TBC1D10B (TBC1 domain family member 10B)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 26000
• Gene name: TBC1 domain family member 10B
• Gene symbol: TBC1D10B
• Synonyms (NCBI Gene): EPI64B, FP2461
• Chromosome: 16
• Chromosome location: 16p11.2
• Summary: Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-act

miRNA Show/Hide all (230)

miRTarBase ID	miRNA	Experiments	Reference
MIRT045563	hsa-miR-149-5p	CLASH	23622248
MIRT043239	hsa-miR-324-5p	CLASH	23622248
MIRT038187	hsa-miR-151a-5p	CLASH	23622248
MIRT709183	hsa-miR-6871-5p	HITS-CLIP	19536157
MIRT709182	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709181	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709180	hsa-miR-2114-3p	HITS-CLIP	19536157
MIRT709179	hsa-miR-6823-3p	HITS-CLIP	19536157
MIRT709178	hsa-miR-4663	HITS-CLIP	19536157
MIRT709177	hsa-miR-6878-5p	HITS-CLIP	19536157
MIRT709176	hsa-miR-6731-5p	HITS-CLIP	19536157
MIRT709175	hsa-miR-8085	HITS-CLIP	19536157
MIRT709174	hsa-miR-30c-1-3p	HITS-CLIP	19536157
MIRT709173	hsa-miR-30c-2-3p	HITS-CLIP	19536157
MIRT709172	hsa-miR-6788-5p	HITS-CLIP	19536157
MIRT726381	hsa-miR-30a-5p	HITS-CLIP	22473208
MIRT726380	hsa-miR-30b-5p	HITS-CLIP	22473208
MIRT726379	hsa-miR-30c-5p	HITS-CLIP	22473208
MIRT726378	hsa-miR-30d-5p	HITS-CLIP	22473208
MIRT726377	hsa-miR-30e-5p	HITS-CLIP	22473208
MIRT709183	hsa-miR-6871-5p	HITS-CLIP	19536157
MIRT709182	hsa-miR-1199-5p	HITS-CLIP	19536157
MIRT709181	hsa-miR-6751-3p	HITS-CLIP	19536157
MIRT709180	hsa-miR-2114-3p	HITS-CLIP	19536157
MIRT709179	hsa-miR-6823-3p	HITS-CLIP	19536157
MIRT709178	hsa-miR-4663	HITS-CLIP	19536157
MIRT709177	hsa-miR-6878-5p	HITS-CLIP	19536157
MIRT709176	hsa-miR-6731-5p	HITS-CLIP	19536157
MIRT709175	hsa-miR-8085	HITS-CLIP	19536157
MIRT709174	hsa-miR-30c-1-3p	HITS-CLIP	19536157
MIRT709173	hsa-miR-30c-2-3p	HITS-CLIP	19536157
MIRT709172	hsa-miR-6788-5p	HITS-CLIP	19536157
MIRT1411899	hsa-miR-1275	CLIP-seq
MIRT1411900	hsa-miR-1321	CLIP-seq
MIRT1411901	hsa-miR-145	CLIP-seq
MIRT1411902	hsa-miR-148a	CLIP-seq
MIRT1411903	hsa-miR-148b	CLIP-seq
MIRT1411904	hsa-miR-152	CLIP-seq
MIRT1411905	hsa-miR-1825	CLIP-seq
MIRT1411906	hsa-miR-199a-5p	CLIP-seq
MIRT1411907	hsa-miR-199b-5p	CLIP-seq
