This gene encodes a member of the small ubiquitin-related modifier (SUMO) family of eukaryotic proteins. The encoded protein is covalently conjugated to other proteins via a post-translation modification known as sumoylation. Sumoylation may play a role i
miRNAmiRNA information provided by mirtarbase database.
Gene ontology (GO)Gene Ontology (GO) annotations describing the biological processes, molecular functions, and cellular components associated with a gene.
Small ubiquitin-related modifier 3 (SUMO-3) (SMT3 homolog 1) (SUMO-2) (Ubiquitin-like protein SMT3A) (Smt3A)
Protein function
Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation pr
["Nucleocytoplasmic transport","Fluid shear stress and atherosclerosis","Formation of Incision Complex in GG-NER","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of intracellular receptors","SUMOylation of transcription factors","SUMOylation of DNA replication proteins","SUMO is proteolytically processed"]
["Formation of Incision Complex in GG-NER","SUMOylation of transcription cofactors","SUMOylation of intracellular receptors","SUMOylation of immune response proteins","SUMOylation of transcription factors","SUMOylation of DNA replication proteins"]
["Nucleocytoplasmic transport","Fluid shear stress and atherosclerosis","Formation of Incision Complex in GG-NER","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of intracellular receptors","SUMOylation of immune response proteins","SUMOylation of transcription factors","SUMOylation of DNA replication proteins","SUMO is proteolytically processed"]
["Nucleocytoplasmic transport","Formation of Incision Complex in GG-NER","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of intracellular receptors","SUMOylation of immune response proteins","SUMOylation of transcription factors","SUMOylation of DNA replication proteins"]
["Formation of Incision Complex in GG-NER","SUMOylation of DNA damage response and repair proteins","SUMOylation of transcription cofactors","SUMOylation of chromatin organization proteins","SUMOylation of intracellular receptors","SUMOylation of transcription factors"]
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Diseases Linked via Similar GenesDiseases curated for genes most similar to SUMO3 (see Related Genes above), that are NOT already directly curated for SUMO3 itself -- a lead worth checking, not a confirmed association.