TBC1D9B (TBC1 domain family member 9B)

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Gene miRNA Gene ontology Other IDs Protein Associated diseases Related genes Diseases linked via similar genes

Gene

• Entrez ID: 23061
• Gene name: TBC1 domain family member 9B
• Gene symbol: TBC1D9B
• Synonyms (NCBI Gene): GRAMD9B
• Chromosome: 5
• Chromosome location: 5q35.3

miRNA Show/Hide all (177)

miRTarBase ID	miRNA	Experiments	Reference
MIRT032112	hsa-let-7d-5p	Sequencing	20371350
MIRT049656	hsa-miR-92a-3p	CLASH	23622248
MIRT049656	hsa-miR-92a-3p	CLASH	23622248
MIRT044119	hsa-miR-30e-3p	CLASH	23622248
MIRT042393	hsa-miR-191-3p	CLASH	23622248
MIRT041369	hsa-miR-193b-3p	CLASH	23622248
MIRT039093	hsa-miR-769-3p	CLASH	23622248
MIRT036808	hsa-miR-877-3p	CLASH	23622248
MIRT036620	hsa-miR-940	CLASH	23622248
MIRT1413889	hsa-miR-18a	CLIP-seq
MIRT1413890	hsa-miR-18b	CLIP-seq
MIRT1413891	hsa-miR-1913	CLIP-seq
MIRT1413892	hsa-miR-216b	CLIP-seq
MIRT1413893	hsa-miR-324-3p	CLIP-seq
MIRT1413894	hsa-miR-34b	CLIP-seq
MIRT1413895	hsa-miR-4264	CLIP-seq
MIRT1413896	hsa-miR-4326	CLIP-seq
MIRT1413897	hsa-miR-4641	CLIP-seq
MIRT1413898	hsa-miR-4704-3p	CLIP-seq
MIRT1413899	hsa-miR-4716-5p	CLIP-seq
MIRT1413900	hsa-miR-4727-5p	CLIP-seq
MIRT1413901	hsa-miR-4735-3p	CLIP-seq
MIRT1413902	hsa-miR-4760-3p	CLIP-seq
MIRT1413903	hsa-miR-4795-3p	CLIP-seq
MIRT1413904	hsa-miR-513a-5p	CLIP-seq
MIRT1413905	hsa-miR-1261	CLIP-seq
MIRT1413906	hsa-miR-1266	CLIP-seq
MIRT1413907	hsa-miR-144	CLIP-seq
MIRT1413908	hsa-miR-153	CLIP-seq
MIRT1413889	hsa-miR-18a	CLIP-seq
MIRT1413890	hsa-miR-18b	CLIP-seq
MIRT1413909	hsa-miR-203	CLIP-seq
MIRT1413892	hsa-miR-216b	CLIP-seq
MIRT1413910	hsa-miR-3074-3p	CLIP-seq
MIRT1413911	hsa-miR-3126-5p	CLIP-seq
MIRT1413912	hsa-miR-3127-5p	CLIP-seq
MIRT1413913	hsa-miR-3148	CLIP-seq
MIRT1413914	hsa-miR-331-3p	CLIP-seq
MIRT1413894	hsa-miR-34b	CLIP-seq
MIRT1413915	hsa-miR-3646	CLIP-seq
MIRT1413916	hsa-miR-3670	CLIP-seq
MIRT1413917	hsa-miR-3691-5p	CLIP-seq
MIRT1413918	hsa-miR-3713	CLIP-seq
MIRT1413919	hsa-miR-3918	CLIP-seq
MIRT1413920	hsa-miR-3924	CLIP-seq
MIRT1413921	hsa-miR-3936	CLIP-seq
MIRT1413922	hsa-miR-4270	CLIP-seq
MIRT1413923	hsa-miR-4307	CLIP-seq
MIRT1413924	hsa-miR-4419a	CLIP-seq
MIRT1413925	hsa-miR-4436a	CLIP-seq