MIRT1411908	hsa-miR-3115	CLIP-seq
MIRT1411909	hsa-miR-3123	CLIP-seq
MIRT1411910	hsa-miR-3127-3p	CLIP-seq
MIRT1411911	hsa-miR-3175	CLIP-seq
MIRT1411912	hsa-miR-3190	CLIP-seq
MIRT1411913	hsa-miR-3202	CLIP-seq
MIRT1411914	hsa-miR-330-3p	CLIP-seq
MIRT1411915	hsa-miR-331-3p	CLIP-seq
MIRT1411916	hsa-miR-337-3p	CLIP-seq
MIRT1411917	hsa-miR-342-5p	CLIP-seq
MIRT1411918	hsa-miR-3667-5p	CLIP-seq
MIRT1411919	hsa-miR-3670	CLIP-seq
MIRT1411920	hsa-miR-3685	CLIP-seq
MIRT1411921	hsa-miR-384	CLIP-seq
MIRT1411922	hsa-miR-4270	CLIP-seq
MIRT1411923	hsa-miR-4292	CLIP-seq
MIRT1411924	hsa-miR-4299	CLIP-seq
MIRT1411925	hsa-miR-4433	CLIP-seq
MIRT1411926	hsa-miR-4441	CLIP-seq
MIRT1411927	hsa-miR-4446-3p	CLIP-seq
MIRT1411928	hsa-miR-4447	CLIP-seq
MIRT1411929	hsa-miR-4472	CLIP-seq
MIRT1411930	hsa-miR-4488	CLIP-seq
MIRT1411931	hsa-miR-4495	CLIP-seq
MIRT1411932	hsa-miR-4525	CLIP-seq
MIRT1411933	hsa-miR-4533	CLIP-seq
MIRT1411934	hsa-miR-4633-3p	CLIP-seq
MIRT1411935	hsa-miR-4651	CLIP-seq
MIRT1411936	hsa-miR-4656	CLIP-seq
MIRT1411937	hsa-miR-4664-5p	CLIP-seq
MIRT1411938	hsa-miR-4665-5p	CLIP-seq
MIRT1411939	hsa-miR-4697-5p	CLIP-seq
MIRT1411940	hsa-miR-4710	CLIP-seq
MIRT1411941	hsa-miR-4721	CLIP-seq
MIRT1411942	hsa-miR-4723-5p	CLIP-seq
MIRT1411943	hsa-miR-4728-5p	CLIP-seq
MIRT1411944	hsa-miR-4739	CLIP-seq
MIRT1411945	hsa-miR-4756-5p	CLIP-seq
MIRT1411946	hsa-miR-4761-5p	CLIP-seq
MIRT1411947	hsa-miR-4792	CLIP-seq
MIRT1411948	hsa-miR-4795-5p	CLIP-seq
MIRT1411949	hsa-miR-486-3p	CLIP-seq
MIRT1411950	hsa-miR-518a-3p	CLIP-seq
MIRT1411951	hsa-miR-518b	CLIP-seq
MIRT1411952	hsa-miR-518c	CLIP-seq
MIRT1411953	hsa-miR-518d-3p	CLIP-seq
MIRT1411954	hsa-miR-518e	CLIP-seq
MIRT1411955	hsa-miR-518f	CLIP-seq
MIRT1411956	hsa-miR-549	CLIP-seq
MIRT1411957	hsa-miR-608	CLIP-seq
MIRT1411958	hsa-miR-624	CLIP-seq
MIRT1411959	hsa-miR-625	CLIP-seq
MIRT1411960	hsa-miR-7	CLIP-seq
MIRT1554464	hsa-miR-1286	CLIP-seq
MIRT1554465	hsa-miR-214	CLIP-seq
MIRT1554466	hsa-miR-3619-5p	CLIP-seq
MIRT1554467	hsa-miR-4419a	CLIP-seq
MIRT1554468	hsa-miR-4476	CLIP-seq
MIRT1554469	hsa-miR-4510	CLIP-seq
MIRT1554470	hsa-miR-4722-5p	CLIP-seq
MIRT1554471	hsa-miR-761	CLIP-seq
MIRT2123710	hsa-miR-146a	CLIP-seq
MIRT2123711	hsa-miR-146b-5p	CLIP-seq
