TADA3 (transcriptional adaptor 3)

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Gene miRNA Gene ontology Other IDs Protein Pathways Related genes Diseases linked via similar genes

Gene

• Entrez ID: 10474
• Gene name: Transcriptional adaptor 3
• Gene symbol: TADA3
• Synonyms (NCBI Gene): ADA3, NGG1, STAF54, TADA3L, hADA3
• Chromosome: 3
• Chromosome location: 3p25.3
• Summary: DNA-binding transcriptional activator proteins increase the rate of transcription by interacting with the transcriptional machinery bound to the basal promoter in conjunction with adaptor proteins, possibly by acetylation and destabilization of nucleosome

miRNA Show/Hide all (190)

miRTarBase ID	miRNA	Experiments	Reference
MIRT028985	hsa-miR-26b-5p	Microarray	19088304
MIRT045064	hsa-miR-186-5p	CLASH	23622248
MIRT715395	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715394	hsa-miR-548ac	HITS-CLIP	19536157
MIRT715393	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT715392	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT715391	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT715390	hsa-miR-548z	HITS-CLIP	19536157
MIRT715389	hsa-miR-548aa	HITS-CLIP	19536157
MIRT715388	hsa-miR-548ap-3p	HITS-CLIP	19536157
MIRT715387	hsa-miR-548t-3p	HITS-CLIP	19536157
MIRT715386	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT715385	hsa-miR-4274	HITS-CLIP	19536157
MIRT715384	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT715383	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT715382	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT715381	hsa-miR-7703	HITS-CLIP	19536157
MIRT715380	hsa-miR-4325	HITS-CLIP	19536157
MIRT715379	hsa-miR-507	HITS-CLIP	19536157
MIRT715378	hsa-miR-557	HITS-CLIP	19536157
MIRT715395	hsa-miR-140-3p	HITS-CLIP	19536157
MIRT715394	hsa-miR-548ac	HITS-CLIP	19536157
MIRT715393	hsa-miR-548bb-3p	HITS-CLIP	19536157
MIRT715392	hsa-miR-548d-3p	HITS-CLIP	19536157
MIRT715391	hsa-miR-548h-3p	HITS-CLIP	19536157
MIRT715390	hsa-miR-548z	HITS-CLIP	19536157
MIRT715389	hsa-miR-548aa	HITS-CLIP	19536157
MIRT715388	hsa-miR-548ap-3p	HITS-CLIP	19536157
MIRT715387	hsa-miR-548t-3p	HITS-CLIP	19536157
MIRT715386	hsa-miR-497-3p	HITS-CLIP	19536157
MIRT715385	hsa-miR-4274	HITS-CLIP	19536157
MIRT715384	hsa-miR-4704-3p	HITS-CLIP	19536157
MIRT715383	hsa-miR-520d-5p	HITS-CLIP	19536157
MIRT715382	hsa-miR-524-5p	HITS-CLIP	19536157
MIRT715381	hsa-miR-7703	HITS-CLIP	19536157
MIRT715380	hsa-miR-4325	HITS-CLIP	19536157
MIRT715379	hsa-miR-507	HITS-CLIP	19536157
MIRT715378	hsa-miR-557	HITS-CLIP	19536157
MIRT1408877	hsa-miR-1193	CLIP-seq
MIRT1408878	hsa-miR-1252	CLIP-seq
MIRT1408879	hsa-miR-1276	CLIP-seq
MIRT1408880	hsa-miR-1321	CLIP-seq
MIRT1408881	hsa-miR-2861	CLIP-seq
MIRT1408882	hsa-miR-3125	CLIP-seq
MIRT1408883	hsa-miR-3162-5p	CLIP-seq
MIRT1408884	hsa-miR-3175	CLIP-seq
MIRT1408885	hsa-miR-3179	CLIP-seq
MIRT1408886	hsa-miR-3916	CLIP-seq
MIRT1408887	hsa-miR-4271	CLIP-seq
MIRT1408888	hsa-miR-4287	CLIP-seq
MIRT1408889	hsa-miR-4311	CLIP-seq
MIRT1408890	hsa-miR-4434	CLIP-seq
MIRT1408891	hsa-miR-4450	CLIP-seq
MIRT1408892	hsa-miR-4457	CLIP-seq
MIRT1408893	hsa-miR-4516	CLIP-seq
MIRT1408894	hsa-miR-4635	CLIP-seq
MIRT1408895	hsa-miR-4685-3p	CLIP-seq
MIRT1408896	hsa-miR-4717-5p	CLIP-seq
MIRT1408897	hsa-miR-4725-3p	CLIP-seq
MIRT1408898	hsa-miR-4739	CLIP-seq
MIRT1408899	hsa-miR-4756-5p	CLIP-seq
MIRT1408900	hsa-miR-4795-5p	CLIP-seq
MIRT1408901	hsa-miR-583	CLIP-seq
MIRT1408902	hsa-miR-1268	CLIP-seq
MIRT1408903	hsa-miR-1268b	CLIP-seq
MIRT1408904	hsa-miR-1273f	CLIP-seq
MIRT1408905	hsa-miR-143	CLIP-seq
MIRT1408906	hsa-miR-3122	CLIP-seq
MIRT1408907	hsa-miR-323-5p	CLIP-seq
MIRT1408908	hsa-miR-3613-3p	CLIP-seq
MIRT1408909	hsa-miR-3613-5p	CLIP-seq
MIRT1408910	hsa-miR-3689a-3p	CLIP-seq
MIRT1408911	hsa-miR-3689c	CLIP-seq
MIRT1408912	hsa-miR-3913-5p	CLIP-seq
MIRT1408913	hsa-miR-3978	CLIP-seq
MIRT1408914	hsa-miR-4486	CLIP-seq
MIRT1408915	hsa-miR-4639-3p	CLIP-seq
MIRT1408916	hsa-miR-4684-5p	CLIP-seq