MIRT1413926	hsa-miR-4441	CLIP-seq
MIRT1413927	hsa-miR-4480	CLIP-seq
MIRT1413928	hsa-miR-4496	CLIP-seq
MIRT1413929	hsa-miR-4510	CLIP-seq
MIRT1413930	hsa-miR-4518	CLIP-seq
MIRT1413931	hsa-miR-4633-3p	CLIP-seq
MIRT1413932	hsa-miR-4662a-5p	CLIP-seq
MIRT1413933	hsa-miR-4718	CLIP-seq
MIRT1413901	hsa-miR-4735-3p	CLIP-seq
MIRT1413934	hsa-miR-4752	CLIP-seq
MIRT1413902	hsa-miR-4760-3p	CLIP-seq
MIRT1413935	hsa-miR-4760-5p	CLIP-seq
MIRT1413936	hsa-miR-4761-3p	CLIP-seq
MIRT1413937	hsa-miR-492	CLIP-seq
MIRT1413904	hsa-miR-513a-5p	CLIP-seq
MIRT1413938	hsa-miR-544b	CLIP-seq
MIRT1413939	hsa-miR-568	CLIP-seq
MIRT1413940	hsa-miR-586	CLIP-seq
MIRT1413908	hsa-miR-153	CLIP-seq
MIRT1413894	hsa-miR-34b	CLIP-seq
MIRT1413920	hsa-miR-3924	CLIP-seq
MIRT1413904	hsa-miR-513a-5p	CLIP-seq
MIRT1413940	hsa-miR-586	CLIP-seq
MIRT2124184	hsa-miR-1205	CLIP-seq
MIRT2124185	hsa-miR-1207-3p	CLIP-seq
MIRT2124186	hsa-miR-1228	CLIP-seq
MIRT2124187	hsa-miR-124	CLIP-seq
MIRT2124188	hsa-miR-1256	CLIP-seq
MIRT2124189	hsa-miR-1272	CLIP-seq
MIRT2124190	hsa-miR-128	CLIP-seq
MIRT2124191	hsa-miR-140-5p	CLIP-seq
MIRT1413889	hsa-miR-18a	CLIP-seq
MIRT1413890	hsa-miR-18b	CLIP-seq
MIRT2124192	hsa-miR-1914	CLIP-seq
MIRT2124193	hsa-miR-2278	CLIP-seq
MIRT2124194	hsa-miR-296-5p	CLIP-seq
MIRT1413910	hsa-miR-3074-3p	CLIP-seq
MIRT1413911	hsa-miR-3126-5p	CLIP-seq
MIRT1413912	hsa-miR-3127-5p	CLIP-seq
MIRT2124195	hsa-miR-3176	CLIP-seq
MIRT2124196	hsa-miR-3184	CLIP-seq
MIRT2124197	hsa-miR-3192	CLIP-seq
MIRT1413894	hsa-miR-34b	CLIP-seq
MIRT2124198	hsa-miR-3663-3p	CLIP-seq
MIRT2124199	hsa-miR-3664-5p	CLIP-seq
MIRT2124200	hsa-miR-3714	CLIP-seq
MIRT2124201	hsa-miR-3910	CLIP-seq
MIRT2124202	hsa-miR-3922-3p	CLIP-seq
MIRT1413920	hsa-miR-3924	CLIP-seq
MIRT2124203	hsa-miR-423-5p	CLIP-seq
MIRT2124204	hsa-miR-4268	CLIP-seq
MIRT1413922	hsa-miR-4270	CLIP-seq
MIRT2124205	hsa-miR-4302	CLIP-seq
MIRT1413923	hsa-miR-4307	CLIP-seq
MIRT2124206	hsa-miR-4313	CLIP-seq
MIRT1413924	hsa-miR-4419a	CLIP-seq
MIRT2124207	hsa-miR-4422	CLIP-seq
MIRT1413925	hsa-miR-4436a	CLIP-seq
MIRT1413926	hsa-miR-4441	CLIP-seq
MIRT2124208	hsa-miR-4459	CLIP-seq
MIRT2124209	hsa-miR-4477a	CLIP-seq
MIRT1413929	hsa-miR-4510	CLIP-seq
MIRT2124210	hsa-miR-4688	CLIP-seq
MIRT2124211	hsa-miR-4722-5p	CLIP-seq
