Gene Gene information from NCBI Gene database. Download as csv Download as pdf
Entrez ID	1155
Gene name	Tubulin folding cofactor B
Gene symbol	TBCB
Synonyms (NCBI Gene)	CG22CKAP1CKAPI
Chromosome	19
Chromosome location	19q13.12

18 Show/Hide all (18)

miRTarBase ID	miRNA	Experiments	Reference
MIRT005195	hsa-miR-30a-5p	pSILAC	18668040
MIRT005195	hsa-miR-30a-5p	Proteomics;Other	18668040
MIRT043042	hsa-miR-324-5p	CLASH	23622248
MIRT040285	hsa-miR-615-3p	CLASH	23622248
MIRT1413955	hsa-miR-1909	CLIP-seq
MIRT1413956	hsa-miR-28-5p	CLIP-seq
MIRT1413957	hsa-miR-3139	CLIP-seq
MIRT1413958	hsa-miR-3160-3p	CLIP-seq
MIRT1413959	hsa-miR-4663	CLIP-seq
MIRT1413960	hsa-miR-610	CLIP-seq
MIRT1413961	hsa-miR-708	CLIP-seq
MIRT1413956	hsa-miR-28-5p	CLIP-seq
MIRT1413957	hsa-miR-3139	CLIP-seq
MIRT1413959	hsa-miR-4663	CLIP-seq
MIRT2124217	hsa-miR-4697-3p	CLIP-seq
MIRT2124218	hsa-miR-486-3p	CLIP-seq
MIRT1413960	hsa-miR-610	CLIP-seq
MIRT1413961	hsa-miR-708	CLIP-seq

18 Show/Hide all (18)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005515	Function	Protein binding	IPI	16303566, 16713569, 22777741, 28514442, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005737	Component	Cytoplasm	IDA	22777741
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IDA
GO:0005829	Component	Cytosol	IEA
GO:0005856	Component	Cytoskeleton	IEA
GO:0005874	Component	Microtubule	IEA
GO:0005938	Component	Cell cortex	IBA
GO:0007021	Process	Tubulin complex assembly	IEA
GO:0007023	Process	Post-chaperonin tubulin folding pathway	IEA
GO:0007399	Process	Nervous system development	IEA
GO:0015630	Component	Microtubule cytoskeleton	TAS	8978778
GO:0030154	Process	Cell differentiation	IEA
GO:0031122	Process	Cytoplasmic microtubule organization	IBA
GO:0035371	Component	Microtubule plus-end	IBA
GO:0043014	Function	Alpha-tubulin binding	IEA
GO:0051010	Function	Microtubule plus-end binding	IBA

MIM	HGNC	e!Ensembl
601303	1989	ENSG00000105254

Q99426

Protein name

Tubulin-folding cofactor B (Cytoskeleton-associated protein 1) (Cytoskeleton-associated protein CKAPI) (Tubulin-specific chaperone B)

Protein function

Binds to alpha-tubulin folding intermediates after their interaction with cytosolic chaperonin in the pathway leading from newly synthesized tubulin to properly folded heterodimer (PubMed:9265649). Involved in regulation of tubulin heterodimer d

Family and domains

Pfam

Accession	ID	Position in sequence	Description	Type
PF01302	CAP_GLY	161 → 229	CAP-Gly domain	Domain
PF14560	Ubiquitin_2	10 → 94	Ubiquitin-like domain	Domain

Tissue specificity

TISSUE SPECIFICITY: Found in most tissues.

Sequence

MEVTGVSAPTVTVFISSSLNTFRSEKRYSRSLTIAEFKCKLELLVGSPASCMELELYGVD
DKFYSKLDQEDALLGSYPVDDGCRIHVIDHSGARLGEYEDVSRVEKYTISQEAYDQRQDT
VRSFLKRSKLGRYNEEERAQQEAEAAQRLAEEKAQASSIPVGSRCEVRAAGQSPRRGTVM
YVGLTDFKPGYWIGVRYDEPLGKNDGSVNGKRYFECQAKYGAFVKPAVVTVGDFPEEDYG
LDEI

Sequence length

244

Interactions

View interactions

Evidence Score: ★☆☆☆☆ Gene-disease association found in Text Mining only ★★☆☆☆ Found in Text Mining and Unknown/Other Associations ★★★☆☆ Reported in Unknown/Other Associations across ≥2 Sources ★★★★☆ ClinVar: Pathogenic/Likely Pathogenic (<5 Variants) ★★★★★ ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Unknown / Other Associations ClinVar entries with uncertain/conflicting evidence, and associations from other databases (OMIM, Orphanet, GWAS, etc.) where the gene is not established as causal.
NEURODEVELOPMENTAL DISORDER WITH BEHAVIORAL ABNORMALITIES AND CHILDHOOD-ONSET SPASTIC PARAPLEGIA	Uncertain significance	ClinVar	—	★★★★★ ★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Associations from Text Mining Disease associations identified through text mining
Amyotrophic Lateral Sclerosis	Amyotrophic Lateral Sclerosis	BEFREE	30030593		★★★★★ ★☆☆☆☆ Found in Text Mining only
Schizophrenia	Schizophrenia	LHGDN	19165527		★★★★★ ★☆☆☆☆ Found in Text Mining only
Trigeminal Neuralgia	Trigeminal neuralgia	Pubtator	38158702	Associate	★★★★★ ★☆☆☆☆ Found in Text Mining only

Related Genes Genes most often co-reported with TBCB across shared curated disease and pathway associations. 0 Download as csv Download as pdf
No strongly related genes found yet for TBCB.

Diseases Linked via Similar Genes Diseases curated for genes most similar to TBCB (see Related Genes above), that are NOT already directly curated for TBCB itself -- a lead worth checking, not a confirmed association. 0 Download as csv Download as pdf
No additional diseases found yet through genes similar to TBCB.

TBCB (tubulin folding cofactor B)

Bookmark This Gene