-CLIP	23824327
MIRT648475	hsa-miR-509-5p	HITS-CLIP	23824327
MIRT648474	hsa-miR-217	HITS-CLIP	23824327
MIRT648473	hsa-miR-6807-3p	HITS-CLIP	23824327
MIRT648472	hsa-miR-6734-3p	HITS-CLIP	23824327
MIRT648471	hsa-miR-3667-3p	HITS-CLIP	23824327
MIRT648470	hsa-miR-1283	HITS-CLIP	23824327
MIRT648469	hsa-miR-6868-3p	HITS-CLIP	23824327
MIRT095688	hsa-miR-299-5p	PAR-CLIP	20371350
MIRT095689	hsa-miR-296-3p	PAR-CLIP	20371350
MIRT561465	hsa-miR-410-3p	PAR-CLIP	20371350
MIRT561464	hsa-miR-5000-5p	PAR-CLIP	20371350
MIRT329362	hsa-miR-3163	PAR-CLIP	20371350
MIRT561463	hsa-miR-5011-5p	PAR-CLIP	20371350
MIRT561462	hsa-miR-4703-3p	PAR-CLIP	20371350
MIRT357882	hsa-miR-5701	PAR-CLIP	20371350
MIRT095692	hsa-miR-3671	PAR-CLIP	20371350
MIRT561461	hsa-miR-29b-2-5p	PAR-CLIP	20371350
MIRT095690	hsa-miR-607	PAR-CLIP	20371350
MIRT1415854	hsa-miR-1228	CLIP-seq
MIRT1415855	hsa-miR-1245b-3p	CLIP-seq
MIRT1415856	hsa-miR-1253	CLIP-seq
MIRT1415857	hsa-miR-1912	CLIP-seq
MIRT1415858	hsa-miR-3647-3p	CLIP-seq
MIRT1415859	hsa-miR-3658	CLIP-seq
MIRT1415860	hsa-miR-3688-3p	CLIP-seq
MIRT1415861	hsa-miR-3692	CLIP-seq
MIRT1415862	hsa-miR-380	CLIP-seq
MIRT1415863	hsa-miR-4251	CLIP-seq
MIRT1415864	hsa-miR-4324	CLIP-seq
MIRT1415865	hsa-miR-4495	CLIP-seq
MIRT1415866	hsa-miR-4749-3p	CLIP-seq
MIRT1415867	hsa-miR-4753-3p	CLIP-seq
MIRT1415868	hsa-miR-496	CLIP-seq
MIRT1415869	hsa-miR-548ac	CLIP-seq
MIRT1415870	hsa-miR-548ae	CLIP-seq
MIRT1415871	hsa-miR-548ag	CLIP-seq
MIRT1415872	hsa-miR-548ai	CLIP-seq
MIRT1415873	hsa-miR-548aj	CLIP-seq
MIRT1415874	hsa-miR-548am	CLIP-seq
MIRT1415875	hsa-miR-548d-3p	CLIP-seq
MIRT1415876	hsa-miR-548m	CLIP-seq
MIRT1415877	hsa-miR-548x	CLIP-seq
MIRT1415878	hsa-miR-548z	CLIP-seq
MIRT1415879	hsa-miR-563	CLIP-seq
MIRT1415880	hsa-miR-587	CLIP-seq
MIRT1415881	hsa-miR-590-3p	CLIP-seq
MIRT1415882	hsa-miR-617	CLIP-seq
MIRT1415883	hsa-miR-7	CLIP-seq
MIRT1415884	hsa-miR-942	CLIP-seq
MIRT1415854	hsa-miR-1228	CLIP-seq
MIRT1415885	hsa-miR-1289	CLIP-seq
MIRT1415886	hsa-miR-1299	CLIP-seq
MIRT1415887	hsa-miR-141	CLIP-seq
MIRT1415857	hsa-miR-1912	CLIP-seq
MIRT1415888	hsa-miR-200a	CLIP-seq
MIRT1415889	hsa-miR-224	CLIP-seq
MIRT1415890	hsa-miR-24	CLIP-seq
MIRT1415891	hsa-miR-28-3p	CLIP-seq
MIRT1415892	hsa-miR-3198	CLIP-seq
MIRT1415858	hsa-miR-3647-3p	CLIP-seq
MIRT1415893	hsa-miR-3682-5p	CLIP-seq
MIRT1415894	hsa-miR-3691-3p	CLIP-seq
MIRT1415861	hsa-miR-3692	CLIP-seq
MIRT1415895	hsa-miR-369-3p	CLIP-seq
MIRT1415896	hsa-miR-374a	CLIP-seq
MIRT1415897	hsa-miR-374b	CLIP-seq
MIRT1415862	hsa-miR-380	CLIP-seq
MIRT1415898	hsa-miR-4276	CLIP-seq
MIRT1415899	hsa-miR-4284	CLIP-seq
MIRT1415900	hsa-miR-4294	CLIP-seq
MIRT1415901	hsa-miR-4302	CLIP-seq
MIRT1415902	hsa-miR-4309	CLIP-seq
MIRT1415903	hsa-miR-432	CLIP-seq
MIRT1415904	hsa-miR-4420	CLIP-seq
MIRT1415905	hsa-miR-4433	CLIP-seq
MIRT1415906	hsa-miR-4476	CLIP-seq
MIRT1415865	hsa-miR-4495	CLIP-seq
MIRT1415907	hsa-miR-4528	CLIP-seq
MIRT1415908	hsa-miR-4536	CLIP-seq
MIRT1415909	hsa-miR-4699-3p	CLIP-seq
MIRT1415869	hsa-miR-548ac	CLIP-seq
MIRT1415870	hsa-miR-548ae	CLIP-seq
MIRT1415871	hsa-miR-548ag	CLIP-seq
MIRT1415872	hsa-miR-548ai	CLIP-seq
MIRT1415873	hsa-miR-548aj	CLIP-seq
MIRT1415874	hsa-miR-548am	CLIP-seq
MIRT1415875	hsa-miR-548d-3p	CLIP-seq
MIRT1415876	hsa-miR-548m	CLIP-seq
MIRT1415877	hsa-miR-548x	CLIP-seq
MIRT1415878	hsa-miR-548z	CLIP-seq
MIRT1415910	hsa-miR-550b	CLIP-seq
MIRT1415879	hsa-miR-563	CLIP-seq
MIRT1415911	hsa-miR-578	CLIP-seq
MIRT1415881	hsa-miR-590-3p	CLIP-seq
MIRT1415882	hsa-miR-617	CLIP-seq
MIRT1415883	hsa-miR-7	CLIP-seq
MIRT1415912	hsa-miR-875-3p	CLIP-seq
MIRT1415913	hsa-miR-885-5p	CLIP-seq
MIRT2124760	hsa-miR-1237	CLIP-seq
MIRT1415855	hsa-miR-1245b-3p	CLIP-seq
MIRT2124761	hsa-miR-1248	CLIP-seq
MIRT2124762	hsa-miR-3182	CLIP-seq
MIRT2124763	hsa-miR-4279	CLIP-seq
MIRT2124764	hsa-miR-4652-3p	CLIP-seq
MIRT2124765	hsa-miR-4719	CLIP-seq
MIRT2124766	hsa-miR-4738-3p	CLIP-seq
MIRT2124767	hsa-miR-548g	CLIP-seq
MIRT2347176	hsa-miR-105	CLIP-seq
MIRT1415856	hsa-miR-1253	CLIP-seq
MIRT1415887	hsa-miR-141	CLIP-seq
MIRT2347177	hsa-miR-181a	CLIP-seq
MIRT2347178	hsa-miR-181b	CLIP-seq
MIRT2347179	hsa-miR-181c	CLIP-seq
MIRT2347180	hsa-miR-181d	CLIP-seq
MIRT1415857	hsa-miR-1912	CLIP-seq
MIRT1415888	hsa-miR-200a	CLIP-seq
MIRT1415889	hsa-miR-224	CLIP-seq
MIRT1415891	hsa-miR-28-3p	CLIP-seq
MIRT2347181	hsa-miR-3143	CLIP-seq
MIRT2347182	hsa-miR-3161	CLIP-seq
MIRT1415858	hsa-miR-3647-3p	CLIP-seq
MIRT1415859	hsa-miR-3658	CLIP-seq
MIRT1415893	hsa-miR-3682-5p	CLIP-seq
MIRT1415894	hsa-miR-3691-3p	CLIP-seq
MIRT1415862	hsa-miR-380	CLIP-seq
MIRT1415863	hsa-miR-4251	CLIP-seq
MIRT2347183	hsa-miR-4262	CLIP-seq
MIRT1415904	hsa-miR-4420	CLIP-seq
MIRT1415905	hsa-miR-4433	CLIP-seq
MIRT1415906	hsa-miR-4476	CLIP-seq
MIRT1415865	hsa-miR-4495	CLIP-seq
MIRT1415909	hsa-miR-4699-3p	CLIP-seq
MIRT2124765	hsa-miR-4719	CLIP-seq
MIRT2347184	hsa-miR-543	CLIP-seq
MIRT1415869	hsa-miR-548ac	CLIP-seq
MIRT1415870	hsa-miR-548ae	CLIP-seq
MIRT1415871	hsa-miR-548ag	CLIP-seq
MIRT1415872	hsa-miR-548ai	CLIP-seq
MIRT1415873	hsa-miR-548aj	CLIP-seq
MIRT1415874	hsa-miR-548am	CLIP-seq
MIRT1415875	hsa-miR-548d-3p	CLIP-seq
MIRT1415876	hsa-miR-548m	CLIP-seq
MIRT1415877	hsa-miR-548x	CLIP-seq
MIRT1415878	hsa-miR-548z	CLIP-seq
MIRT1415910	hsa-miR-550b	CLIP-seq
MIRT1415881	hsa-miR-590-3p	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
SF1	Repression	11604498