MIRT1408917	hsa-miR-4708-5p	CLIP-seq
MIRT1408918	hsa-miR-4728-5p	CLIP-seq
MIRT1408919	hsa-miR-4770	CLIP-seq
MIRT1408920	hsa-miR-541	CLIP-seq
MIRT1408921	hsa-miR-548c-3p	CLIP-seq
MIRT1408922	hsa-miR-585	CLIP-seq
MIRT1408923	hsa-miR-654-5p	CLIP-seq
MIRT1408924	hsa-miR-876-3p	CLIP-seq
MIRT1408877	hsa-miR-1193	CLIP-seq
MIRT1554387	hsa-miR-1275	CLIP-seq
MIRT1408879	hsa-miR-1276	CLIP-seq
MIRT1554388	hsa-miR-1912	CLIP-seq
MIRT1408882	hsa-miR-3125	CLIP-seq
MIRT1554389	hsa-miR-3667-5p	CLIP-seq
MIRT1408886	hsa-miR-3916	CLIP-seq
MIRT1408887	hsa-miR-4271	CLIP-seq
MIRT1408889	hsa-miR-4311	CLIP-seq
MIRT1554390	hsa-miR-4447	CLIP-seq
MIRT1554391	hsa-miR-4472	CLIP-seq
MIRT1554392	hsa-miR-4481	CLIP-seq
MIRT1554393	hsa-miR-4525	CLIP-seq
MIRT1554394	hsa-miR-4665-5p	CLIP-seq
MIRT1554395	hsa-miR-4723-5p	CLIP-seq
MIRT1408897	hsa-miR-4725-3p	CLIP-seq
MIRT1554396	hsa-miR-4745-5p	CLIP-seq
MIRT1408901	hsa-miR-583	CLIP-seq
MIRT1554397	hsa-miR-625	CLIP-seq
MIRT1554398	hsa-miR-7	CLIP-seq
MIRT2122645	hsa-miR-1245b-5p	CLIP-seq
MIRT2122646	hsa-miR-1266	CLIP-seq
MIRT2122647	hsa-miR-1914	CLIP-seq
MIRT2122648	hsa-miR-214	CLIP-seq
MIRT1408881	hsa-miR-2861	CLIP-seq
MIRT2122649	hsa-miR-3142	CLIP-seq
MIRT2122650	hsa-miR-3155	CLIP-seq
MIRT2122651	hsa-miR-3155b	CLIP-seq
MIRT2122652	hsa-miR-3158-3p	CLIP-seq
MIRT1408883	hsa-miR-3162-5p	CLIP-seq
MIRT1408884	hsa-miR-3175	CLIP-seq
MIRT1408885	hsa-miR-3179	CLIP-seq
MIRT2122653	hsa-miR-3202	CLIP-seq
MIRT2122654	hsa-miR-323b-5p	CLIP-seq
MIRT1408909	hsa-miR-3613-5p	CLIP-seq
MIRT2122655	hsa-miR-3619-5p	CLIP-seq
MIRT2122656	hsa-miR-3657	CLIP-seq
MIRT1408887	hsa-miR-4271	CLIP-seq
MIRT1408888	hsa-miR-4287	CLIP-seq
MIRT1408890	hsa-miR-4434	CLIP-seq
MIRT1408891	hsa-miR-4450	CLIP-seq
MIRT1408893	hsa-miR-4516	CLIP-seq
MIRT2122657	hsa-miR-4518	CLIP-seq
MIRT2122658	hsa-miR-4530	CLIP-seq
MIRT1408894	hsa-miR-4635	CLIP-seq
MIRT2122659	hsa-miR-4669	CLIP-seq
MIRT1408895	hsa-miR-4685-3p	CLIP-seq
MIRT1408897	hsa-miR-4725-3p	CLIP-seq
MIRT2122660	hsa-miR-4747-5p	CLIP-seq
MIRT2122661	hsa-miR-484	CLIP-seq
MIRT2122662	hsa-miR-516a-3p	CLIP-seq
MIRT2122663	hsa-miR-761	CLIP-seq
MIRT1408887	hsa-miR-4271	CLIP-seq
MIRT1408897	hsa-miR-4725-3p	CLIP-seq
MIRT1408902	hsa-miR-1268	CLIP-seq
MIRT1408903	hsa-miR-1268b	CLIP-seq
MIRT1408906	hsa-miR-3122	CLIP-seq
MIRT2461060	hsa-miR-3165	CLIP-seq
MIRT1408907	hsa-miR-323-5p	CLIP-seq
MIRT1408908	hsa-miR-3613-3p	CLIP-seq
MIRT2461061	hsa-miR-3656	CLIP-seq
MIRT1408910	hsa-miR-3689a-3p	CLIP-seq
MIRT1408911	hsa-miR-3689c	CLIP-seq
MIRT1408912	hsa-miR-3913-5p	CLIP-seq
MIRT1408914	hsa-miR-4486	CLIP-seq
MIRT1408916	hsa-miR-4684-5p	CLIP-seq
MIRT1408918	hsa-miR-4728-5p	CLIP-seq
MIRT1408920	hsa-miR-541	CLIP-seq
MIRT1408921	hsa-miR-548c-3p	CLIP-seq
MIRT2461062	hsa-miR-550a	CLIP-seq
MIRT1408922	hsa-miR-585	CLIP-seq
MIRT1408923	hsa-miR-654-5p	CLIP-seq
MIRT1408924	hsa-miR-876-3p	CLIP-seq
MIRT1408902	hsa-miR-1268	CLIP-seq
MIRT1408903	hsa-miR-1268b	CLIP-seq
MIRT1408906	hsa-miR-3122	CLIP-seq
MIRT1408908	hsa-miR-3613-3p	CLIP-seq
MIRT1408910	hsa-miR-3689a-3p	CLIP-seq
MIRT1408911	hsa-miR-3689c	CLIP-seq
MIRT1408912	hsa-miR-3913-5p	CLIP-seq
MIRT1408914	hsa-miR-4486	CLIP-seq
MIRT1408916	hsa-miR-4684-5p	CLIP-seq
MIRT1408918	hsa-miR-4728-5p	CLIP-seq
MIRT1408921	hsa-miR-548c-3p	CLIP-seq
MIRT1408922	hsa-miR-585	CLIP-seq
MIRT1408878	hsa-miR-1252	CLIP-seq
MIRT2122647	hsa-miR-1914	CLIP-seq
MIRT2638120	hsa-miR-1972	CLIP-seq
MIRT1408881	hsa-miR-2861	CLIP-seq
MIRT2638121	hsa-miR-3074-5p	CLIP-seq
MIRT1408888	hsa-miR-4287	CLIP-seq
MIRT2638122	hsa-miR-4293	CLIP-seq
MIRT1408895	hsa-miR-4685-3p	CLIP-seq
MIRT1408896	hsa-miR-4717-5p	CLIP-seq
MIRT1408900	hsa-miR-4795-5p	CLIP-seq
MIRT1408878	hsa-miR-1252	CLIP-seq
MIRT2122647	hsa-miR-1914	CLIP-seq
MIRT2638120	hsa-miR-1972	CLIP-seq
MIRT1408881	hsa-miR-2861	CLIP-seq
MIRT2638121	hsa-miR-3074-5p	CLIP-seq
MIRT1408888	hsa-miR-4287	CLIP-seq
MIRT1408895	hsa-miR-4685-3p	CLIP-seq
MIRT1408896	hsa-miR-4717-5p	CLIP-seq
MIRT1408900	hsa-miR-4795-5p	CLIP-seq