MIRT1413901	hsa-miR-4735-3p	CLIP-seq
MIRT1413902	hsa-miR-4760-3p	CLIP-seq
MIRT2124212	hsa-miR-4779	CLIP-seq
MIRT1413937	hsa-miR-492	CLIP-seq
MIRT2124213	hsa-miR-506	CLIP-seq
MIRT1413904	hsa-miR-513a-5p	CLIP-seq
MIRT1413938	hsa-miR-544b	CLIP-seq
MIRT2124214	hsa-miR-556-5p	CLIP-seq
MIRT1413940	hsa-miR-586	CLIP-seq
MIRT2124215	hsa-miR-933	CLIP-seq
MIRT2124187	hsa-miR-124	CLIP-seq
MIRT2124188	hsa-miR-1256	CLIP-seq
MIRT2124190	hsa-miR-128	CLIP-seq
MIRT2346522	hsa-miR-141	CLIP-seq
MIRT1413889	hsa-miR-18a	CLIP-seq
MIRT1413890	hsa-miR-18b	CLIP-seq
MIRT2124192	hsa-miR-1914	CLIP-seq
MIRT2346523	hsa-miR-19a	CLIP-seq
MIRT2346524	hsa-miR-19b	CLIP-seq
MIRT2346525	hsa-miR-200a	CLIP-seq
MIRT1413892	hsa-miR-216b	CLIP-seq
MIRT1413910	hsa-miR-3074-3p	CLIP-seq
MIRT1413911	hsa-miR-3126-5p	CLIP-seq
MIRT1413912	hsa-miR-3127-5p	CLIP-seq
MIRT2346526	hsa-miR-3177-5p	CLIP-seq
MIRT1413894	hsa-miR-34b	CLIP-seq
MIRT2346527	hsa-miR-3654	CLIP-seq
MIRT2124198	hsa-miR-3663-3p	CLIP-seq
MIRT2124199	hsa-miR-3664-5p	CLIP-seq
MIRT2124200	hsa-miR-3714	CLIP-seq
MIRT2124201	hsa-miR-3910	CLIP-seq
MIRT2124204	hsa-miR-4268	CLIP-seq
MIRT1413922	hsa-miR-4270	CLIP-seq
MIRT1413923	hsa-miR-4307	CLIP-seq
MIRT1413924	hsa-miR-4419a	CLIP-seq
MIRT1413925	hsa-miR-4436a	CLIP-seq
MIRT1413926	hsa-miR-4441	CLIP-seq
MIRT2124209	hsa-miR-4477a	CLIP-seq
MIRT2346528	hsa-miR-4488	CLIP-seq
MIRT1413929	hsa-miR-4510	CLIP-seq
MIRT2346529	hsa-miR-4638-3p	CLIP-seq
MIRT2346530	hsa-miR-4691-3p	CLIP-seq
MIRT2346531	hsa-miR-4697-5p	CLIP-seq
MIRT1413901	hsa-miR-4735-3p	CLIP-seq
MIRT1413902	hsa-miR-4760-3p	CLIP-seq
MIRT1413937	hsa-miR-492	CLIP-seq
MIRT2124213	hsa-miR-506	CLIP-seq
MIRT1413904	hsa-miR-513a-5p	CLIP-seq
MIRT1413938	hsa-miR-544b	CLIP-seq
MIRT2124215	hsa-miR-933	CLIP-seq
MIRT2124184	hsa-miR-1205	CLIP-seq
MIRT2124185	hsa-miR-1207-3p	CLIP-seq
MIRT2639175	hsa-miR-1286	CLIP-seq
MIRT2639176	hsa-miR-140-3p	CLIP-seq
MIRT2639177	hsa-miR-22	CLIP-seq
MIRT1413911	hsa-miR-3126-5p	CLIP-seq
MIRT2124195	hsa-miR-3176	CLIP-seq
MIRT2124202	hsa-miR-3922-3p	CLIP-seq
MIRT2124207	hsa-miR-4422	CLIP-seq
MIRT2639178	hsa-miR-4534	CLIP-seq
MIRT2124211	hsa-miR-4722-5p	CLIP-seq
MIRT2639179	hsa-miR-4802-5p	CLIP-seq
MIRT2639180	hsa-miR-512-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (7)

