TBRG1 (transforming growth factor beta regulator 1)
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Gene
Gene information from NCBI Gene database.
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| Entrez ID | 84897 |
| Gene name | Transforming growth factor beta regulator 1 |
| Gene symbol | TBRG1 |
| Synonyms (NCBI Gene) |
NIAMTB-5
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| Chromosome | 11 |
| Chromosome location | 11q24.2 |
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miRNA
miRNA information provided by mirtarbase database.
642
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Gene ontology (GO)
Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
11
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Other IDs
Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
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Protein
Protein information from UniProt database.
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UniProt ID
Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
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Q3YBR2 | |||||||||||||||
| Protein name | Transforming growth factor beta regulator 1 (Nuclear interactor of ARF and Mdm2) | |||||||||||||||
| Protein function | Acts as a growth inhibitor. Can activate p53/TP53, causes G1 arrest and collaborates with CDKN2A to restrict proliferation, but does not require either protein to inhibit DNA synthesis. Redistributes CDKN2A into the nucleoplasm. Involved in main | |||||||||||||||
| PDB | 2WZO | |||||||||||||||
| Family and domains |
Pfam
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| Tissue specificity | TISSUE SPECIFICITY: Widely expressed at low levels in most tissues, with highest levels in pancreas, lung and liver. Expression is decreased in primary tumors including lung, liver, breast, pancreas and kidney carcinomas, chronic lymphocytic leukemia and | |||||||||||||||
| Sequence |
MSLLDGLASSPRAPLQSSKARMKKLPKKSQNEKYRLKYLRLRKAAKATVFENAAICDEIA |
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| Sequence length | 411 | |||||||||||||||
| Interactions | View interactions | |||||||||||||||
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Associated diseases
Disease associations from ClinVar (causal & non-causal) and other databases (OMIM, Orphanet, GWAS, etc.).
2
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Evidence Score:
★☆☆☆☆ Gene-disease association found in Text Mining only
★★☆☆☆ Found in Text Mining and Unknown/Other Associations
★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources
★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)
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Related Genes
Genes most often co-reported with TBRG1 across shared curated disease and pathway associations.
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Diseases Linked via Similar Genes
Diseases curated for genes most similar to TBRG1 (see Related Genes above), that are NOT already directly curated for TBRG1 itself -- a lead worth checking, not a confirmed association.
0
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