SYTL4 (synaptotagmin like 4)

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Gene miRNA Transcription factors Gene ontology Other IDs Protein Pathways Diseases linked via similar genes

Gene

• Entrez ID: 94121
• Gene name: Synaptotagmin like 4
• Gene symbol: SYTL4
• Synonyms (NCBI Gene): SLP4
• Chromosome: X
• Chromosome location: Xq22.1
• Summary: This gene encodes a member of the synaptotagmin like protein family. Members of this family are characterized by an N-terminal Rab27 binding domain and C-terminal tandem C2 domains. The encoded protein binds specific small Rab GTPases and is involved in i

miRNA Show/Hide all (235)

miRTarBase ID	miRNA	Experiments	Reference
MIRT713612	hsa-miR-301a-5p	HITS-CLIP	19536157
MIRT713611	hsa-miR-301b-5p	HITS-CLIP	19536157
MIRT713610	hsa-miR-4750-3p	HITS-CLIP	19536157
MIRT713609	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT713608	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT713607	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT713606	hsa-miR-3661	HITS-CLIP	19536157
MIRT713605	hsa-miR-631	HITS-CLIP	19536157
MIRT713604	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT713603	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT713602	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT713601	hsa-miR-4256	HITS-CLIP	19536157
MIRT713600	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT713599	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT713598	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616937	hsa-miR-8485	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT665976	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT665975	hsa-miR-4457	HITS-CLIP	23824327
MIRT665974	hsa-miR-125b-2-3p	HITS-CLIP	23824327
MIRT645632	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT645635	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT645634	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT645633	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT645632	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT645631	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT645630	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT645629	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT634283	hsa-miR-4643	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT634282	hsa-miR-466	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616937	hsa-miR-8485	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT616938	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT616938	hsa-miR-329-3p	HITS-CLIP	27418678
MIRT616939	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT616939	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT616939	hsa-miR-362-3p	HITS-CLIP	27418678
MIRT616934	hsa-miR-3941	HITS-CLIP	27418678
MIRT616934	hsa-miR-3941	HITS-CLIP	27418678
MIRT616934	hsa-miR-3941	HITS-CLIP	27418678