MIRT2123712	hsa-miR-1909	CLIP-seq
MIRT2123713	hsa-miR-1915	CLIP-seq
MIRT1554465	hsa-miR-214	CLIP-seq
MIRT2123714	hsa-miR-2355-5p	CLIP-seq
MIRT2123715	hsa-miR-2861	CLIP-seq
MIRT1411913	hsa-miR-3202	CLIP-seq
MIRT1411917	hsa-miR-342-5p	CLIP-seq
MIRT1554466	hsa-miR-3619-5p	CLIP-seq
MIRT2123716	hsa-miR-3679-3p	CLIP-seq
MIRT2123717	hsa-miR-3936	CLIP-seq
MIRT2123718	hsa-miR-4251	CLIP-seq
MIRT2123719	hsa-miR-4300	CLIP-seq
MIRT2123720	hsa-miR-4323	CLIP-seq
MIRT2123721	hsa-miR-4324	CLIP-seq
MIRT2123722	hsa-miR-4436b-3p	CLIP-seq
MIRT1411928	hsa-miR-4447	CLIP-seq
MIRT1411929	hsa-miR-4472	CLIP-seq
MIRT1411930	hsa-miR-4488	CLIP-seq
MIRT1411933	hsa-miR-4533	CLIP-seq
MIRT2123723	hsa-miR-455-3p	CLIP-seq
MIRT1411934	hsa-miR-4633-3p	CLIP-seq
MIRT1411935	hsa-miR-4651	CLIP-seq
MIRT1411937	hsa-miR-4664-5p	CLIP-seq
MIRT2123724	hsa-miR-4685-5p	CLIP-seq
MIRT1411939	hsa-miR-4697-5p	CLIP-seq
MIRT2123725	hsa-miR-4802-5p	CLIP-seq
MIRT1411949	hsa-miR-486-3p	CLIP-seq
MIRT2123726	hsa-miR-589	CLIP-seq
MIRT1411957	hsa-miR-608	CLIP-seq
MIRT1554471	hsa-miR-761	CLIP-seq
MIRT2123727	hsa-miR-920	CLIP-seq
MIRT2123728	hsa-miR-939	CLIP-seq
MIRT2345755	hsa-miR-1233	CLIP-seq
MIRT1554465	hsa-miR-214	CLIP-seq
MIRT1411914	hsa-miR-330-3p	CLIP-seq
MIRT1554466	hsa-miR-3619-5p	CLIP-seq
MIRT2345756	hsa-miR-4435	CLIP-seq
MIRT2345757	hsa-miR-4712-3p	CLIP-seq
MIRT1411950	hsa-miR-518a-3p	CLIP-seq
MIRT1411951	hsa-miR-518b	CLIP-seq
MIRT1411952	hsa-miR-518c	CLIP-seq
MIRT1411953	hsa-miR-518d-3p	CLIP-seq
MIRT1411954	hsa-miR-518e	CLIP-seq
MIRT1411955	hsa-miR-518f	CLIP-seq
MIRT2345758	hsa-miR-579	CLIP-seq
MIRT2345759	hsa-miR-657	CLIP-seq
MIRT1554471	hsa-miR-761	CLIP-seq
MIRT1411899	hsa-miR-1275	CLIP-seq
MIRT1554465	hsa-miR-214	CLIP-seq
MIRT1411917	hsa-miR-342-5p	CLIP-seq
MIRT1554466	hsa-miR-3619-5p	CLIP-seq
MIRT1411932	hsa-miR-4525	CLIP-seq
MIRT1411935	hsa-miR-4651	CLIP-seq
MIRT1411937	hsa-miR-4664-5p	CLIP-seq
MIRT1411938	hsa-miR-4665-5p	CLIP-seq
MIRT1411942	hsa-miR-4723-5p	CLIP-seq
MIRT1411957	hsa-miR-608	CLIP-seq
MIRT1411959	hsa-miR-625	CLIP-seq
MIRT1554471	hsa-miR-761	CLIP-seq
MIRT1554465	hsa-miR-214	CLIP-seq
MIRT1554466	hsa-miR-3619-5p	CLIP-seq
MIRT1554467	hsa-miR-4419a	CLIP-seq
MIRT2461174	hsa-miR-4443	CLIP-seq
