TADA2A (transcriptional adaptor 2A)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6871
• Gene name: Transcriptional adaptor 2A
• Gene symbol: TADA2A
• Synonyms (NCBI Gene): ADA2, ADA2A, KL04P, TADA2L, hADA2
• Chromosome: 17
• Chromosome location: 17q12
• Summary: Many DNA-binding transcriptional activator proteins enhance the initiation rate of RNA polymerase II-mediated gene transcription by interacting functionally with the general transcription machinery bound at the basal promoter. Adaptor proteins are usually

miRNA Show/Hide all (86)

miRTarBase ID	miRNA	Experiments	Reference
MIRT709406	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT709405	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT709404	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT709403	hsa-miR-4711-3p	HITS-CLIP	19536157
MIRT709402	hsa-miR-5696	HITS-CLIP	19536157
MIRT709401	hsa-miR-579-3p	HITS-CLIP	19536157
MIRT709400	hsa-miR-664b-3p	HITS-CLIP	19536157
MIRT709399	hsa-miR-511-5p	HITS-CLIP	19536157
MIRT709398	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT662368	hsa-miR-541-5p	HITS-CLIP	23824327
MIRT662367	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT662366	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT662365	hsa-miR-3145-3p	HITS-CLIP	23824327
MIRT662364	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT662363	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT662362	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT644523	hsa-miR-302f	HITS-CLIP	23824327
MIRT644522	hsa-miR-154-3p	HITS-CLIP	23824327
MIRT644521	hsa-miR-487a-3p	HITS-CLIP	23824327
MIRT644520	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT644519	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT644518	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT644517	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT644516	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT644515	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT644514	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT644513	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT644512	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT644511	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT644510	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT533983	hsa-miR-452-5p	PAR-CLIP	22012620
MIRT533981	hsa-miR-4676-3p	PAR-CLIP	22012620
MIRT533982	hsa-miR-892c-3p	PAR-CLIP	22012620
MIRT533978	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT533980	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT533979	hsa-miR-873-3p	PAR-CLIP	22012620
MIRT533977	hsa-miR-6832-5p	PAR-CLIP	22012620
MIRT533978	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT533976	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT533974	hsa-miR-5096	PAR-CLIP	22012620
MIRT735835	hsa-miR-374a-3p	Luciferase reporter assay, Western blotting, qRT-PCR	32799891
MIRT709406	hsa-miR-188-5p	HITS-CLIP	19536157
MIRT709405	hsa-miR-6866-3p	HITS-CLIP	19536157
MIRT709404	hsa-miR-6830-3p	HITS-CLIP	19536157
MIRT709403	hsa-miR-4711-3p	HITS-CLIP	19536157
MIRT709402	hsa-miR-5696	HITS-CLIP	19536157
MIRT709401	hsa-miR-579-3p	HITS-CLIP	19536157
MIRT709400	hsa-miR-664b-3p	HITS-CLIP	19536157
MIRT709399	hsa-miR-511-5p	HITS-CLIP	19536157
MIRT709398	hsa-miR-335-3p	HITS-CLIP	19536157
MIRT662368	hsa-miR-541-5p	HITS-CLIP	23824327
MIRT662367	hsa-miR-3127-3p	HITS-CLIP	23824327
MIRT662366	hsa-miR-6756-3p	HITS-CLIP	23824327
MIRT662365	hsa-miR-3145-3p	HITS-CLIP	23824327
MIRT662364	hsa-miR-6875-3p	HITS-CLIP	23824327
MIRT662363	hsa-miR-4659a-3p	HITS-CLIP	23824327
MIRT662362	hsa-miR-4659b-3p	HITS-CLIP	23824327
MIRT644523	hsa-miR-302f	HITS-CLIP	23824327
MIRT644522	hsa-miR-154-3p	HITS-CLIP	23824327
MIRT644521	hsa-miR-487a-3p	HITS-CLIP	23824327
MIRT644520	hsa-miR-153-5p	HITS-CLIP	23824327
MIRT644519	hsa-miR-7110-3p	HITS-CLIP	23824327
MIRT644518	hsa-miR-6817-3p	HITS-CLIP	23824327
MIRT644517	hsa-miR-6515-3p	HITS-CLIP	23824327
MIRT644516	hsa-miR-1236-3p	HITS-CLIP	23824327
MIRT644515	hsa-miR-4769-3p	HITS-CLIP	23824327
MIRT644514	hsa-miR-6817-5p	HITS-CLIP	23824327
MIRT644513	hsa-miR-942-5p	HITS-CLIP	23824327
MIRT644512	hsa-miR-4684-5p	HITS-CLIP	23824327
MIRT644511	hsa-miR-6873-3p	HITS-CLIP	23824327
MIRT644510	hsa-miR-4727-5p	HITS-CLIP	23824327
MIRT533983	hsa-miR-452-5p	PAR-CLIP	22012620
MIRT533981	hsa-miR-4676-3p	PAR-CLIP	22012620
MIRT533982	hsa-miR-892c-3p	PAR-CLIP	22012620
MIRT533978	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT533980	hsa-miR-4716-5p	PAR-CLIP	22012620
MIRT533979	hsa-miR-873-3p	PAR-CLIP	22012620
MIRT533977	hsa-miR-6832-5p	PAR-CLIP	22012620
MIRT533978	hsa-miR-411-5p	PAR-CLIP	22012620
MIRT533976	hsa-miR-197-3p	PAR-CLIP	22012620
MIRT533974	hsa-miR-5096	PAR-CLIP	22012620
MIRT2344984	hsa-miR-1207-3p	CLIP-seq
MIRT2344985	hsa-miR-1279	CLIP-seq
MIRT2344986	hsa-miR-365	CLIP-seq
MIRT2344987	hsa-miR-3925-3p	CLIP-seq
MIRT2344988	hsa-miR-766	CLIP-seq