MIRT634283	hsa-miR-4643	HITS-CLIP	27418678
MIRT634282	hsa-miR-466	HITS-CLIP	27418678
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	27418678
MIRT616936	hsa-miR-603	HITS-CLIP	27418678
MIRT616936	hsa-miR-603	HITS-CLIP	27418678
MIRT616936	hsa-miR-603	HITS-CLIP	27418678
MIRT616937	hsa-miR-8485	HITS-CLIP	27418678
MIRT616937	hsa-miR-8485	HITS-CLIP	27418678
MIRT616937	hsa-miR-8485	HITS-CLIP	27418678
MIRT713612	hsa-miR-301a-5p	HITS-CLIP	19536157
MIRT713611	hsa-miR-301b-5p	HITS-CLIP	19536157
MIRT713610	hsa-miR-4750-3p	HITS-CLIP	19536157
MIRT713609	hsa-miR-412-3p	HITS-CLIP	19536157
MIRT713608	hsa-miR-6754-3p	HITS-CLIP	19536157
MIRT713607	hsa-miR-6837-3p	HITS-CLIP	19536157
MIRT713606	hsa-miR-3661	HITS-CLIP	19536157
MIRT713605	hsa-miR-631	HITS-CLIP	19536157
MIRT713604	hsa-miR-7111-3p	HITS-CLIP	19536157
MIRT713603	hsa-miR-6780a-3p	HITS-CLIP	19536157
MIRT713602	hsa-miR-6881-3p	HITS-CLIP	19536157
MIRT713601	hsa-miR-4256	HITS-CLIP	19536157
MIRT713600	hsa-miR-6875-3p	HITS-CLIP	19536157
MIRT713599	hsa-miR-4659a-3p	HITS-CLIP	19536157
MIRT713598	hsa-miR-4659b-3p	HITS-CLIP	19536157
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616937	hsa-miR-8485	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT665976	hsa-miR-3680-5p	HITS-CLIP	23824327
MIRT665975	hsa-miR-4457	HITS-CLIP	23824327
MIRT665974	hsa-miR-125b-2-3p	HITS-CLIP	23824327
MIRT645632	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT645635	hsa-miR-3120-5p	HITS-CLIP	23824327
MIRT645634	hsa-miR-6895-3p	HITS-CLIP	23824327
MIRT645633	hsa-miR-593-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT645632	hsa-miR-513b-5p	HITS-CLIP	23824327
MIRT645631	hsa-miR-3191-5p	HITS-CLIP	23824327
MIRT645630	hsa-miR-6888-3p	HITS-CLIP	23824327
MIRT645629	hsa-miR-6818-3p	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT634283	hsa-miR-4643	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT634282	hsa-miR-466	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT616939	hsa-miR-362-3p	HITS-CLIP	23824327
MIRT616938	hsa-miR-329-3p	HITS-CLIP	23824327
MIRT616937	hsa-miR-8485	HITS-CLIP	23824327
MIRT616936	hsa-miR-603	HITS-CLIP	23824327
MIRT616935	hsa-miR-4789-3p	HITS-CLIP	23824327
MIRT616934	hsa-miR-3941	HITS-CLIP	23824327
MIRT1407836	hsa-miR-1233	CLIP-seq
MIRT1407837	hsa-miR-1252	CLIP-seq
MIRT1407838	hsa-miR-128	CLIP-seq
MIRT1407839	hsa-miR-129-3p	CLIP-seq
MIRT1407840	hsa-miR-132	CLIP-seq
MIRT1407841	hsa-miR-181a	CLIP-seq
MIRT1407842	hsa-miR-181b	CLIP-seq
MIRT1407843	hsa-miR-181c	CLIP-seq
MIRT1407844	hsa-miR-181d	CLIP-seq
MIRT1407845	hsa-miR-204	CLIP-seq
MIRT1407846	hsa-miR-211	CLIP-seq
MIRT1407847	hsa-miR-212	CLIP-seq
MIRT1407848	hsa-miR-2355-5p	CLIP-seq
MIRT1407849	hsa-miR-3125	CLIP-seq
MIRT1407850	hsa-miR-3158-3p	CLIP-seq
MIRT1407851	hsa-miR-3182	CLIP-seq
MIRT1407852	hsa-miR-3618	CLIP-seq