Gene ontology (GO) Show/Hide all (48)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000122	Process	Negative regulation of transcription by RNA polymerase II	IDA	18838386
GO:0000124	Component	SAGA complex	IBA
GO:0000124	Component	SAGA complex	IDA	11564863
GO:0000124	Component	SAGA complex	IEA
GO:0000124	Component	SAGA complex	NAS	9674425, 19114550
GO:0000278	Process	Mitotic cell cycle	IEA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IDA	11564863, 20413580
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0005515	Function	Protein binding	IPI	15383276, 16189514, 22644376, 24981860, 25416956, 26496610, 26871637, 28514442, 29232376, 29534157, 32296183, 32814053, 33961781
GO:0005634	Component	Nucleus	IDA	11564863
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	9674425
GO:0005654	Component	Nucleoplasm	IDA
GO:0005654	Component	Nucleoplasm	TAS
GO:0006282	Process	Regulation of DNA repair	NAS	11406595, 11564863
GO:0006325	Process	Chromatin organization	IEA
GO:0006355	Process	Regulation of DNA-templated transcription	IMP	19936620
GO:0006355	Process	Regulation of DNA-templated transcription	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	17694077
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	9603525, 22055187
GO:0006357	Process	Regulation of transcription by RNA polymerase II	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	9674425
GO:0010628	Process	Positive regulation of gene expression	IMP	20413580
GO:0016922	Function	Nuclear receptor binding	IPI	20413580
GO:0019904	Function	Protein domain specific binding	IPI	20413580
GO:0030520	Process	Estrogen receptor signaling pathway	TAS	20413580
GO:0031647	Process	Regulation of protein stability	IEA
GO:0033276	Component	Transcription factor TFTC complex	IDA	10373431
GO:0033276	Component	Transcription factor TFTC complex	NAS	10373431
GO:0043484	Process	Regulation of RNA splicing	NAS	11564863
GO:0045893	Process	Positive regulation of DNA-templated transcription	IDA	20413580
GO:0045893	Process	Positive regulation of DNA-templated transcription	NAS	18206972
GO:0045995	Process	Regulation of embryonic development	IEA
GO:0045995	Process	Regulation of embryonic development	ISO
GO:0045995	Process	Regulation of embryonic development	ISS
GO:0051302	Process	Regulation of cell division	IDA	20562830
GO:0051302	Process	Regulation of cell division	IEA
GO:0051302	Process	Regulation of cell division	ISS
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	19103755
GO:0051726	Process	Regulation of cell cycle	ISS
GO:0072686	Component	Mitotic spindle	IEA
GO:0072686	Component	Mitotic spindle	NAS	20562830
GO:0140672	Component	ATAC complex	IDA	18838386, 19936620
GO:0140672	Component	ATAC complex	IEA
GO:0140672	Component	ATAC complex	ISO

