SYT5 (synaptotagmin 5)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 6861
• Gene name: Synaptotagmin 5
• Gene symbol: SYT5
• Synonyms (NCBI Gene): -
• Chromosome: 19
• Chromosome location: 19q13.42|11p
• Summary: Synaptotagmins, such as SYT5, are a family of type III membrane proteins characterized by cytoplasmic repeats related to protein kinase C (see MIM 176960) regulatory (C2) domains, which are thought to bind calcium. Synaptotagmins may act both as negative

miRNA Show/Hide all (207)

miRTarBase ID	miRNA	Experiments	Reference
MIRT017244	hsa-miR-335-5p	Microarray	18185580
MIRT541577	hsa-miR-8485	HITS-CLIP	21572407
MIRT541576	hsa-miR-603	HITS-CLIP	21572407
MIRT541574	hsa-miR-342-3p	HITS-CLIP	21572407
MIRT541575	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT541577	hsa-miR-8485	HITS-CLIP	23313552
MIRT541576	hsa-miR-603	HITS-CLIP	23313552
MIRT625039	hsa-miR-4643	HITS-CLIP	23313552
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT633233	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT633232	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT633231	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT633230	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT633233	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT633232	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT633231	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT633230	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT633233	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT633232	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT633231	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT633230	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	24906430
MIRT541576	hsa-miR-603	HITS-CLIP	24906430
MIRT541574	hsa-miR-342-3p	HITS-CLIP	24906430
MIRT541575	hsa-miR-377-3p	HITS-CLIP	24906430
MIRT541577	hsa-miR-8485	HITS-CLIP	24906430
MIRT541576	hsa-miR-603	HITS-CLIP	24906430
MIRT541574	hsa-miR-342-3p	HITS-CLIP	24906430
MIRT541575	hsa-miR-377-3p	HITS-CLIP	24906430
MIRT541577	hsa-miR-8485	PAR-CLIP	21572407
MIRT541576	hsa-miR-603	PAR-CLIP	21572407
MIRT541574	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT541575	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT439491	hsa-miR-544a	HITS-CLIP	24374217
MIRT439491	hsa-miR-544a	HITS-CLIP	24374217
MIRT541574	hsa-miR-342-3p	HITS-CLIP	27418678
MIRT541574	hsa-miR-342-3p	HITS-CLIP	27418678
MIRT541574	hsa-miR-342-3p	HITS-CLIP	27418678
MIRT541575	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT541575	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT541575	hsa-miR-377-3p	HITS-CLIP	27418678
MIRT625039	hsa-miR-4643	HITS-CLIP	27418678
MIRT625039	hsa-miR-4643	HITS-CLIP	27418678
MIRT541576	hsa-miR-603	HITS-CLIP	27418678
MIRT541576	hsa-miR-603	HITS-CLIP	27418678
MIRT541576	hsa-miR-603	HITS-CLIP	27418678
MIRT541577	hsa-miR-8485	HITS-CLIP	27418678
MIRT541577	hsa-miR-8485	HITS-CLIP	27418678
MIRT541577	hsa-miR-8485	HITS-CLIP	27418678
MIRT541577	hsa-miR-8485	HITS-CLIP	21572407
MIRT541576	hsa-miR-603	HITS-CLIP	21572407
MIRT541574	hsa-miR-342-3p	HITS-CLIP	21572407
MIRT541575	hsa-miR-377-3p	HITS-CLIP	21572407
MIRT541577	hsa-miR-8485	HITS-CLIP	23313552
MIRT541576	hsa-miR-603	HITS-CLIP	23313552
MIRT625039	hsa-miR-4643	HITS-CLIP	23313552
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT633233	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT633232	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT633231	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT633230	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT633233	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT633232	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT633231	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT633230	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT633233	hsa-miR-6856-3p	HITS-CLIP	23824327
MIRT633232	hsa-miR-449b-3p	HITS-CLIP	23824327
MIRT633231	hsa-miR-4691-3p	HITS-CLIP	23824327
MIRT633230	hsa-miR-139-5p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT625039	hsa-miR-4643	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	HITS-CLIP	23824327
MIRT541576	hsa-miR-603	HITS-CLIP	23824327
MIRT541574	hsa-miR-342-3p	HITS-CLIP	23824327
MIRT541575	hsa-miR-377-3p	HITS-CLIP	23824327
MIRT541577	hsa-miR-8485	PAR-CLIP	21572407
MIRT541576	hsa-miR-603	PAR-CLIP	21572407
MIRT541574	hsa-miR-342-3p	PAR-CLIP	21572407
MIRT541575	hsa-miR-377-3p	PAR-CLIP	21572407
MIRT2344466	hsa-miR-148a	CLIP-seq
MIRT2344467	hsa-miR-148b	CLIP-seq
MIRT2344468	hsa-miR-152	CLIP-seq
MIRT2344469	hsa-miR-1587	CLIP-seq
MIRT2344470	hsa-miR-1909	CLIP-seq
MIRT2344471	hsa-miR-4492	CLIP-seq
MIRT2344472	hsa-miR-4498	CLIP-seq
MIRT2344473	hsa-miR-4519	CLIP-seq
MIRT2344474	hsa-miR-4656	CLIP-seq
MIRT2344475	hsa-miR-4675	CLIP-seq
MIRT2344476	hsa-miR-4741	CLIP-seq
MIRT2344477	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (35)