MIRT1407853	hsa-miR-3664-5p	CLIP-seq
MIRT1407854	hsa-miR-3668	CLIP-seq
MIRT1407855	hsa-miR-3680	CLIP-seq
MIRT1407856	hsa-miR-384	CLIP-seq
MIRT1407857	hsa-miR-3916	CLIP-seq
MIRT1407858	hsa-miR-3938	CLIP-seq
MIRT1407859	hsa-miR-4261	CLIP-seq
MIRT1407860	hsa-miR-4262	CLIP-seq
MIRT1407861	hsa-miR-4270	CLIP-seq
MIRT1407862	hsa-miR-4441	CLIP-seq
MIRT1407863	hsa-miR-4476	CLIP-seq
MIRT1407864	hsa-miR-4496	CLIP-seq
MIRT1407865	hsa-miR-4522	CLIP-seq
MIRT1407866	hsa-miR-4533	CLIP-seq
MIRT1407867	hsa-miR-4654	CLIP-seq
MIRT1407868	hsa-miR-4676-5p	CLIP-seq
MIRT1407869	hsa-miR-4685-5p	CLIP-seq
MIRT1407870	hsa-miR-4755-5p	CLIP-seq
MIRT1407871	hsa-miR-4769-5p	CLIP-seq
MIRT1407872	hsa-miR-4798-3p	CLIP-seq
MIRT1407873	hsa-miR-514	CLIP-seq
MIRT1407874	hsa-miR-514b-3p	CLIP-seq
MIRT1407875	hsa-miR-516a-3p	CLIP-seq
MIRT1407876	hsa-miR-548m	CLIP-seq
MIRT1407877	hsa-miR-563	CLIP-seq
MIRT1407878	hsa-miR-575	CLIP-seq
MIRT1407879	hsa-miR-583	CLIP-seq
MIRT1407880	hsa-miR-606	CLIP-seq
MIRT1407881	hsa-miR-623	CLIP-seq
MIRT1407882	hsa-miR-642b	CLIP-seq
MIRT1407883	hsa-miR-651	CLIP-seq
MIRT1407884	hsa-miR-934	CLIP-seq
MIRT1407885	hsa-miR-938	CLIP-seq
MIRT2122293	hsa-miR-2054	CLIP-seq
MIRT2122294	hsa-miR-380	CLIP-seq
MIRT2122295	hsa-miR-4517	CLIP-seq
MIRT2344559	hsa-miR-329	CLIP-seq
MIRT2344560	hsa-miR-4789-5p	CLIP-seq
MIRT2344561	hsa-miR-885-5p	CLIP-seq
MIRT2395484	hsa-miR-451b	CLIP-seq
MIRT2395485	hsa-miR-4696	CLIP-seq
MIRT2395486	hsa-miR-577	CLIP-seq
MIRT2637917	hsa-miR-1185	CLIP-seq
MIRT1407838	hsa-miR-128	CLIP-seq
MIRT2637918	hsa-miR-3161	CLIP-seq
MIRT2637919	hsa-miR-3194-3p	CLIP-seq
MIRT2344559	hsa-miR-329	CLIP-seq
MIRT2637920	hsa-miR-3605-5p	CLIP-seq
MIRT2637921	hsa-miR-3617	CLIP-seq
MIRT1407854	hsa-miR-3668	CLIP-seq
MIRT2637922	hsa-miR-3679-5p	CLIP-seq
MIRT2637923	hsa-miR-4536	CLIP-seq
MIRT1407867	hsa-miR-4654	CLIP-seq
MIRT1407871	hsa-miR-4769-5p	CLIP-seq
MIRT2637924	hsa-miR-576-3p	CLIP-seq
MIRT2637925	hsa-miR-591	CLIP-seq
MIRT2637926	hsa-miR-641	CLIP-seq
MIRT1407882	hsa-miR-642b	CLIP-seq
MIRT2637917	hsa-miR-1185	CLIP-seq
MIRT1407838	hsa-miR-128	CLIP-seq
MIRT2692575	hsa-miR-1298	CLIP-seq
MIRT2692576	hsa-miR-28-5p	CLIP-seq
MIRT2692577	hsa-miR-3139	CLIP-seq
MIRT2692578	hsa-miR-3150b-3p	CLIP-seq
MIRT2637918	hsa-miR-3161	CLIP-seq
MIRT2637919	hsa-miR-3194-3p	CLIP-seq
MIRT2344559	hsa-miR-329	CLIP-seq
MIRT2637920	hsa-miR-3605-5p	CLIP-seq
MIRT2637921	hsa-miR-3617	CLIP-seq
MIRT1407854	hsa-miR-3668	CLIP-seq
MIRT2637922	hsa-miR-3679-5p	CLIP-seq
MIRT2637923	hsa-miR-4536	CLIP-seq
MIRT1407867	hsa-miR-4654	CLIP-seq
MIRT2692579	hsa-miR-4689	CLIP-seq
MIRT1407871	hsa-miR-4769-5p	CLIP-seq
MIRT2692580	hsa-miR-4784	CLIP-seq
MIRT2692581	hsa-miR-539	CLIP-seq
MIRT2637924	hsa-miR-576-3p	CLIP-seq
MIRT2637925	hsa-miR-591	CLIP-seq
MIRT2637926	hsa-miR-641	CLIP-seq
MIRT1407882	hsa-miR-642b	CLIP-seq
MIRT2692582	hsa-miR-708	CLIP-seq

