SUSD4 (sushi domain containing 4)

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Gene miRNA Gene ontology Other IDs Protein Related genes Diseases linked via similar genes

Gene

• Entrez ID: 55061
• Gene name: Sushi domain containing 4
• Gene symbol: SUSD4
• Synonyms (NCBI Gene): PRO222
• Chromosome: 1
• Chromosome location: 1q41

miRNA Show/Hide all (103)

miRTarBase ID	miRNA	Experiments	Reference
MIRT439504	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT439504	hsa-miR-218-5p	HITS-CLIP	23212916
MIRT1404064	hsa-miR-190	CLIP-seq
MIRT1404065	hsa-miR-190b	CLIP-seq
MIRT1404066	hsa-miR-2467-5p	CLIP-seq
MIRT1404067	hsa-miR-3201	CLIP-seq
MIRT1404068	hsa-miR-4303	CLIP-seq
MIRT1404069	hsa-miR-4307	CLIP-seq
MIRT1404070	hsa-miR-433	CLIP-seq
MIRT1404071	hsa-miR-4791	CLIP-seq
MIRT1404072	hsa-miR-493	CLIP-seq
MIRT1554336	hsa-miR-1285	CLIP-seq
MIRT1554337	hsa-miR-1587	CLIP-seq
MIRT1554338	hsa-miR-3126-3p	CLIP-seq
MIRT1554339	hsa-miR-3187-5p	CLIP-seq
MIRT1554340	hsa-miR-3192	CLIP-seq
MIRT1554341	hsa-miR-378g	CLIP-seq
MIRT1554342	hsa-miR-4486	CLIP-seq
MIRT1554343	hsa-miR-4492	CLIP-seq
MIRT1554344	hsa-miR-4498	CLIP-seq
MIRT1554345	hsa-miR-4505	CLIP-seq
MIRT1554346	hsa-miR-4656	CLIP-seq
MIRT1554347	hsa-miR-4663	CLIP-seq
MIRT1554348	hsa-miR-4675	CLIP-seq
MIRT1554349	hsa-miR-4741	CLIP-seq
MIRT1554350	hsa-miR-610	CLIP-seq
MIRT1554351	hsa-miR-612	CLIP-seq
MIRT1554352	hsa-miR-762	CLIP-seq
MIRT1920940	hsa-miR-4709-3p	CLIP-seq
MIRT1920940	hsa-miR-4709-3p	CLIP-seq
MIRT1920940	hsa-miR-4709-3p	CLIP-seq
MIRT2121212	hsa-miR-1273f	CLIP-seq
MIRT1554336	hsa-miR-1285	CLIP-seq
MIRT2121213	hsa-miR-143	CLIP-seq
MIRT1554337	hsa-miR-1587	CLIP-seq
MIRT1404064	hsa-miR-190	CLIP-seq
MIRT1404065	hsa-miR-190b	CLIP-seq
MIRT2121214	hsa-miR-3124-3p	CLIP-seq
MIRT1554338	hsa-miR-3126-3p	CLIP-seq
MIRT2121215	hsa-miR-3171	CLIP-seq
MIRT1554339	hsa-miR-3187-5p	CLIP-seq
MIRT1554340	hsa-miR-3192	CLIP-seq
MIRT1404067	hsa-miR-3201	CLIP-seq
MIRT1554341	hsa-miR-378g	CLIP-seq
MIRT1404069	hsa-miR-4307	CLIP-seq
MIRT1554342	hsa-miR-4486	CLIP-seq
MIRT1554343	hsa-miR-4492	CLIP-seq
MIRT1554344	hsa-miR-4498	CLIP-seq
MIRT1554345	hsa-miR-4505	CLIP-seq
MIRT1554346	hsa-miR-4656	CLIP-seq
MIRT1554347	hsa-miR-4663	CLIP-seq
MIRT1554348	hsa-miR-4675	CLIP-seq
MIRT2121216	hsa-miR-4708-5p	CLIP-seq
MIRT1554349	hsa-miR-4741	CLIP-seq
MIRT2121217	hsa-miR-4770	CLIP-seq
MIRT1404071	hsa-miR-4791	CLIP-seq
MIRT1404072	hsa-miR-493	CLIP-seq
MIRT1554350	hsa-miR-610	CLIP-seq
MIRT1554351	hsa-miR-612	CLIP-seq
MIRT1554352	hsa-miR-762	CLIP-seq
MIRT2121212	hsa-miR-1273f	CLIP-seq
MIRT1554336	hsa-miR-1285	CLIP-seq
MIRT2121213	hsa-miR-143	CLIP-seq
MIRT1554337	hsa-miR-1587	CLIP-seq
MIRT1554338	hsa-miR-3126-3p	CLIP-seq
MIRT2121215	hsa-miR-3171	CLIP-seq
MIRT1554339	hsa-miR-3187-5p	CLIP-seq
MIRT1554340	hsa-miR-3192	CLIP-seq
MIRT2343152	hsa-miR-3194-5p	CLIP-seq
MIRT2343153	hsa-miR-3689a-3p	CLIP-seq
MIRT2343154	hsa-miR-3689c	CLIP-seq
MIRT1554341	hsa-miR-378g	CLIP-seq
MIRT1554342	hsa-miR-4486	CLIP-seq
MIRT1554343	hsa-miR-4492	CLIP-seq
MIRT1554344	hsa-miR-4498	CLIP-seq
MIRT1554345	hsa-miR-4505	CLIP-seq
MIRT1554346	hsa-miR-4656	CLIP-seq
MIRT1554347	hsa-miR-4663	CLIP-seq
MIRT1554348	hsa-miR-4675	CLIP-seq
MIRT2121216	hsa-miR-4708-5p	CLIP-seq
MIRT2343155	hsa-miR-4728-5p	CLIP-seq
MIRT1554349	hsa-miR-4741	CLIP-seq
MIRT2121217	hsa-miR-4770	CLIP-seq
MIRT1554350	hsa-miR-610	CLIP-seq
MIRT1554351	hsa-miR-612	CLIP-seq
MIRT1554352	hsa-miR-762	CLIP-seq
MIRT1554336	hsa-miR-1285	CLIP-seq
MIRT1554337	hsa-miR-1587	CLIP-seq
MIRT1554338	hsa-miR-3126-3p	CLIP-seq
MIRT1554339	hsa-miR-3187-5p	CLIP-seq
MIRT1554340	hsa-miR-3192	CLIP-seq
MIRT1554341	hsa-miR-378g	CLIP-seq
MIRT1554342	hsa-miR-4486	CLIP-seq
MIRT1554343	hsa-miR-4492	CLIP-seq
MIRT1554344	hsa-miR-4498	CLIP-seq
MIRT1554345	hsa-miR-4505	CLIP-seq
MIRT1554346	hsa-miR-4656	CLIP-seq
MIRT1554347	hsa-miR-4663	CLIP-seq
MIRT1554348	hsa-miR-4675	CLIP-seq
MIRT1554349	hsa-miR-4741	CLIP-seq
MIRT1554350	hsa-miR-610	CLIP-seq
MIRT1554351	hsa-miR-612	CLIP-seq
MIRT1554352	hsa-miR-762	CLIP-seq