Gene ontology (GO) Show/Hide all (24)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	20956529
GO:0003711	Function	Transcription elongation factor activity	TAS	20215116
GO:0003712	Function	Transcription coregulator activity	IBA
GO:0003713	Function	Transcription coactivator activity	TAS	9315662
GO:0003714	Function	Transcription corepressor activity	IDA	20956529
GO:0003723	Function	RNA binding	HDA	22658674, 22681889
GO:0005515	Function	Protein binding	IPI	15383276, 17500595
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9315662
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006397	Process	MRNA processing	IDA	20215116
GO:0008380	Process	RNA splicing	IDA	20215116
GO:0016607	Component	Nuclear speck	TAS	20215116
GO:0032968	Process	Positive regulation of transcription elongation by RNA polymerase II	TAS	20215116
GO:0034244	Process	Negative regulation of transcription elongation by RNA polymerase II	TAS	20215116
GO:0042802	Function	Identical protein binding	IPI	17060612
GO:0044390	Function	Ubiquitin-like protein conjugating enzyme binding	IPI	20215116
GO:0045944	Process	Positive regulation of transcription by RNA polymerase II	IDA	20215116
GO:0061629	Function	RNA polymerase II-specific DNA-binding transcription factor binding	IPI	20956529
GO:0070063	Function	RNA polymerase binding	IBA
GO:0070063	Function	RNA polymerase binding	IEA
GO:0070063	Function	RNA polymerase binding	TAS	20215116