MIRT1554469	hsa-miR-4510	CLIP-seq
MIRT1554471	hsa-miR-761	CLIP-seq
MIRT2638746	hsa-miR-1301	CLIP-seq
MIRT2638747	hsa-miR-143	CLIP-seq
MIRT2638748	hsa-miR-18a	CLIP-seq
MIRT2638749	hsa-miR-18b	CLIP-seq
MIRT2638750	hsa-miR-2116	CLIP-seq
MIRT2638751	hsa-miR-22	CLIP-seq
MIRT2638752	hsa-miR-2467-5p	CLIP-seq
MIRT2638753	hsa-miR-3126-5p	CLIP-seq
MIRT2638754	hsa-miR-3153	CLIP-seq
MIRT2638755	hsa-miR-3189-3p	CLIP-seq
MIRT2638756	hsa-miR-4278	CLIP-seq
MIRT1554467	hsa-miR-4419a	CLIP-seq
MIRT1554469	hsa-miR-4510	CLIP-seq
MIRT2638757	hsa-miR-4640-5p	CLIP-seq
MIRT2638758	hsa-miR-4641	CLIP-seq
MIRT2638759	hsa-miR-4650-5p	CLIP-seq
MIRT1411935	hsa-miR-4651	CLIP-seq
MIRT2638760	hsa-miR-4660	CLIP-seq
MIRT2638761	hsa-miR-4677-5p	CLIP-seq
MIRT2345757	hsa-miR-4712-3p	CLIP-seq
MIRT2638762	hsa-miR-4716-3p	CLIP-seq
MIRT2638763	hsa-miR-4722-3p	CLIP-seq
MIRT2638764	hsa-miR-4726-5p	CLIP-seq
MIRT2638765	hsa-miR-4735-3p	CLIP-seq
MIRT2638766	hsa-miR-4755-3p	CLIP-seq
MIRT1411946	hsa-miR-4761-5p	CLIP-seq
MIRT2638767	hsa-miR-4770	CLIP-seq
MIRT2638768	hsa-miR-5047	CLIP-seq
MIRT2345758	hsa-miR-579	CLIP-seq
MIRT2638769	hsa-miR-583	CLIP-seq
MIRT1411957	hsa-miR-608	CLIP-seq
MIRT1411958	hsa-miR-624	CLIP-seq
MIRT2638770	hsa-miR-635	CLIP-seq
MIRT2638771	hsa-miR-647	CLIP-seq
MIRT2638746	hsa-miR-1301	CLIP-seq
MIRT2638747	hsa-miR-143	CLIP-seq
MIRT2638748	hsa-miR-18a	CLIP-seq
MIRT2638749	hsa-miR-18b	CLIP-seq
MIRT2638750	hsa-miR-2116	CLIP-seq
MIRT2638751	hsa-miR-22	CLIP-seq
MIRT2638752	hsa-miR-2467-5p	CLIP-seq
MIRT2638755	hsa-miR-3189-3p	CLIP-seq
MIRT2638756	hsa-miR-4278	CLIP-seq
MIRT2638757	hsa-miR-4640-5p	CLIP-seq
MIRT2638758	hsa-miR-4641	CLIP-seq
MIRT2638759	hsa-miR-4650-5p	CLIP-seq
MIRT1411935	hsa-miR-4651	CLIP-seq
MIRT2638760	hsa-miR-4660	CLIP-seq
MIRT2638761	hsa-miR-4677-5p	CLIP-seq
MIRT2345757	hsa-miR-4712-3p	CLIP-seq
MIRT2638762	hsa-miR-4716-3p	CLIP-seq
MIRT2638764	hsa-miR-4726-5p	CLIP-seq
MIRT2638765	hsa-miR-4735-3p	CLIP-seq
MIRT2638766	hsa-miR-4755-3p	CLIP-seq
MIRT1411946	hsa-miR-4761-5p	CLIP-seq
MIRT2638767	hsa-miR-4770	CLIP-seq
MIRT2638768	hsa-miR-5047	CLIP-seq
MIRT2345758	hsa-miR-579	CLIP-seq
MIRT1411957	hsa-miR-608	CLIP-seq
MIRT1411958	hsa-miR-624	CLIP-seq
MIRT2638770	hsa-miR-635	CLIP-seq