GO ID	Ontology	Definition	Evidence	Reference
GO:0000149	Function	SNARE binding	IBA
GO:0000149	Function	SNARE binding	IEA
GO:0001786	Function	Phosphatidylserine binding	IEA
GO:0005509	Function	Calcium ion binding	IDA	27793683
GO:0005544	Function	Calcium-dependent phospholipid binding	IBA
GO:0005544	Function	Calcium-dependent phospholipid binding	IEA
GO:0005546	Function	Phosphatidylinositol-4,5-bisphosphate binding	IEA
GO:0005768	Component	Endosome	IEA
GO:0005886	Component	Plasma membrane	IBA
GO:0007268	Process	Chemical synaptic transmission	TAS	9177789
GO:0016020	Component	Membrane	IEA
GO:0016192	Process	Vesicle-mediated transport	IBA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IBA
GO:0017158	Process	Regulation of calcium ion-dependent exocytosis	IEA
GO:0019905	Function	Syntaxin binding	IEA
GO:0030276	Function	Clathrin binding	IEA
GO:0030424	Component	Axon	IBA
GO:0030672	Component	Synaptic vesicle membrane	IBA
GO:0030672	Component	Synaptic vesicle membrane	IEA
GO:0031045	Component	Dense core granule	IBA
GO:0031045	Component	Dense core granule	IEA
GO:0031410	Component	Cytoplasmic vesicle	IEA
GO:0043005	Component	Neuron projection	IEA
GO:0043025	Component	Neuronal cell body	IEA
GO:0045202	Component	Synapse	IEA
GO:0046872	Function	Metal ion binding	IEA
GO:0046982	Function	Protein heterodimerization activity	IEA
GO:0048471	Component	Perinuclear region of cytoplasm	IEA
GO:0055038	Component	Recycling endosome membrane	IEA
GO:0061891	Function	Calcium ion sensor activity	IBA
GO:0070382	Component	Exocytic vesicle	IBA
GO:0099012	Component	Neuronal dense core vesicle membrane	IEA
GO:0099502	Process	Calcium-dependent activation of synaptic vesicle fusion	IBA
GO:1990769	Component	Proximal neuron projection	IEA
GO:2000300	Process	Regulation of synaptic vesicle exocytosis	IBA

Other IDs

• MIM: 600782
• HGNC: 11513
• e!Ensembl: ENSG00000129990

Protein

• UniProt ID: O00445
• Protein name: Synaptotagmin-5 (Synaptotagmin V) (SytV)
• Protein function: May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent s
• PDB: 5H4Y , 5H4Z
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00168	C2	254 → 371	C2 domain	Domain
  PF00168	C2	123 → 229	C2 domain	Domain

• Sequence:

  MFPEPPTPGPPSPDTPPDSSRISHGPVPPWALATIVLVSGLLIFSCCFCLYRKSCRRRTG
  KKSQAQAQVHLQEVKGLGQSYIDKVQPEVEELEPAPSGPGQQVADKHELGRLQYSLDYDF
  QSGQLLVGILQAMGLAALDLGGSSDPYVRVYLLPDKRRRYETKVHRQTLNPHFGETFAFK
  VPYVELGGRVLVMAVYDFDRFSRNDAIGEVRVPMSSVDLGRPVQAWRELQAAPREEQEKL
  GDICFSLRYVPTAGKLTVIVLEAKNLKKMDVGGLSDPYVKVHLLQGGKKVRKKKTTIKKN
  TLNPYYNEAFSFEVPCDQVQKVQVELTVLDYDKLGKNEAIGRVAVGAAAGGAGLRHWADM
  LANPRRPIAQWHSLRPPDRVRLLPAP

• Sequence length: 386

Related Genes

No strongly related genes found yet for SYT5.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SYT5.