Log in to bookmark this gene

Bookmark This Gene

Gene Gene information from NCBI Gene database.
Entrez ID 6612
Gene name Small ubiquitin like modifier 3
Gene symbol SUMO3
Synonyms (NCBI Gene)
SMT3ASMT3H1SUMO-3Smt3B
Chromosome 21
Chromosome location 21q22.3
Summary This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role i
miRNA miRNA information provided by mirtarbase database.
480 Show/Hide all (480)
miRTarBase ID miRNA Experiments Reference
MIRT030396 hsa-miR-24-3p Microarray 19748357
MIRT439508 ebv-miR-BART10-3p HITS-CLIP 22473208
MIRT439508 ebv-miR-BART10-3p HITS-CLIP 22473208
MIRT1403195 hsa-miR-101 CLIP-seq
MIRT1403196 hsa-miR-1179 CLIP-seq
Gene ontology (GO) Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
17 Show/Hide all (17)
GO ID Ontology Definition Evidence Reference
GO:0000776 Component Kinetochore TAS 9119407
GO:0005515 Function Protein binding IPI 17000644, 17099700, 18538659, 22878415, 25416956, 25556234, 27068747, 32296183, 32814053, 33961781, 35914814
GO:0005634 Component Nucleus IBA
GO:0005634 Component Nucleus IDA 21965678
GO:0005634 Component Nucleus IEA
Other IDs Other IDs provides unique identifiers for this gene in OMIM, HGNC, and Ensembl databases.
MIM HGNC e!Ensembl
602231 11124 ENSG00000184900
Protein Protein information from UniProt database.
UniProt ID Unique identifier for the protein in the UniProt database. Click to view detailed protein information.
P55854
Protein name Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Protein function Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation pr
PDB 1U4A , 2IO1 , 2MP2 , 6K5R , 6NNQ , 7R2E , 7ZJU
Family and domains

Pfam

Accession ID Position in sequence Description Type
PF11976 Rad60-SLD 17 → 87 Ubiquitin-2 like Rad60 SUMO-like Family
Tissue specificity TISSUE SPECIFICITY: Expressed predominantly in liver. {ECO:0000269|PubMed:15487983}.
Sequence
Sequence length 103
Interactions View interactions
Pathways Pathway information has different metabolic/signaling pathways associated with genes.
KEGG Pathway Reactome Pathway
Nucleocytoplasmic transport SUMO is proteolytically processed
Fluid shear stress and atherosclerosis SUMOylation of DNA damage response and repair proteins
  SUMOylation of transcription factors
  SUMOylation of transcription cofactors
  SUMOylation of intracellular receptors
  SUMOylation of chromatin organization proteins
  SUMOylation of DNA replication proteins
  SUMOylation of immune response proteins
  Formation of Incision Complex in GG-NER