Gene ontology (GO) Show/Hide all (14)

GO ID	Ontology	Definition	Evidence	Reference
GO:0005096	Function	GTPase activator activity	IBA
GO:0005096	Function	GTPase activator activity	IDA	19077034
GO:0005096	Function	GTPase activator activity	IEA
GO:0005515	Function	Protein binding	IPI	22354992, 32296183
GO:0005737	Component	Cytoplasm	IEA
GO:0005829	Component	Cytosol	IEA
GO:0005886	Component	Plasma membrane	IDA	17562788
GO:0005886	Component	Plasma membrane	IEA
GO:0016020	Component	Membrane	IEA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IBA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IEA
GO:0042147	Process	Retrograde transport, endosome to Golgi	IMP	17562788
GO:0043087	Process	Regulation of GTPase activity	IDA	19077034
GO:1902017	Process	Regulation of cilium assembly	IMP	17646400

Other IDs

• MIM: 613620
• HGNC: 24510
• e!Ensembl: ENSG00000169221

Protein

• UniProt ID: Q4KMP7
• Protein name: TBC1 domain family member 10B (Rab27A-GAP-beta)
• Protein function: Acts as a GTPase-activating protein for RAB3A, RAB22A, RAB27A, and RAB35. Does not act on RAB2A and RAB6A.
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00566	RabGAP-TBC	363 → 565	Rab-GTPase-TBC domain	Family

• Sequence:

  METGTAPLVAPPRRHGAPAAPSPPPRGSRAGPVVVVAPGPPVTTATSAPVTLVAPGEARP
  AWVPGSAETSAPAPAPAPAPAPAVTGSTVVVLTLEASPEAPKPQLPSGPESPEPAAVAGV
  ETSRALAAGADSPKTEEARPSPAPGPGTPTGTPTRTPSRTAPGALTAKPPLAPKPGTTVA
  SGVTARSASGQVTGGHGAAAATSASAGQAPEDPSGPGTGPSGTCEAPVAVVTVTPAPEPA
  ENSQDLGSTSSLGPGISGPRGQAPDTLSYLDSVSLMSGTLESLADDVSSMGSDSEINGLA
  LRKTDKYGFLGGSQYSGSLESSIPVDVARQRELKWLDMFSNWDKWLSRRFQKVKLRCRKG
  IPSSLRAKAWQYLSNSKELLEQNPGKFEELERAPGDPKWLDVIEKDLHRQFPFHEMFAAR
  GGHGQQDLYRILKAYTIYRPDEGYCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLPGYY
  SAGLEAIQLDGEIFFALLRRASPLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRV
  WDMFFCEGVKIIFRVALVLLRHTLGSVEKLRSCQGMYETMEQLRNLPQQCMQEDFLVHEV
  TNLPVTEALIERENAAQLKKWRETRGELQYRPSRRLHGSRAIHEERRRQQPPLGPSSSLL
  SLPGLKSRGSRAAGGAPSPPPPVRRASAGPAPGPVVTAEGLHPSLPSPTGNSTPLGSSKE
  TRKQEKERQKQEKERQKQEKEREKERQKQEKEREKQEKEREKQEKERQKQEKKAQGRKLS
  LRRKADGPPGPHDGGDRPSAEARQDAYF

• Sequence length: 808

Pathways

Reactome Pathway:

TBC/RABGAPs

Related Genes

No strongly related genes found yet for TBC1D10B.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TBC1D10B.