Other IDs

• MIM: 602945
• HGNC: 19422
• e!Ensembl: ENSG00000171148

Protein

• UniProt ID: O75528
• Protein name: Transcriptional adapter 3 (ADA3 homolog) (hADA3) (STAF54) (Transcriptional adapter 3-like) (ADA3-like protein)
• Protein function: Functions as a component of the PCAF complex. The PCAF complex is capable of efficiently acetylating histones in a nucleosomal context. The PCAF complex could be considered as the human version of the yeast SAGA complex. Also known as a coactiva
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF10198	Ada3	309 → 428	Histone acetyltransferases subunit 3	Family

• Tissue specificity: TISSUE SPECIFICITY: Ubiquitously expressed.
• Sequence:

  MSELKDCPLQFHDFKSVDHLKVCPRYTAVLARSEDDGIGIEELDTLQLELETLLSSASRR
  LRVLEAETQILTDWQDKKGDRRFLKLGRDHELGAPPKHGKPKKQKLEGKAGHGPGPGPGR
  PKSKNLQPKIQEYEFTDDPIDVPRIPKNDAPNRFWASVEPYCADITSEEVRTLEELLKPP
  EDEAEHYKIPPLGKHYSQRWAQEDLLEEQKDGARAAAVADKKKGLMGPLTELDTKDVDAL
  LKKSEAQHEQPEDGCPFGALTQRLLQALVEENIISPMEDSPIPDMSGKESGADGASTSPR
  NQNKPFSVPHTKSLESRIKEELIAQGLLESEDRPAEDSEDEVLAELRKRQAELKALSAHN
  RTKKHDLLRLAKEEVSRQELRQRVRMADNEVMDAFRKIMAARQKKRTPTKKEKDQAWKTL
  KERESILKLLDG

• Sequence length: 432

Pathways

KEGG Pathway:

Human papillomavirus infection

Reactome Pathway:

Ub-specific processing proteases

Related Genes

No strongly related genes found yet for TADA3.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TADA3.