Gene ontology (GO) Show/Hide all (38)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000124	Component	SAGA complex	IDA	9674425
GO:0000124	Component	SAGA complex	NAS	9674425
GO:0003677	Function	DNA binding	IEA
GO:0003682	Function	Chromatin binding	IBA
GO:0003713	Function	Transcription coactivator activity	IBA
GO:0003713	Function	Transcription coactivator activity	IEA
GO:0004402	Function	Histone acetyltransferase activity	IDA	9674425
GO:0005515	Function	Protein binding	IPI	16189514, 20508642, 20562830, 22644376, 25416956, 26871637, 29232376, 32296183, 32911434, 33961781
GO:0005634	Component	Nucleus	IBA
GO:0005634	Component	Nucleus	IEA
GO:0005634	Component	Nucleus	TAS	8552087
GO:0005654	Component	Nucleoplasm	TAS
GO:0005694	Component	Chromosome	IEA
GO:0006338	Process	Chromatin remodeling	IBA
GO:0006355	Process	Regulation of DNA-templated transcription	IMP	19936620
GO:0006355	Process	Regulation of DNA-templated transcription	ISS
GO:0006355	Process	Regulation of DNA-templated transcription	NAS	17694077
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IBA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IDA	22055187
GO:0006357	Process	Regulation of transcription by RNA polymerase II	IEA
GO:0006357	Process	Regulation of transcription by RNA polymerase II	ISS
GO:0006357	Process	Regulation of transcription by RNA polymerase II	TAS	8552087
GO:0008270	Function	Zinc ion binding	IEA
GO:0045893	Process	Positive regulation of DNA-templated transcription	IEA
GO:0045995	Process	Regulation of embryonic development	ISO
GO:0045995	Process	Regulation of embryonic development	ISS
GO:0046872	Function	Metal ion binding	IEA
GO:0051302	Process	Regulation of cell division	IDA	20562830
GO:0051302	Process	Regulation of cell division	IEA
GO:0051302	Process	Regulation of cell division	ISS
GO:0051726	Process	Regulation of cell cycle	IEA
GO:0051726	Process	Regulation of cell cycle	IMP	19103755
GO:0051726	Process	Regulation of cell cycle	ISS
GO:0070461	Component	SAGA-type complex	IBA
GO:0072686	Component	Mitotic spindle	NAS	20562830
GO:0140672	Component	ATAC complex	IDA	19936620
GO:0140672	Component	ATAC complex	IEA
GO:0140672	Component	ATAC complex	ISO

Other IDs

• MIM: 602276
• HGNC: 11531
• e!Ensembl: ENSG00000276234

Protein

• UniProt ID: O75478
• Protein name: Transcriptional adapter 2-alpha (Transcriptional adapter 2-like) (ADA2-like protein)
• Protein function: Component of the ATAC complex, a complex with histone acetyltransferase activity on histones H3 and H4. Required for the function of some acidic activation domains, which activate transcription from a distant site (By similarity). Binds double-s
• PDB: 1X41
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00249	Myb_DNA-binding	72 → 118	Myb-like DNA-binding domain	Domain
  PF04433	SWIRM	371 → 442	SWIRM domain	Domain

• Tissue specificity: TISSUE SPECIFICITY: Expressed in all tissues, but most abundantly in testis.
• Sequence:

  MDRLGPFSNDPSDKPPCRGCSSYLMEPYIKCAECGPPPFFLCLQCFTRGFEYKKHQSDHT
  YEIMTSDFPVLDPSWTAQEEMALLEAVMDCGFGNWQDVANQMCTKTKEECEKHYMKHFIN
  NPLFASTLLNLKQAEEAKTADTAIPFHSTDDPPRPTFDSLLSRDMAGYMPARADFIEEFD
  NYAEWDLRDIDFVEDDSDILHALKMAVVDIYHSRLKERQRRKKIIRDHGLINLRKFQLME
  RRYPKEVQDLYETMRRFARIVGPVEHDKFIESHALEFELRREIKRLQEYRTAGITNFCSA
  RTYDHLKKTREEERLKRTMLSEVLQYIQDSSACQQWLRRQADIDSGLSPSIPMASNSGRR
  SAPPLNLTGLPGTEKLNEKEKELCQMVRLVPGAYLEYKSALLNECNKQGGLRLAQARALI
  KIDVNKTRKIYDFLIREGYITKG

• Sequence length: 443

Related Genes

No strongly related genes found yet for TADA2A.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to TADA2A.