Transcription factors

Transcription factor	Regulation	Reference
ONECUT2	Repression	16831872

Gene ontology (GO) Show/Hide all (31)

GO ID	Ontology	Definition	Evidence	Reference
GO:0001778	Process	Plasma membrane repair	IDA	27325790
GO:0005515	Function	Protein binding	IPI	25416956, 31515488, 32296183, 33961781
GO:0005543	Function	Phospholipid binding	IEA
GO:0005543	Function	Phospholipid binding	ISS
GO:0005768	Component	Endosome	IDA	19966785
GO:0005886	Component	Plasma membrane	IBA
GO:0005886	Component	Plasma membrane	IEA
GO:0005886	Component	Plasma membrane	ISS
GO:0005886	Component	Plasma membrane	TAS
GO:0006886	Process	Intracellular protein transport	IEA
GO:0006887	Process	Exocytosis	IBA
GO:0006887	Process	Exocytosis	IEA
GO:0008270	Function	Zinc ion binding	IEA
GO:0016020	Component	Membrane	IEA
GO:0030073	Process	Insulin secretion	IEA
GO:0030141	Component	Secretory granule	IEA
GO:0030658	Component	Transport vesicle membrane	IEA
GO:0031092	Component	Platelet alpha granule membrane	TAS
GO:0031267	Function	Small GTPase binding	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0032418	Process	Lysosome localization	IMP	2732579
GO:0042043	Function	Neurexin family protein binding	IBA
GO:0042043	Function	Neurexin family protein binding	IEA
GO:0042043	Function	Neurexin family protein binding	ISS
GO:0045921	Process	Positive regulation of exocytosis	IMP	19966785
GO:0046676	Process	Negative regulation of insulin secretion	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0050714	Process	Positive regulation of protein secretion	IMP	19966785
GO:0070382	Component	Exocytic vesicle	IBA
GO:0071985	Process	Multivesicular body sorting pathway	IMP	19966785
GO:1905684	Process	Regulation of plasma membrane repair	IMP	2732579

Other IDs

• MIM: 300723
• HGNC: 15588
• e!Ensembl: ENSG00000102362

Protein

• UniProt ID: Q96C24
• Protein name: Synaptotagmin-like protein 4 (Exophilin-2) (Granuphilin)
• Protein function: Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
• PDB: 2CSZ , 3FDW , 5X6T
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	526 → 635	C2 domain	Domain
  PF00168	C2	371 → 480	C2 domain	Domain
  PF02318	FYVE_2	8 → 123	FYVE-type zinc finger	Family

• Sequence:

  MSELLDLSFLSEEEKDLILSVLQRDEEVRKADEKRIRRLKNELLEIKRKGAKRGSQHYSD
  RTCARCQESLGRLSPKTNTCRGCNHLVCRDCRIQESNGTWRCKVCAKEIELKKATGDWFY
  DQKVNRFAYRTGSEIIRMSLRHKPAVSKRETVGQSLLHQTQMGDIWPGRKIIQERQKEPS
  VLFEVPKLKSGKSALEAESESLDSFTADSDSTSRRDSLDKSGLFPEWKKMSAPKSQVEKE
  TQPGGQNVVFVDEGEMIFKKNTRKILRPSEYTKSVIDLRPEDVVHESGSLGDRSKSVPGL
  NVDMEEEEEEEDIDHLVKLHRQKLARSSMQSGSSMSTIGSMMSIYSEAGDFGNIFVTGRI
  AFSLKYEQQTQSLVVHVKECHQLAYADEAKKRSNPYVKTYLLPDKSRQGKRKTSIKRDTI
  NPLYDETLRYEIPESLLAQRTLQFSVWHHGRFGRNTFLGEAEIQMDSWKLDKKLDHCLPL
  HGKISAESPTGLPSHKGELVVSLKYIPASKTPVGGDRKKSKGGEGGELQVWIKEAKNLTA
  AKAGGTSDSFVKGYLLPMRNKASKRKTPVMKKTLNPHYNHTFVYNGVRLEDLQHMCLELT
  VWDREPLASNDFLGGVRLGVGTGISNGEVVDWMDSTGEEVSLWQKMRQYPGSWAEGTLQL
  RSSMAKQKLGL

• Sequence length: 671

Pathways

Reactome Pathway:

Platelet degranulation

Related Genes

No strongly related genes found yet for SYTL4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SYTL4.