Gene ontology (GO) Show/Hide all (13)

GO ID	Ontology	Definition	Evidence	Reference
GO:0002376	Process	Immune system process	IEA
GO:0005515	Function	Protein binding	IPI	32296183
GO:0005576	Component	Extracellular region	IEA
GO:0006958	Process	Complement activation, classical pathway	IEA
GO:0016020	Component	Membrane	IEA
GO:0030449	Process	Regulation of complement activation	IDA	23482636
GO:0030449	Process	Regulation of complement activation	IEA
GO:0045087	Process	Innate immune response	IEA
GO:0045211	Component	Postsynaptic membrane	IEA
GO:0045957	Process	Negative regulation of complement activation, alternative pathway	IDA	23482636
GO:0045959	Process	Negative regulation of complement activation, classical pathway	IDA	23482636
GO:0098688	Component	Parallel fiber to Purkinje cell synapse	IEA
GO:0099149	Process	Regulation of postsynaptic neurotransmitter receptor internalization	IEA

Other IDs

• MIM: 615827
• HGNC: 25470
• e!Ensembl: ENSG00000143502

Protein

• UniProt ID: Q5VX71
• Protein name: Sushi domain-containing protein 4
• Protein function: Acts as a complement inhibitor by disrupting the formation of the classical C3 convertase. Isoform 3 inhibits the classical complement pathway, while membrane-bound isoform 1 inhibits deposition of C3b via both the classical and alternative comp
• Family and domains:

  Pfam

  Accession	ID	Position in sequence	Description	Type
  PF00084	Sushi	180 → 237	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	243 → 302	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	122 → 177	Sushi repeat (SCR repeat)	Domain
  PF00084	Sushi	57 → 117	Sushi repeat (SCR repeat)	Domain

• Tissue specificity: TISSUE SPECIFICITY: Isoform 3 is the predominant isoform in all tissues except cortex, cerebellum, kidney, and breast. Isoform 1 is found primarily in the esophagus and the brain. {ECO:0000269|PubMed:23482636}.
• Sequence:

  MYHGMNPSNGDGFLEQQQQQQQPQSPQRLLAVILWFQLALCFGPAQLTGGFDDLQVCADP
  GIPENGFRTPSGGVFFEGSVARFHCQDGFKLKGATKRLCLKHFNGTLGWIPSDNSICVQE
  DCRIPQIEDAEIHNKTYRHGEKLIITCHEGFKIRYPDLHNMVSLCRDDGTWNNLPICQGC
  LRPLASSNGYVNISELQTSFPVGTVISYRCFPGFKLDGSAYLECLQNLIWSSSPPRCLAL
  EVCPLPPMVSHGDFVCHPRPCERYNHGTVVEFYCDPGYSLTSDYKYITCQYGEWFPSYQV
  YCIKSEQTWPSTHETLLTTWKIVAFTATSVLLVLLLVILARMFQTKFKAHFPPRGPPRSS
  SSDPDFVVVDGVPVMLPSYDEAVSGGLSALGPGYMASVGQGCPLPVDDQSPPAYPGSGDT
  DTGPGESETCDSVSGSSELLQSLYSPPRCQESTHPASDNPDIIASTAEEVASTSPGIDIA
  DEIPLMEEDP

• Sequence length: 490

Related Genes

No strongly related genes found yet for SUSD4.

Diseases Linked via Similar Genes

No additional diseases found yet through genes similar to SUSD4.