Other IDs

• MIM: 605409
• HGNC: 15630
• e!Ensembl: ENSG00000113649

Protein

• UniProt ID: O14776
• Protein name: Transcription elongation regulator 1 (TATA box-binding protein-associated factor 2S) (Transcription factor CA150)
• Protein function: Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodefi
• PDB: 2DK7 , 2DOD , 2DOE , 2DOF , 2E71 , 2KIQ , 2KIS , 2MW9 , 2MWA , 2MWB , 2MWD , 2MWE , 2MWF , 2N4R , 2N4S , 2N4T , 2N4U , 2N4V , 2N4W , 2NNT , 3HFH , 3Q1I , 4FQG , 7ABF , 7ABG , 8Q7N , 8QO9
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00397	WW	134 → 162	WW domain	Domain
  PF00397	WW	432 → 460	WW domain	Domain
  PF01846	FF	794 → 843	FF domain	Family
  PF01846	FF	1014 → 1074	FF domain	Family
  PF01846	FF	727 → 776	FF domain	Family
  PF01846	FF	661 → 709	FF domain	Family
  PF01846	FF	956 → 1007	FF domain	Family
  PF01846	FF	898 → 949	FF domain	Family

• Tissue specificity: TISSUE SPECIFICITY: Detected in brain neurons. {ECO:0000269|PubMed:11172033}.
• Sequence:

  MAERGGDGGESERFNPGELRMAQQQALRFRGPAPPPNAVMRGPPPLMRPPPPFGMMRGPP
  PPPRPPFGRPPFDPNMPPMPPPGGIPPPMGPPHLQRPPFMPPPMSSMPPPPGMMFPPGMP
  PVTAPGTPALPPTEEIWVENKTPDGKVYYYNARTRESAWTKPDGVKVIQQSELTPMLAAQ
  AQVQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQAQ
  AQVQAQVQAQVQAQAVGASTPTTSSPAPAVSTSTSSSTPSSTTSTTTTATSVAQTVSTPT
  TQDQTPSSAVSVATPTVSVSTPAPTATPVQTVPQPHPQTLPPAVPHSVPQPTTAIPAFPP
  VMVPPFRVPLPGMPIPLPGVAMMQIVSCPYVKTVATTKTGVLPGMAPPIVPMIHPQVAIA
  ASPATLAGATAVSEWTEYKTADGKTYYYNNRTLESTWEKPQELKEKEKLEEKIKEPIKEP
  SEEPLPMETEEEDPKEEPIKEIKEEPKEEEMTEEEKAAQKAKPVATAPIPGTPWCVVWTG
  DERVFFYNPTTRLSMWDRPDDLIGRADVDKIIQEPPHKKGMEELKKLRHPTPTMLSIQKW
  QFSMSAIKEEQELMEEINEDEPVKAKKRKRDDNKDIDSEKEAAMEAEIKAARERAIVPLE
  ARMKQFKDMLLERGVSAFSTWEKELHKIVFDPRYLLLNPKERKQVFDQYVKTRAEEERRE
  KKNKIMQAKEDFKKMMEEAKFNPRATFSEFAAKHAKDSRFKAIEKMKDREALFNEFVAAA
  RKKEKEDSKTRGEKIKSDFFELLSNHHLDSQSRWSKVKDKVESDPRYKAVDSSSMREDLF
  KQYIEKIAKNLDSEKEKELERQARIEASLREREREVQKARSEQTKEIDREREQHKREEAI
  QNFKALLSDMVRSSDVSWSDTRRTLRKDHRWESGSLLEREEKEKLFNEHIEALTKKKREH
  FRQLLDETSAITLTSTWKEVKKIIKEDPRCIKFSSSDRKKQREFEEYIRDKYITAKADFR
  TLLKETKFITYRSKKLIQESDQHLKDVEKILQNDKRYLVLDCVPEERRKLIVAYVDDLDR
  RGPPPPPTASEPTRRSTK

• Sequence length: 1098

Pathways

KEGG Pathway:

Spliceosome

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Causal
Phenotype Name	Clinical Significance	dbSNP ID	RCV Accession	Evidence Score
Colorectal cancer	Pathogenic	rs1762720125	RCV001293848	★★★★☆ ClinVar: Pathogenic / Likely Pathogenic (<5 Variants)

Unknown / Other Associations
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
CHRONIC VENOUS HYPERTENSION	—	GWAS catalog	39024449	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
MIGRAINE DISORDER	—	GWAS catalog	23793025, 34294844, 35115687	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
RHEUMATOID ARTHRITIS	—	GWAS catalog	35793592	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
SCOLIOSIS	—	GWAS catalog	30019117	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining Show/Hide Text Mining Associations (8)
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Huntington Disease	Huntington Disease	BEFREE	12821179, 17018562, 27844289		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington Disease	LHGDN	17018562		★☆☆☆☆ Found in Text Mining only
Huntington Disease	Huntington disease	Pubtator	17018562	Associate	★☆☆☆☆ Found in Text Mining only
Multiple Sclerosis	Multiple sclerosis	Pubtator	31805175	Associate	★☆☆☆☆ Found in Text Mining only
Narcolepsy	Narcolepsy	GWASDB_DG	19629137		★☆☆☆☆ Found in Text Mining only
nervous system disorder	Nervous System Disorder	BEFREE	27844289		★☆☆☆☆ Found in Text Mining only
Neuroblastoma	Neuroblastoma	BEFREE	27844289		★☆☆☆☆ Found in Text Mining only
Neurodegenerative Disorders	Neurodegenerative Disorders	BEFREE	27844289		★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for TCERG1.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TCERG1.