GO ID	Ontology	Definition	Evidence	Reference
GO:0003008	Process	System process	IEA
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IEA
GO:0005509	Function	Calcium ion binding	IEA
GO:0005515	Function	Protein binding	IPI	22354992, 25416956
GO:0016020	Component	Membrane	IEA
GO:1902017	Process	Regulation of cilium assembly	IMP	17646400

Other IDs

• MIM: 618039
• HGNC: 29097
• e!Ensembl: ENSG00000197226

Protein

• UniProt ID: Q66K14
• Protein name: TBC1 domain family member 9B
• Protein function: May act as a GTPase-activating protein for Rab family protein(s).
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00566	RabGAP-TBC	511 → 715	Rab-GTPase-TBC domain	Family
  PF02893	GRAM	142 → 250	GRAM domain	Domain
  PF02893	GRAM	288 → 398	GRAM domain	Domain

• Sequence:

  MWLSPEEVLVANALWVTERANPFFVLQRRRGHGRGGGLTGLLVGTLDVVLDSSARVAPYR
  ILHQTQDSQVYWTVACGSSRKEITKHWEWLENNLLQTLSIFDSEEDITTFVKGKIHGIIA
  EENKNLQPQGDEDPGKFKEAELKMRKQFGMPEGEKLVNYYSCSYWKGRVPRQGWLYLTVN
  HLCFYSFLLGKEVSLVVQWVDITRLEKNATLLFPESIRVDTRDQELFFSMFLNIGETFKL
  MEQLANLAMRQLLDSEGFLEDKALPRPIRPHRNISALKRDLDARAKNECYRATFRLPRDE
  RLDGHTSCTLWTPFNKLHIPGQMFISNNYICFASKEEDACHLIIPLREVTIVEKADSSSV
  LPSPLSISTKSKMTFLFANLKDRDFLVQRISDFLQKTPSKQPGSIGSRKASVVDPSTESS
  PAPQEGSEQPASPASPLSSRQSFCAQEAPTASQGLLKLFQKNSPMEDLGAKGAKEKMKEE
  SWHIHFFEYGRGVCMYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMVTHPGYYAELVE
  KSTGKYSLATEEIERDLHRSMPEHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVT
  SVLLLYGSEEEAFWLLVALCERMLPDYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDL
  GVISSISLSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSDE
  GEAMTMLGRYLDNVVNKQSVSPPIPHLRALLSSSDDPPAEVDIFELLKVSYEKFSSLRAE
  DIEQMRFKQRLKVIQSLEDTAKRSVVRAIPVDIGFSIEELEDLYMVFKAKHLASQYWGCS
  RTMAGRRDPSLPYLEQYRIDASQFRELFASLTPWACGSHTPLLAGRMFRLLDENKDSLIN
  FKEFVTGMSGMYHGDLTEKLKVLYKLHLPPALSPEEAESALEAAHYFTEDSSSEASPLAS
  DLDLFLPWEAQEALPQEEQEGSGSEERGEEKGTSSPDYRHYLRMWAKEKEAQKETIKDLP
  KMNQEQFIELCKTLYNMFSEDPMEQDLYHAIATVASLLLRIGEVGKKFSARTGRKPRDCA
  TEEDEPPAPELHQDAARELQPPAAGDPQAKAGGDTHLGKAPQESQVVVEGGSGEGQGSPS
  QLLSDDETKDDMSMSSYSVVSTGSLQCEDLADDTVLVGGEACSPTARIGGTVDTDWCISF
  EQILASILTESVLVNFFEKRVDIGLKIKDQKKVERQFSTASDHEQPGVSG

• Sequence length: 1250

Associated diseases

Evidence Score:

• ★☆☆☆☆  Gene-disease association found in Text Mining only
• ★★☆☆☆  Found in Text Mining and Unknown/Other Associations
• ★★★☆☆  Reported in Unknown/Other Associations across ≥2 Sources
• ★★★★☆  ClinVar: Pathogenic/Likely Pathogenic (<5 Variants)
• ★★★★★  ClinVar: Pathogenic/Likely Pathogenic (≥5 Variants)

Unknown / Other Associations Show/Hide Unknown Diseases (11)
Phenotype Name	Clinical Significance	Source	Reference	Evidence Score
Acute myeloid leukemia	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Adrenocortical carcinoma, hereditary	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Colon adenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Familial cancer of breast	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Hepatocellular carcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Lung cancer	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Malignant tumor of esophagus	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Melanoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Ovarian serous cystadenocarcinoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Sarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations
Uterine carcinosarcoma	Benign	ClinVar	—	★★☆☆☆ Found in Text Mining + Unknown/Other Associations

Associations from Text Mining
Disease Name	Disease (Merged)	Source	PMID	Relationship Type	Evidence Score
Malignant neoplasm of breast	Breast Cancer	UNIPROT_DG			★☆☆☆☆ Found in Text Mining only
Moyamoya Disease	Moyamoya disease	Pubtator	40722175	Associate	★☆☆☆☆ Found in Text Mining only

Related Genes

No strongly related genes found yet for TBC1D9B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TBC1D9B.